Genentech: Publications

January 11, 2016

A quantitative investigation of linker histone interactions with nucleosomes and chromatin

Scientific Reports, ISSN: 20452322

Alison E. White; Aaron R. Hieb; Karolin Luger

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January 11, 2016

Ubiquitin in the activation and attenuation of innate antiviral immunity

Journal of Experimental Medicine, ISSN: 15409538 00221007

Steven M. Heaton; Natalie A. Borg; Vishva M. Dixit

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January 7, 2016

Randomized phase 2 study of obinutuzumab monotherapy in symptomatic, Previously untreated chronic lymphocytic leukemia

Blood, ISSN: 15280020 00064971

John C. Byrd; Joseph M. Flynn; Thomas J. Kipps; Michael Boxer; Kathryn S. Kolibaba; David J. Carlile; Guenter Fingerle-Rowson; Nicola Tyson; Jamie Hirata; Jeff P. Sharman

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January 7, 2016

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

Nature, ISSN: 14764687 00280836

Elaine E. Storm; Durinck; Felipe de Sousa e Melo; Jarrod Tremayne; Noelyn Kljavin; Christine Tan; Ye; Cecilia Chiu; Thinh Q. Pham; Hongo; Travis W. Bainbridge; Ron Firestein; Elizabeth M. Blackwood; Ciara Metcalfe; Eric Stawiski; Robert Yauch; Yan Wu; Frederic J. De Sauvage

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January 6, 2016

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

Neuron, ISSN: 10974199 08966273

Y. Joy Yu Zuchero; Xiaocheng Chen; Nga Bien-Ly; Daniela Bumbaca; Raymond K. Tong; Xiaoying Gao; Shuo Zhang; Kwame Hoyte; Wilman Luk; Melanie A. Huntley; Lilian Phu; Christine Tan; Dara Y. Kallop; Robby M. Weimer; Yanmei Lu; Donald S. Kirkpatrick; James A. Ernst; Ben Chih; Dennis; Ryan J. Watts

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January 5, 2016

Clinical and economic burden of idiopathic pulmonary fibrosis: A retrospective cohort study

BMC Pulmonary Medicine, ISSN: 14712466

Karina Raimundo; Eunice Chang; Michael S. Broder; Kimberly Alexander; James L. Zazzali; Jeffrey J. Swigris

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January 5, 2016

Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling

Structure, ISSN: 18784186 09692126

Cameron Noland; Sarah Gierke; Paul D. Schnier; Jeremy Murray; Wendy N. Sandoval; Meredith Sagolla; Anwesha Dey; Rami N. Hannoush; Wayne J. Fairbrother; Christian N. Cunningham

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January 5, 2016

Chemical de-conjugation for investigating the stability of small molecule drugs in antibody-drug conjugates

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Tao Chen; Dian Su; Jason Gruenhagen; Christine Gu; Yi Li; Peter M. Yehl; Nik P. Chetwyn; Colin D. Medley

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January 5, 2016

Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma

eLife, ISSN: 2050084X

Andrew R. Conery; Richard C. Centore; Adrianne Neiss; Patricia J. Keller; Shivangi Joshi; Kerry L. Spillane; Peter Sandy; Charlie Hatton; Eneida Pardo; Laura E. Zawadzke; Archana Bommi-Reddy; Karen Gascoigne; Barbara M. Bryant; Jennifer A. Mertz; Robert J. Sims

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January 2, 2016

Optimized method for murine bone marrow collection, fixation and staining for microscopic evaluation

Journal of Histotechnology, ISSN: 20460236 01478885

Marjie Van Hoy; Monika Larson; Victor Nunez; Angela Martzall; Laurie Leong; Oded Foreman; Paula Katavolos

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January 1, 2016

Reply

Ophthalmology, ISSN: 15494713 01616420

Raafay Sophie; Na Lu; Peter A. Campochiaro

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January 1, 2016

Discovery and characterization of hydroxylysine in recombinant monoclonal antibodies

mAbs, ISSN: 19420870 19420862

Qing Xie; Benjamin Moore; Richard L Beardsley

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January 1, 2016

Multi-site N-glycan mapping study 1: Capillary electrophoresis – laser induced fluorescence

mAbs, ISSN: 19420870 19420862

Ákos Szekrényes; Park; Marcia Santos; Clarence Lew; Aled Jones; Ted Haxo; Michael Kimzey; Shiva Pourkaveh; Zoltán Szabó; Zoran Sosic; Peng Feng; Csaba Váradi; Francois De L'Escaille; Jean-Bernard Falmagne; Preeti Sejwal; Thomas Niedringhaus; David A. Michels; Gordon Freckleton; Melissa Hamm; Anastasiya Manuilov; Melissa Schwartz; Jiann-Kae Luo; Jonathan van Dyck; Pui-King Leung; Marcell Olajos; Yingmei Gu; Kai Gao; Wenbo Wang; Jo Wegstein; Samnang Tep; András Guttman

