Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7751 - 7800 OF 15658 RESULTS

Cerebrovascular accidents in patients treated for choroidal neovascularization with ranibizumab in randomized controlled trials
Retina, ISSN: 0275004X 15392864
Neil M. Bressler; David S. Boyer; David F. Williams; Steven Butler; Steve Francom; Benton Brown; Flavia Di Nucci; Timothy Cramm; Lisa Tuomi; Tsontcho Ianchulev; Roman G. Rubio
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Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model
Thrombosis Research, ISSN: 00493848 18792472
Anna L. Hampton; Jose A. Diaz; Angela E. Hawley; Shirley K. Wrobleski; Jian-Guo Wang; Rebecca D. Lee; Daniel Kirchhofer; Robert E. Sigler; Thomas W. Wakefield; Nigel Mackman; Daniel D. Myers Jr.
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Genomic landscape of liver cancer
Nature Genetics, ISSN: 10614036 15461718
Zemin Zhang
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Mycobacterium marinum SecA2 promotes stable granulomas and induces tumor necrosis factor alpha in Vivo
Infection and Immunity, ISSN: 00199567 10985522
Brigitte Y. Watkins; Shilpa A. Joshi; David A. Ball; Hadley Leggett; Summer Park; Janice Kim; Cary D. Austin; Andres Paler Martinez; Min Xu; Kenneth H. Downing; Eric J. Brown
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The genetics of type I interferon in systemic lupus erythematosus
Current Opinion in Immunology, ISSN: 09527915 18790372
Paola G. Bronson; Christina Chaivorapol; Ward Ortmann; Timothy W. Behrens; Robert R. Graham
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Risk of Significant Infection in Rheumatoid Arthritis Patients Switching Anti-Tumor Necrosis Factor-α Drugs
Seminars in Arthritis and Rheumatism, ISSN: 00490172 1532866X
Bao-Anh Nguyen-Khoa; Earl L. Goehring; Kimberly Alexander; Wei Dong; Pavel Napalkov; Judith K. Jones
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Cost utility of palivizumab prophylaxis among pre-term infants in the United States: A national policy perspective
Journal of Medical Economics, ISSN: 13696998 1941837X
Parthiv J. Mahadevia; Anthony Masaquel; Mark J. Polak; Leonard B. Weiner
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European genetic ancestry is associated with a decreased risk of lupus nephritis
Arthritis and Rheumatism, ISSN: 00043591 15290131
Ilana B. Richman; Kimberly E. Taylor; Sharon A. Chung; Laura Trupin; Michelle Petri; Edward Yelin; Robert R. Graham; Annette T. Lee; Timothy W. Behrens; Peter K. Gregersen; Michael F. Seldin; Lindsey A. Criswell
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Cerebrovascular accidents in patients treated for choroidal neovascularization with ranibizumab in randomized controlled trials
Retina, ISSN: 0275004X 15392864
Neil M. Bressler; David S. Boyer; David F. Williams; Butler; Steve Francom; Benton Brown; Flavia Di Nucci; Timothy Cramm; Lisa Tuomi; Tsontcho Ianchulev; Roman G. Rubio
View on Scopus
Novel nanoparticles formulation for cassette dosing via intravenous injection in rats for high throughput pharmacokinetic screening and potential applications
Journal of Nanoscience and Nanotechnology, ISSN: 15334880 15334899
Po-Chang Chiang; Yuzhong Deng; Savita Ubhayakar; Hank La; Yong Cui; Kang-Jye Chou; Yingqing Ran; Harvey Wong
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Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
Nature Genetics, ISSN: 10614036 15461718
Charles M. Rudin; Durinck; Eric Stawiski; John T. Poirier; Zora Modrusan; David S. Shames; Emily A. Bergbower; Yinghui Guan; James Shin; Joseph Guillory; Rivers; Catherine K. Foo; Deepali Bhatt; Stinson; Florian Gnad; Matthias Peter; Robert Gentleman; Subhra Chaudhuri; Vasantharajan Janakiraman; Bijay S. Jaiswal; Chaitali Parikh; Yuan; Zemin Zhang; Koeppen; Thomas D Wu; Howard M. Stern; Robert Yauch; Kenneth E. Huffman; Diego D. Paskulin; Peter B. Illei; Marileila Varella-Garcia; Adi Gazdar; Frederic J. De Sauvage; Richard Bourgon; Minna; Malcolm V. Brock; Somasekar Seshagiri
