Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6101 - 6150 OF 15658 RESULTS

January 8, 2015

Inhibitors of p21-activated kinases (PAKs)

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Joachim Rudolph; James J. Crawford; Klaus P. Hoeflich; Weiru Wang

January 8, 2015

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Snahel Patel; Frederick Cohen; Brian J. Dean; Kelly De La Torre; Gauri Deshmukh; Anthony A. Estrada; Arundhati Sengupta Ghosh; Paul Gibbons; Amy Gustafson; Malcolm P. Huestis; Claire E. Le Pichon; Han Lin; Wendy Liu; Xingrong Liu; Yichin Liu; Cuong Q. Ly; Joseph P. Lyssikatos; Changyou Ma; Kimberly Scearce-Levie; Young G. Shin; Hilda Solanoy; Kimberly L. Stark; Jian Wang; Bei Wang; Xianrui Zhao; Joe Lewcock; Michael Siu

January 6, 2015

Immunogenicity of Antibody Drug Conjugates: Bioanalytical Methods and Monitoring Strategy for a Novel Therapeutic Modality

AAPS Journal, ISSN: 15507416

M. Benjamin Hock; Karen Thudium; Montserrat Carrasco-Triguero; Nikolai F. Schwabe

January 6, 2015

Emerging Technologies to Increase Ligand Binding Assay Sensitivity

AAPS Journal, ISSN: 15507416

Saloumeh Kadkhodayan Fischer; Alison Joyce; Mark Spengler; Tong-Yuan Yang; Yao Zhuang; Marianne Scheel Fjording; Alvydas Mikulskis

January 6, 2015

Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics

AAPS Journal, ISSN: 15507416

Rand Jenkins; Jeff Duggan; Anne-Françoise Aubry; Jianing Zeng; Jean W. Lee; Laura Cojocaru; Dawn Dufield; Fabio Garofolo; Surinder Kaur; Gary Schultz; Keyang Xu; Ziping Yang; John Yu; Yan J. Zhang; Faye Vazvaei

January 5, 2015

The Management of Schizophrenia in Clinical Practice (MOSAIC) Registry: A focus on patients, caregivers, illness severity, functional status, disease burden and healthcare utilization

Schizophrenia Research, ISSN: 15732509 09209964

Henry A. Nasrallah; Philip D. Harvey; Daniel Casey; Csilla Csoboth; James I. Hudson; Laura Julian; Lentz; Keith H. Nuechterlein; Diana O. Perkins; Nirali Kotowsky; Tracey G. Skale; Lonnie R. Snowden; Rajiv Tandon; Cenk Tek; Dawn Velligan; Sophia Vinogradov; Cedric O'Gorman

January 2, 2015

Experimental and Computational Studies of the Diastereoselective Alkylations of 3-Substituted γ-Sultams

Journal of Organic Chemistry, ISSN: 15206904 00223263

Benjamin P. Fauber; Kyle Clagg; Paul Gibbons; Olivier René

January 1, 2015

Recommendations for adaptation and validation of commercial kits for biomarker quantification in drug development

Bioanalysis, ISSN: 17576199 17576180

Masood U. Khan; Ronald Bowsher; Mark Cameron; Viswanath Devanarayan; Steve Keller; Lindsay King; Jean W. Lee; Alyssa M. Morimoto; Paul Rhyne; Laurie Stephen; Yuling Wu; Tim Wyant; D Richard Lachno

January 1, 2015

A comprehensive transcriptional portrait of human cancer cell lines

Nature Biotechnology, ISSN: 15461696 10870156

Christiaan N. Klijn; Durinck; Eric Stawiski; Matthias Peter; Zhaoshi Jiang; Hanbin Liu; Jeremiah D. Degenhardt; Oleg Mayba; Florian Gnad; Jinfeng Liu; Gregoire Pau; Jens Reeder; Yi Cao; Kiran Mukhyala; Suresh K Selvaraj; Mamie Yu; Gregory J Zynda; Matthew J. Brauer; Thomas D Wu; Robert Gentleman; Gerard Manning; Robert Yauch; Richard Bourgon; David Stokoe; Zora Modrusan; Richard M. Neve; Frederic J. De Sauvage; Jeffrey Settleman; Somasekar Seshagiri; Zemin Zhang

January 1, 2015

Symptoms and toxicity of rituximab maintenance relative to observation following immunochemotherapy in patients with follicular Lymphoma

Hematology, ISSN: 16078454 10245332

Zhou; Jianmin Wang; Jessica Zhang; Catherine Copley-Merriman; Yasuhiro Torigoe; Carolina Reyes; John F. Seymour; Fritz C. Offner; Marek Trneny; Gilles Salles

