Genentech: Jacqueline M McBride | Director and Principal Scientist, OMNI Biomarker Development

Scientists / Our Scientists

"Imagination is more important than knowledge"

Years at Genentech

Publications at Genentech

Awards & Honors

I am native Scot and Basic Immunologist. I began my science career at the university of Glasgow in one of the first Immunology degree courses offered in the UK. I continued to grow my passion for science in Europe at the IMP Biocenter in Vienna looking to understand the mechanisms of dendritic cell tolerance. From here I sought to expand my knowledge in Clinical Immunology at Stanford School of medicine and then joined the postdoctoral program at Genentech in Immunology discovery. I soon realized my passion and curiosity was in biotechnology and translational science and joined the OMNI-Biomarker development group in Development Sciences as a Scientist. I currently work as a Scientist and a Biomarker Subteam leader and supporting the development of novel therapeutics such as Influenza A, Etrolizumab, and anti- PD-L1 combos.

Featured Publication

Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: results of a phase I, placebo-controlled, double-blind, dose-escalation study.

Arthritis Rheum. 2012 Nov;64(11):3666-76.

McBride JM, Jiang J, Abbas AR, Morimoto A, Li J, Maciuca R, Townsend M, Wallace DJ, Kennedy WP, Drappa J.

View Abstract

I am currently a Scientist and Biomarker subteam leader for both early and late stage development molecules. Internally I collaborate with many functions from research through development to drive the delivery of a safe and efficacious product. Externally I also engage with global thought leaders and investigators, which allows the generation of vital knowledge and technologies in specialized patient populations that inform the development of our clinical candidates. I am accountable for the delivery of both predictive and pharmacodynamics biomarker strategies, providing high quality assays and data. These goal of my work is to enable decision making including refining our knowledge of the MOA of a given molecule, inform dose selection, demonstrating proof of activity in pre-clinical and clinical studies, and mechanistic differentiation from competitor molecules. I am fortunate to have worked in many disease indications including Autoimmune diseases, infectious Diseases and Oncology.

Etrolizumab versus adalimumab or placebo as induction therapy for moderately to severely active ulcerative colitis (HIBISCUS): two phase 3 randomised, controlled trials

