Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5601 - 5650 OF 15657 RESULTS

Assessing the Utility of Circular Dichroism and FTIR Spectroscopy in Monoclonal-Antibody Comparability Studies
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Jasper C. Lin; Zephania Kwong Glover; Alavattam Sreedhara
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Cdk8 deletion in the ApcMin murine tumour model represses EZH2 activity and accelerates tumourigenesis
Journal of Pathology, ISSN: 10969896 00223417
Mark L. McCleland; Tim M. Soukup; Scot D. Liu; Jonathan H Esensten; Felipe de Sousa e Melo; Murat Yaylaoglu; Søren Warming; Merone Roose-Girma; Ron Firestein
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Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets
Journal of Clinical Investigation, ISSN: 15588238 00219738
Jessica R. Hitchcock; Charlotte N. Cook; Saeeda Bobat; Ewan A. Ross; Adriana Flores-Langarica; Kate L. Lowe; Mahmood Khan; Coral Dominguez-Medina; Sian Lax; Manuela Carvalho-Gaspar; Stefan Hubscher; Ed Rainger; Mark Cobbold; Christopher D. Buckley; Tim J. Mitchell; Andrea Mitchell; Nick D. Jones; Nico Van Rooijen; Daniel Kirchhofer; Ian R. Henderson; David H. Adams; Steve P. Watson; Adam F. Cunningham
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Phase II pilot study of vemurafenib in patients with metastatic BRAF-mutated colorectal cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Scott Kopetz; Jayesh Desai; Emily Chan; Joel Randolph Hecht; Peter J. O'Dwyer; Dipen Maru; Van Morris; Filip Janku; Arvind Dasari; Woonbook Chung; Jean-Pierre J. Issa; Peter Gibbs; Brian James; Garth Powis; Keith B. Nolop; Suman Bhattacharya; Leonard Saltz
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Fc glycans of therapeutic antibodies as critical quality attributes
Glycobiology, ISSN: 14602423 09596658
Dietmar Reusch; Max L. Tejada
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Langerhans cells from women with cervical precancerous lesions become functionally responsive against human papillomavirus after activation with stabilized Poly-I:C
Clinical Immunology, ISSN: 15217035 15216616
Diane M. Da Silva; Andrew W. Woodham; Joseph G. Skeate; Laurie K. Rijkee; Julia R. Taylor; Heike E. Brand; Laila I. Muderspach; Lynda D. Roman; Annie A. Yessaian; Huyen Q. Pham; Koji Matsuo; Yvonne G. Lin; Greg M. McKee; Andres M. Salazar; Martin Kast
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The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody
Biochemical Journal, ISSN: 14708728 02646021
Claudio Ciferri; Michael T. Lipari; Wei-Ching Liang; Alberto Estevez; Julie Qi Hang; Scott Stawicki; Yan Wu; Paul Moran; J. Michael Elliott; Eigenbrot; Kenneth J. Katschke Jr.; Menno Van Lookeren Campagne; Daniel Kirchhofer
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2015 White Paper on recent issues in bioanalysis: Focus on new technologies and biomarkers (Part 2 - Hybrid LBA/LCMS and input from regulatory agencies)
Bioanalysis, ISSN: 17576199 17576180
Brad Ackermann; Hendrik Neubert; Nicola Hughes; Fabio Garofolo; Lee Abberley; Stephen C. Alley; Patricia Brown-Augsburger; Mark Bustard; Lin-Zhi Chen; Julia Heinrich; Noriko Katori; Surinder Kaur; Leo Kirkovsky; Omar Laterza; Olivier Le Blaye; Ann Lévesque; Gustavo Mendes Lima Santos; Timothy Olah; Natasha Savoie; Michael Skelly; Susan Spitz; Matthew Szapacs; Nilufer Tampal; Jian Wang; Jan Welink; Jaap Wieling; Sam Haidar; Stephen Vinter; Emma Whale; Bärbel Witte