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Omalizumab and the risk of malignancy: Results from a pooled analysis
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
William W. Busse; Roland Buhl; Carlos Fernandez Vidaurre; Martin Blogg; Jin Zhu; Mark D. Eisner; Janice Canvin
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Hepatitis C virus induces epidermal growth factor receptor activation via CD81 binding for viral internalization and entry
Journal of Virology, ISSN: 0022538X 10985514
Jingyu Diao; Homer Pantua; Hai Ngu; László Kömüves; Laurie Diehl; Gabriele Schaefer; Sharookh B. Kapadia
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Studying host cell protein interactions with monoclonal antibodies using high throughput protein A chromatography
Biotechnology Journal, ISSN: 18606768 18607314
Vikram N. Sisodiya; Joshua Lequieu; Maricel Rodriguez; Paul McDonald; Kathlyn P. Lazzareschi
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Improvements in health-related quality of life after treatment with tocilizumab in patients with rheumatoid arthritis refractory to tumour necrosis factor inhibitors: Results from the 24-week randomized controlled radiate study
Rheumatology, ISSN: 14620324 14620332
Vibeke Strand; Gerd R. Burmester; Sarika Ogale; Jenny Devenport; Ani John; Paul Emery
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Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification
Cell, ISSN: 10974172 00928674
Robert M. Samstein; Aaron Arvey; Steven Z. Josefowicz; Xiao Peng; Alex Reynolds; Richard Sandstrom; Shane Neph; Peter Sabo; Kim; Will Liao; Ming Li; Christina Leslie; John A. Stamatoyannopoulos; Alexander Y. Rudensky
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The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Timothy P. Heffron; Laurent Salphati; Bruno Alicke; Jonathan Cheong; Jennafer Dotson; Kyle A. Edgar; Richard Goldsmith; Stephen Gould; Leslie Lee; John Lesnick; Lewis; Chudi O. Ndubaku; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Emile G. Plise; Steve Sideris; Sean Trapp; Jeffery J. Wallin; Lan Wang; Xiaolin Zhang
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Cross-neutralization of influenza A viruses mediated by a single antibody loop
Nature, ISSN: 00280836 14764687
Damian C. Ekiert; Arun K. Kashyap; John Steel; Adam Rubrum; Gira Bhabha; Reza Khayat; Jeong Hyun Lee; Michael Dillon; Ryann E. O'Neil; Aleksandr M. Faynboym; Michael Horowitz; Lawrence Horowitz; Andrew B. Ward; Peter Palese; Richard Webby; Richard A. Lerner; Ramesh R. Bhatt; Ian A. Wilson
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Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
James F. Blake; Rui Xu; Josef R. Bencsik; Dengming Xiao; Nicholas C. Kallan; Stephen Schlachter; Ian S. Mitchell; Keith L. Spencer; Anna L. Banka; Eli M. Wallace; Susan L. Gloor; Matthew Martinson; Richard D. Woessner; Guy Vigers; Barbara J. Brandhuber; Jun Liang; Brian S. Safina; Jun Li; Birong Zhang; Christine Chabot; Steven Do; Leslie Lee; Jason Oeh; Deepak Sampath; Brian Lee; Kui Lin; Bianca M. Liederer; Nicholas J. Skelton
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Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT
Blood, ISSN: 15280020 00064971
Raghuveer Singh Mali; Peilin Ma; Li-Fan Zeng; Holly Martin; Baskar Ramdas; Yantao He; Emily Sims; Sarah Nabinger; Joydeep Ghosh; Namit Sharma; Veerendra Munugalavadla; Anindya Chatterjee; Shuo Li; Sandusky; Andrew W. Craig; Kevin D. Bunting; Gen-Sheng Feng; Rebecca J. Chan; Zhong-Yin Zhang; Reuben Kapur
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Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
James F. Blake; Rui Xu; Josef R. Bencsik; Dengming Xiao; Nicholas C. Kallan; Stephen Schlachter; Ian S. Mitchell; Keith L. Spencer; Anna L. Banka; Eli M. Wallace; Susan L. Gloor; Matthew Martinson; Richard D. Woessner; Guy Vigers; Barbara J. Brandhuber; Jun Liang; Brian S. Safina; Jun Li; Birong Zhang; Christine Chabot; Steven Do; Leslie Lee; Jason Oeh; Deepak Sampath; Brian B. Lee; Kui Lin; Bianca M. Liederer; Nicholas J. Skelton
