Noel Dybdal
Director and Principal Scientist, Safety Assessment Pathology, Department of Development Sciences
"The environment at Genentech is always stimulating and the opportunity to work with some of the brightest and most innovative scientists imaginable working toward a common and urgent goal of providing new and better options for patients is continuously rewarding. The urgency of our mission drives us to bring our best selves to work every day."
27
Years at Genentech
32
Publications
1
Awards & Honors
Following completion of residency training in Pathology and post-doctoral work in Endocrine Pathology, I joined Genentech as a Scientist-Pathologist in 1992. I was most attracted by the Genentech reputation for rigor. Happily, given my interest and training in pathology, receptor ligand biology and radioimmunoassay and immunohistochemistry techniques, I became involved early with the oncology program teams, in particular the anti-HER2 projects. My responsibilities have also included growing the Safety Assessment Pathology group to meet the needs of all Genentech programs.
Featured Publication
Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab.
Breast Cancer Res Treat. 2005 Sep; 93(1): 3-11.
Dybdal N, Leiberman G, Anderson S, McCune B, Bajamonde A, Cohen RL, Mass RD, Sanders C, Press MF.
My Focus
Providing expertise in pathology, veterinary medicine and comparative medicine to enhance the timely development of safe Genentech medicines. Working in a highly collaborative environment with colleagues from across the gRED and Product Development to design and implement programs in support of optimal drug candidate development at Genentech. Building and supporting an industry leading Safety Assessment Pathology group. Actively driving innovation in preclinical drug development approaches, supporting and participating in internal and cross-industry efforts to increase drug development efficiency and success while building data to support regulatory acceptance.
Publications
AAPS Journal, ISSN: 15507416
Danielle Mandikian; Isabel Figueroa; Amy Oldendorp; Hanine Rafidi; Sheila Ulufatu; Michelle Schweiger; Jessica Couch; Noel Dybdal; Sean B. Joseph; Saileta Prabhu; Greg Ferl; Andy Boswell
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Jinze Li; Eric Morinello; Thomas Larsen; Denzil Frost; Ivor Caro; Stephen Gould; Lisa Wong; Angela Hendricks; Noel Dybdal; Donna Dambach; Melissa Schutten
Placental and fetal effects of onartuzumab, a Met/HGF signaling antagonist, when administered to pregnant cynomolgus monkeys
Toxicological Sciences, ISSN: 10966080
Prell; Noel Dybdal; Akihiro Arima; Yutaka Chihaya; Ihsan Nijem; Wendy Halpern
Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X
Helen Prior; Anna Bottomley; Pascal Champéroux; Jason Cordes; Eric Delpy; Noel Dybdal; Nick Edmunds; Mike Engwall; Mike Foley; Michael Hoffmann; Robert Kaiser; Ken Meecham; Stéphane Milano; Aileen Milne; Rick Nelson; Brian Roche; Jean-Pierre Valentin; Gemma Ward; Kathryn Chapman
Cell Death and Disease, ISSN: 20414889
Christina de Zafra; Avi Ashkenazi; Walter Darbonne; Melissa Cheu; Klara Totpal; Shirley Ortega; Heather Flores; Mark D. Walker; Bruce Kabakoff; Lum; Barbara J. Mounho-Zamora; Scot Marsters; Noel Dybdal
Journal of Veterinary Internal Medicine, ISSN: 19391676
Page; Baneux; Vail; Duda; Olson; Anestidou; Noel Dybdal; Golab; Shelton; Salgaller; Hardy
Science Translational Medicine, ISSN: 19466242
Laura Sun; Diego Ellerman; Mary Mathieu; Maria Hristopoulos; Xiaocheng Chen; Yijin Li; Xiaojie Yan; Robyn Clark; Art Reyes; Eric Stefanich; Elaine Mai; Judy Young; Clarissa Johnson; Mahrukh Huseni; Grace Wang; Yvonne Chen; Peiyin Wang; Hong Wang; Noel Dybdal; Wayne Chu; Nicholas Chiorazzi; Justin Scheer; Teemu Junttila; Klara Totpal; Mark Dennis; Allen Ebens
Toxicology and Applied Pharmacology, ISSN: 0041008X
Kirsten Achilles Poon; Kelly Flagella; Joe Beyer; Jack (Jay) Tibbitts; Surinder Kaur; Ola Saad; Joo-Hee Yi; Sandhya Girish; Noel Dybdal; Theresa Reynolds
