Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5651 - 5700 OF 15657 RESULTS

Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Burdick; Shumei Wang; Christopher E. Heise; Borlan Pan; Jake Drummond; Jianping Yin; Lauren Goeser; Steven Magnuson; Jeff Blaney; John Moffat; Weiru Wang; Huifen Chen
View on Scopus
Design of clinical trials with failure-time endpoints and interim analyses: An update after fifteen years
Contemporary Clinical Trials, ISSN: 15592030 15517144
Pei He; Tze Leung Lai; Zheng Su
View on Scopus
TRAF2 is a biologically important necroptosis suppressor
Cell Death and Differentiation, ISSN: 14765403 13509047
Sean Petersen; Tom T. Chen; David Lawrence; Scot A. Marsters; François Gonzalvez; Avi Ashkenazi
View on Scopus
Host cell proteins in biotechnology-derived products: A risk assessment framework
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Christina de Zafra; Quarmby; Kathleen Francissen; Vanderlaan; Judith Zhu-Shimoni
View on Scopus
Fully-automated, high-throughput micro-computed tomography analysis of body composition enables therapeutic efficacy monitoring in preclinical models
International Journal of Obesity, ISSN: 14765497 03070565
Shelby K. Wyatt; Kai H. Barck; Lance Kates; Jose Zavala-Solorio; Ross; Ganesh Kolumam; Junichiro Sonoda; Richard A. D. Carano
View on Scopus
Disease characteristics, treatment patterns, and outcomes of follicular lymphoma in patients 40 years of age and younger: An analysis from the National Lymphocare Study
Annals of Oncology, ISSN: 15698041 09237534
Carla Casulo; Bann-Mo Day; Keith Dawson; Zhou; Christopher R. Flowers; Charles M. Farber; John Hainsworth; James R. Cerhan; Brian K. Link; Zelenetz; Jonathan W. Friedberg
View on Scopus
Evaluation of the International Prognostic Score (IPS-7) and a Simpler Prognostic Score (IPS-3) for advanced Hodgkin lymphoma in the modern era
British Journal of Haematology, ISSN: 13652141 00071048
Catherine S. Diefenbach; Hailun Li; Fangxin Hong; Leo I. Gordon; Richard I. Fisher; Nancy L. Bartlett; Michael Crump; Randy D. Gascoyne; Henry Wagner; Patrick J. Stiff; Bruce D. Cheson; Douglas A. Stewart; Brad Kahl; Jonathan W. Friedberg; Kristie A Blum; Thomas M. Habermann; Joseph M. Tuscano; Richard T. Hoppe; Sandra J. Horning; Ranjana H. Advani
View on Scopus
Considerations for Requiring Subjects to Provide a Response to Electronic Patient-Reported Outcome Instruments
Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790
Paul O’Donohoe; J. Jason Lundy; Ari Gnanasakthy; Alison Greene
View on Scopus
Non-clinical disposition and metabolism of DM1, a component of trastuzumab emtansine (T-DM1), in sprague dawley rats
Drug Metabolism Letters, ISSN: 18723128
Shen; Daniela Bumbaca; Qin Yue; Ola M. Saad; Jay Tibbitts; S. Cyrus Khojasteh; Sandhya Girish
View on Scopus
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
European Respiratory Journal, ISSN: 13993003 09031936