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January 1, 2016

The INNs and outs of antibody nonproprietary names

mAbs, ISSN: 19420870 19420862

Tim D. Jones; Paul J. Carter; Pluckthun; Max Vásquez; Robert G. E. Holgate; Isidro Hötzel; Andrew G. Popplewell; Paul W. H. I. Parren; Markus Enzelberger; Hendrik J. Rademaker; Michael R. Clark; David C. Lowe; Bassil I. Dahiyat; Victoria Smith; John M. Lambert; Herren Wu; Mary Reilly; John S. Haurum; Stefan Dübel; James S. Huston; Thomas Schirrmann; Richard A. J. Janssen; Martin Steegmaier; Jane A. Gross; Andrew Bradbury; Dennis R. Burton; Dimiter S. Dimitrov; Kerry A. Chester; Martin J. Glennie; Julian Davies; Adam Walker; Steve Martin; John McCafferty; Matthew P. Baker

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January 1, 2016

Estimating the population benefits and costs of Rituximab therapy in the United States from 1998 to 2013 using real-world data

Medical Care, ISSN: 15371948 00257079

Mark Danese; Carolina Reyes; Michelle Gleeson; Marc Halperin; Sandra Skettino; Joseph Mikhael

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January 1, 2016

Application of a plug-and-play immunogenicity assay in cynomolgus monkey serum for ADCs at early stages of drug development

Journal of Immunology Research, ISSN: 23147156 23148861

Montserrat Carrasco-Triguero; Helen Davis; Yuda Zhu; Daniel A. Coleman; Denise Nazzal; Paul Vu; Surinder Kaur

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January 1, 2016

Detecting Data Quality Issues in Clinical Trials: Current Practices and Recommendations

Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790

David Knepper; Christian Fenske; Patrick Nadolny; Alun Bedding; Elena Gribkova; John Polzer; Jennifer Neumann; Brett Wilson; Joanne Benedict; Andy Lawton

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January 1, 2016

VH-VL orientation prediction for antibody humanization candidate selection: A case study

mAbs, ISSN: 19420870 19420862

Alexander Bujotzek; Florian Lipsmeier; Seth F. Harris; Jörg Benz; Andreas Kuglstatter; Guy J. Georges

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January 1, 2016

Quantitative evaluation of first, second, and third generation hairpin systems reveals the limit of mammalian vector-based RNAi

RNA Biology, ISSN: 15558584 15476286

Colin K. Watanabe; Trinna L. Cuellar; Benjamin Haley

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January 1, 2016

Short-Term Efficacy Reliably Predicts Long-Term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-Based Meta-Analysis

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Yehong Wang; Rui Zhu; Jim J. Xiao; John C. Davis; Jaap W. Mandema; Jin Y. Jin; Meina Tao Tang

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January 1, 2016

Preexisting antibodies to an F(ab′)2 Antibody therapeutic and novel method for immunogenicity assessment

Journal of Immunology Research, ISSN: 23147156 23148861

Jane Ruppel; Ann Brady; Rebecca Elliott; Cecilia Leddy; Marco Palencia; Daniel A. Coleman; Jessica A. Couch; Eric Wakshull

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January 1, 2016

De novo guanine biosynthesis but not the riboswitch-regulated purine salvage pathway is required for Staphylococcus aureus infection in vivo

Journal of Bacteriology, ISSN: 10985530 00219193

Eric M. Kofoed; Donghong Yan; Anand K. Katakam; Mike Reichelt; Baiwei Lin; Janice Kim; Summer Park; Shailesh V. Date; Ian R. Monk; Min Xu; Cary D. Austin; Till Maurer; Man-Wah Tan

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January 1, 2016

Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Wendy Lee; James J. Crawford; Ignacio Aliagas; Lesley J. Murray; Suzanne Tay; Weiru Wang; Christopher E. Heise; Klaus P. Hoeflich; Hank La; Simon Mathieu; Robert Mintzer; Sreemathy Ramaswamy; Lionel Rouge; Joachim Rudolph

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January 1, 2016

Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Jun Liang; Birong Zhang; Sharada Labadie; Daniel F. Ortwine; Maia Vinogradova; James R. Kiefer; Victor S Gehling; Jean-Christophe Harmange; Richard T Cummings; Tommy Lai; Jiangpeng Liao; Xiaoping Zheng; Yichin Liu; Amy Gustafson; Erica Vanderporten; Weifeng Mao; Bianca M. Liederer; Gauri Deshmukh; Marie Classon; Patrick Trojer; Peter Dragovich; Lesley J. Murray