January 1, 2015

Metal ion interactions with mAbs: Part 1 pH and conformation modulate copper-mediated site-specific fragmentation of the IgG1 hinge region

mAbs, ISSN: 19420870 19420862

Zephania Kwong Glover; Basa; Benjamin Moore; Jennifer S. Laurence; Alavattam Sreedhara

January 1, 2015

John T. Stults

The Encyclopedia of Mass Spectrometry: Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry,

Stults

January 1, 2015

Implications of understanding the signaling, cellular, and cytotoxic mechanisms afforded by afucosylated antibodies

OncoImmunology, ISSN: 2162402X 21624011

Scot D. Liu; John Lowe

January 1, 2015

Asthma biomarkers: What constitutes a 'gold standard'?

Thorax, ISSN: 14683296 00406376

Joseph R. Arron; Kenji Izuhara

January 1, 2015

Getting the most value from your screens: Advances in hardware, software, and methodologies to enhance surface plasmon resonance based fragment screening and hit-to-lead support

RSC Drug Discovery Series, ISSN: 20413211 20413203

Anthony M. Giannetti; Houston N. Gilbert; Donald P. Huddler; Mac Reiter; Chris Strande; Keith Pitts; Brandon Bravo

January 1, 2015

Diagnostic pathways to Alzheimer disease costs incurred in a medicare population

Alzheimer Disease and Associated Disorders, ISSN: 08930341

Daniel M. Gilden; Joanna M. Kubisiak; Khaled Sarsour; Craig A. Hunter

January 1, 2015

Lack of a pharmacokinetic interaction between trastuzumab and carboplatin in the presence of docetaxel: Results from a phase Ib study in patients with HER2-positive metastatic or locally advanced inoperable solid tumors

Anti-Cancer Drugs, ISSN: 14735741 09594973

Stephen M. Eppler; Michael S. Gordon; Charles H. Redfern; Caroline Trudeau; Xu; Kelong Han; Bert L. Lum

January 1, 2015

Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization

Nature Communications, ISSN: 20411723

Nadia Martinez-Martin; Abel Viejo-Borbolla; Rocío Martín; Soledad Blanco; Jeffrey L. Benovic; Marcus Thelen; Antonio Alcamí

January 1, 2015

Applying green chemistry principles in biologics drug development

RSC Drug Discovery Series, ISSN: 20413211 20413203

Kristi L. Budzinski

January 1, 2015

First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) Inhibitor, in patients with advanced solid tumors

Clinical Cancer Research, ISSN: 15573265 10780432

Debashis Sarker; Joo Ern Ang; Richard Baird; Rebecca Kristeleit; Krunal Shah; Victor Moreno; Paul A. Clarke; Florence I. Raynaud; Gallia Levy; Joseph A. Ware; Kathryn Mazina; Ray Lin; Jenny Q. Wu; Jill Fredrickson; Jill M. Spoerke; Lackner; Yibing Yan; Lori S. Friedman; Stanley B. Kaye; Mika K. Derynck; Paul Workman; De Bono

January 1, 2015

Mixed-effects modeling of clinical DCE-MRI Data: Application to colorectal liver metastases treated with bevacizumab

Journal of Magnetic Resonance Imaging, ISSN: 15222586 10531807

Gregory Z. Ferl; James P.B. O'Connor; Geoff J. M. Parker; Richard A. D. Carano; Shiv J. Acharya; Gordon C. Jayson; Ruediger E. Port

January 1, 2015

Quantification of tumor burden in a genetically engineered mouse model of lung cancer by micro-CT and automated analysis

Translational Oncology, ISSN: 19365233

Kai H. Barck; Hani Bou-Reslan; Ujjawal Rastogi; Timothy Sakhuja; Jason E. Long; Rafael Molina; Anthony Lima; Patricia Hamilton; Melissa Junttila; Leisa Johnson; Richard A. D. Carano

January 1, 2015

The Patient-Reported Outcome (PRO) Consortium: Lessons Learned Along the Path to PRO Instrument Qualification

Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790

Risa P. Hayes; Steven I. Blum; Mark Forrest Gordon; Elisabeth Piault; Laurie B. Burke; Ashley F. Slagle; Stephen Joel Coons

January 1, 2015

Induction dosing of peginterferon Alfa-2a (40KD) and/or high-dose ribavirin in genotype 1 CHC patients with difficult-to-treat characteristics: Pharmacokinetic and viral kinetic (PK/VK) assessment from progress

Hepato-Gastroenterology, ISSN: 01726390

Peter N. Morcos; Ruby Leong; James A. Thommes; Jean De Pamphilis; Joseph F. Grippo; Barbara J. Brennan

