Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7801 - 7850 OF 15658 RESULTS

Compartmental tissue distribution of antibody therapeutics: Experimental approaches and interpretations
AAPS Journal, ISSN: 15507416
C. Andrew Boswell; Daniela Bumbaca; Fielder; Leslie A. Khawli
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Differential effects of predosing on tumor and tissue uptake of an 111in-labeled anti-TENB2 antibody-drug conjugate
Journal of Nuclear Medicine, ISSN: 01615505
C. Andrew Boswell; Eduardo E. Mundo; Crystal Zhang; Shannon Stainton; Shang-Fan Yu; Jennifer A. Lacap; Mao; Katherine R. Kozak; Aimee Fourie-O'Donohue; Paul G. Polakis; Leslie A. Khawli; Kedan Lin
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QbD for biologics
BioProcess International, ISSN: 15426319
Steven Kozlowski; Wassim Nashabeh; Mark Schenerman; Howard Anderson; Ilse Blumentals; Kowid Ho; Rohin Mahtre; Barbara Rellahan; Victor Vinci; Lorna McLeod
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Pre-use/post-sterilization integrity testing of sterilizing grade filters
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440 19482124
Karen Bartel; Harold S. Baseman; Gabriele Gori; Richard V. Levy; Hemisha Ly; Maik W. Jornitz; Russell Madsen; Michiel Rook; Sue Schniepp
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Evaluating the Impact of Patient Recruitment and Retention Practices
Drug Information Journal, ISSN: 00928615
Mary Jo Lamberti; Adam Mathias; Jane E. Myles; Deborah Howe; Ken Getz
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A generic HPLC/UV platform method for cleaning verification
American Pharmaceutical Review, ISSN: 10998012
Michael W. Dong; Eileen X. Zhao; Derrick T. Yazzie; Christine Gu; Jackson D. Pellett
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Utilizing design of experiments to characterize assay robustness
Bioanalysis, ISSN: 17576180 17576199
Kyra J. Cowan; Erickson; Brian Sue; Reginald Delarosa; Bert Gunter; Daniel A. Coleman; Houston N. Gilbert; An Song; Saloumeh Kadkhodayan Fischer
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The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy
Experimental Oncology, ISSN: 18129269
Maria Cristina De Almagro; Domagoj Vucic
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Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex
Nature Protocols, ISSN: 17542189 17502799
Gerard M. J. Beaudoin III; Seung-Hye Lee; Dipika Singh; Yang Yuan; Yu-Gie Ng; Louis F. Reichardt; Jyothi Arikkath
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Risk factors for rate of decline in FEV1 in adults with cystic fibrosis
Journal of Cystic Fibrosis, ISSN: 15691993 18735010
Michael W. Konstan; Wagener; Donald R. VanDevanter; David J. Pasta; Ashley Yegin; Lawrence Rasouliyan; Morgan
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Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Laurent Salphati; Jodie Pang; Emile G. Plise; Leslie Lee; Alan G. Olivero; Wei Wei Prior; Deepak Sampath; Susan C. Wong; Xiaolin Zhang
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Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration
Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783
Kelly M. Loyet; Laura DeForge; Kenneth J. Katschke Jr.; Laurie Diehl; Robert R. Graham; Lily Pao; Lizette Sturgeon; Sock-Cheng Lewin-Koh; Joe G. Hollyfield; Menno Van Lookeren Campagne
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Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes
Ophthalmology, ISSN: 01616420 15494713
Lucia Sobrin; Stephan Ripke; Yi Yu; Jesen Fagerness; Tushar Bhangale; Perciliz L. Tan; Eric H. Souied; Gabriëlle H.S. Buitendijk; Joanna E. Merriam; Andrea J. Richardson; Soumya Raychaudhuri; Robyn Reynolds; Kimberly A. Chin; Aaron Y. Lee; Nicolas Leveziel; Donald J. Zack; Peter A. Campochiaro; R. Theodore Smith; Gaetano R. Barile; Ruth E. Hogg; Usha Chakravarthy; Timothy W. Behrens; André G. Uitterlinden; Cornelia M. Van Duijn; Johannes R. Vingerling; Milam A. Brantley Jr.; Paul N. Baird; Caroline C.W. Klaver; Rando Allikmets; Nicholas Katsanis; Robert R. Graham; John P.A. Ioannidis; Mark J. Daly; Johanna M. Seddon
