David Hackos
Senior Scientist, Neuroscience
Postdoc Mentor
"My passion is to do great science that will someday result in innovative new medicines that will make patient's lives better."
10
Years at Genentech
25
Publications
4
Awards & Honors
Ever since I was a graduate student at the University of California San Francisco, I have been fascinated by the structure, function, and pharmacology of ion channels. These critical proteins form the functional basis of the nervous system, and without them, our neurons would not be able to send signals down their axons or communicate with each other through synaptic transmission. Despite their importance in physiology, ion channels also make excellent drug targets for a variety of neurological disorders, as long as we can figure out how to target them selectively and in the right way. Currently my lab is leading efforts in the development of novel pain drugs that take advantage on ion channels as targets.
Postdoctoral Mentor
Genentech is a place where you can do science at the highest possible level within a highly multi-disciplinary research environment with cutting-edge infrastructure. The postdoc program at Genentech provides a place for young scientists to dive into this environment and make fundamental contributions to our understanding of the biology of neurological disorders, laying the groundwork for the discovery of the next generation of high-impact therapeutics.
Featured Publication
My Focus
One major focus of my lab is the development of selective voltage-gated sodium channel modulators. Our work on Nav1.7, an important pain target, has led to the discovery of a novel binding site that allows the development of highly isoform-selective sodium channel blockers that some day might lead to a revolutionary new type of pain drug. Another focus has been on selective positive allosteric modulators of NMDA receptors, which could lead to new drugs for epilepsy, schizophrenia, or Alzheimer's disease. Also, our work on the human genetics of pain and studies of the circuitry of pain within the spinal cord are yielding new mechanistic insights that may lead to novel ways to target pain in the future.
Publications
Science, ISSN: 10959203 00368075
Thomas Clairfeuille; Alexander Cloake; Daniel T. Infield; José P. Llongueras; Christopher P. Arthur; Zhong Rong Li; Yuwen Jian; Marie-France Martin-Eauclaire; Pierre E. Bougis; Claudio Ciferri; Christopher A. Ahern; Frank Bosmans; David Hackos; Alexis Rohou; Jian Payandeh
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin
Cell, ISSN: 00928674
Hui Xu; Tianbo Li; Alexis Rohou; Christopher P. Arthur; Foteini Tzakoniati; Evera Wong; Alberto Estevez; Christine Kugel; Yvonne Franke; Jun Chen; Claudio Ciferri; David Hackos; Chris Koth; Jian Payandeh
Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV 1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers
Clinical Drug Investigation, ISSN: 11732563
Michael E. Rothenberg; Tagen; Jae H. Chang; Janel Boyce-Rustay; Michel Friesenhahn; David Hackos; Avis Hains; Dan Sutherlin; Michael Ward; William Cho
Clinical Drug Investigation, ISSN: 11791918 11732563
Michael E. Rothenberg; Tagen; Jae H. Chang; Janel Boyce-Rustay; Michel Friesenhahn; David Hackos; Avis Hains; Dan Sutherlin; Michael Ward; William Cho
