Shahram Misaghi - Technical Development Prin Scientist, Cell Culture and Bioprocess Operations (CCBO)

Shahram Misaghi

Technical Development Prin Scientist, Cell Culture and Bioprocess Operations (CCBO)

Postdoc Mentor
"A hypothesis should not be a fixed concept, it should change and evolve based on data and new findings and as scientists, we should constantly challenge our hypotheses."
Years at Genentech
Publications at Genentech
Awards & Honors

I am a principal scientist and a group leader at the Cell Culture and Bioprocess Operations (CCBO) department at Genentech. I joined the CCBO department in 2010, after completing my postdoctoral work here at Genentech in Physiological Chemistry department under supervision of Dr. Vishva Dixit.

My educational background is as following:

  • Associate Science: Merritt Community College (Peralta community colleges), Oakland, California.
  • Bachelor: University of California Berkeley, Molecular and Cell Biology.
  • PhD: Harvard University, Biological and Biomedical Sciences (Hidde Ploegh lab).
  • Post-doctoral fellow at Massachusetts Institute of Technology (MIT, Ploegh lab).
  • Post-doctoral fellow at Genentech (Vishva Dixit lab).

Postdoctoral Mentor

As a current postdoc mentor and previous Genentech postdoc, I am very proud of our postdoc program. Every postdoc brings with himself/herself new and exciting ways to look at and solve problems. Postdocs want to learn and discover and, in the process, they help us to think and look outside of the box. I truly enjoy interacting with these brilliant minds and believe that as mentors we should foster, support, and supervise them so that they become independent and confident researchers, as they will be leading our science into the future.

Featured Publication

UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD.

J Cell Biol. 2020 Jul 6;219(7):e201908087. doi: 10.1083/jcb.201908087

Tang D, Sandoval W, Lam C, Haley B, Liu P, Xue D, Roy D, Patapoff T, Louie S, Snedecor B, Misaghi S.

Pyruvate Kinase Muscle-1 Expression Appears to Drive Lactogenic Behavior in CHO Cell Lines, Triggering Lower Viability and Productivity: A Case Study.

Biotechnol J. 2019 Apr;14(4):e1800332. doi: 10.1002/biot.201800332

Tang D, Subramanian J, Haley B, Baker J, Luo L, Hsu W, Liu P, Sandoval W, Laird MW, Snedecor B, Shiratori M, Misaghi S.

FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality.

Louie S, Haley B, Marshall B, Heidersbach A, Yim M, Brozynski M, Tang D, Lam C, Petryniak B, Shaw D, Shim J, Miller A, Lowe JB, Snedecor B, Misaghi S.

Biotechnol Bioeng. 2017 Mar;114(3):632-644.