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Protein Aggregation in Frozen Trehalose Formulations: Effects of Composition, Cooling Rate, and Storage Temperature
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Brian D. Connolly; Lan Le; Thomas W. Patapoff; Cromwell; Jamie M. R. Moore; Philippe Lam
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Erratum: A phase 1 dose-escalation study of the safety and pharmacokinetics of once-daily oral foretinib, a multi-kinase inhibitor, in patients with solid tumors (Investigational New Drugs (2013) 31 (742-750) DOI 10.1007/s10637-012-9881-z)
Investigational New Drugs, ISSN: 15730646 01676997
Geoffrey I. Shapiro; Stewart McCallum; Laurel M. Adams; Laurie Sherman; Steve Weller; Suzanne Swann; Harold Keer; Dale Miles; Thomas Müller; Daniel C. Rabe; Fabiola Cecchi; Donald P. Bottaro; Patricia M. LoRusso
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The humanistic and economic burden of providing care for a patient with schizophrenia
International Journal of Social Psychiatry, ISSN: 17412854 00207640
Csilla Csoboth; Edward A. Witt; Kathleen F. Villa; Cedric O'Gorman
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Attitudes and stereotypes in lung cancer versus breast cancer
PLoS ONE, ISSN: 19326203
Sriram; Jennifer Mills; Edward Lang; Holli K. Dickson; Heidi A. Hamann; Brian A. Nosek; Joan H. Schiller
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Effectiveness and safety of post-induction phase bevacizumab treatment for patients with non-small-cell lung cancer: results from the ARIES observational cohort study
Targeted Oncology, ISSN: 1776260X 17762596
Michael Kosty; Antoinette J. Wozniak; Mohammad Jahanzeb; Larry Leon; Susan Fish; Sebastien J. Hazard; Thomas J. Lynch
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Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
Nature Genetics, ISSN: 15461718 10614036
James Bentham; David L. Morris; Deborah S. Cunninghame Graham; Christopher L. Pinder; Philip Tombleson; Timothy W. Behrens; Javier Martin; Benjamin P. Fairfax; Julian C. Knight; Lingyan Chen; Joseph Replogle; Ann-Christine Syvänen; Lars Rönnblom; Robert R. Graham; Joan E. Wither; John D. Rioux; Marta E. Alarcón-Riquelme; Timothy J. Vyse
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Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response
Science Signaling, ISSN: 19379145 19450877
Yonglian Sun; Ivan Peng; Webster; Eric Suto; Justin Lesch; Xiumin Wu; Kate Senger; George Francis; Kathy Barrett; Jenna L. Collier; Jason D. Burch; Meijuan Zhou; Yuan Chen; Connie Chan; Jeffrey Eastham-Anderson; Hai Ngu; Olga Li; Tracy Staton; Charles Havnar; Allan Jaochico; Janet Jackman; Surinc Er Jeet; Lorena Riol-Blanco; Lawren C. Wu; David F. Choy; Joseph R. Arron; Brent Mckenzie; Nico Ghilardi; Moulay Hicham Alaoui Ismaili; Zhonghua Pei; Jason Devoss; Cary D. Austin; Wyne P. Lee; Ali A. Zarrin
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2015 White Paper on recent issues in bioanalysis: Focus on new technologies and biomarkers (Part 3-LBA, biomarkers and immunogenicity)
Bioanalysis, ISSN: 17576199 17576180