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Steven J. McKerrall; Teresa Nguyen; Kwong Wah Lai; Philippe Bergeron; Lunbin Deng; Antonio DiPasquale; Jae Chang; Jun Chen; Tania Chernov-Rogan; David Hackos; Jonathan M. Maher; Dan Ortwine; Jodie Pang; Jian Payandeh; Will Proctor; Shannon Shields; Jennifer Vogt; Pengfei Ji; Wenfeng Liu; Elisa Ballini; Lilia Schumann; Glauco Tarozzo; Girish Bankar; Sultan Chowdhury; Abid Hasan; Johnson; Kuldip Khakh; Sophia Lin; Charles J. Cohen; Christoph Dehnhardt; Brian Safina; Dan Sutherlin
Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors
Journal of Neuroscience,
Shannon Shields; Lunbin Deng; Rebecca M. Reese; Michelle Dourado; Janet Tao; Oded Foreman; Jae H. Chang; David Hackos
Cell Reports, ISSN: 22111247
Girish Bankar; Samuel J. Goodchild; Sarah Howard; Karen Nelkenbrecher; Matthew Waldbrook; Michelle Dourado; Noah Shuart; Sophia Lin; Clint Young; Zhiwei Xie; Kuldip Khakh; Elaine Chang; Luis E. Sojo; Andrea Lindgren; Sultan Chowdhury; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Christoph Dehnhardt; Jodie Pang; Jae H. Chang; Brian Safina; Dan Sutherlin; James P. Johnson; David Hackos; C. Lee Robinette; Charles J. Cohen
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Thilo Focken; Sultan Chowdhury; Alla Zenova; Michael Grimwood; Christine Chabot; Tao Sheng; Ivan Hemeon; Shannon M. Decker; Michael Wilson; Paul Bichler; Qi Jia; Shaoyi Sun; Clint Young; Sophia Lin; Samuel J. Goodchild; Noah Shuart; Elaine Chang; Zhiwei Xie; Bowen Li; Kuldip Khakh; Girish Bankar; Matthew Waldbrook; Rainbow Kwan; Karen Nelkenbrecher; Parisa Karimi Tari; Navjot Chahal; Luis E. Sojo; C. Lee Robinette; Andrew D. White; Chien-An Chen; Yi Zhang; Jodie Pang; Jae Chang; David Hackos; Johnson; Charles J. Cohen; Dan Ortwine; Dan Sutherlin; Christoph Dehnhardt; Brian Safina
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Huifen Chen; Matthew Volgraf; Steven Do; Aleksandr Kolesnikov; Daniel Shore; Vishal Verma; Elisia Villemure; Lan Wang; Yong Chen; Baihua Hu; Aijun Lu; Guosheng Wu; Xiaofeng Xu; Po-Wai Yuen; Yamin Zhang; Shawn D. Erickson; Martin Dahl; Christine Brotherton-Pleiss; Suzanne Brown; Justin Ly; Lesley Murray; Jun Chen; Desiree Amm; Wienke Lange; David Hackos; Rebecca M. Reese; Shannon Shields; Joe Lyssikatos; Brian Safina; Tony Estrada
Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Tania Chernov-Rogan; Tianbo Li; Gang Lu; Henry Verschoof; Kuldip Khakh; Steven W Jones; Maureen Beresini; Chang Liu; Dan Ortwine; Steven J. McKerrall; David Hackos; Dan Sutherlin; Charles J. Cohen; Jun Chen
Handbook of Experimental Pharmacology, ISSN: 18650325 01712004
Jian Payandeh; David Hackos
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Shaoyi Sun; Qi Jia; Alla Zenova; Michael S. Wilson; Sultan Chowdhury; Thilo Focken; Jun Li; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Ivan Hemeon; Tao Sheng; Chien-An Chen; Andrew D. White; David Hackos; Lunbin Deng; Girish Bankar; Kuldip Khakh; Elaine Chang; Rainbow Kwan; Sophia Lin; Karen Nelkenbrecher; Ben Sellers; Antonio DiPasquale; Jae H. Chang; Jodie Pang; Luis E. Sojo; Andrea Lindgren; Matthew Waldbrook; Zhiwei Xie; Clint Young; James P. Johnson; C. Lee Robinette; Charles J. Cohen; Brian Safina; Dan Sutherlin; Dan Ortwine; Christoph Dehnhardt
Neuropharmacology, ISSN: 18737064
Tzu-Ming Wang; Brandon M. Brown; Lunbin Deng; Ben Sellers; Patrick Lupardus; Heidi Ackerly Wallweber; Amy Gustafson; Evera Wong; Matthew Volgraf; Jacob Schwarz; David Hackos; Jesse Hanson
