Genentech: Publications

March 15, 2006

Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice

Cancer Research, ISSN: 00085472

Lauren Wallner; Jinlu Dai; June Escara-Wilke; Jian Zhang; Zhi Yao; Yi Lu; Mohit Trikha; Jeffrey A. Nemeth; Mohamed H. Zaki; Evan T. Keller

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March 15, 2006

CDK2/cyclinA inhibitors: Targeting the cyclinA recruitment site with small molecules derived from peptide leads

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Georgette M. Castanedo; Clark; Shumei Wang; Vickie Tsui; Mengling Wong; John B. Nicholas; Dineli Wickramasinghe; James C. Marsters Jr.; Daniel P. Sutherlin

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March 14, 2006

A versatile platform for nanotechnology based on circular permutation of a chaperonin protein

Nanotechnology, ISSN: 09574484

Paavola; Chan; Li; Mazzarella; McMillan; Trent

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March 10, 2006

Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin™ Fab

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Fuh; Ping Wu; Wei-Ching Liang; Ultsch; Chingwei V. Lee; Moffat; Wiesmann

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March 10, 2006

CRIg: A macrophage complement receptor required for phagocytosis of circulating pathogens

Cell, ISSN: 00928674

Karim Y. Helmy; Kenneth J. Katschke Jr.; Nick N. Gorgani; Noelyn Kljavin; J. Michael Elliott; Laurie Diehl; Suzie J. Scales; Nico Ghilardi; Menno Van Lookeren Campagne

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March 9, 2006

Calorimetric investigation of protein/amino acid interactions in the solid state

International Journal of Pharmaceutics, ISSN: 03785173

Fei Tian; Samir Sane; J. Howard Rytting

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March 9, 2006

Cryopyrin activates the inflammasome in response to toxins and ATP

Nature, ISSN: 14764687 00280836

Sanjeev Mariathasan; David S. Weiss; Kim Newton; Jacqueline McBride; Karen M. O'Rourke; Merone Roose-Girma; Wyne P. Lee; Yvette Weinrauch; Denise M. Monack; Vishva M. Dixit

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March 8, 2006

The role of receptor internalization in CD95 signaling

EMBO Journal, ISSN: 02614189 14602075

Kyeong-Hee Lee; Christine Feig; Vladimir Tchikov; Robert Schickel; Cora Hallas; Stefan Schütze; Marcus E. Peter; Andrew A. Chan

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March 6, 2006

A recombinant 63-kDa form of Bacillus anthracis protective antigen produced in the yeast Saccharomyces cerevisiae provides protection in rabbit and primate inhalational challenge models of anthrax infection

Vaccine, ISSN: 0264410X

Robert W. Hepler; Rosemarie Kelly; Tessie B. McNeely; Hongxia Fan; Maria C. Losada; Hugh George; Andrea Woods; Leslie D. Cope; Alka Bansal; James C. Cook; Gina Zang; Steven L. Cohen; Xiaorong Wei; Paul M. Keller; Elizabeth Leffel; Joseph G. Joyce; Louise Pitt; Loren D. Schultz; Kathrin U. Jansen; Myra Kurtz

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March 6, 2006

Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly2-Pro1-cleaving specificity

FEBS Letters, ISSN: 00145793

Conrad Yap Edosada; Quan; Thuy Tran; Victoria Pham; Wiesmann; Wayne J. Fairbrother; Beni B. Wolf

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March 2, 2006

The above letters were referred to genentech, the manufacturer of bevacizumab, which offers the following reply [22]

New England Journal of Medicine, ISSN: 00284793

Hal V. Barron

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March 1, 2006

Biogenerics at the crossroads

Nature Biotechnology, ISSN: 10870156 15461696

Carole S. Ben-Maimon; Robert L. Garnick

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March 1, 2006

Large-scale trends in the evolution of gene structures within 11 animal genomes

PLoS Computational Biology, ISSN: 1553734X 15537358

Mark Yandell; Chris J. Mungall; Chris Smith; Simon Prochnik; Joshua S. Kaminker; George Hartzell; Suzanna E. Lewis; Gerald M. Rubin

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March 1, 2006

Targeting VEGF & EGFR pathways in solid tumors

Journal of Gynecologic Oncology Nursing, ISSN: 15369935

Karen Oleszewski

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March 1, 2006

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

Nature Immunology, ISSN: 15292908 15292916

Dario S. Zamboni; Koichi S. Kobayashi; Tiana Kohlsdorf; Yasunori Ogura; E. Michelle Long; Russell E. Vance; Keisuke Kuida; Sanjeev Mariathasan; Vishva M. Dixit; Richard A. Flavell; William F. Dietrich; Craig R. Roy

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March 1, 2006

Community-based trial of a triple-combination agent for the treatment of facial melasma

Cutis, ISSN: 00114162

Pearl Grimes; A. Paul Kelly; Helen Torok; Isaac Willis

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March 1, 2006

Synapse disassembly and formation of new synapses in postnatal muscle upon conditional inactivation of MuSK