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Neuropilin-2 expression in cancer
Histopathology, ISSN: 03090167 13652559
Adrian M. Jubb; Susan Sa; Navneet Ratti; Laura A. Strickland; Maike Schmidt; Christopher Callahan; Koeppen
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Long-term effects of ranibizumab on diabetic retinopathy severity and progression
Archives of Ophthalmology, ISSN: 00039950 15383601
Michael S. Ip; Amitha Domalpally; J. Jill Hopkins; Pamela Wong; Jason S. Ehrlich
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Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics
AAPS Journal, ISSN: 15507416
Daniela Bumbaca; C. Andrew Boswell; Fielder; Leslie A. Khawli
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The assay design used for measurement of therapeutic antibody concentrations can affect pharmacokinetic parameters: Case studies
mAbs, ISSN: 19420862 19420870
Saloumeh Kadkhodayan Fischer; Yang; Banmeet S. Anand; Kyra J. Cowan; Robert Hendricks; Jing Li; Nakamura; An Song
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2012 White paper on recent issues in bioanalysis and alignment of multiple guidelines
Bioanalysis, ISSN: 17576180 17576199
Binodh DeSilva; Fabio Garofolo; Mario Rocci; Suzanne Martinez; Isabelle Dumont; France Landry; Catherine Dicaire; Gabriella Szekely-Klepser; Russell Weiner; Mark Arnold; Surendra Bansal; Kevin Bateman; Ronald Bauer; Brian Booth; Scott Davis; Sherri Dudal; Dominique Gouty; John Grundy; Sam Haidar; Roger Hayes; Mohammed Jemal; Surinder Kaur; Marian Kelley; Magnus Knutsson; Olivier Le Blaye; Jean W. Lee; Steve Lowes; Mark Ma; Toshinari Mitsuoka; João Tavares Neto; Robert Nicholson; Eric Ormsby; Jeff M. Sailstad; Lauren Stevenson; Daniel Tang; Jan Welink; Viswanathan; Laixin Wang; Eric Woolf; Eric Yang
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Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Jun Luo; Jian Zhang; Diya Ren; Wen-Lin Tsai; Feng Li; Ashraf Amanullah; Terry Hudson
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Safety and biodistribution of an equine infectious anemia virus-based gene therapy, retinostat®, for age-related macular degeneration
Human Gene Therapy, ISSN: 10430342 15577422
Katie Binley; Peter S. Widdowson; Michelle Kelleher; Jackie De Belin; Julie Loader; Georgina Ferrige; Marie Carlucci; Margaret Esapa; Daniel Chipchase; Diana Angell-Manning; Scott Ellis; Kyriacos Mitrophanous; James Miskin; Vlad Bantseev; Michael Nork; Paul Miller; Stuart Naylor
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Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I-III breast cancer (HannaH study): A phase 3, open-label, multicentre, randomised trial
The Lancet Oncology, ISSN: 14702045 14745488
Gustavo Ismael; Roberto Hegg; Susanne Muehlbauer; Dominik Heinzmann; Bert L. Lum; Sung-Bae Kim; Tadeusz Pienkowski; Mikhail Lichinitser; Vladimir Semiglazov; Melichar; Christian Jackisch
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Sequencing and analysis of a South Asian-Indian personal genome
BMC Genomics, ISSN: 14712164
Ravi Gupta; Aakrosh Ratan; Changanamkandath Rajesh; Rong Chen; Hie Lim Kim; Richard Burhans; Webb Miller; Sam Santhosh; Ramana V. Davuluri; Atul J. Butte; Stephan C. Schuster; Somasekar Seshagiri; George Thomas
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Recurrent R-spondin fusions in colon cancer
Nature, ISSN: 00280836 14764687
Somasekar Seshagiri; Eric Stawiski; Durinck; Zora Modrusan; Elaine E. Storm; Caitlin B. Conboy; Subhra Chaudhuri; Yinghui Guan; Vasantharajan Janakiraman; Bijay S. Jaiswal; Joseph Guillory; Connie Ha; Gerrit J. P. Dijkgraaf; Stinson; Florian Gnad; Melanie A. Huntley; Jeremiah D. Degenhardt; Matthias Peter; Richard Bourgon; Weiru Wang; Koeppen; Robert Gentleman; Timothy Starr; Zemin Zhang; David A. Largaespada; Thomas D Wu; Frederic J. De Sauvage
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Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway
EMBO Journal, ISSN: 02614189 14602075
Guanglei Zhuang; Xiumin Wu; Zhaoshi Jiang; Ian Kasman; Jenny Yao; Yinghui Guan; Jason Oeh; Zora Modrusan; Carlos Bais; Deepak Sampath; Napoleone Ferrara
