Scientists / Publications

Publications

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DISPLAYING 5701 - 5750 OF 15657 RESULTS

Synthetic protein lipidation
Current Opinion in Chemical Biology, ISSN: 18790402 13675931
Rami N. Hannoush
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More similar than different: Host cell protein production using three null CHO cell lines
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Inn H. Yuk; Julie C. Nishihara; Donald Walker; Eric Huang; Feny Gunawan; Jayashree Subramanian; Abigail F.J. Pynn; X. Christopher Yu; Judith Zhu-Shimoni; Vanderlaan; Denise C. Krawitz
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Patient-centered decision support in acute ischemic stroke: Qualitative study of patients' and providers' perspectives
Circulation: Cardiovascular Quality and Outcomes, ISSN: 19417705 19417713
Carole Decker; Emily Chhatriwalla; Elizabeth Gialde; Brian Garavalia; Debbie Summers; Miriam E. Quinlan; Eric Cheng; Marilyn Rymer; Jeffrey L. Saver; Er Chen; David M. Kent; John A. Spertus
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Scientific and Regulatory Policy Committee Points-to-consider Paper∗: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part I. Biotherapeutics
Toxicologic Pathology, ISSN: 15331601 01926233
Kendall S. Frazier; Jeffery A. Engelhardt; Pierluigi Fant; Silvia Guionaud; Scott P. Henry; Michael W. Leach; Calvert Louden; Marshall S. Scicchitano; James L. Weaver; Tanja S. Zabka
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Scientific and Regulatory Policy Committee Points-to-consider Paper∗: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part 2. Antisense Oligonucleotides
Toxicologic Pathology, ISSN: 15331601 01926233
Jeffery A. Engelhardt; Pierluigi Fant; Silvia Guionaud; Scott P. Henry; Michael W. Leach; Calvert Louden; Marshall S. Scicchitano; James L. Weaver; Tanja S. Zabka; Kendall S. Frazier
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Therapeutic antibodies: Discovery, design and deployment
Molecular Immunology, ISSN: 18729142 01615890
Paul A. Ramsland; Andrew T. Hutchinson; Paul J. Carter
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Patients with slowly proliferative early breast cancer have low five-year recurrence rates in a phase III adjuvant trial of capecitabine
Clinical Cancer Research, ISSN: 15573265 10780432
O'Shaughnessy; Koeppen; Yuanyuan Xiao; Lackner; Devchand Paul; Christopher Stokoe; John Pippen; Lea Krekow; Frankie Ann Holmes; Svetislava Vukelja; Deborah Lindquist; Scot Sedlacek; Ragene Rivera; Robert Brooks; Kristi McIntyre; Carrie Brownstein; Silke Hoersch; Blum; Stephen Jones
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Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Benjamin P. Fauber; Alberto Gobbi; Pascal P. A. Savy; Brenda Burton; Yuzhong Deng; Christine Everett; Hank La; Adam R. Johnson; Peter Lockey; Maxine Norman; Harvey Wong
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Redesigning a monospecific anti-FGFR3 antibody to add selectivity for FGFR2 and expand antitumor activity
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Yiyuan Yin; Stevan N. Djakovic; Scot A. Marsters; Janet Y. Tien; Jing Peng; Jarrod Tremayne; Genee Y. Lee; Richard M. Neve; Yan Wu; Mark Merchant; Avi Ashkenazi; Paul J. Carter
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NatHER: Protocol for systematic evaluation of trends in survival among patients with HER2-positive advanced breast cancer
Systematic Reviews, ISSN: 20464053
Korner; Anne Morris; I. Elaine Allen; Sara A. Hurvitz; Beattie; Bindu Kalesan
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Alternative molecular formats and therapeutic applications for bispecific antibodies
Molecular Immunology, ISSN: 18729142 01615890
Christoph Spiess; Qianting Zhai; Paul J. Carter
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Investigation of Fragment Antibody Stability and Its Release Mechanism from Poly(Lactide-co-Glycolide)-Triacetin Depots for Sustained-Release Applications
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Debby P. Chang; Vivek Kumar Garripelli; Jennifer C. Rea; Robert F. Kelley; Karthikan Rajagopal
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Final overall survival and safety analysis of OCEANS, a phase 3 trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent ovarian cancer