Scientific Reports, ISSN: 20452322
Anton V. Sinitskiy; Nathaniel H. Stanley; David Hackos; Jesse Hanson; Ben Sellers; Vijay S. Pande
Nature Communications, ISSN: 20411723
Eugene Chiang; Tianbo Li; Surinder Jeet; Peng; Juan Zhang; Wyne Lee; Jason DeVoss; Patrick Caplazi; Jun Chen; Soren Warming; David Hackos; Susmith Mukund; Chris Koth; Jane Grogan
ACS Medicinal Chemistry Letters, ISSN: 19485875
Elisia Villemure; Matthew Volgraf; Yu Jiang; Guosheng Wu; Cuong Ly; Po-Wai Yuen; Aijun Lu; Xifeng Luo; Mingcui Liu; Shun Zhang; Patrick Lupardus; Heidi Ackerly Wallweber; Bianca Liederer; Gauri Deshmukh; Emile Plise; Suzanne Brown; Tzu-Ming Wang; Jesse Hanson; David Hackos; Kimberly Scearce-Levie; Jacob Schwarz; Ben Sellers
Journal of Medicinal Chemistry, ISSN: 15204804
Matthew Volgraf; Ben Sellers; Yu Jiang; Guosheng Wu; Cuong Ly; Elisia Villemure; Rich Pastor; Po-Wai Yuen; Aijun Lu; Xifeng Luo; Mingcui Liu; Shun Zhang; Liang Sun; Yuhong Fu; Patrick Lupardus; Heidi Ackerly Wallweber; Bianca Liederer; Gauri Deshmukh; Emile Plise; Suzanne Brown; Paul Reynen; James Herrington; Amy Gustafson; Yichin Liu; Akim Dirksen; Matthias G. A. Dietz; Yanzhou Liu; Tzu-Ming Wang; Jesse Hanson; David Hackos; Kimberly Scearce-Levie; Jacob Schwarz
Neuron, ISSN: 10974199
David Hackos; Patrick Lupardus; Teddy Grand; Yelin Chen; Tzu-Ming Wang; Paul Reynen; Amy Gustafson; Heidi Ackerly Wallweber; Matthew Volgraf; Ben Sellers; Jacob Schwarz; Pierre Paoletti; Morgan Sheng; Qiang Zhou; Jesse Hanson
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Vishal Verma; Daniel Shore; Huifen Chen; Jun Chen; Steven Do; David Hackos; Aleksandr Kolesnikov; Joe Lyssikatos; Suzanne Brown; Lan Wang; Tony Estrada
Science, ISSN: 10959203
Shivani Ahuja; Susmith Mukund; Lunbin Deng; Kuldip Khakh; Elaine Chang; Hoangdung Ho; Stephanie Shriver; Clint Young; Sophia Lin; Johnson; Ping Wu; Jun Li; Mary Coons; Christine Tam; Bobby Brillantes; Honorio Sampang; Kyle Mortara; Krista Bowman; Kevin Clark; Alberto Estevez; Zhiwei Xie; Henry Verschoof; Michael Grimwood; Christoph Dehnhardt; Jean-Christophe Andrez; Thilo Focken; Dan Sutherlin; Brian Safina; Melissa Starovasnik; Dan Ortwine; Yvonne Franke; Charles J. Cohen; David Hackos; Chris Koth; Jian Payandeh
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN: 14321912
Jun Chen; David Hackos
PLoS ONE, ISSN: 19326203
Michelle Dourado; Evera Wong; David Hackos
Journal of Neuroscience, ISSN: 02706474
Jesse Hanson; Lunbin Deng; David Hackos; Shih-Ching Lo; Ben Lauffer; Pascal Steiner; Qiang Zhou
Journal of Immunology, ISSN: 00221767
Yan Qu; Shahram Misaghi; Kim Newton; Laurie Appling; Salina Louie; Jim Cupp; George R. Dubyak; David Hackos; Vishva Dixit
British Journal of Pharmacology, ISSN: 14765381
Joel R. Gever; Rothschild Soto; Robert A. Henningsen; Renee S. Martin; David Hackos; Sandip Panicker; Werner Rubas; Ian B. Oglesby; Michael P. Dillon; Marcos E. Milla; Geoffrey Burnstock; Anthony P. D. W. Ford
Education
- University of California, San Francisco, PhD in Biophysics – 1998
- Johns Hopkins University, B.A. in Biophysics – 1991
Awards & Honors
- NIGMS PRAT Program Fellowship Award – 1999-2001
- ARCS Foundation Scholarship Award – 1997-1998
- Howard Hughes Medical Institute Pre-doctoral Fellowship – 1992-1997
- Howard Hughes Medical Institute Undergraduate Fellowship – 1990-1991