January 1, 2015

Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1)

Clinical Cancer Research, ISSN: 15573265 10780432

Hirdesh Uppal; Estelle Doudement; Kaushiki Mahapatra; Darbonne; Daniela Bumbaca; Shen; Xiaoyan Du; Ola M. Saad; Kristin Harden; Steve Olsen; Gail L. Phillips; Dylan P. Hartley; Mark X. Sliwkowski; Sandhya Girish; Donna M. Dambach; Vanitha Ramakrishnan

January 1, 2015

New stent leaves no polymer behind

Managed Care, ISSN: 10623388

Thomas Morrow

January 1, 2015

Hamster phospholipase B-like 2 (PLBL2): A host-cell protein impurity in therapeutic monoclonal antibodies derived from chinese hamster ovary cells

BioProcess International, ISSN: 15426319

Vanderlaan; Wendy N. Sandoval; Peter S. Liu; Julie C. Nishihara; George Tsui; Margaret Lin; Feny Gunawan; Sara Parker; Robert Ming Wong; Justin Low; Xiangdan Wang; Yang; Karthik Veeravalli; McKay; X. Christopher Yu; O'Connell; Benjamin Tran; Rajesh Vij; Chris Fong; Kathleen Francissen; Judith Zhu-Shimoni; Quarmby; Denise C. Krawitz

January 1, 2015

Sequence variants and sequence variant analysis in biotherapeutic proteins

ACS Symposium Series, ISSN: 19475918 00976156

Oleg V. Borisov; Melissa Alvarez; James A. Carroll; Paul W. Brown

January 1, 2015

Predicting response to HER2 kinase inhibition

Oncotarget, ISSN: 19492553

Jeffrey Settleman

January 1, 2015

MEK inhibitors beyond monotherapy: Current and future development

Current Opinion in Pharmacology, ISSN: 14714973 14714892

Ian E. Templeton; Luna Musib

January 1, 2015

Dual B cell immunotherapy is superior to individual Anti-CD20 depletion or baff blockade in murine models of spontaneous or accelerated lupus

Arthritis and Rheumatology, ISSN: 23265205 23265191

Wei Yu Lin; Dhaya Seshasayee; Wyne P. Lee; Patrick Caplazi; Sami McVay; Eric Suto; Allen Nguyen; Zhonghua Lin; Yonglian Sun; Laura DeForge; Mercedesz Balazs; Flavius Martin; Ali A. Zarrin

January 1, 2015

Antibody isotype switching in vertebrates

Results and Problems in Cell Differentiation, ISSN: 18610412 00801844

Kate Senger; Jason A. Hackney; Jian Payandeh; Ali A. Zarrin

January 1, 2015

Mericitabine and ritonavir-boosted danoprevir with or without ribavirin in treatment-naive HCV genotype 1 patients: INFORM-SVR study

Liver International, ISSN: 14783231 14783223

Edward J. Gane; Pockros; Stefan Zeuzem; Marcellin; Anna Shikhman; Coen A. Bernaards; Julian Zhou; Ellen S. Yetzer; Rosa Ballester; Cindy Dwyer; Xiao Tong; Nájera; Anne Bertasso; Janet Hammond; Amy Kindrick; Peter N. Morcos; Patrick F. Smith; Saray Stancic; Nancy Shulman

January 1, 2015

Reply

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Aidan Long; Kenneth J. Rothman; Hubert Chen; Gillis Carrigan; Stanley J. Szefler

January 1, 2015

Functional and structural abnormalities in deferoxamine retinopathy: A review of the literature

BioMed Research International, ISSN: 23146141 23146133

Maura Di Nicola; Giulio Barteselli; Laura Dell'Arti; Roberto Ratiglia; Francesco Viola

January 1, 2015

CMC considerations when a drug development project is assigned breakthrough therapy status

Pharmaceutical Engineering, ISSN: 02738139

Earl S. Dye; John Groskoph; Kelley; George Millili; Moheb Nasr; Christopher J. Potter; Eric Thostesen; Hans Vermeersch

January 1, 2015

Imaging the distribution of an antibody-drug conjugate constituent targeting mesothelin with 89Zr and IRDye 800CW in mice bearing human pancreatic tumor xenografts

Oncotarget, ISSN: 19492553

Eva J. ter Weele; Anton G.T. Terwisscha van Scheltinga; Jos G.W. Kosterink; Linda Pot; Silke R. Vedelaar; Laetitia E. Lamberts; Simon P. Williams; Marjolijn N. Lub-de Hooge; Elisabeth G. E. De Vries