Gynecologic Oncology, ISSN: 10956859 00908258
Carol Aghajanian; Barbara Goff; Lawrence R. Nycum; Yan Wang; Amreen Husain; Stephanie V. Blank
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Evaluation of fluorophotometry to assess the vitreal pharmacokinetics of protein therapeutics
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Leslie Dickmann; Victor Yip; Cuiwen Li; Juan Abundes; Mauricio Maia; Cynthia Young; Shannon Stainton; Hass; Sean B. Joseph; Saileta Prabhu; C. Andrew Boswell
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Comparison of physiologic and pharmacologic parameters in Asian and mauritius cynomolgus macaques
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
John C. Kozlosky; Jagannatha Mysore; Shawn P. Clark; Holly N. Burr; Jinze Li; Nelly Aranibar; Ragini Vuppugalla; Ronald C. West; Raja S. Mangipudy; Michael J. Graziano
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Membrane display and functional analysis of juxtacrine ligand-receptor signaling
BioTechniques, ISSN: 19409818 07366205
Pradeep Nair; Hai Ngu; Eric Torres; Scot A. Marsters; David Lawrence; Jean-Philippe Stephan; László Kömüves; Avi Ashkenazi
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Drug-induced Skin Lesions in Cynomolgus Macaques Treated with Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulators
Toxicologic Pathology, ISSN: 15331601 01926233
Gopinath S. Palanisamy; John M. Marcek; Gregg D. Cappon; Jessica Whritenour; Christopher L. Shaffer; Joseph T. Brady; Christopher Houle
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MTORC2 balances AKT activation and eIF2α serine 51 phosphorylation to promote survival under stress
Molecular Cancer Research, ISSN: 15573125 15417786
Clara Tenkerian; Jothilatha Krishnamoorthy; Zineb Mounir; Urszula Kazimierczak; Arkady Khoutorsky; Kirk A. Staschke; Arnold S. Kristof; Shuo Wang; Maria Hatzoglou; Antonis E. Koromilas
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Population Pharmacokinetics and Pharmacodynamics of Lampalizumab Administered Intravitreally to Patients with Geographic Atrophy
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Kha Le; Leonid Gibiansky; Menno Van Lookeren Campagne; Jeremy Good; Teresa Davancaze; Kelly M. Loyet; Alyssa M. Morimoto; Erich C. Strauss; Jin Y. Jin
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Polysorbate 20 Degradation in Biopharmaceutical Formulations: Quantification of Free Fatty Acids, Characterization of Particulates, and Insights into the Degradation Mechanism
Molecular Pharmaceutics, ISSN: 15438392 15438384
Anthony Tomlinson; Barthélemy Demeule; Baiwei Lin; Sandeep Yadav
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Understanding Particle Formation: Solubility of Free Fatty Acids as Polysorbate 20 Degradation Byproducts in Therapeutic Monoclonal Antibody Formulations
Molecular Pharmaceutics, ISSN: 15438392 15438384
Nidhi Doshi; Barthélemy Demeule; Sandeep Yadav
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PTPRF Expression as a Potential Prognostic/Predictive Marker for Treatment with Erlotinib in Non-Small-Cell Lung Cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Denis Soulières; Fred R. Hirsch; Frances A. Shepherd; Walter Bordogna; Paul Delmar; David S. Shames; Barbara Klughammer
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Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions
Molecular Pharmaceutics, ISSN: 15438392 15438384
Mariya Pindrus; Steven J. Shire; Robert F. Kelley; Barthélemy Demeule; Wong; Yiren Xu; Sandeep Yadav
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Mouse Models of Rheumatoid Arthritis
Veterinary Pathology, ISSN: 15442217 03009858
Patrick Caplazi; Miriam Baca; Kai H. Barck; Richard A. D. Carano; Jason Devoss; Wyne P. Lee; Brad Bolon; Laurie Diehl
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A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis
Journal of Experimental Medicine, ISSN: 15409538 00221007
Ling Wu; Xing Chen; Junjie Zhao; Bradley Martin; Jarod A. Zepp; Jennifer S. Ko; Chunfang Gu; Gang Cai; Wenjun Ouyang; Ganes Sen; George R. Stark; Bing Su; Charlotte M. Vines; Cathy Tournier; Thomas A. Hamilton; Allison Vidimos; Brian Gastman; Caini Liu; Xiaoxia Li
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Simultaneous PET/MRI imaging during mouse cerebral hypoxia-ischemia
Journal of Visualized Experiments, ISSN: 1940087X
