Jacqueline M McBride
Senior Scientist, OMNI Biomarker Development
"Imagination is more important than knowledge"
14
Years at Genentech
23
Publications
7
Awards & Honors
I am native Scot and Basic Immunologist. I began my science career at the university of Glasgow in one of the first Immunology degree courses offered in the UK. I continued to grow my passion for science in Europe at the IMP Biocenter in Vienna looking to understand the mechanisms of dendritic cell tolerance. From here I sought to expand my knowledge in Clinical Immunology at Stanford School of medicine and then joined the postdoctoral program at Genentech in Immunology discovery. I soon realized my passion and curiosity was in biotechnology and translational science and joined the OMNI-Biomarker development group in Development Sciences as a Scientist. I currently work as a Scientist and a Biomarker Subteam leader and supporting the development of novel therapeutics such as Influenza A, Etrolizumab, and anti- PD-L1 combos.
Featured Publication
Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: results of a phase I, placebo-controlled, double-blind, dose-escalation study.
Arthritis Rheum. 2012 Nov;64(11):3666-76.
McBride JM, Jiang J, Abbas AR, Morimoto A, Li J, Maciuca R, Townsend M, Wallace DJ, Kennedy WP, Drappa J.
My Focus
I am currently a Scientist and Biomarker subteam leader for both early and late stage development molecules. Internally I collaborate with many functions from research through development to drive the delivery of a safe and efficacious product. Externally I also engage with global thought leaders and investigators, which allows the generation of vital knowledge and technologies in specialized patient populations that inform the development of our clinical candidates. I am accountable for the delivery of both predictive and pharmacodynamics biomarker strategies, providing high quality assays and data. These goal of my work is to enable decision making including refining our knowledge of the MOA of a given molecule, inform dose selection, demonstrating proof of activity in pre-clinical and clinical studies, and mechanistic differentiation from competitor molecules. I am fortunate to have worked in many disease indications including Autoimmune diseases, infectious Diseases and Oncology.
Publications
The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti-integrin therapies
Medicinal Research Reviews, ISSN: 01986325
Iris Dotan; Matthieu Allez; Silvio Danese; Mary Keir; Swati Tole; Jacqueline McBride
In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection
Toxicological Sciences,
Gautham K. Rao; Rodney Prell; Steven Laing; Stefanie C M Burleson; Allen Nguyen; Jacqueline McBride; Crystal Zhang; Daniel Sheinson; Wendy Halpern
Correlation of cytomegalovirus (CMV) disease severity and mortality with CMV viral burden in CMV-seropositive donor and CMV-seronegative solid organ transplant recipients
Open Forum Infectious Diseases,
Jacqueline McBride; Daniel Sheinson; Jenny Jiang; Nicholas Lewin-Koh; Barbara G. Werner; Jennifer K.L. Chow; Xiaoning Wu; Jorge Tavel; David R. Snydman
Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma
Blood Cancer Journal,