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Spatially coordinated kinase signaling regulates local axon degeneration
Journal of Neuroscience, ISSN: 02706474 15292401
Mark Chen; Janice Maloney; Dara Y. Kallop; Jasvinder K. Atwal; Stephen Tam; Kristin Baer; Holger Kissel; Joshua S. Kaminker; Joe Lewcock; Robby M. Weimer; Ryan J. Watts
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Loss of the tumor suppressor BAP1 causes myeloid transformation
Science, ISSN: 10959203 00368075
Anwesha Dey; Dhaya Seshasayee; Rajkumar Noubade; French; Jinfeng Liu; Mira S. Chaurushiya; Donald S. Kirkpatrick; Victoria Pham; Jennie R. Lill; Corey Bakalarski; Jiansheng Wu; Lilian Phu; Paula Katavolos; Lindsay M. LaFave; Omar Abdel-Wahab; Zora Modrusan; Somasekar Seshagiri; Ken Dong; Zhonghua Lin; Mercedesz Balazs; Rowena Suriben; Kim Newton; Sarah G. Hymowitz; Guillermo Garcia-Manero; Flavius Martin; Ross L. Levine; Vishva M. Dixit
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Effectiveness of first-line management strategies for stage I follicular lymphoma: Analysis of the National Lymphocare Study
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Jonathan W. Friedberg; Michelle Byrtek; Brian K. Link; Christopher R. Flowers; Taylor; John Hainsworth; James R. Cerhan; Zelenetz; Jamie Hirata; Thomas P. Miller
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Childhood disorders of the synapse: Challenges and opportunities
Science Translational Medicine, ISSN: 19466234 19466242
Virginia Hughes; Morgan Sheng; Huda Y. Zoghbi
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Impact of hemodialysis catheter dysfunction on dialysis and other medical services: An observational cohort study
International Journal of Nephrology, ISSN: 2090214X 20902158
Robert I. Griffiths; Britt B. Newsome; Grace Leung; Geoffrey A. Block; Robert J. Herbert; Mark Danese
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Validity of cost and utility results?
PharmacoEconomics, ISSN: 11707690 11792027
Alex Diamantopoulos; Laura Sawyer; Sarika Ogale; Fred Dejonckheere
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Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging
PLoS ONE, ISSN: 19326203
Amrita Kamath; Simon P. Williams; Sherron Bullens; Kyra J. Cowan; Yvonne Stenberg; Simon R. Cherry; Stephen Rendig; David L. Kukis; Chris Griesemer; Lisa A. Damico; Bunting
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Ras inhibition via direct Ras binding - Is there a path forward?
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Weiru Wang; Guowei Fang; Joachim Rudolph
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Potent and highly selective benzimidazole inhibitors of PI3-kinase delta
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Jeremy Murray; Zachary K. Sweeney; Bryan K. Chan; Mercedesz Balazs; Erin K. Bradley; Georgette M. Castanedo; Christine Chabot; David Chantry; Michael Flagella; David M. Goldstein; Rama Kondru; John Lesnick; Jun Li; Matthew C. Lucas; Jim Nonomiya; Jodie Pang; Stephen Price; Laurent Salphati; Brian S. Safina; Pascal P. A. Savy; Eileen Seward; Ultsch; Daniel P. Sutherlin
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RPN-6 determines C. elegans longevity under proteotoxic stress conditions
Nature, ISSN: 00280836 14764687
David Vilchez; Ianessa Morantte; Zheng Liu; Peter M. Douglas; Carsten Merkwirth; Ana P. C. Rodrigues; Gerard Manning; Andrew Dillin
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A phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Ian E. Krop; Patricia M. LoRusso; Kathy Miller; Shanu Modi; Denise A. Yardley; Gladys Rodriguez; Ellie Guardino; Michael W. Lu; Maoxia Zheng; Sandhya Girish; Lukas Amler; Eric P. Winer; Hope S. Rugo
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High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)-mediated inhibition of platelet production
Blood, ISSN: 15280020 00064971
Jonathan N. Thon; Matthew T. Devine; Antonija Jurak Begonja; Jay Tibbitts; Joseph E. Italiano Jr.
