Laetitia Comps-Agrar

The main focus of my lab is to support large molecule therapeutic candidate identification and characterization in a highly collaborative environment. This involves establishing and implementing state-of-the-art technologies enabling the development of functional and bioanalytical assays such as potency, PD biomarker, pharmacokinetic, immunogenicity and stability assays. A particular emphasis is put on identifying physiologically relevant assays that can help predict clinical efficacy and impact the development of lead candidates.

In addition, my lab also supports identification of complex mechanism of actions of candidate molecules by combining cell based biophysical and structure function approaches with identification of cell-signaling pathways activated following target engagement.

I especially have a strong interest in studying protein:protein interactions in a healthy versus a diseased context and understand the impact of therapeutics on these interactions. To this end, my lab has participated in understanding the biology of several cancer immunology targets.

• University of Montpellier II, France, Ph.D. in Molecular Pharmacology – 2010
• University of Montpellier II, France, M.S. in Biotechnology – 2006
• Paul Sabatier University, Toulouse III, France, B.S. in Biotechnology – 2005

• Genentech Key Contributor Award – 2019
• Industrial Ph.D. Fellowship, CIFRE - ANRT – 2006