Yu Ouyang; Martin S. Judenhofer; Jeffrey H. Walton; Jan Marik; Simon P. Williams; Simon R. Cherry
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Comparative effectiveness and safety of rituximab versus subsequent anti-tumor necrosis factor therapy in patients with rheumatoid arthritis with prior exposure to anti-tumor necrosis factor therapies in the United States Corrona registry
Arthritis Research and Therapy, ISSN: 14786362 14786354
Leslie R. Harrold; Reed; Robert Magner; Ashwini Shewade; Ani John; Jeffrey D. Greenberg; Joel M. Kremer
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The staphylococcus aureus ABC-type manganese transporter MntABC is critical for reinitiation of bacterial replication following exposure to phagocytic oxidative burst
PLoS ONE, ISSN: 19326203
Alison Coady; Min Xu; Qui Phung; Tommy K. Cheung; Corey Bakalarski; Mary Kate Alexander; Sophie M. Lehar; Janice Kim; Summer Park; Man-Wah Tan; Mireille Nishiyama
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Parkinson's disease: From human genetics to clinical trials
Science Translational Medicine, ISSN: 19466242 19466234
Marcel P Van Der Brug; Andy Singleton; Thomas Gasser; Patrick A. Lewis
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Identification of Endoglin as an epigenetically regulated tumour-suppressor gene in lung cancer
British Journal of Cancer, ISSN: 15321827 00070920
O'Leary; Alice Shia; Cavicchioli; Haley; Comino; Merlano; Mauri; Kimberly Walter; Lackner; Wischnewsky; Crook; Lo Nigro; Schmid
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Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody
Nature Communications, ISSN: 20411723
Sumana Chandramouli; Claudio Ciferri; Pavel A. Nikitin; Stefano Caló; Rachel Gerrein; Kara Balabanis; James Monroe; Christy M. Hebner; Anders E. Lilja; Ethan C. Settembre; Andrea Carfi
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The Hippo pathway promotes cell survival in response to chemical stress
Cell Death and Differentiation, ISSN: 14765403 13509047
Di Cara; Tobias Maile; Parsons; Magico; Basu; Tapon; King-Jones
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A charged aerosol detector/chemiluminescent nitrogen detector/liquid chromatography/mass spectrometry system for regular and fragment compound analysis in drug discovery
Journal of Chromatography A, ISSN: 18733778 00219673
Yutao Jiang; Daniel Hascall; Delia Li; Joseph H. Pease
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Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Anthony A. Estrada; Zachary K. Sweeney
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Integrated risk assessment of suicidal ideation and behavior in drug development
Drug Discovery Today, ISSN: 18785832 13596446
Patrick Y. Muller; Donna M. Dambach; Brian Gemzik; Andreas Hartmann; Sian Ratcliffe; Christian Trendelenburg; Laszlo Urban
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Predicting the Agitation-Induced Aggregation of Monoclonal Antibodies Using Surface Tensiometry
Molecular Pharmaceutics, ISSN: 15438392 15438384
Ian C. Shieh; Ankit Patel
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Identification of Subvisible Particles in Biopharmaceutical Formulations Using Raman Spectroscopy Provides Insight into Polysorbate 20 Degradation Pathway
Pharmaceutical Research, ISSN: 1573904X 07248741
Miguel Saggu; Jun Liu; Ankit Patel
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Deep sequencing-guided design of a high affinity dual specificity antibody to target two angiogenic factors in neovascular age-related macular degeneration
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Patrick Koenig; Chingwei V. Lee; Sarah Sanowar; Ping Wu; Stinson; Seth F. Harris; Fuh
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Patients with proneural glioblastoma may derive overall survival benefit from the addition of bevacizumab to first-line radiotherapy and temozolomide: Retrospective analysis of the AVAglio trial
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Thomas Sandmann; Richard Bourgon; Josep Garcia; Congfen Li; Timothy Cloughesy; Olivier L. Chinot; Wick; Ryo Nishikawa; Warren Mason; Roger Henriksson; Frank Saran; Albert Lai; Moore; Samir Kharbanda; Franklin V. Peale Jr.; Priti Hegde; Lauren E. Abrey; Phillips; Carlos Bais
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Optimization and automation of an end-to-end high throughput microscale transient protein production process