Lakshmi Amaravadi; An Song; Heather Myler; Theingi Thway; Susan Kirshner; Viswanath Devanarayan; Yan Ni; Fabio Garofolo; Herbert Birnboeck; Richards; Shalini Gupta; Linlin Luo; Clare Kingsley; Laura Salazar-Fontana; Stephanie Fraser; Boris Gorovits; John Allinson; Troy Barger; Shannon Chilewski; Marianne Scheel Fjording; Sam Haidar; Rafiqul Islam; Birgit Jaitner; John Kamerud; Noriko Katori; Corinna Krinos-Fiorotti; David Lanham; Mark Ma; Jim McNally; Alyssa M. Morimoto; Daniel Mytych; Andre Nogueira Da Costa; Apollon Papadimitriou; Renuka Pillutla; Soma Ray; Afshin Safavi; Natasha Savoie; Martin Schaefer; Judy Shih; John Smeraglia; Michael Skelly; Jeffrey Spond; Roland F Staack; Bruce C. Stouffer; Nilufer Tampal; Albert Torri; Jan Welink; Tong-Yuan Yang; Jad Zoghbi
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Mapping of Fab-1:VEGF Interface Using Carboxyl Group Footprinting Mass Spectrometry
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
Aaron T. Wecksler; Matt S. Kalo; Galahad Deperalta
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Sudden occurrence of Roth spots and retinal hemorrhages following endoscopic adhesiolysis: An SD-OCT evaluation
European Journal of Ophthalmology, ISSN: 11206721
Laura Dell’Arti; Giulio Barteselli; Valentina Pinna; Alessandro Invernizzi; Chiara Mapelli; Francesco Viola
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Multiple gastrointestinal polyps in patients treated with BRAF inhibitors
Clinical Cancer Research, ISSN: 15573265 10780432
Ravi K. Amaravadi; Kathryn E. Hamilton; Xiaohong Ma; Shengfu Piao; Armando Del Portillo; Katherine L. Nathanson; Matteo S. Carlino; Georgina V. Long; Igor Puzanov; Xiaowei Xu; Jennifer J.D. Morrissette; Kenneth Y. Tsai; Keith Flaherty; Jeffrey A. Sosman; Grant R. Goodman; McArthur; Anil K. Rustgi; David C. Metz; Lynn Schuchter; Paul B. Chapman; Antonia R. Sepulveda
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Clinical and economic burden of antineutrophil cytoplasmic antibody-associated vasculitis in the United States
Journal of Rheumatology, ISSN: 14992752 0315162X
Karina Raimundo; Amanda M. Farr; Gilwan Kim; George Duna
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Short communication elucidating the mechanisms of formation for two unusual cytochrome P450-mediated fused ring metabolites of GDC-0623, a MAPK/ERK kinase inhibitor
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Shuguang Ma; Sarah J. Robinson; Qin Yue; Edna F. Choo; S. Cyrus Khojasteh
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Optimizing antibody expression by using the naturally occurring framework diversity in a live bacterial antibody display system
Scientific Reports, ISSN: 20452322
T. Noelle Lombana; Michael Dillon; Jack Bevers; Christoph Spiess
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The value of process capability
Pharmaceutical Engineering, ISSN: 02738139
Roger Nosal; George Millili; Philippe Cini; Julia O'Neil; Dafni Bika; Aaron Goerke; Charles Hoiberg; Steven Tyler; Roel De Meest; Eda Ross Montgomery
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Outcomes with as-needed ranibizumab after initial monthly therapy: Long-term outcomes of the phase III RIDE and RISE trials
Ophthalmology, ISSN: 15494713 01616420
David S. Boyer; Quan Dong Nguyen; David M. Brown; Karen Basu; Jason S. Ehrlich
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Comparative Toxicity of Tapentadol and Tramadol Utilizing Data Reported to the National Poison Data System
Annals of Pharmacotherapy, ISSN: 15426270 10600280
Ben T. Tsutaoka; Raymond Y. Ho; Stacey M. Fung; Thomas E. Kearney
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Is all cancer therapy immunotherapy?