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Structural transitions of transmembrane helix 6 in the formation of Metarhodopsin i
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Markus Eilers; Joseph A. Goncalves; Shivani Ahuja; Colleen Kirkup; Amiram Hirshfeld; Carlos Simmerling; Philip J. Reeves; Mordechai Sheves; Steven O. Smith
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Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells
Blood, ISSN: 15280020 00064971
Bithi Chatterjee; Anna Smed-Sörensen; Lillian Cohn; Cecile Chalouni; Richard L. Vandlen; Byoung-Chul Lee; Jenifer Widger; Tibor Keler; Lélia Delamarre; Ira Mellman
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Dr. Sekulic and colleagues reply
New England Journal of Medicine, ISSN: 15334406 00284793
Aleksandar Sekulic; Josina C. Reddy; Axel Hauschild
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Binding mechanism of metalṡNTP substrates and stringent-response alarmones to bacterial DnaG-type primases
Structure, ISSN: 18784186 09692126
Richard U. Rymer; Francisco A. Solorio; Ashley K. Tehranchi; Clement Chu; Jacob E. Corn; James L. Keck; Jue D. Wang; James M. Berger
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Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation
Journal of Clinical Investigation, ISSN: 00219738 15588238
Yanqiu Liu; Agnes D. Berendsen; Shidong Jia; Sutada Lotinun; Roland Baron; Napoleone Ferrara; Bjorn R. Olsen
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Molecular basis for negative regulation of the glucagon receptor
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Christopher M. Koth; Jeremy Murray; Susmith Mukund; Azadeh Madjidi; Alexandra Minn; Holly J. Clarke; Wong; Vicki Chiang; Luis; Alberto Estevez; Jesus Rondon; Yingnan Zhang; Isidro Hötzel; Bernard B. Allan
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FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice
Journal of Clinical Investigation, ISSN: 00219738 15588238
Sunyoung Lee; Roland Meier; Saori Furuta; Marc E. Lenburg; Paraic A. Kenny; Ren Xu; Mina J. Bissell
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Anti-neuropilin-1 (MNRP1685A): Unexpected pharmacokinetic differences across species, from preclinical models to humans
Pharmaceutical Research, ISSN: 07248741 1573904X
Yan Xin; Shuang Bai; Lisa A. Damico; Denise Jin; Wei-Ching Liang; Yan Wu; Frank-Peter Theil; Amita Joshi; Yanmei Lu; John Lowe; Mauricio Maia; Rainer Brachmann; Hong Xiang
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Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): An Emphasis on preclinical and clinical catabolism
Current Drug Metabolism, ISSN: 13892002 18755453
Shen; Daniela Bumbaca; Ola M. Saad; Qin Yue; Cinthia V Pastuskovas; S. Cyrus Khojasteh; Jay Tibbitts; Surinder Kaur; Wang; Yu-Waye Chu; Patricia M. LoRusso; Sandhya Girish
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Pharmacokinetic considerations for antibody drug conjugates
Pharmaceutical Research, ISSN: 07248741 1573904X
Kedan Lin; Jay Tibbitts
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Psychometric evaluation of the cystic fibrosis questionnaire-revised in a national sample
Quality of Life Research, ISSN: 09629343
Alexandra L. Quittner; Gregory S. Sawicki; Ann McMullen; Lawrence Rasouliyan; David J. Pasta; Ashley Yegin; Michael W. Konstan
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A role for Th17 cells in the regulation of tertiary lymphoid follicles
European Journal of Immunology, ISSN: 00142980 15214141
Jane L. Grogan; Wenjun Ouyang
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Tissue distribution studies of protein therapeutics using molecular probes: Molecular imaging
AAPS Journal, ISSN: 15507416
Simon P. Williams
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Dyslipidemia and changes in lipid profiles associated with rheumatoid arthritis and initiation of anti-tumor necrosis factor therapy
Arthritis Care and Research, ISSN: 2151464X 21514658
Jeffrey R. Curtis; Ani John; Onur Baser
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Drug interaction potential of trastuzumab emtansine (T-DM1) combined with pertuzumab in patients with HER2-positive metastatic breast cancer
Current Drug Metabolism, ISSN: 13892002 18755453
Dan Lu; Howard A. Burris; Wang; E. Claire Dees; Javier Cortés; Amita Joshi; Manish Gupta; Joo-Hee Yi; Yu-Waye Chu; Ted Shih; Liang Fang; Sandhya Girish
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Diagnosis and management of childhood obstructive sleep apnea syndrome
Pediatrics, ISSN: 00314005 10984275
Carole L. Marcus; Lee Jay Brooks; Kari A. Draper; David Gozal; Ann Carol Halbower; Jacqueline Jones; Michael S. Schechter; Stephen Howard Sheldon; Karen Spruyt; Sally Davidson Ward; Christopher Lehmann; Richard N. Shiffman
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Diagnosis and management of childhood obstructive sleep apnea syndrome
Pediatrics, ISSN: 00314005 10984275
Carole L. Marcus; Lee Jay Brooks; Sally Davidson Ward; Kari A. Draper; David Gozal; Ann Carol Halbower; Jacqueline Jones; Christopher Lehmann; Michael S. Schechter; Stephen Howard Sheldon; Richard N. Shiffman; Karen Spruyt
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