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Aaron B. Bos; Patricia Luhn; Joseph N. Duque; Dorothea Reilly; Peter D. Harms; Athena W. Wong
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Sirt1 Regulates Microtubule Dynamics Through Negative Regulation of Plk1 in Mitosis
Journal of Cellular Biochemistry, ISSN: 10974644 07302312
Jin-Ju Kim; Na-Yeon Gil; Xiang Hua Zhang; Kwang-Hoon Chun; Guowei Fang; Joon Kim; Hyeseong Cho; Chang-Young Jang; Hyuk-Jin Cha
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The incidence of metastatic basal cell carcinoma (mBCC) in Denmark, 1997-2010
European Journal of Dermatology, ISSN: 19524013 11671122
Mary Nguyen-Nielsen; Lisa I. Wang; Lars Pedersen; Anne Braae Olesen; Jeannie Hou; Howard M. Mackey; Margaret McCusker; Nicole Basset-Seguin; Jon Fryzek; Mogens Vyberg
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Estimated Life-Years Saved in Women with HER2-Positive Metastatic Breast Cancer Receiving First-Line Trastuzumab and Pertuzumab in the United States
Value in Health, ISSN: 15244733 10983015
Mark Danese; Anthony Masaquel; Eduardo Santos; Melissa Brammer; Abraham Lee; Deepa Lalla
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Structural basis of the broadly neutralizing anti-interferon-α antibody rontalizumab
Protein Science, ISSN: 1469896X 09618368
Brigitte Maurer; Ivan Bosanac; Steven Shia; Mandy Kwong; Corpuz; Richard L. Vandlen; Kerstin N. Schmidt; Eigenbrot
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Antitumor effects of MEHD7945A, a dual-specific antibody against EGFR and HER3, in combination with radiation in lung and head and neck cancers
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Chunrong Li; Shyhmin Huang; Eric A. Armstrong; David M. Francis; Lauryn R. Werner; Mark X. Sliwkowski; Albert Van Der Kogel; Paul M. Harari
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Synthesis of Tricyclic 1,2,3-Triazolopyridines
Synthesis (Germany), ISSN: 1437210X 00397881
Jessica J. Frick; Cuong Q. Ly; Jacob B. Schwarz
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Large-scale interlaboratory study to develop, analytically validate and apply highly multiplexed, quantitative peptide assays to measure cancer-relevant proteins in plasma
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Susan E. Abbatiello; Birgit Schilling; Mani; Lisa J. Zimmerman; Steven C. Hall; Brendan MacLean; Matthew Albertolle; Simon Allen; Michael Burgess; Michael P. Cusack; Mousumi Gosh; Victoria Hedrick; Jason M. Held; H. Dorota Inerowicz; Angela Jackson; Hasmik Keshishian; Christopher R. Kinsinger; John Lyssand; Lee Makowski; Mehdi Mesri; Henry Rodriguez; Paul Rudnick; Pawel Sadowski; Nell Sedransk; Kent Shaddox; Stephen J. Skates; Eric Kuhn; Derek Smith; Jeffery R. Whiteaker; Corbin Whitwell; Shucha Zhang; Christoph H. Borchers; Susan J. Fisher; Bradford W. Gibson; Daniel C. Liebler; Michael J. MacCoss; Thomas A. Neubert; Amanda G. Paulovich; Fred E. Regnier; Paul Tempst; Steve A. Carr
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Interlaboratory study to evaluate the robustness of capillary electrophoresis-mass spectrometry for peptide mapping
Journal of Separation Science, ISSN: 16159314 16159306
Christian Wenz; Coral Barbas; Ángeles Lõpez-Gonzálvez; Antonia Garcia; Fernando Benavente; Victoria Sanz-Nebot; Tim Blanc; Gordon Freckleton; Philip Britz-McKibbin; Meera Shanmuganathan; Francois De L'Escaille; Johann Far; Rob Haselberg; Sean Huang; Carolin Huhn; Martin Pattky; David A. Michels; Si Mou; Feng Yang; Christian Neusuess; Nora Tromsdorf; Edward E.K. Baidoo; Jay D. Keasling; Park
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The minimal important difference for measures of urticaria disease activity: Updated findings
Allergy and Asthma Proceedings, ISSN: 15396304 10885412
Susan D. Mathias; Ross D. Crosby; Karin Rosén; James L. Zazzali
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A phase II trial of RCHOP followed by radioimmunotherapy for early stage (stages I/II) diffuse large B-cell non-Hodgkin lymphoma: ECOG3402
British Journal of Haematology, ISSN: 13652141 00071048
Witzig; Fangxin Hong; Ivana N. Micallef; Randy D. Gascoyne; Ahmet Dogan; Henry Wagner; Brad Kahl; Ranjana H. Advani; Sandra J. Horning
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