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January 1, 2016

Identification of potent, selective KDM5 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Victor S Gehling; Steve Bellon; Jean-Christophe Harmange; Yves Leblanc; Florence Poy; Shobu Odate; Shane Buker; Fei Lan; Shilpi Arora; Kaylyn E Williamson; Peter Sandy; Richard T Cummings; Christopher Bailey; Louise Bergeron; Weifeng Mao; Amy Gustafson; Yichin Liu; Erica Vanderporten; James E. Audia; Patrick Trojer; Brian K Albrecht

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January 1, 2016

Assessment of placental transfer and the effect on embryo-fetal development of a humanized monoclonal antibody targeting lymphotoxin-alpha in non-human primates

Reproductive Toxicology, ISSN: 18731708 08906238

Hong Wang; Chris Schuetz; Akihiro Arima; Yutaka Chihaya; Gerhard F. Weinbauer; Gunnar Habermann; Jim J. Xiao; Cynthia Woods; Jane L. Grogan; Thomas R. Gelzleichter; Cain

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January 1, 2016

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers

Oncotarget, ISSN: 19492553

Sonja C. Lueck; Annika C. Russ; Ursula Botzenhardt; Richard F. Schlenk; Zobel; Deshayes; Domagoj Vucic; Hartmut Doḧner; Konstanze Döhner; Fulda; Lars Bullinger

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January 1, 2016

In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats

Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782

Karen E. Parrish; Jialin Mao; Jacob Z. Chen; Allan Jaochico; Justin Ly; Quynh Ho; Sophie Mukadam; Matthew Wright

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January 1, 2016

Evaluation of a 3-hydroxypyridin-2-one (2,3-HOPO) based macrocyclic chelator for 89Zr4+ and its use for immunoPET imaging of HER2 positive model of ovarian carcinoma in mice

Theranostics, ISSN: 18387640

Jeff N. Tinianow; Darpan N. Pandya; Sylvie L. Pailloux; Annie Ogasawara; Alexander N. Vanderbilt; Herman S. Gill; Simon P. Williams; Thaddeus J. Wadas; Darren Magda; Jan Marik

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January 1, 2016

HER2-targeted polyinosine/polycytosine therapy inhibits tumor growth and modulates the tumor immune microenvironment

Cancer immunology research, ISSN: 23266074 23266066

Maya Zigler; Alexei Shir; Salim Joubran; Anna Sagalov; Shoshana Klein; Nufar Edinger; Jeffrey Lau; Shang-Fan Yu; Gabriel Mizraji; Anat Globerson Levin; Mark X. Sliwkowski; Alexander Levitzki

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January 1, 2016

Recent Advances in Assessing Immunogenicity of Therapeutic Proteins: Impact on Biotherapeutic Development

Journal of Immunology Research, ISSN: 23147156 23148861

Yanmei Lu; Leslie A. Khawli; Shobha Purushothama; Frank-Peter Theil; Michael A. Partridge

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January 1, 2016

Knockout and humanised animal models to study membrane transporters in drug development

RSC Drug Discovery Series, ISSN: 20413211 20413203

Nico Scheer; Xiaoyan Chu; Laurent Salphati; Zamek-Gliszczynski

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January 1, 2016

Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies

Journal of Immunology Research, ISSN: 23147156 23148861

Michael A. Partridge; Shobha Purushothama; Chinnasamy Elango; Yanmei Lu

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January 1, 2016

Malignancy rates in patients with rheumatoid arthritis treated with tocilizumab

RMD Open, ISSN: 20565933

Rubbert-Roth; Anthony Sebba; Laura Brockwell; Ariella Kelman; Benjamin Porter-Brown; Jennifer Pulley; Pavel Napalkov; Ronald Van Vollenhoven

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January 1, 2016

Application of LCMS in small-molecule drug development

European Pharmaceutical Review, ISSN: 13608606

Chunang Gu; David J. Russell; Peter M. Yehl

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January 1, 2016

Analogues of DNA minor groove cross-linking agents incorporating aminoCBI, an amino derivative of the duocarmycins: Synthesis, cytotoxicity, and potential as payloads for antibody–drug conjugates

Bioorganic and Medicinal Chemistry, ISSN: 14643391 09680896

Anna C. Giddens; Ho H. Lee; Guo-Liang Lu; Christian K. Miller; Jun Guo; Gail L. Phillips; Thomas H. Pillow; Moana Tercel

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January 1, 2016

Single-step synthesis of 3-hydroxycarbazoles by annulation of electron-rich anilines and quinones