Dominick E. Shaw; Ana R. Sousa; Stephen J. Fowler; Louise J. Fleming; Graham Roberts; Julie Corfield; Ioannis Pandis; Aruna T. Bansal; Elisabeth H. Bel; Charles Auffray; Chris H. Compton; Hans Bisgaard; Enrica Bucchioni; Massimo Caruso; Chanez; Barbro Dahlén; Sven-Erik Dahlen; Kerry Dyson; Urs Frey; Thomas Geiser; Maria Gerhardsson De Verdier; David Gibeon; Yi-Ke Guo; Simone Hashimoto; Gunilla Hedlin; Elizabeth Jeyasingham; Pieter-Paul W. Hekking; Tim Higenbottam; Ildikó Horváth; Alan J. Knox; Norbert Krug; Veit J. Erpenbeck; Lars X. Larsson; Nikos Lazarinis; Matthews; Roelinde Middelveld; Paolo Montuschi; Jacek Musial; David Myles; Laurie Pahus; Thomas Sandström; Wolfgang Seibold; Florian Singer; Karin Strandberg; Jorgen Vestbo; Nadja Vissing; Christophe Von Garnier; Ian Adcock; Scott Wagers; Anthony Rowe; Peter Howarth; Ariane H. Wagener; Ratko Djukanovic; Peter J. Sterk; Kian Fan Chung
View on Scopus
Randomized trial of efficacy and safety of dornase alfa delivered by eRapid nebulizer in cystic fibrosis patients
Journal of Cystic Fibrosis, ISSN: 18735010 15691993
Gregory S. Sawicki; Will Chou; Karina Raimundo; Benjamin L. Trzaskoma; Michael W. Konstan
View on Scopus
Immunological hallmarks of stromal cells in the tumour microenvironment
Nature Reviews Immunology, ISSN: 14741741 14741733
Shannon J. Turley; Viviana Cremasco; Jillian L. Astarita
View on Scopus
Evaluation of the International Prognostic Score (IPS-7) and a Simpler Prognostic Score (IPS-3) for advanced Hodgkin lymphoma in the modern era
British Journal of Haematology, ISSN: 13652141 00071048
Catherine S. Diefenbach; Hailun Li; Fangxin Hong; Leo I. Gordon; Richard I. Fisher; Nancy L. Bartlett; Michael Crump; Randy D. Gascoyne; Henry Wagner; Patrick J. Stiff; Bruce D. Cheson; Douglas A. Stewart; Wojciech Jurczak; Jonathan W. Friedberg; Kristie A Blum; Thomas M. Habermann; Joseph M. Tuscano; Richard T. Hoppe; Sandra J. Horning; Ranjana H. Advani
View on Scopus
Efficient conditional knockout targeting vector construction using co-selection BAC recombineering (CoSBR)
Nucleic Acids Research, ISSN: 13624962 03051048
Robert J. Newman; Merone Roose-Girma; Søren Warming
View on Scopus
Blinding properties of methods for supplying drug kits to investigational sites
Contemporary Clinical Trials Communications, ISSN: 24518654
Ron Yu; Daniel A. Coleman
View on Scopus
A novel design for randomized immuno-oncology clinical trials with potentially delayed treatment effects
Contemporary Clinical Trials Communications, ISSN: 24518654
Pei He; Zheng Su
View on Scopus
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nature, ISSN: 14764687 00280836
Nobuhiko Kayagaki; Irma B. Stowe; Bettina L. Lee; Karen M. O'Rourke; Keith R. Anderson; Søren Warming; Trinna L. Cuellar; Benjamin Haley; Merone Roose-Girma; Qui Phung; Peter S. Liu; Jennie R. Lill; Hong Li; Jiansheng Wu; Sarah K. Kummerfeld; Juan Zhang; Wyne P. Lee; Scott J. Snipas; Guy S. Salvesen; Lucy X. Morris; Linda Fitzgerald; Yafei Zhang; Edward M. Bertram; Christopher C. Goodnow; Vishva M. Dixit
View on Scopus
Survival and Racial Differences of Non-Small Cell Lung Cancer in the United States Military
Journal of General Internal Medicine, ISSN: 15251497 08848734
Christina Brzezniak; Sacha Satram-Hoang; Hans-Peter Goertz; Carolina Reyes; Ashok Gunuganti; Christopher Gallagher; Corey A. Carter
View on Scopus
Inhibition of DYRK1A and GSK3B induces human β-cell proliferation
Nature Communications, ISSN: 20411723
