Genentech: Publications

March 19, 2015

An industry statistician's perspective on personalized health care drug development

Design and Analysis of Clinical Trials for Predictive Medicine,

Jane Fridlyand; Ru-Fang Yeh; Howard M. Mackey; Thomas Bengtsson; Paul Delmar; Spaniolo; Lieberman

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March 18, 2015

Regulation of the oncoprotein Smoothened by small molecules

Nature Chemical Biology, ISSN: 15524469 15524450

Hayley J. Sharpe; Weiru Wang; Rami N. Hannoush; Frederic J. De Sauvage

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March 18, 2015

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Science Translational Medicine, ISSN: 19466242 19466234

Joel D. Leverson; Darren C. Phillips; Michael J. Mitten; Erwin R. Boghaert; Dolores Diaz; Stephen K. Tahir; Lisa D. Belmont; Paul M. Nimmer; Yu Xiao; Xiaoju Max Ma; Kym N Lowes; Peter J. Kovar; Jun Chen; Sha Jin; Morey L. Smith; John Xue; Haichao Zhang; Anatol Oleksijew; Terrance J. Magoc; Kedar S. Vaidya; Daniel H. Albert; Jacqueline M. Tarrant; Nghi La; Le Wang; Zhi-Fu Tao; Michael D. Wendt; Deepak Sampath; Saul H. Rosenberg; Chris Tse; David C.S. Huang; Wayne J. Fairbrother; Steven W. Elmore; Andrew J. Souers

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March 18, 2015

GPU-accelerated compartmental modeling analysis of DCE-MRI data from glioblastoma patients treated with bevacizumab

PLoS ONE, ISSN: 19326203

Yu-Han H. Hsu; Ziyin Huang; Gregory Z. Ferl; Chee Ng

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March 15, 2015

A probabilistic method to report predictions from a human liver microsomes stability QSAR model: A practical tool for drug discovery

Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X

Ignacio Aliagas; Alberto Gobbi; Timothy P. Heffron; Man-Ling Lee; Daniel F. Ortwine; Mark Zak; S. Cyrus Khojasteh

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March 15, 2015

Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Wendy B. Young; Jim Barbosa; Peter Blomgren; Meire C. Bremer; James J. Crawford; Donna M. Dambach; Steven L. Gallion; Sarah G. Hymowitz; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen MacAluso; Patricia M. MacIejewski; Brigitte Maurer; Scott A. Mitchell; Daniel F. Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; C. Gregory Sowell; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Kevin S. Currie

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March 15, 2015

TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation

Journal of Immunology, ISSN: 15506606 00221767

Jarod A. Zepp; Ling Wu; Wen Qian; Wenjun Ouyang; Mark Aronica; Serpil Erzurum; Xiaoxia Li

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March 15, 2015

Transient blockade of delta-like notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation

Journal of Immunology, ISSN: 15506606 00221767

Sherri Wood; Jiane Feng; Jooho Chung; Vedran Radojcic; Ashley R. Sandy-Sloat; Ann Friedman; Amy Shelton; Minhong Yan; Christian W. Siebel; D. Keith Bishop; Ivan Maillard

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March 14, 2015

Effect of a Modified Saquinavir/Ritonavir Dosing Regimen with Lower Dose Lead-In Phase on QTc Interval, Pharmacokinetics, Antiviral Activity and Safety in Treatment-Naïve HIV-1-Infected Patients

Drugs in R and D, ISSN: 11796901 11745886

Marta Boffito; Akil Jackson; Anton Pozniak; Mylene Giraudon; Rohit Kulkarni; Maria Connie Abelardo; Indravadan H. Patel; Peter N. Morcos

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March 14, 2015

Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis

Mucosal Immunology, ISSN: 19353456 19330219

Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Jiabing Ding; Ho; Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl

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March 14, 2015

Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis

Mucosal Immunology, ISSN: 19353456 19330219

Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Jiabing Ding; Ho; Scot D. Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl

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March 14, 2015

Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis

Mucosal Immunology, ISSN: 19353456 19330219

Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Ding; Ho; Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl

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March 13, 2015

Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Jacomijn P. Dijksterhuis; Bolormaa Baljinnyam; Karen Stanger; Hakki O. Sercan; Yun Ji; Osler Andres; Jeffrey S. Rubin; Rami N. Hannoush; Gunnar Schulte

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March 12, 2015

Considerations on Immunogenicity

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,

Thomas R. Gelzleichter; Eric Wakshull

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March 12, 2015

Minor structural change to tertiary sulfonamide RORC ligands led to opposite mechanisms of action

ACS Medicinal Chemistry Letters, ISSN: 19485875

Olivier René; Benjamin P. Fauber; Gladys De Leon Boenig; Brenda Burton; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Sarah G. Hymowitz; Adam R. Johnson; James R. Kiefer; Marya Liimatta; Peter Lockey; Maxine Norman; Wenjun Ouyang; Heidi J. A. Wallweber; Harvey Wong

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March 12, 2015

Gaps and Future Challenges

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,

Joerg Bluemel; Sven Korte; Emanuel Schenck; Gerhard F. Weinbauer

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March 12, 2015

Opportunities for Implementing the 3 Rs in Drug Development and Safety Assessment Studies Using Nonhuman Primates

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,

Kathryn Chapman; Kathryn Bayne; Jessica A. Couch; Thierry Decelle; John Finch; Lolke de Haan; Tina Koban; Lars Fris Mikkelsen; Wolfgang Müller; Helen Palmer; Mark Prescott

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March 12, 2015

Developmental and Reproductive Toxicity Testing

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,

Gerhard F. Weinbauer; Christopher J. Bowman; Wendy Halpern; Gary Chellman

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March 12, 2015

Rapid antidepressants stimulate the decoupling of GABA B receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η

Molecular Psychiatry, ISSN: 14765578 13594184

Workman; Patrick C. G. Haddick; Bush; Dilly; Niere; Zemelman; Raab-Graham

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March 10, 2015

IgE/FcεRI-mediated antigen cross-presentation by dendritic cells enhances anti-tumor immune responses

Cell Reports, ISSN: 22111247

Barbara Platzer; KutluG. Elpek; Viviana Cremasco; Kristi Baker; MadeleineM. Stout; Cornelia Schultz; Eleonora Dehlink; Kai-TingC. Shade; RobertM. Anthony; Blumberg; Shannon J. Turley; Edda Fiebiger

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March 9, 2015

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

Cancer Cell, ISSN: 18783686 15356108

Hayley J. Sharpe; Gregoire Pau; Gerrit J. P. Dijkgraaf; Nicole Basset-Seguin; Zora Modrusan; Thomas Januario; Vickie Tsui; Alison B. Durham; Andrzej A. Dlugosz; Matthias Peter; Richard Bourgon; Jean Y. Tang; Kavita Y. Sarin; Luc Dirix; David C. Fisher; Charles M. Rudin; Howard Sofen; Michael R. Migden; Robert Yauch; Frederic J. De Sauvage

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March 3, 2015

β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Chunmei Fu; Xinjun Liang; Weiguo Cui; Julia L. Ober-Blöbaum; Joseph Vazzana; Protul A. Shrikant; Kelvin P. Lee; Björn E. Clausen; Ira Mellman; Aimin Jiang

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March 2, 2015

Investigation of Drug-Excipient Interactions in Lapatinib Amorphous Solid Dispersions Using Solid-State NMR Spectroscopy

Molecular Pharmaceutics, ISSN: 15438392 15438384

Yang Song; Xinghao Yang; Xin Chen; Haichen Nie; Stephen Byrn; Joseph W. Lubach

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March 2, 2015

Distinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T

Current Biology, ISSN: 18790445 09609822

Florencia Rago; Karen Gascoigne; Iain M. Cheeseman

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March 1, 2015

Author reply

Ophthalmology, ISSN: 15494713 01616420

Sophie J. Bakri; Darius M. Moshfeghi; Steve Francom; Amy Chen Rundle; Daniel S. Reshef; Paul P. Lee; Carol Schaeffer; Roman G. Rubio; Phillip Lai