Toxicological Sciences, ISSN: 10966080
Rebecca Erickson; Jacqueline Tarrant; Gary Cain; Sock-Cheng Lewin-Koh; Noel Dybdal; Harvey Wong; Beth Blackwood; Kristina West; Ronald Steigerwalt; Michael Mamounas; John Flygare; Kenjie Amemiya; Donna Dambach; Wayne Fairbrother; Dolo Diaz
Journal of Pharmacological and Toxicological Methods, ISSN: 10568719
Leishman; Beck; Noel Dybdal; Gallacher; Guth; Holbrook; Brian Roche; Wallis
Journal of Equine Veterinary Science, ISSN: 07370806
Christiana M. Glover; Lisa M. Miller; Noel Dybdal; Alfonso Lopez; Wendy M. Duckett; Dianne McFarlane
Toxicologic Pathology, ISSN: 01926233
Darrell L. Tuomari; Ramon K. Kemp; Rani Sellers; John T. Yarrington; Frank J. Geoly; Xavier L. M. Fouillet; Noel Dybdal; Rick Perry
Cancer Immunology, Immunotherapy, ISSN: 03407004
Camellia Adams; David Allison; Kelly Flagella; Leonard G. Presta; Janet B. Clarke; Noel Dybdal; Kathleen McKeever; Mark Sliwkowski
American Journal of Veterinary Research, ISSN: 00029645
Dianne McFarlane; Lisa M. Miller; Linden E. Craig; Noel Dybdal; Perry L. Habecker; Margaret A. Miller; Jon S. Patterson; Alastair E. Cribb
Breast Cancer Research and Treatment, ISSN: 01676806
Noel Dybdal; Grazyna Leiberman; Steven M. Anderson; Bryan McCune; Alex Bajamonde; Robert Cohen; Robert Mass; Corsee Sanders; Michael F. Press
Journal of Neuroendocrinology, ISSN: 09538194
Dianne McFarlane; Noel Dybdal; Donaldson; Lisa M. Miller; Alastair E. Cribb
Clinical Breast Cancer, ISSN: 15268209
Robert Mass; Michael F. Press; Steven M. Anderson; Melody A. Cobleigh; Charles L. Vogel; Noel Dybdal; Grazyna Leiberman; Dennis J. Slamon; Ginny Paton
Drug Metabolism and Disposition, ISSN: 00909556
Hong Xiang; Cindy Nguyen; Sean Kelley; Noel Dybdal; Escandon
Seminars in Oncology, ISSN: 00937754
Pamela Klein; Noel Dybdal
Biomaterials, ISSN: 01429612
Franklin W. Okumu; Le Dao; Paul Fielder; Noel Dybdal; Dennis A. Brooks; Samir Sane; Jeffrey L. Cleland
Histopathology, ISSN: 03090167
Hartmut Koeppen; Barbara D. Wright; Burt; Phil Quirke; McNicol; Noel Dybdal; Mark Sliwkowski; Kenneth Hillan
Drug Metabolism and Disposition, ISSN: 00909556
Cindy Nguyen; Louise A. Harris; Szonyi; Sharon A. Baughman; Victoria Grace Hale; Noel Dybdal; Michael Sadick; Escandon
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN: 10795642
Renhui Yang; Lyn Powell-Braxton; Annie Ko Ogaoawara; Noel Dybdal; Stuart Bunting; Osamu Ohneda; Hongkui Jin
Compendium on Continuing Education for the Practicing Veterinarian, ISSN: 01931903
Michel Levy; Janice E. Sojka; Noel Dybdal
Nature Medicine, ISSN: 10788956
Lyn Powell-Braxton; Murielle Véniant; Richard D. Latvala; Ken-Ichi Hirano; Wesley B. Won; Jed Ross; Noel Dybdal; Connie Zlot; Stephen G. Young; Nicholas O. Davidson
Lupus, ISSN: 09612033
Verthelyi; Noel Dybdal; Kathleen Ann Elias; Klinman
Annals of the New York Academy of Sciences, ISSN: 00778923
Sharma; Kelly Elizabeth Hagler; Noel Dybdal; Chronwall
Diabetes, ISSN: 00121797
Bruce H. Hultgren; Xiaojian Huang; Noel Dybdal; Timothy A. Stewart
Annals of Neurology, ISSN: 15318249
Wei-Qiang Gao; Noel Dybdal; Natasha Shinsky; Amy Murnane; Charles Schmelzer; Mark Siegel; Gilbert-Andre Keller; Franz F. Hefti; Heidi Phillips; John Winslow
Current Biology, ISSN: 09609822
David Hoke; Mebius; Noel Dybdal; Don Dowbenko; Peter Gribling; Carrie Kyle; Susanne Baumhueter; Susan Watson
Immunity, ISSN: 10747613
Xiaojian Huang; Bruce H. Hultgren; Noel Dybdal; Timothy A. Stewart
Blood, ISSN: 00064971
Susanne Baumhueter; Noel Dybdal; Carrie Kyle; Laurence A. Lasky
Education
- University of California, Davis, Ph.D. in Comparative Pathology – 1989
- University of California, Davis, D.V.M. – 1981
- University of California, Davis, M.A. in Endocrinology – 1977
- University of California, Davis, B.S. in Animal Physiology – 1973
Awards & Honors
- Diplomate, American College of Veterinary Pathology –