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Transforming quality of care and improving outcomes after acute MI: Lessons from the national registry of myocardial infarction
JAMA - Journal of the American Medical Association, ISSN: 15383598 00987484
William J. French; Vanessa S. Reddy; Hal V. Barron
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Profiling antibody drug conjugate positional isomers: A system-of-equations approach
Analytical Chemistry, ISSN: 15206882 00032700
Lan N. Le; Jamie M. R. Moore; Jun Ouyang; Xiaoying Chen; Mary D. H. Nguyen; William J. Galush
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Evaluation of an accurate mass approach for the simultaneous detection of drug and metabolite distributions via whole-body mass spectrometric imaging
Analytical Chemistry, ISSN: 00032700 15206882
Sheerin Shahidi-Latham; Sucharita M. Dutta; Maria C. Prieto Conaway; Patrick J. Rudewicz
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Identification and characterization of buried unpaired cysteines in a recombinant monoclonal igg1 antibody
Analytical Chemistry, ISSN: 00032700 15206882
Taylor Zhang; Jennifer Zhang; Daniel Hewitt; Ben Tran; Xiaoying Gao; Zhihua Julia Qiu; Max L. Tejada; Hélène Gazzano-Santoro; Kao
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Step-economic synthesis of (+)-crocacin C: A concise crotylboronation/[3,3] -sigmatropic rearrangement approach
Journal of Organic Chemistry, ISSN: 00223263 15206904
Adele E. Pasqua; Frank D. Ferrari; Chris Hamman; Yanzhou Liu; James J. Crawford; Rodolfo Marquez
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Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Hoanh Tran; Paul G. Polakis
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Balancing continuous and categorical baseline covariates in sequential clinical trials using the area between empirical cumulative distribution functions
Statistics in Medicine, ISSN: 02776715 10970258
Yunzhi Lin; Zheng Su
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Cardiovascular and systemic microvascular-effects of anti-vascular endothelial growth factor therapy for cancer
Journal of the American College of Cardiology, ISSN: 07351097 15583597
J. Todd Belcik; Yue Qi; Beat A. Kaufmann; Aris Xie; Sherron Bullens; Terry K. Morgan; Susan P. Bagby; Ganesh Kolumam; Joe Kowalski; Jon A. Oyer; Bunting; Jonathan R. Lindner
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Pari passu dimers of dimers
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Mark X. Sliwkowski
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Functional significance of isoform diversification in the protocadherin gamma gene cluster
Neuron, ISSN: 08966273 10974199
Weisheng V. Chen; Francisco J. Alvarez; Julie L. Lefebvre; Brad A. Friedman; Chiamaka Nwakeze; Eric Geiman; Courtney Smith; Chan Aye Thu; Juan Carlos Tapia; Bosiljka Tasic; Joshua R. Sanes; Tom Maniatis
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Quantification and characterization of micrometer and submicrometer subvisible particles in protein therapeutics by use of a suspended microchannel resonator
Analytical Chemistry, ISSN: 00032700 15206882
Ankit Patel; Doris Lau; Jun Liu
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Function, targets, and evolution of Caenorhabditis elegans piRNAs
Science, ISSN: 10959203 00368075
Marloes P. Bagijn; Leonard D. Goldstein; Alexandra Sapetschnig; Eva-Maria Weick; Samir Bouasker; Nicolas J. Lehrbach; Martin J. Simard; Eric A. Miska
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Patient out-of-pocket payments for oral oncolytics: Results from a 2009 us claims data analysis
American Journal of Managed Care, ISSN: 10880224
Martin L. Raborn; Elise M. Pelletier; Daniel B. Smith; Carolina Reyes
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A mutation in APP protects against Alzheimer‘s disease and age-related cognitive decline
Nature, ISSN: 00280836