Molecular and Cellular Neuroscience, ISSN: 10447431

Boris A. Hesser; Oliver Henschel; Veit Witzemann

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March 1, 2006

Enantioselective total synthesis of batzelladine F and definition of its structure

Journal of the American Chemical Society, ISSN: 00027863

Frederick Cohen; Larry E. Overman

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March 1, 2006

Metabolism and excretion of erlotinib, a small molecule inhibitor of epidermal growth factor receptor tyrosine kinase, in healthy male volunteers

Drug Metabolism and Disposition, ISSN: 00909556

Jie Ling; Kim A. Johnson; Zhuang Miao; Ashok Rakhit; Michael P. Pantze; Marta Hamilton; Bert L. Lum; Chandra Prakash

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March 1, 2006

A rapid method for estimation of baculovirus titer based on viable cell size

Journal of Virological Methods, ISSN: 01660934

Vasantharajan Janakiraman; William F. Forrest; Bernard Chow; Somasekar Seshagiri

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March 1, 2006

Evaluation of the absolute oral bioavailability and bioequivalence of erlotinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in a randomized, crossover study in healthy subjects

Journal of Clinical Pharmacology, ISSN: 00912700 15524604

Paul Frohna; Jian-Feng Lu; Stephen M. Eppler; Marta Hamilton; Julie Wolf; Ashok Rakhit; Jie Ling; Sara Kenkare-Mitra; Bert L. Lum

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March 1, 2006

Effect of overexpression of a soluble pyridine nucleotide transhydrogenase (UdhA) on the production of poly(3-hydroxybutyrate) in Escherichia coli

Biotechnology Progress, ISSN: 87567938

Ailen M. Sánchez; Jared Andrews; Insiya Hussein; George N. Bennett; Ka-Yiu San

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March 1, 2006

Mitochondrial localization of CNP2 is regulated by phosphorylation of the N-terminal targeting signal by PKC: Implications of a mitochondrial function for CNP2 in glial and non-glial cells

Molecular and Cellular Neuroscience, ISSN: 10447431

John Lee; Ryan C. O'Neill; Min Woo Park; Michel Gravel; Peter E. Braun

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March 1, 2006

Vascular endothelial growth factor A signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival

Journal of the American Society of Nephrology, ISSN: 10466673

Vera Eremina; Shiying Cui; Hans-Peter Gerber; Napoleone Ferrara; Jody Haigh; Andras Nagy; Masatsugu Ema; Janet Rossant; Serge Jothy; Jeffrey H. Miner; Susan E. Quaggin

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March 1, 2006

The vascular basement membrane: A niche for insulin gene expression and β cell proliferation

Developmental Cell, ISSN: 15345807

Ganka Nikolova; Normund Jabs; Irena Konstantinova; Anna Domogatskaya; Karl Tryggvason; Lydia Sorokin; Reinhard Fässler; Guoqiang Gu; Hans-Peter Gerber; Napoleone Ferrara; Douglas A. Melton; Eckhard Lammert

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March 1, 2006

Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis

International Journal of Cancer, ISSN: 00207136 10970215

Michael Scott; W. Glenn McCluggage; Kenneth J. Hillan; Peter A. Hall; S. E. Hilary Russell

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March 1, 2006

Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis

Development (Cambridge), ISSN: 09501991

Phyllis Strickland; Grace C. Shin; Andrew Plump; Marc Tessier-Lavigne; Hinck

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March 1, 2006

Compaction agent protection of nucleic acids during mechanical lysis

Biotechnology Progress, ISSN: 87567938

Jason C. Murphy; Tony Cano; George E. Fox; Richard C. Willson

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February 24, 2006

Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit: Differences in structure and function relative to unliganded UL44

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Brent A. Appleton; Justin Brooks; Arianna Loregian; David J. Filman; Donald M. Coen; James M. Hogle

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February 15, 2006

Cutting edge: Novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods

Journal of Immunology, ISSN: 00221767

Pisabarro; Beatrice Leung; Mandy Kwong; Corpuz; Gretchen D. Frantz; Nancy Y. Chiang; Richard L. Vandlen; Laurie Diehl; Nicholas J. Skelton; Hok Seon Kim; Dan L. Eaton; Kerstin N. Schmidt

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February 9, 2006

Dr. Mastrianni's letter was referred to Genentech, the manufacturer of trastuzumab, which offers the following reply [9]

New England Journal of Medicine, ISSN: 00284793 15334406

Hal V. Barron

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February 3, 2006

New neurons follow the flow of cerebrospinal fluid in the adult brain

Science, ISSN: 00368075 10959203

Kazunobu Sawamoto; Hynek Wichterle; Oscar Gonzalez-Perez; Jeremy A. Cholfin; Masayuki Yamada; Nathalie Spassky; Noel S. Murcia; Jose Manuel Garcia-Verdugo; Oscar Marín; John L. R. Rubenstein; Marc Tessier-Lavigne; Hideyuki Okano; Arturo Alvarez-Buylla