January 1, 2015

Antibody engineering & therapeutics 2015: The antibody society’s annual meeting december 7–10, 2015, San Diego, CA

mAbs, ISSN: 19420870 19420862

Paul W. H. I. Parren; Dennis R. Burton; Andrew Bradbury; James S. Huston; Paul J. Carter; Trudi Veldman; Kerry A. Chester; James W. Larrick; Mark R. Alfenito; Jamie K. Scott; Louis M. Weiner; Gregory P. Adams; Janice M. Reichert

January 1, 2015

Ocular angiogenesis: Vascular endothelial growth factor and other factors

Developments in Ophthalmology, ISSN: 16622790 02503751

Roman G. Rubio; Anthony P. Adamis

January 1, 2015

100% Container closure integrity testing of lyophilized drug products by the oxygen head space analysis methodology

Pharmazeutische Industrie, ISSN: 0031711X

Tobias Posset; Misael Schleger; Fred Lim; Mumenthaler; Sebastian Schneider; Thomas Kaiser

January 1, 2015

Prediction of Drug Distribution in Subcutaneous Xenografts of Human Tumor Cell Lines and Healthy Tissues in Mouse: Application of the Tissue Composition-Based Model to Antineoplastic Drugs

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Yunghsiang Chen; Xiao Ding; Stephen Gould; Cornelis E. Hop; Kirsten Messick; Jason Oeh; Bianca M. Liederer

January 1, 2015

Analytical technologies for genotoxic impurities in pharmaceutical compounds

LCGC North America, ISSN: 15275949

Archana Kumar; Kelly Zhang; Larry Wigman

January 1, 2015

Separation science in drug development, part I: High-throughput purification

LCGC North America, ISSN: 15275949

Joseph H. Pease; Brent Murphy; Mengling Wong; Michael W. Dong

January 1, 2015

Separation science in drug development, part II: High-throughput characterization

LCGC North America, ISSN: 15275949

Baiwei Lin; Joseph H. Pease; Michael W. Dong

January 1, 2015

Iridium(III)-catalyzed benzylic amine directed C-H sulfonamidation of arenes with sulfonyl azides

ChemCatChem, ISSN: 18673899 18673880

Heng Chen; Malcolm P. Huestis

January 1, 2015

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Nature Genetics, ISSN: 15461718 10614036

Durinck; Eric Stawiski; Andrea Pavía-Jiménez; Zora Modrusan; Payal Kapur; Bijay S. Jaiswal; Na Zhang; Vanina Toffessi-Tcheuyap; Thong T Nguyen; Kanika Bajaj Pahuja; Ying-Jiun J. Chen; Sadia Saleem; Subhra Chaudhuri; Sherry Heldens; Marlena Jackson; Samuel Peña-Llopis; Joseph Guillory; Toy; Connie Ha; Corissa J. Harris; Eboni Holloman; Haley M Hill; Stinson; Rivers; Vasantharajan Janakiraman; Weiru Wang; Lisa N. Kinch; Nick V Grishin; Matthias Peter; Bernard Chow; Julian S. Gehring; Jens Reeder; Gregoire Pau; Thomas D Wu; Vitaly Margulis; Yair Lotan; Arthur Sagalowsky; Ivan Pedrosa; Frederic J. De Sauvage; James Brugarolas; Somasekar Seshagiri

January 1, 2015

Manufacturing of High-Concentration Monoclonal Antibody Formulations via Spray Drying-the Road to Manufacturing Scale

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Benson Gikanga; Robert Turok; Ada Hui; Mayumi Bowen; Oliver B. Stauch; Maa

January 1, 2015

Cognitive deficits, changes in synaptic function, and brain pathology in a mouse model of normal aging

eNeuro, ISSN: 23732822

Martin Weber; Tiffany Wu; Jesse E. Hanson; Nazia M. Alam; Hilda Solanoy; Hai Ngu; Benjamin E. Lauffer; Han H. Lin; Sara L. Dominguez; Jens Reeder; Jennifer A. Tom; Pascal Steiner; Oded Foreman; Glen T. Prusky; Kimberly Scearce-Levie

January 1, 2015

Comparison of Healthcare Costs Between Rheumatoid Arthritis Patients Treated with Infused Biologics After Switching from Another Biologic

Drugs - Real World Outcomes, ISSN: 21989788 21991154

Stephen S. Johnston; Donna McMorrow; Amanda M. Farr; Paul Juneau; Sarika Ogale

January 1, 2015

Exploring protein-protein interactions using peptide libraries displayed on phage

Phage Display in Biotechnology and Drug Discovery, Second Edition,

Deshayes; Jacob E. Corn

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