Weijun Shen; Brandon Taylor; Qihui Jin; Van Nguyen-Tran; Shelly Meeusen; You-Qing Zhang; Anwesh Kamireddy; Austin Swafford; Andrew F. Powers; John Walker; John Lamb; Badry Bursalaya; Michael Didonato; George Harb; Minhua Qiu; Christophe Filippi; Lisa Deaton; Carolina N. Turk; Wilma L. Suarez-Pinzon; Yahu Liu; Xueshi Hao; Tingting Mo; Shanshan Yan; Jing Li; Ann E. Herman; Bernhard J. Hering; Tom Wu; Martin Seidel; Peter McNamara; Richard Glynne; Bryan A. Laffitte
View on Scopus
Interactions between Peptide and Preservatives: Effects on Peptide Self-Interactions and Antimicrobial Efficiency in Aqueous Multi-Dose Formulations
Pharmaceutical Research, ISSN: 1573904X 07248741
Heljo; Ross; Isidro E. Zarraga; Pappenberger; Hanns-Christian Mahler
View on Scopus
Prepregnancy Risk Factors for Preterm Birth and the Role of Maternal Nativity in a Low-Income, Hispanic Population
Maternal and Child Health Journal, ISSN: 15736628 10927875
Stephanie A. Leonard; Catherine M. Crespi; Denise Gee; Yuda Zhu; Shannon E. Whaley
View on Scopus
The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression
Science, ISSN: 10959203 00368075
Hung; Pratt; Sundararaman; Towsend; Christina Chaivorapol; Tushar Bhangale; Robert R. Graham; Ward Ortmann; Criswell; Yeo; Timothy W. Behrens
View on Scopus
Kinome screen identifies PFKFB3 and glucose metabolism as important regulators of the insulin/insulin-like growth factor (IGF)-1 signaling pathway
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Sophie Trefely; Poh-Sim Khoo; James R. Krycer; Rima Chaudhuri; Daniel J. Fazakerley; Benjamin L. Parker; Ghazal Sultani; James Lee; Jean-Philippe Stephan; Eric Torres; Kenneth Jung; Coenraad Kuijl; David E. James; Jagath R. Junutula; Jacqueline Stöckli
View on Scopus
Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies
Neuron, ISSN: 10974199 08966273
Nga Bien-Ly; C. Andrew Boswell; Surinc Er Jeet; Thomas G. Beach; Kwame Hoyte; Wilman Luk; Vera Shihadeh; Sheila Ulufatu; Oded Foreman; Yanmei Lu; Jason Devoss; Marcel P Van Der Brug; Ryan J. Watts
View on Scopus
Absolute Quantitation of Intact Recombinant Antibody Product Variants Using Mass Spectrometry
Analytical Chemistry, ISSN: 15206882 00032700
Frank D. Macchi; Feng Yang; Charlene Li; Chenchen Wang; Anh Nguyen Dang; Joseph C. Marhoul; Hui-Min Zhang; Timothy Tully; Hongbin Liu; X. Christopher Yu; David A. Michels
View on Scopus
Randomized phase II trial comparing obinutuzumab (GA101) with rituximab in patients with relapsed CD20+ indolent B-Cell non-hodgkin lymphoma: Final analysis of the GAUSS study
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Laurie H. Sehn; Andre Goy; Fritz C. Offner; Giovanni Martinelli; Dolores Caballero; Ole Gadeberg; Tara Baetz; Zelenetz; Gianluca Gaidano; Luis E. Fayad; Rena Buckstein; Jonathan W. Friedberg; Michael Crump; Branimir Jaksic; Pier Luigi Zinzani; Swaminathan Padmanabhan Iyer; Deniz Sahin; Akiko Chai; Guenter Fingerle-Rowson; Oliver W. Press
View on Scopus
Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses
Immunity, ISSN: 10974180 10747613
Tangsheng Yi; Jianhua Li; Hsin Chen; Jiaxi Wu; Jinping An; Ying Xu; Yongmei Hu; Clifford Lowell; Jason G. Cyster
View on Scopus
PTEN loss in circulating tumour cells correlates with PTEN loss in fresh tumour tissue from castration-resistant prostate cancer patients
British Journal of Cancer, ISSN: 15321827 00070920