Tetrahedron Letters, ISSN: 18733581 00404039

Eugenia Pushkarskaya; Brian Wong; Chong Han; Simona S. Capomolla; Christine Gu; Brian M. Stoltz; Haiming Zhang

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January 1, 2016

Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma

Oncotarget, ISSN: 19492553

Anne Lynn S. Chang; Karl Lewis; Sarah T. Arron; Michael R. Migden; James A. Solomon; Simon Yoo; Bann-Mo Day; Edward McKenna; Aleksandar Sekulic

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January 1, 2016

Human monoclonal antibody 81.39a effectively neutralizes emerging influenza A viruses of group 1 and 2 hemagglutinins

Journal of Virology, ISSN: 10985514 0022538X

Henju Marjuki; Vasiliy P. Mishin; Ning Chai; Man-Wah Tan; Elizabeth Newton; John Tegeris; Karl Erlandson; Melissa Willis; Joyce Jones; Todd Davis; James Stevens; Larisa V. Gubareva

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January 1, 2016

The Medicinal Chemistry and Commercial Manufacturing behind the Discovery and Development of the Hedgehog Inhibitor Vismodegib

ACS Symposium Series, ISSN: 19475918 00976156

Remy Angelaud; Daniel P. Sutherlin; Mark E. Reynolds; Scott Savage; Andreas Stumpf

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January 1, 2016

The Discovery and Process Chemistry Development of GDC-0084, a Brain Penetrating Inhibitor of PI3K and mTOR

ACS Symposium Series, ISSN: 19475918 00976156

Timothy P. Heffron; Andrew McClory; Andreas Stumpf

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January 1, 2016

Discovery and Process Development of Class i PI3K and Class i PI3K/mTOR Inhibitors GDC-0941 and GDC-0980

ACS Symposium Series, ISSN: 19475918 00976156

Srinivasan Babu; Francis Gosselin; Theresa Humphries; Alan G. Olivero; Daniel P. Sutherlin; Qingping Tian

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January 1, 2016

Periostin levels and eosinophilic inflammation in poorly-controlled asthma

BMC Pulmonary Medicine, ISSN: 14712466

Jodie L. Simpson; Ian A. Yang; John W. Upham; Paul N. Reynolds; Sandra Hodge; Alan L. James; Christine Jenkins; Matthew J. Peters; Guiquan Jia; Cécile T.J. Holweg; Peter G. Gibson

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January 1, 2016

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

Chemical Science, ISSN: 20416539 20416520

Thomas H. Pillow; Jack D. Sadowsky; Donglu Zhang; Shang-Fan Yu; Geoffrey Del Rosario; Keyang Xu; Jintang He; Sunil Bhakta; Rachana Ohri; Katherine R. Kozak; Edward Ha; Jagath R. Junutula; Flygare

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January 1, 2016

Bitpacking techniques for indexing genomes: II. Enhanced suffix arrays

Algorithms for Molecular Biology, ISSN: 17487188

Thomas D Wu

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January 1, 2016

Bitpacking techniques for indexing genomes: I. Hash tables

Algorithms for Molecular Biology, ISSN: 17487188

Thomas D Wu

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January 1, 2016

Natural killer cell granules converge to avoid collateral damage

Journal of Cell Biology, ISSN: 15408140 00219525

Alex T. Ritter; Ira Mellman

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January 1, 2016

Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-An Industry Perspective

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Tonika Bohnert; Aarti H. Patel; Ian E. Templeton; Yuan Chen; Chuang Lu; George Lai; Louis Leung; Susanna Tse; Heidi J. Einolf; Ying-Hong Wang; Michael Sinz; Ralph Stearns; Robert L. Walsky; Wanping Geng; Sirimas Sudsakorn; David J. Moore; Ling He; Jan Wahlstrom; Jim Keirns; Rangaraj Narayanan; Dieter Lang; Xiaoqing Yang

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January 1, 2016

Impact of vial capping on residual seal force and container closure integrity

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Roman Mathaes; Hanns-Christian Mahler; Yves Roggo; Robert Ovadia; Philippe Lam; Oliver B. Stauch; Martin Vogt; Holger Roehl; Joerg Huwyler; Silke Mohl; Alexander Streubel

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January 1, 2016

De-risking immunotherapy: Report of a consensus workshop of the cancer immunotherapy consortium of the cancer research institute

Cancer immunology research, ISSN: 23266074 23266066

Ira Mellman; Vanessa M. Hubbard-Lucey; Matthew J. Tontonoz; Michael D. Kalos; Daniel S. Chen; James P. Allison; Charles G. Drake; Hy Levitsky; Nils Lonberg; Sjoerd H. van der Burg; Douglas T. Fearon; E. John Wherry; Israel Lowy; Robert Hvonderheide; Patrick Hwu

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