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March 1, 2015

Incidence of giant cell arteritis and characteristics of patients: Data-driven analysis of comorbidities

Arthritis Care and Research, ISSN: 21514658 2151464X

Hans Petri; Alan Nevitt; Khaled Sarsour; Pavel Napalkov; Neil Collinson

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March 1, 2015

Economic evaluation of tocilizumab monotherapy compared to adalimumab monotherapy in the treatment of severe active rheumatoid arthritis

Value in Health, ISSN: 15244733 10983015

Josh J. Carlson; Sarika Ogale; Fred Dejonckheere; Sean D. Sullivan

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March 1, 2015

The Consequences of Diminishing Industry Support on the Independent Education Landscape: An Evidence-Based Analysis of the Perceived and Realistic Impact on Professional Development and Patient Care Among Oncologists

Journal of Cancer Education, ISSN: 15430154 08858195

Caroline Robinson; John Ruggiero; Mazi Abdolrasulnia; B. Stephen Burton

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March 1, 2015

Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Laura M. Paulin; Gregory B. Diette; Paul D. Blanc; Nirupama Putcha; Mark D. Eisner; Richard E. Kanner; Andrew J. Belli; Stephanie Christenson; Donald P. Tashkin; MeiLan Han; Graham Barr; Nadia N. Hansel

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March 1, 2015

Necroptosis: Pathway diversity and characteristics

Seminars in Cell and Developmental Biology, ISSN: 10963634 10849521

Maria Cristina De Almagro; Domagoj Vucic

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March 1, 2015

Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase

Toxicological Sciences, ISSN: 10960929 10966080

Tanja S. Zabka; Jatinder Singh; Preeti Dhawan; Bianca M. Liederer; Jason Oeh; Ariel Kauss; Yang Xiao; Mark Zak; Tori Lin; Bobbi McCray; Nghi La; Trung Nguyen; Joseph Beyer; Cindy A. Farman; Hirdesh Uppal; Peter Dragovich; Thomas O'Brien; Deepak Sampath; Misner

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March 1, 2015

Anxiety and health-related quality of life among patients with low-tumor burden non-Hodgkin lymphoma randomly assigned to two different rituximab dosing regimens: Results from ECOG Trial E4402 (RESORT)

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Lynne I. Wagner; Fengmin Zhao; Fangxin Hong; Marna Williams; Randy D. Gascoyne; John C. Krauss; Ranjana H. Advani; Ronald S. Go; Thomas M. Habermann; Joseph W. Leach; Brian O'Connor; Stephen J. Schuster; Cella; Sandra J. Horning; Wojciech Jurczak

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March 1, 2015

A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Xuejun Fan; Randall J. Brezski; Hui Deng; Pooja M. Dhupkar; Yun Shi; Anneliese Gonzalez; Songlin Zhang; Michael Rycyzyn; William R. Strohl; Robert E. Jordan; Ningyan Zhang; Zhiqiang An

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March 1, 2015

Comparison of statistical and operational properties of subject randomization procedures for large multicenter clinical trial treating medical emergencies

Contemporary Clinical Trials, ISSN: 15592030 15517144

Wenle Zhao; Yunming Mu; Darren Tayama; Sharon D. Yeatts

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March 1, 2015

A prospective observational study of oseltamivir safety and tolerability in infants and young children ≤24 months

Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569

Barbara A. Rath; William A. Blumentals; Mary K. Miller; Kathryn Starzyk; Boguslaw Tetiurka; Martina Wollenhaupt

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March 1, 2015

Preclinical Pharmacokinetic/Pharmacodynamic Modeling and Simulation in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape

AAPS Journal, ISSN: 15507416

Edgar Schuck; Tonika Bohnert; Arijit Chakravarty; Valeriu Damian-Iordache; Christopher Gibson; Cheng-Pang Hsu; Tycho Heimbach; Anu Shilpa Krishnatry; Bianca M. Liederer; Jing Lin; Tristan Maurer; Jerome T Mettetal; Daniel R Mudra; Marjoleen JMA Nijsen; Joseph Raybon; Patricia Schroeder; Virna Schuck; Satyendra Suryawanshi; Yaming Su; Patrick Trapa; Alice Tsai; Majid Vakilynejad; Shining Wang; Harvey Wong

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March 1, 2015

Anxiety and health-related quality of life among patients with low-tumor burden non-Hodgkin lymphoma randomly assigned to two different rituximab dosing regimens: Results from ECOG Trial E4402 (RESORT)

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Lynne I. Wagner; Fengmin Zhao; Fangxin Hong; Marna Williams; Randy D. Gascoyne; John C. Krauss; Ranjana H. Advani; Ronald S. Go; Thomas M. Habermann; Joseph W. Leach; Brian O'Connor; Stephen J. Schuster; Cella; Sandra J. Horning; Brad Kahl

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March 1, 2015

Efficacy of Hedgehog pathway inhibitors in basal cell carcinoma

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Nicole Basset-Seguin; Hayley J. Sharpe; Frederic J. De Sauvage

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March 1, 2015

Symptom burden and quality of life among women with HER2+ metastatic breast cancer

Breast Journal, ISSN: 15244741 1075122X

Musa Mayer; Kathleen Lang; Sara A. Hurvitz; Deepa Lalla; Victoria Federico; Melissa Brammer; Joseph Menzin; Debasish Tripathy

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March 1, 2015

Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayerss

Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565

Tianxiang Han; William R. Proctor; Chester L. Costales; Hao Cai; Ruth S. Everett; Dhiren R. Thakker

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March 1, 2015

Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid

Toxicology Mechanisms and Methods, ISSN: 15376524 15376516

Jacqueline M. Tarrant; Preeti Dhawan; Jatinder Singh; Tanja S. Zabka; Emer Clarke; Garry Dossantos; Peter Dragovich; Deepak Sampath; Tori Lin; Bobbi McCray; Nghi La; Trung Nguyen; Ariel Kauss; Donna M. Dambach; Misner; Dolores Diaz; Hirdesh Uppal

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March 1, 2015

Catch-up growth during tocilizumab therapy for systemic juvenile idiopathic arthritis: Results from a phase iii trial

Arthritis and Rheumatology, ISSN: 23265205 23265191

Fabrizio De Benedetti; Hermine Brunner; Nicolino Ruperto; Rayfel Schneider; Ricardo Xavier; Roger Allen; Diane E. Brown; Jeffrey Chaitow; Manuela Pardeo; Graciela Espada; Valeria Gerloni; Barry L. Myones; James W. Frane; Jianmei Wang; Terri H. Lipman; Kamal N. Bharucha; Alberto Martini; Daniel Lovell

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March 1, 2015

Primary tumor location as a prognostic factor in metastatic colorectal cancer

Journal of the National Cancer Institute, ISSN: 14602105 00278874

Fotios Loupakis; Dongyun Yang; Linda Yau; Shibao Feng; Chiara Cremolini; Wu Zhang; Martin K. H. Maus; Carlotta Antoniotti; Christiane Langer; Stefan J. Scherer; Thomas Müller; Herbert Hurwitz; Leonard Saltz; Alfredo Falcone; Heinz-Josef Lenz

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March 1, 2015

In response to L.N. Newcomer et al

Journal of Oncology Practice, ISSN: 1935469X 15547477

Art Small; Melissa Brammer

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March 1, 2015

Bioprocessing roundtable

American Pharmaceutical Review, ISSN: 10998012

Todd Kapp; Nick Hutchinson; Melvin G. Whitehead; Michael Hodgkinson; Jerry Martin

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March 1, 2015