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Scientists / Our Scientists

Weiru Wang

Principal Scientist, Structural Biology

Postdoc Mentor

Years at Genentech

Publications

I started my lab at Genentech in June 2007. Being a scientist at Genentech is both exciting and challenging. I enjoy having the privilege of collaborating with many extremely talented colleagues. Together, we harness opportunities to discover basic science and to translate them into innovative medicine that we hope can make a difference in patients’ lives. My lab has interests in understanding the molecular basis of protein-drug interactions using biophysical methods, primarily macromolecular crystallography. At Genentech, our drug discovery efforts aim at tackling protein targets with “atomic precision”. My lab’s research provides structural insights into disease-related biological molecules, and enables structure-based design of small-molecule and antibody drugs.

Prior to Genentech, I was a senior scientist in Structural Biology at Plexxikon, a biotech start-up in Berkeley, CA, where I worked on drug discovery programs for cancer and metabolic disorder. Prior to Plexxikon, I was a staff scientist in the Physical Biosciences Division at Lawrence Berkeley National Laboratory, where I worked on structural genomics projects.

Featured Publication

Small-molecule ligands bind to a distinct pocket in RAS and inhibit nucleotide exchange activity.

(2012) Proc Natl Acad Sci USA, 109(14):5299-304

Maurer T, Garrenton LS, Oh A, Pitts K, Anderson DJ, Skelton NJ, Fauber BP, Pan B, Malek S, Stokoe D, Ludlam MJ, Bowman KK, Wu J, Giannetti AM, Starovasnik MA, Mellman I, Jackson PK, Rudolph J, Wang W, Fang G.

View Abstract

My lab’s research activities are focused on the structure determination of drug targets, mostly in the field of oncology and neurodegeneration.

Co-crystallography is vital to structure-based drug design. We collaborate with Medicinal Chemistry and Antibody Engineering on multiple drug discovery projects.

On the basic research side, we have interests in gaining structural insights into biological molecules and molecular assemblies with therapeutic importance. We expect that such knowledge can provide the basis for developing future drug discovery strategy.

We also play a critical role in technology development. An important aspect of my lab’s activity is to improve and implement the high-throughput crystallography platform within the Structural Biology Department.

Disruption of IRE1α through its kinase domain attenuates multiple myeloma

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Jonathan Harnoss; Adrien Le Thomas; Anna Shemorry; Scot Marsters; David Lawrence; Min Lu; Yung-Chia Ariel Chen; Jing Qing; Klara Totpal; David Kan; Ehud Segal; Mark Merchant; Mike Reichelt; Heidi Ackerly Wallweber; Weiru Wang; Kevin Clark; Susan Kaufman; Maureen Beresini; Steven T. Laing; Wendy Sandoval; Maria Lorenzo; Jiansheng Wu; Justin Ly; Tom De Bruyn; Amy Heidersbach; Benjamin Haley; Alvin Gogineni; Robby Weimer; Dong Lee; Marie-Gabrielle Braun; Joachim Rudolph; Michael J. VanWyngarden; Daniel W. Sherbenou; Patricia Gomez-Bougie; Amiot; Diego Acosta-Alvear; Peter Walter; Avi Ashkenazi

Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2

Proceedings of the National Academy of Sciences of the United States of America,

Laurel M. Pegram; Jennifer C. Liddle; Yao Xiao; Maria Hoh; Johannes Rudolph; Dylan B. Iverson; Guy Vigers; Darin Smith; Hailong Zhang; Weiru Wang; John Moffat; Natalie G. Ahn

Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies

Bioconjugate Chemistry, ISSN: 10431802

Nicholas Vance; Neelie Zacharias; Mark Ultsch; Ginny Li; Aimee Fourie; Peter Liu; Julien Lafrance-Vanasse; James Ernst; Wendy Sandoval; Kathy Kozak; Gail Phillips; Weiru Wang; Jack D. Sadowsky

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer

Structure,

Ping Wu; Christopher J. Sneeringer; Keith E. Pitts; Eric S. Day; Bryan Chan; Binqing Wei; Isabelle Lehoux; Kyle Mortara; Hong Li; Jiansheng Wu; Yvonne Franke; John Moffat; Jane Grogan; Tim Heffron; Weiru Wang

Erratum to: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells (Nature Chemical Biology, (2018), 14, 6, (582-590), 10.1038/s41589-018-0035-2)

Nature Chemical Biology, ISSN: 15524469 15524450

Aaron Nile; Felipe de Sousa e Melo; Susmith Mukund; Robert Piskol; Simon Hansen; Lijuan Zhou; Yingnan Zhang; Yue Fu; Emily Gogol; László Kömüves; Zora Modrusan; Stephane Angers; Yvonne Franke; Chris Koth; Wayne Fairbrother; Weiru Wang; Frederic De Sauvage; Rami Hannoush

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Weiru Wang

Principal Scientist, Structural Biology

Featured Publication

Small-molecule ligands bind to a distinct pocket in RAS and inhibit nucleotide exchange activity.