Science Translational Medicine, ISSN: 19466242 19466234
Marcia Belvin; Ira Mellman
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Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Robert Heald; Krista K. Bowman; Marian C. Bryan; Burdick; Bryan K. Chan; Emily Chan; Yuan Chen; Saundra Clausen; Belen Dominguez-Fernandez; Eigenbrot; Richard Elliott; Emily J. Hanan; Philip Jackson; Jamie Knight; Hank La; Michael Lainchbury; Shiva Malek; Sam E. Mann; Mark Merchant; Kyle Mortara; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Eileen Seward; Steve Sideris; Lily Shao; Shumei Wang; Kuen Yeap; Ivana Yen; Christine Yu; Timothy P. Heffron
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Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Anand K. Katakam; Hans D. Brightbill; Christian Franci; Chung Kung; Victor Nunez; Charles Jones III; Ivan Peng; Surinc Er Jeet; Lawren C. Wu; Ira Mellman; Lélia Delamarre; Cary D. Austin
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Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2
Science, ISSN: 10959203 00368075
Alexander Jaworski; Irene Tom; Raymond K. Tong; Holly K. Gildea; Alexander W. Koch; Lino C. Gonzalez Jr.; Marc Tessier-Lavigne
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Novel antibody-antibiotic conjugate eliminates intracellular S. aureus
Nature, ISSN: 14764687 00280836
Sophie M. Lehar; Thomas H. Pillow; Min Xu; Leanna Staben; Kimberly K. Kajihara; Richard L. Vandlen; Laura DePalatis; Helga Raab; Wouter L. W. Hazenbos; Hiroshi Morisaki; Janice Kim; Summer Park; Martine Darwish; Byoung-Chul Lee; Hilda Hernandez; Kelly M. Loyet; Patrick J. Lupardus; Rina Fong; Donghong Yan; Cecile Chalouni; Luis; Yana Khalfin; Emile G. Plise; Jonathan Cheong; Joseph P. Lyssikatos; Magnus Strandh; Klaus Koefoed; Peter S. Andersen; Flygare; Man-Wah Tan; Eric J. Brown; Sanjeev Mariathasan
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Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer
Science Translational Medicine, ISSN: 19466242 19466234
Melissa Junttila; Mao; Xi Wang; Bu-Er Wang; Thinh Q. Pham; Flygare; Shang-Fan Yu; Sharon Fong Yee; David Goldenberg; Carter Fields; Jeffrey Eastham-Anderson; Mallika Singh; Rajesh Vij; Hongo; Ron Firestein; Melissa Schutten; Kelly Flagella; Paul G. Polakis; Andrew G. Polson
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Preclinical development of an anti-NaPi2b (SLC34A2) antibody-drug conjugate as a therapeutic for non-small cell lung and ovarian cancers
Clinical Cancer Research, ISSN: 15573265 10780432
Kedan Lin; Bonnee Rubinfeld; Crystal Zhang; Ron Firestein; Eric Harstad; Roth; Siao Ping Tsai; Melissa Schutten; Keyang Xu; Maria Hristopoulos; Paul G. Polakis
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Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Huiyong Hu; Xiaojing Wang; Grace Chan; Jae H. Chang; Steven Do; Jake Drummond; Allen Ebens; Wendy Lee; Justin Ly; Joseph P. Lyssikatos; Jeremy Murray; John Moffat; Qi Chao; Vickie Tsui; Heidi J. A. Wallweber; Aleksandr Kolesnikov
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Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity
npj Systems Biology and Applications, ISSN: 20567189
Rima Chaudhuri; Poh-Sim Khoo; Tonks; Jagath R. Junutula; Ganesh Kolumam; Zora Modrusan; Samocha-Bonet; Christopher C. Meoli; Samantha L. Hocking; Daniel J. Fazakerley; Jacqueline Stöckli; Kyle L. Hoehn; Greenfield; Yang; David E. James
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Incidence and complications of interstitial lung disease in users of tocilizumab, rituximab, abatacept and anti-tumor necrosis factor aα agents, a retrospective cohort study
Arthritis Research and Therapy, ISSN: 14786362 14786354
Jeffrey R. Curtis; Khaled Sarsour; Pavel Napalkov; Laurie A. Costa; Kathy L. Schulman
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Oxygen regulation of breathing through an olfactory receptor activated by lactate
Nature, ISSN: 14764687 00280836
Andy J. Chang; Fabian E. Ortega; Johannes Riegler; Daniel V. Madison; Mark A. Krasnow