Elizabeth A. Punnoose; Roberta Ferraldeschi; Edith Szafer-Glusman; Eric K Tucker; Sankar Mohan; Penelope Flohr; Ruth Riisnaes; Susana Miranda; Ines Figueiredo; Daniel Nava Rodrigues; Aurelius Omlin; Carmel Pezaro; Jin Zhu; Lukas Amler; Premal Patel; Yibing Yan; Natalee Bales; Shannon L. Werner; Jessica Louw; Ajay Pandita; Dena Marrinucci; Gerhardt Attard; De Bono
View on Scopus
Palladium-Catalyzed Ring Expansion of Spirocyclopropanes to Form Caprolactams and Azepanes
Journal of Organic Chemistry, ISSN: 15206904 00223263
Olivier René; Iain A. Stepek; Alberto Gobbi; Benjamin P. Fauber; Simon Gaines
View on Scopus
Role of Cosolute-Protein Interactions in the Dissociation of Monoclonal Antibody Clusters
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Thomas M. Scherer
View on Scopus
Lipids assist the membrane insertion of a BAM-independent outer membrane protein
Scientific Reports, ISSN: 20452322
Gerard H. M. Huysmans; Ingrid Guilvout; Mohamed Chami; Nicholas N. Nickerson; Anthony P. Pugsley
View on Scopus
Notch signal strength controls cell fate in the haemogenic endothelium
Nature Communications, ISSN: 20411723
Leonor Gama-Norton; Eva Ferrando; Cristina Ruiz-Herguido; Zenhy Liu; Jordi Guiu; Abul B.M.M.K. Islam; Sung-Uk Lee; Minhong Yan; Cynthia J. Guidos; Nuria López-Bigas; Takahiro Maeda; Lluis Espinosa; Raphael Kopan; Anna Bigas
View on Scopus
Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe
Cell Reports, ISSN: 22111247
Jaakko Mattila; Essi Havula; Erja Suominen; Mari Teesalu; Ida Surakka; Riikka Hynynen; Helena Kilpinen; Juho Väänänen; Iiris Hovatta; Reijo Käkelä; Samuli Ripatti; Thomas Sandmann; Ville Hietakangas
View on Scopus
Safety of onartuzumab in patients with solid tumors: Experience to date from the onartuzumab clinical trial program
PLoS ONE, ISSN: 19326203
Roland Morley; Alison Cardenas; Peter Hawkins; Yasuyo Suzuki; Virginia Paton; See Phan; Mark Merchant; Jessie Hsu; Wei Yu; Qi Xia; Daniel Koralek; Patricia Luhn; Wassim Aldairy
View on Scopus
A subset of human bromodomains recognizes butyryllysine and crotonyllysine histone peptide modifications
Structure, ISSN: 18784186 09692126
E. Megan Flynn; Oscar W Huang; Florence Poy; Mariano Oppikofer; Steve Bellon; Yong Tang; Andrea G Cochran
View on Scopus
A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia
Leukemia and Lymphoma, ISSN: 10292403 10428194
Thomas J. Kipps; Herbert Eradat; Sebastian Grosicki; John Catalano; Walter Cosolo; Iryna S. Dyagil; Sreeni Yalamanchili; Akiko Chai; Srikumar Sahasranaman; Elizabeth A. Punnoose; Deborah Hurst; Halyna Pylypenko
View on Scopus
Negishi Approach to 1,5-Disubstituted 3-Amino-1H-1,2,4-triazoles
Organic Letters, ISSN: 15237052 15237060
Jeff Shen; Brian Wong; Christine Gu; Haiming Zhang
View on Scopus
Gene expression of INPP5F as an independent prognostic marker in fludarabine-based therapy of chronic lymphocytic leukemia
Blood Cancer Journal, ISSN: 20445385
Palermo; Maisel; Martin Barrett; Helen Smith; Guillemette Duchateau-Nguyen; Tri Quang Nguyen; Ru-Fang Yeh; Annika Dufour; Tadeusz Robak; David Dornan; Martin Weisser
View on Scopus
Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Snahel Patel; Seth F. Harris; Paul Gibbons; Gauri Deshmukh; Amy Gustafson; Terry Kellar; Han Lin; Xingrong Liu; Yanzhou Liu; Yichin Liu; Changyou Ma; Kimberly Scearce-Levie; Arundhati Sengupta Ghosh; Young G. Shin; Hilda Solanoy; Jian Wang; Bei Wang; Jianping Yin; Michael Siu; Joe Lewcock
View on Scopus
Unliganded fibroblast growth factor receptor 1 forms density-independent dimers
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Laetitia Comps-Agrar; Diana Ronai Dunshee; Dan L. Eaton; Junichiro Sonoda
View on Scopus
Intravitreal administration of known phototoxicants in the rabbit fails to produce phototoxicity: Implications for phototoxicity testing of intravitreally administered small molecule therapeutics
Cutaneous and Ocular Toxicology, ISSN: 15569535 15569527
Evan A Thackaberry; Cindy A. Farman; Vlad Bantseev; Chris Schuetz; Julia F. Baker; Michael H. Brown; Douglas B. Learn
View on Scopus
The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease
Trends in Immunology, ISSN: 14714981 14714906
Jose Ordovas-Montanes; Seth Rakoff-Nahoum; Siyi Huang; Lorena Riol-Blanco; Olga Barreiro; Ulrich H. von Andrian
View on Scopus
IgSimulator: A versatile immunosequencing simulator
Bioinformatics, ISSN: 14602059 13674803
Yana Safonova; Alla Lapidus; Jennie R. Lill
View on Scopus
Asthma exacerbations and lung function in patients with severe or difficult-to-treat asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
William J. Calhoun; Tmirah Haselkorn; Dave P. Miller; Theodore A. Omachi
View on Scopus
Phase II Randomized Study of Ixabepilone Versus Observation in Patients with Significant Residual Disease after Neoadjuvant Systemic Therapy for HER2-Negative Breast Cancer
Clinical Breast Cancer, ISSN: 19380666 15268209
Ana M. Gonzalez-Angulo; Xiudong Lei; Richardo H. Alvarez; Marjorie Green; James L. Murray; Vicente Valero; Kimberly B. Koenig; Nuhad K. Ibrahim; Jennifer K. Litton; Lakshmy Nair; Savitri Krishnamurthy; Hortobagyi; Funda Meric-Bernstam
View on Scopus
Pathology consultation on gene mutations in acute myeloid leukemia
American Journal of Clinical Pathology, ISSN: 19437722 00029173
James Ziai; Alexa J. Siddon
View on Scopus
Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor
Prostate, ISSN: 10970045 02704137
Kayvan R. Keshari; David M. Wilson; Mark Van Criekinge; Renuka Sriram; Bertram L. Koelsch; Zhen J. Wang; Henry F. Vanbrocklin; Donna M. Peehl; Thomas O'Brien; Deepak Sampath; Richard A. D. Carano; John Kurhanewicz
View on Scopus
The airway microbiome in patients with severe asthma: Associations with disease features and severity
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Yvonne J. Huang; Snehal Nariya; Harris; Susan V. Lynch; David F. Choy; Joseph R. Arron; Homer Boushey
View on Scopus
Considerations on the appropriateness of the John Cunningham virus antibody assay use in patients with rheumatoid arthritis
Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172
Dominic Borie; Joel M. Kremer
View on Scopus
Modular protein expression by RNA trans-splicing enables flexible expression of antibody formats in mammalian cells from a dual-host phage display vector
Protein Engineering, Design and Selection, ISSN: 17410134 17410126
Yonglei Shang; Devin B. Tesar; Isidro Hötzel
View on Scopus
© 2025 Genentech, Inc. All rights reserved. This site is intended for US residents only.