Thorlakur Jonsson; Jasvinder K. Atwal; Stacy Steinberg; Jon Snaedal; Palmi V. Jonsson; Sigurbjorn Bjornsson; Hreinn Stefansson; Patrick Sulem; Daniel Gudbjartsson; Janice Maloney; Kwame Hoyte; Amy Gustafson; Yichin Liu; Yanmei Lu; Tushar Bhangale; Robert R. Graham; Johanna Huttenlocher; Gyda Bjornsdottir; Ole A. Andreassen; Erik G. Jönsson; Aarno Palotie; Timothy W. Behrens; Olafur T. Magnusson; Augustine Kong; Unnur Thorsteinsdottir; Ryan J. Watts; Kari Stefansson
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An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan
Aging Cell, ISSN: 14749718 14749726
Kwame Twumasi-Boateng; Tim W. Wang; Linda Tsai; Kuang-Hui Lee; Ali Salehpour; Sudarshan Bhat; Man-Wah Tan; Michael Shapira
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Effect of rifampin and rifabutin on the pharmacokinetics of lersivirine and effect of lersivirine on the pharmacokinetics of rifabutin and 25-O-desacetyl-rifabutin in healthy subjects
Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596
Manoli Vourvahis; John Davis; Rong Wang; Gary Layton; Heng Wee Choo; Chew Lan Chong; Margaret Tawadrous
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The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis
Protein Science, ISSN: 09618368 1469896X
Christian N. Cunningham; Daniel R. Southworth; Kristin A. Krukenberg; David A. Agard
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Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin
Hepatology, ISSN: 02709139 15273350
Stephen A. Harrison; Hamzeh; Jian Han; Prashant K. Pandya; Muhammed Y. Sheikh; John M. Vierling
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Pharmacokinetics and safety of coadministered oseltamivir and rimantadine in healthy volunteers: An open-label, multiple-dose, randomized, crossover study
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Georgina Cirrincione-Dall; Barbara J. Brennan; Rosa M. Ballester-Sanchis; Mercidita T. Navarro; Brian E. Davies
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Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth
Nature Neuroscience, ISSN: 10976256 15461726
Erik Mire; Cecilia Mezzera; Eduardo Leyva-Diáz; Ana V. Paternain; Paola Squarzoni; Lisa Bluy; Mar Castillo-Paterna; María José López; Sandra Peregrín; Marc Tessier-Lavigne; Sonia Garel; Joan Galcerán; Juan Lerma; Guillermina López-Bendito
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Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors
Journal of Pathology, ISSN: 00223417 10969896
Alicia S Chung; Marcin Kowanetz; Xiumin Wu; Guanglei Zhuang; Hai Ngu; David Finkle; László Kömüves; Franklin V. Peale Jr.; Napoleone Ferrara
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Longitudinal changes in asthma control with omalizumab: 2-year interim data from the EXCELS study
Journal of Asthma, ISSN: 02770903 15324303
Mark D. Eisner; James L. Zazzali; Mary K. Miller; Mary S. Bradley; Michael Schatz
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Stability of GABAB receptor oligomers revealed by dual TR-FRET and drug-induced cell surface targeting
FASEB Journal, ISSN: 08926638 15306860
Laetitia Comps-Agrar; Julie Kniazeff; Arsten Brock; Eric Trinquet; Jean-Philippe Pin
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Validation of a tool to assess medication treatment satisfaction in patients with Type2 diabetes: The Diabetes Medication System Rating Questionnaire (DMSRQ)
Diabetic Medicine, ISSN: 07423071 14645491
Peyrot; Harshaw; Shillington; Yaping Xu; Rubin
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Pcadmix: Principal components-based assignment of ancestry along each chromosome in individuals with admixed ancestry from two or more populations
Human Biology, ISSN: 00187143 15346617
Abra Brisbin; Katarzyna Bryc; Jake Byrnes; Fouad Zakharia; Larsson Omberg; Jeremiah D. Degenhardt; Andy Reynolds; Harry Ostrer; Jason G. Mezey; Carlos D. Bustamante
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DNA methylation alterations in response to pesticide exposure in vitro
Environmental and Molecular Mutagenesis, ISSN: 08936692 10982280
Xiao Zhang; Andrew D. Wallace; Pan Du; Warren A. Kibbe; Nadereh Jafari; Hehuang Xie; Simon Lin; Andrea A. Baccarelli; Marcelo Bento Soares; Lifang Hou
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