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FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching
Developmental Cell, ISSN: 18781551 15345807
John C. Herriges; Jamie M. Verheyden; Zhen Zhang; Pengfei Sui; Ying Zhang; Matthew J. Anderson; Deborah A. Swing; Yan Zhang; Mark Lewandoski; Xin Sun
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The Hedgehog Hold on Homeostasis
Cell Stem Cell, ISSN: 18759777 19345909
Ciara Metcalfe; Christian W. Siebel
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Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46
Structure, ISSN: 18784186 09692126
Jianping Yin; Allyn J. Schoeffler; Katherine E. Wickliffe; Kim Newton; Melissa A. Starovasnik; Erin C. Dueber; Seth F. Harris
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Investigation of Phase Mixing in Amorphous Solid Dispersions of AMG 517 in HPMC-AS Using DSC, Solid-State NMR, and Solution Calorimetry
Molecular Pharmaceutics, ISSN: 15438392 15438384
Julie L. Calahan; Stephanie C. Azali; Eric Munson; Karthik Nagapudi
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Microfluidic co-cultures with hydrogel-based ligand trap to study paracrine signals giving rise to cancer drug resistance
Lab on a Chip - Miniaturisation for Chemistry and Biology, ISSN: 14730189 14730197
Dipali Patel; Yandong Gao; Kyungjin Son; Christian Siltanen; Richard M. Neve; Katherine Ferrara; Alexander Revzin
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A mechanistic pharmacokinetic/pharmacodynamic model of factor D inhibition in cynomolgus monkeys by lampalizumab for the treatment of geographic atrophy
Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565
Kha Le; Leonid Gibiansky; Jeremy Good; Teresa Davancaze; Menno Van Lookeren Campagne; Kelly M. Loyet; Alyssa M. Morimoto; Jin Jin; Lisa A. Damico; William D. Hanley
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Stratified medicine in inflammatory disorders: From theory to practice
Clinical Immunology, ISSN: 15217035 15216616
Joseph R. Arron; Michael J. Townsend; Mary E. Keir; Brian L. Yaspan; Andrew A. Chan
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Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates
Pharmaceutical Research, ISSN: 1573904X 07248741
Amrita Kamath; Suhasini Iyer
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Semi-mechanism-based population pharmacokinetic modeling of the hedgehog pathway inhibitor vismodegib
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Lu; Wang; Gao; Mark J. Dresser; Richard A. Graham; Jin Y. Jin
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Clinical pharmacology, creating current and future success in drug development
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Mark Rogge; Mark J. Dresser; Michael J. Fossler; Donald Heald; S. Aubrey Stoch; Konstantina M. Vanevski; Akintunde Bello
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Population pharmacokinetics of oseltamivir in non-pregnant and pregnant women
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Venkateswaran C. Pillai; Kelong Han; Richard H. Beigi; Gary D. Hankins; Shannon Clark; Mary F. Hebert; Thomas R. Easterling; Anne Zajicek; Zhaoxia Ren; Steve N. Caritis; Raman Venkataramanan
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Baseline predictors of 12-month treatment response to ranibizumab in patients with wet age-related macular degeneration
American Journal of Ophthalmology, ISSN: 18791891 00029394
Carl D. Regillo; Brandon G. Busbee; Allen C. Ho; Beiying Ding; Zdenka Haskova
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Outcome-driven cluster analysis with application to microarray data
PLoS ONE, ISSN: 19326203
Jessie Hsu; Dianne M. Finkelstein; David Schoenfeld
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Population pharmacokinetics and dosing implications for cobimetinib in patients with solid tumors
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Kelong Han; Jin Y. Jin; Mathilde Marchand; Stephen M. Eppler; Nicholas Choong; Stephen P. Hack; Nalin Tikoo; Rene Bruno; Mark J. Dresser; Luna Musib; Nageshwar Budha
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