The Lancet Gastroenterology and Hepatology, ISSN: 24681253

David T Rubin; Iris Dotan; Aaron DuVall; Yoram Bouhnik; Graham Radford-Smith; Peter D R Higgins; Daniel S. Mishkin; Pablo Arrisi; Astrid Scalori; Young S. Oh; Swati Tole; Akiko Chai; Kirsten Chamberlain-James; Stuart Lacey; Jacqueline McBride; Julián Panés; Rustem Abdulkhakov; Norasiah Abu Bakar; Humberto Aguilar; Diego Aizenberg; Hale Akpinar; Evangelos Akriviadis; Olga Alexeeva; Bagdadi Alikhanov; Andres Alvarisqueta; Ashwin Ananthakrishnan; Jane Andrews; Tomasz Arlukowicz; Nathan Atkinson; Ozlen Atug; Mauro Bafutto; Jozef Balaz; George Bamias; Marko Banic; Andrey Baranovsky; Guerino Barbalaco Neto; Metin Basaranoglu; Curtis Baum; Stefan Baydanov; William Bennetts; Fatih Besisik; Sudhir Bhaskar; Andrzej Bielasik; Leonid Bilianskyi; Bahri Bilir; Pavol Blaha; Verle Bohman; Julia Borissova; Vladimir Borzan; Francisco Javier Bosques Padilla; James Brooker; Tetiana Budko; Igor Budzak; Ivan Bunganic; Jonathon Chapman; Azlida Che' Aun; Tatiana Chernykh; Michael Chiorean; Ivan Chopey; Dimitrios Christodoulou; Pui Shan Chu; Galina Chumakova; Andrew Cummins; Robert Cunliffe; Mirjana Cvetkovic; Ulku Dagli; Wit Cezary Danilkiewicz; Olena Datsenko; Carlos Fernando De Magalhães Francesconi; Henry Debinski; Elena Deminova; Jelena Derova; John Nik Ding; Julia Dmitrieva; Oleg Dolgikh; Tomas Douda; Piotr Drobinski; Gerald Dryden; Pedro Duarte Gaburri; George Aaron DuVall; Dvorkin; Craig Ennis; Yusuf Erzin; Galyna Fadieienko; Oleksandr Fediv; Olga Fedorishina; Miroslav Fedurco; Roland Fejes; Jorge Fernandez; Monica Lorena Fernandez; Lucky Flores; Bradley Freilich; Keith Friedenberg; Sergio Fuster; Beata Gawdis-Wojnarska; Fabio Leonel Gil Parada; Edgardo Daniel Gimenez; Nataliia Golovchenko; Oleksandr Golovchenko; Maciej Gonciarz; Glenn Gordon; Milos Gregus; Vladimir Grinevich; Rogelio Guajardo Rodriguez; Stephen Hall; John Hanson; Marek Hartleb; Xavier Hebuterne; Peter Hendy; Robert Herring; Peter Higgins; Raouf Hilal; Ida Normiha Hilmi; Tibor Hlavaty; Richard Holman; Gerald Holtmann; John Hong; Frantisek Horvath; Ihor Hospodarskyy; Irena Hrstic; Sadettin Hulagu; Luis Alberto Ibarra Verdugo; Ikechukwu Ibegbu; Stephen Inns; Vladimir Ivashkin; James Izanec; Rajesh Jain; Zofia Jamrozik-Kruk; Victor Kamburov; John Karagiannis; Tarkan Karakan; Marek Karczewski; Irina Kasherininova; Seymour Katz; Barry Kaufman; Edita Kazenaite; Irina Kholina; Sunil Khurana; Anzela Kiselevska; Dariusz Kleczkowski; Volodymyr Klymenko; Slavko Knezevic; Malgorzata Kondusz-Szklarz; Natalya Korablina; Bartosz Korczowski; Lyubomir Kosturkov; Iskren Kotzev; Georgios Kouklakis; Ioannis Koutroubakis; Richard Krause; Ian Kronborg; Miodrag Krstic; Zeljko Krznaric; Mikolaj Krzyzanowski; Grazyna Kulig; Karin Kull; Limas Kupcinskas; Mark Lamet; Tatjana Latinovic Radakovic; Rupert Leong; Wai Keung Leung; Henry Levine; Michael Kin Kong Li; Lúcia Libanez Bessa Campelo Braga; Maria Livzan; Tetiana Lohdanidi; Maria Helena Louzada Pereira; John Lowe; Kresimir Luetic; Milan Lukas; Yurii Lymar; Finlay Macrae; Anu Mäelt; Igor Maev; Arkadiusz Mamos; Gerasimos Mantzaris; Benno Margus; Ivanka Marinova; Inna Markevych; Mario Markov; Srdjan Markovic; Juan Ricardo Marquez Velasquez; Felipe Mazzoleni; Konstantinos Mimidis; Brent Mitchell; Gregory Moore; Luis Alonso Morales Garza; Salvatore Moscatello; Yuriy Mostovoy; Reme Mountifield; Aleksandar Nagorni; Viacheslav Neshta; Andrey Obrezan; Oleksandr Oliinyk; Genoile Oliveira Santana Silva; Maria Orzeszko; Vladimir Pavlenko; Dimitar Pavlov; Mariana Penkova; Sasa Peric; Plamen Petkov; Asen Petrov; Plamen Petrov; Michaela Petrova; Raymond Phillips; Sergio Pintor Chacon; Igor Polianskyi; Ludmyla Prystupa; Mykhailo Pugach; Aldis Pukitis; Jiri Pumprla; Volodymyr Pyrogovskyy; Istvan Racz; Raja Affendi Raja Ali; Daniel Ramos Castañeda; Odery Ramos Júnior; David Rausher; Andrey Rebrov; Jaroslaw Regula; Amir Rezk; Viktoriia Reznikova; Iaroslava Rishko; Xavier Roblin; Grigory Rodoman; Carlos Arturo Rojas Rodriguez; Jerzy Rozciecha; David Rubin; Maciej Rupinski; Jacek Rzucidlo; Oleg Sablin; Halil Sahin; Douglas Samuel; Antonio Scafuto Scotton; Robert Schnabel; Michael Schulman; Michael Schultz; John Scott; Shahriar Sedghi; Ahmad Shaban; Marina Shapina; Natalia Shaposhnikova; Oksana Shchukina; Alex Sherman; Irina Shumikhina; Vladimir Simanenkov; Vladislav Simonov; Giedrius Simulionis; Igor Skrypnyk; Zbigniew Sliwowski; Jan Smid; Mahmood Solaiman; Najm Soofi; Konstantinos Soufleris; Zoia Spassova; Mykola Stanislavchuk; Krystyna Stec-Michalska; Jonathas Stifft; Simeon Stoinov; Girgina Stoyanova; Keith Sultan; Lindsey Surace; Dimitar Takov; Jaak Tälli; Ludmila Tankova; Hugo Tanno; Dino Tarabar; Elias Tarakji; Konstantin Tchernev; Lena Thin; Carlton Thomas; Irina Tishaeva; Tsveta Todorova; Oleksandr Tokarenko; Ivars Tolmanis; Ratko Tomasevic; Vasiliy Trofimov; Zsolt Tulassay; Belkis Unsal; Alma Uzunova-Genova; John F Valentine; Ekaterina Valuyskikh; Eduardo Vasconcellos; Galina Vasileva; Sergiy Vasylyuk; Byron Vaughn; Francisco Velazquez; Vadym Vizir; Borislav Vladimirov; Miroslava Volfova; Petr Vyhnalek; Ian Wallace; Marek Waluga; William Watkins; John Weber; Anna Wiechowska-Kozlowska; Nathaniel Winstead; Pawel Wojtkiewicz; Barbara Wozniak-Stolarska; Bruce R. Yacyshyn; Alexey Yakovlev; Ziad Younes; Lígia Yukie Sassaki; Ilhami Yuksel; Jan Zachar; Cyrla Zaltman; Natasa Zdravkovic Petrovic; Vyacheslav Zhdan; Maryna Zinchenko; Maciej Zymla

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Jacqueline M McBride

Director and Principal Scientist, OMNI Biomarker Development

Featured Publication

Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: results of a phase I, placebo-controlled, double-blind, dose-escalation study.