Chen Mao
Distinguished Scientist (Technology), Small Molecule Pharmaceutical Sciences, Drug Discovery
"I consider it a great privilege to work with so many talented scientists with immensely diverse background, yet all laser focused toward the same goal – to discover and develop best possible medicinal products for patients."
I joined Genentech in 2013 as a Scientist in the Small Molecule Pharmaceutical Sciences department. My primary focus is the development of solid dosage formulations for small molecule drugs. I’m also interested in applying modeling to facilitate material and process understanding in formulation development. I was drawn to Genentech because of its long-standing tradition: unwavering dedication to science and empowerment of scientists in pursuit of best medicines for patients.
Featured Publication
Solubility Advantage (and Disadvantage) of Pharmaceutical Amorphous Solid Dispersions.
J Pharm Sci. 2016 Dec;105(12):3549-3561.
Huang S, Mao C, Williams RO 3rd, Yang CY.
The primary focus of my group is solid dosage formulation development for small molecule pharmaceutical compounds, and materials science topics relevant to dosage form development, manufacturing, and scale up. In particular, we are interested in the behaviors of pharmaceutical powder involved in drug product manufacturing, such as powder flow, compaction, and agglomeration. We investigate these powder behaviors through a combination of experimental and computational tools.
Additionally, we are also interested the supramolecular level characterization of pharmaceutical solids, particularly the multi-component systems such as amorphous solid dispersion. Our main research interest in this area is to combine calorimetric and spectroscopic techniques with phase equilibria and thermodynamics to understand the performance of multi-component pharmaceutical solids, such as solubility, mobility, and phase behavior.
- Purdue University, Ph.D. in Industrial and Physical Pharmacy – 2006
- University of Georgia, M.S. in Biological Engineering – 2002
- Nanjing University of Technology, B.S. in Bioengineering – 1997