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February 1, 2006

Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma

Cancer, ISSN: 0008543X 10970142

Brian I. Rini; Vivian Weinberg; Sarah Dunlap; Alexandra Elchinoff; Nancy Yu; Robert Bok; Jeffery Simko; Small

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February 1, 2006

Identification and immunotherapeutic targeting of antigens induced by chemotherapy

Nature Biotechnology, ISSN: 10870156 15461696

Bonnee Rubinfeld; Archana Upadhyay; Suzanna Clark; Fong; Victoria Smith; Koeppen; Ross; Paul G. Polakis

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February 1, 2006

Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the αl subunit of lymphocyte function-associated antigen-1

Protein Science, ISSN: 09618368 1469896X

Keating; Clark; Lisa D. Stefanich; Arellano; Caroline P. Edwards; Bodary; Steven A. Spencer; Thomas Gadek; James C. Marsters Jr.; Beresini

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February 1, 2006

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

Developmental Biology, ISSN: 00121606

Xi-De Wang; Ching Ching Leow; Jiping Zha; Zhijun Tang; Zora Modrusan; Freddy Radtke; Michel Aguet; Frederic J. De Sauvage; Gao

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February 1, 2006

Ocular versus extraocular neovascularization: Mirror images or vague resemblances

Investigative Ophthalmology and Visual Science, ISSN: 01460404

Peter A. Campochiaro; Rhoda Alani; Kari Alitalo; Peter Brooks; Ruth Caldwell; Peter Carmeliet; Pier Paolo Claudio; Robert D'Amato; Arup Das; Rainer De Martin; Michael Detmar; Napoleone Ferrara; Robert N. Frank; Marcus Fruttiger; Antonio Giordano; Maria Grant; Hans-Peter Hammes; Mats Hellstrom; David Hinton; Eli Keshet; Alisa Koch; Richard Lang; Donald M. McDonald; Jeremy Nathans; Dario Neri; Gera Neufeld; Jean Plouet; Gregg Semenza; Nader Sheibani; David T. Shima; Philip Thorpe; Rubin Tuder; Olga Volpert; Elizabeth Wagner; Bernhard Weber; Stanley Wiegand

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January 20, 2006

In reply [2]

Journal of Clinical Oncology, ISSN: 0732183X

Fairooz F. Kabbinavar; Julie Hambleton; Robert Mass; Somnath Sarkar

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January 15, 2006

Oncogenic BRAF is required for tumor growth and maintenance in melanoma models

Cancer Research, ISSN: 00085472

Klaus P. Hoeflich; Daniel C. Gray; Mike Eby; Janet Y. Tien; Leo Wong; Janeko Bower; Alvin Gogineni; Jiping Zha; Mary J. Cole; Howard M. Stern; Lesley J. Murray; David P. Davis; Somasekar Seshagiri

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January 15, 2006

Redundant roles of VEGF-B and PlGF during selective VEGF-A blockade in mice

Blood, ISSN: 00064971 00064971

Ajay K. Malik; Megan E. Baldwin; Franklin V. Peale Jr.; Fuh; Wei-Ching Liang; Henry B. Lowman; Meng; Napoleone Ferrara; Hans-Peter Gerber

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January 13, 2006

When proteomes collide

Science, ISSN: 00368075 10959203

Joel S. Bader; John Chant

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January 13, 2006

Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Wei-Ching Liang; Xiumin Wu; Franklin V. Peale Jr.; Chingwei V. Lee; Meng; Johnny Gutierrez; Ling Fu; Ajay K. Malik; Hans-Peter Gerber; Napoleone Ferrara; Fuh

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January 10, 2006

Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer

Journal of Clinical Oncology, ISSN: 0732183X

Adrian M. Jubb; Herbert Hurwitz; Wei Bai; Holmgren; Tobin; A. Steven Guerrero; Fairooz F. Kabbinavar; Scott N. Holden; Novotny; Gretchen D. Frantz; Kenneth J. Hillan; Koeppen

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January 3, 2006

Hospital improvement in time to reperfusion in patients with acute myocardial infarction, 1999 to 2002

Journal of the American College of Cardiology, ISSN: 07351097

Robert L. McNamara; Jeph Herrin; Elizabeth H. Bradley; Edward L. Portnay; Jeptha P. Curtis; Yongfei Wang; David J. Magid; Martha Blaney; Harlan M. Krumholz

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January 1, 2006

Counterpoint: Why biogenerics are a strawman

Nature Biotechnology, ISSN: 15461696 10870156

Robert L. Garnick

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January 1, 2006

Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liver immunopathology

American Journal of Pathology, ISSN: 00029440

Lucia E. Rosas; Anjali A. Satoskar; Kimberly M. Roth; Tracy L. Keiser; Joseph Barbi; Christopher A. Hunter; Frederic J. De Sauvage; Abhay R. Satoskar

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January 1, 2006