A. Keith Stewart; Amrita Y. Krishnan; Seema Singhal; Ralph V. Boccia; Manish R. Patel; Ruben Niesvizky; Chanan-Khan; Sikander Ailawadhi; Jochen Brumm; Kirsten Mundt; Kyu Hong; Jacqueline McBride; Quyen Shon-Nguyen; Yuanyuan Xiao; Vanitha Ramakrishnan; Andy Polson; Divya Samineni; Douglas Leipold; Eric Humke; James Scott McClellan; Jesus G. Berdeja
Cellular mechanisms of etrolizumab treatment in inflammatory bowel disease
Frontiers in Pharmacology,
Charlotte Lichnog; Sha Klabunde; Emily Becker; Franklin Fuh; Philipp Tripal; Raja Atreya; Entcho Klenske; Rich Erickson; Henry Chiu; Chae Reed; Shan Chung; Clemens Neufert; Imke Atreya; Jacqueline McBride; Markus F. Neurath; Sebastian Zundler
Alimentary Pharmacology and Therapeutics, ISSN: 13652036 02692813
Meina Tao Tang; Mary Keir; Rich Erickson; Eric Stefanich; Franklin Fuh; Teresa Ramirez Montagut; Jacqueline McBride; Dimitry Danilenko
Pharmacokinetics and exposure-response analysis of RG7667, a combination of two anticytomegalovirus monoclonal antibodies, in a phase 2a randomized trial to prevent cytomegalovirus infection in high-risk kidney transplant recipients
Antimicrobial Agents and Chemotherapy, ISSN: 00664804
Rong Deng; Yehong Wang; Mauricio Maia; Tracy Burgess; Jacqueline McBride; X. Charlene Liao; Jorge Tavel; William D. Hanley
Reply to hunsberger and memoli, "efficacy analysis in healthy-volunteer influenza challenge trials: Intention to treat"
Antimicrobial Agents and Chemotherapy, ISSN: 00664804
Jacqueline McBride; Jeremy Lim; Tracy Burgess; Rong Deng; Michael Derby; Mauricio Maia; Priscilla Horn; Omer Siddiqui; Daniel Sheinson; Haiyin Chen; Elizabeth Newton; Dimitri Fillos; Denise Nazzal; Carrie Rosenberger; Maikke Ohlson; Rob Lambkin-Williams; Hosnieh Fathi; Jeff Harris; Jorge A. Tavela
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Jacqueline McBride; Jeremy Lim; Tracy Burgess; Rong Deng; Michael Derby; Mauricio Maia; Priscilla Horn; Omer Siddiqui; Daniel Sheinson; Haiyin Chen; Elizabeth Newton; Dimitri Fillos; Denise Nazzal; Carrie Rosenberger; Maikke B. Ohlson; Rob Lambkin-Williams; Hosnieh Fathi; Jeffrey M. Harris; Jorge A. Tavela
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice
Nature Communications,
Janet Lau; Jeanne Cheung; Armando Navarro; Steve Lianoglou; Benjamin Haley; Klara Totpal; Laura Sanders (Strickland); Hartmut Koeppen; Patrick Caplazi; Jacqueline McBride; Henry Chiu; Rebecca Hong Thibodeau; Jane Grogan; Vincent Javinal; Bob Yauch; Bryan Irving; Marcia Belvin; Ira Mellman; Jeong Kim; Maike Schmidt
Antimicrobial Agents and Chemotherapy, ISSN: 10986596
Julie H. Ishida; Anita Patel; Aneesh K. Mehta; Philippe Gatault; Jacqueline McBride; Tracy Burgess; Michael Derby; David R. Snydman; Brinda Emu; Becket Feierbach; Ashley Fouts; Mauricio Maia; Rong Deng; Carrie Rosenberger; Lynn Gennaro; Natalee S. Striano; X. Charlene Liao; Jorge Tavel
British Journal of Pharmacology, ISSN: 14765381
Franklin Fuh; Carrie Looney; Dongwei Li; Kirsten Achilles Poon; Randy Dere; Dimitry Danilenko; Jacqueline McBride; Chae Reed; Shan Chung; Bing Zheng; Rod Mathews; Andy Polson; Saileta Prabhu; Marna Williams
Journal of Infectious Diseases, ISSN: 15376613
Sinthujan Jegaskanda; Catherine Luke; Heather D. Hickman; Mark Y. Sangster; Wendy F. Wieland-Alter; Jacqueline M. McBride; Jon W. Yewdell; Peter Wright; John Treanor; Carrie Rosenberger; Kanta Subbarao
PLoS Pathogens, ISSN: 15537374
Ning Chai; Lee R. Swem; Mike Reichelt; Haiyin Chen; Elizabeth Luis; Summer Park; Ashley Fouts; Patrick Lupardus; Thomas Wu; Olga Li; Jacqueline McBride; Michael Lawrence; Min Xu; Man Wah Tan
mAbs, ISSN: 19420870
Rong Deng; Daniela Yadav; Cinthia Pastuskovas; Andy Boswell; David West; Kyra Cowan; Henry Chiu; Jacqueline McBride; Clarissa Johnson; Yan Xin; Hartmut Koeppen; Maya Leabman; Suhas Iyer
Annals of the Rheumatic Diseases, ISSN: 14682060
Kenneth C. Kalunian; Joan T. Merrill; Romeo Maciuca; Jacqueline McBride; Michael Townsend; Xiaohui Wei; John C. Davis; William Kennedy
Lupus Science and Medicine, ISSN: 20538790
William Kennedy; Romeo Maciuca; Kristen Wolslegel; Wei Tew; Alexander Abbas; Christina Chaivorapol; Alyssa Morimoto; Jacqueline McBride; Paul Brunetta; Bruce C. Richardson; John C. Davis; Tim Behrens; Michael Townsend
Molecular Cancer Therapeutics, ISSN: 15357163
Dongwei Li; Kirsten Achilles Poon; Shang-Fan Yu; Randy Dere; MaryAnn Go; Jeffrey Lau; Bing Zheng; Kristi Elkins; Dimitry Danilenko; Kathy Kozak; Pamela Chan; Josefa Chuh; Lily Shi; Denise Nazzal; Franklin Fuh; Jacqueline McBride; Vanitha Ramakrishnan; Ruth De Tute; Andy Rawstron; Andrew S. Jack; Rong Deng; Wayne Chu; David Dornan; Marna Williams; Bill Ho; Allen Ebens; Saileta Prabhu; Andy Polson
Arthritis and Rheumatism, ISSN: 00043591
Jacqueline McBride; Jenny Jiang; Alexander Abbas; Alyssa Morimoto; Jing Li; Romeo Maciuca; Michael Townsend; Daniel J. Wallace; William Kennedy; Jorn Drappa
Molecular Cancer Therapeutics, ISSN: 15357163
Kristi Elkins; Bing Zheng; MaryAnn Go; Dion Slaga; Changchun Du; Suzie Scales; Shang-Fan Yu; Jacqueline McBride; Ruth De Tute; Andy Rawstron; Andrew S. Jack; Allen Ebens; Andy Polson
Leukemia, ISSN: 08876924
Andy Polson; Marna Williams; Alane Gray; Reina Fuji; Kirsten Achilles Poon; Jacqueline McBride; Helga Raab; Tom Januario; MaryAnn Go; Jeffrey Lau; Shang-Fan Yu; Changchun Du; Franklin Fuh; Christine Tan; Yan Wu; Wei-Ching Liang; Saileta Prabhu; Daniel Stephan; Jo-Anne Hongo; Randy Dere; Rong Deng; Cullen; Ruth De Tute; Bennett; Andy Rawstron; Andrew S. Jack; Allen Ebens
Blood, ISSN: 00064971
David Dornan; Bennett; Yvonne Chen; Mark Dennis; Dan Eaton; Kristi Elkins; Dorothy French; MaryAnn Go; Andrew S. Jack; Jagath Reddy Junutula; Hartmut Koeppen; Jeffrey Lau; Jacqueline McBride; Andy Rawstron; Lily Shi; Nancy Yu; Shang-Fan Yu; Peng Yue; Bing Zheng; Allen Ebens; Andy Polson
Blood, ISSN: 00064971
Asja Praetor; Jacqueline McBride; Henry Chiu; Linda Rangell; Lorena Cabote; Wyne Lee; Jim Cupp; Dimitry Danilenko; Sherman Fong
Education
- Genentech , Post-Doctoral studies – 2006
- Stanford School of Medicine Post, Doctoral studies in Clinical Immunology – 2002
- University of Vienna, Ph.D. Microbiology – 2001
- University of Glasgow, BSc Honors Immunology – 1997
Awards & Honors
- Recognition Award: Teamwork and collaboration – 2016
- Key Contributor Award Development Sciences – 2016
- Recognition Award: Achieving results – 2015
- Recognition Award: Achieving results – 2014
- Recognition Award –Significant Contribution – 2013
- Recognition Award- Significant Contribution – 2011
- Recognition Award -Significant Contribution – 2010