Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10551 - 10600 OF 15598 RESULTS

Proteomic studies support the use of multi-product immunoassays to monitor host cell protein impurities
Proteomics, ISSN: 16159853 16159861
Denise C. Krawitz; William F. Forrest; G. Tony Moreno; Joshua Kittleson; Kathleen M. Champion
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Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma
AIDS Research and Human Retroviruses, ISSN: 08892229
Seth Rakoff-Nahoum; Peter Kuebler; Jonas J. Heymann; Megan E. Sheehy; Gabriel M. Ortiz; Graham S. Ogg; Jason D. Barbour; Jack Lenz; Alan D. Steinfeld; Douglas F. Nixon
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Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei
International Journal of Infectious Diseases, ISSN: 12019712
Steven P. LaRosa; Steven M. Opal; Barbara Utterback; Sau Chi Betty Yan; Jeffrey D. Helterbrand; Andrew J.H. Simpson; Wipada Chaowagul; Nicholas J. White; Charles J. Fisher Jr.
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Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers
Pharmaceutical Research, ISSN: 07248741
Chee Ng; Stefanich; Banmeet S. Anand; Fielder; Louis Vaickus
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Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis
Journal of Allergy and Clinical Immunology, ISSN: 00916749
Thomas B. Casale; William W. Busse; Joel N. Kline; Zuhair K. Ballas; Mark H. Moss; Robert G. Townley; Masoud Mokhtarani; Vicki Seyfert-Margolis; Adam Asare; Kirk Bateman; Yamo Deniz
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Mayo Clinic consensus statement for the use of bisphosphonates in multiple myeloma
Mayo Clinic Proceedings, ISSN: 00256196
Martha Lacy; Angela Dispenzieri; Morie A. Gertz; Philip R. Greipp; Kimberly L. Gollbach; Suzanne R. Hayman; Shaji Kumar; John A. Lust; S. Vincent Rajkumar; Stephen J. Russell; Witzig; Steven R. Zeldenrust; David Dingli; P. Lief Bergsagel; Rafael Fonseca; Craig B. Reeder; A. Keith Stewart; Vivek Roy; Robert J. Dalton; Alan B. Carr; Deepak Kademani; Eugene E. Keller; Christopher F. Viozzi; Robert A. Kyle
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Erratum: Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution (Journal of Pharmaceutical Sciences [2005] 94 [1928-1940] DOI: 10.1002/jps.20347)
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Jun Liu; Mary D. H. Nguyen; Andya; Steven J. Shire
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Somatic mutations lead to an oncogenic deletion of Met in lung cancer
Cancer Research, ISSN: 00085472
Monica Kong-Beltran; Somasekar Seshagiri; Jiping Zha; Wenjing Zhu; Kaumudi Bhawe; Nerissa Mendoza; Thomas Holcomb; Kanan Pujara; Stinson; Ling Fu; Christophe Severin; Linda Rangell; Ralph H. Schwall; Lukas Amier; Dineli Wickramasinghe; Robert Yauch
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Concordance between central and local laboratory HER2 testing from a community-based clinical study
Clinical Breast Cancer, ISSN: 15268209
Josina C. Reddy; Reimann; Steven M. Anderson; Pam Klein
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Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma
Neuro-Oncology, ISSN: 15228517
Michael D. Prados; Kathleen R. Lamborn; Susan Chang; Eric Burton; Nicholas Butowski; Mary Malec; Ami Kapadia; Jane Rabbit; Margaretta S. Page; Ann Fedoroff; Dong Xie; Kelley
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Self-association of therapeutic proteins: Implications for product development
Misbehaving Proteins: Protein (Mis)Folding, Aggregation, and Stability,
Cromwell; Chantal Felten; Heather Flores; Jun Liu; Steven J. Shire
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An overview of the pharmacokinetics and pharmacodynamics of efalizumab: A monoclonal antibody approved for use in psoriasis
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Amita Joshi; Bauer; Peter Kuebler; Mark White; Cecilia Leddy; Peter Compton; Marvin Garovoy; Paul Kwon; Patricia Walicke; Russell L Dedrick
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Effect of intravitreal injection of ranibizumab in combination with verteporfin PDT on normal primate retina and choroid
Investigative Ophthalmology and Visual Science, ISSN: 01460404
Ivana K. Kim; Deeba Husain; Norman Michaud; Edward Connolly; Anne Marie Lane; Khayyam Durrani; Ali Hafezi-Moghadam; Evangelos S. Gragoudas; Charles A. O'Neill; Joseph Beyer; Joan W. Miller
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A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys
American Journal of Pathology, ISSN: 00029440
Yulia Vugmeyster; Dhaya Seshasayee; Wesley S. Chang; Anahid Storn; Howell; Susan Sa; Tenea Nelson; Flavius Martin; Iqbal S. Grewal; Ellen Gilkerson; Ben Wu; Jeffrey S. Thompson; Barbara N. Ehrenfels; Song Ren; An Song; Thomas R. Gelzleichter; Dimitry Danilenko
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Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
Cancer Cell, ISSN: 15356108
Phillips; Samir Kharbanda; Ruihuan Chen; William F. Forrest; Robert Soriano; Thomas D Wu; Anjan Misra; Janice M. Nigro; Howard Colman; Liliana Soroceanu; P. Mickey Williams; Zora Modrusan; Burt G. Feuerstein; Kenneth D. Aldape
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Asthma in older adults: Observations from the Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study
Annals of Allergy, Asthma and Immunology, ISSN: 10811206
Raymond G. Slavin; Tmirah Haselkorn; June H. Lee; Zheng; Yamo Deniz; Sally E. Wenzel
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Survivin expression in breast cancer predicts clinical outcome and is associated with HER2, VEGF, urokinase plasminogen activator and PAI-1
Annals of Oncology, ISSN: 15698041 09237534
Brid M. Ryan; Gottfried E. Konecny; Kahlert; Wang; Untch; Meng; Pegram; Podratz; John Crown; Dennis J. Slamon; Duffy
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Potential inhibitors of chemokine function: Analysis of noncovalent complexes of CC chemokine and small polyanionic molecules by ESI FT-ICR mass spectrometry
Journal of the American Society for Mass Spectrometry, ISSN: 10440305
Yonghao Yu; Matthew D. Sweeney; Ola M. Saad; Julie A. Leary
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Tolerability and Efficacy of Multiple Escalating Doses of Ranibizumab (Lucentis) for Neovascular Age-Related Macular Degeneration
Ophthalmology, ISSN: 01616420
Philip J. Rosenfeld; Jeffrey S. Heier; Gary Hantsbarger; Naveed Shams
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Ranibizumab for Treatment of Neovascular Age-Related Macular Degeneration. A Phase I/II Multicenter, Controlled, Multidose Study
Ophthalmology, ISSN: 01616420
Jeffrey S. Heier; Andrew N. Antoszyk; Peter Reed Pavan; Steven R. Leff; Philip J. Rosenfeld; Thomas A. Ciulla; Richard F. Dreyer; Ronald C. Gentile; Judy P. Sy; Gary Hantsbarger; Naveed Shams
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Apples and oranges: Comparing computer systems audits
Drug Information Journal, ISSN: 00928615
Jacques Mourrain
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The application of mechanism-based PK/PD modeling in pharmacodynamic-based dose selection of muM17, a surrogate monoclonal antibody for efalizumab
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Benjamin Wu; Amita Joshi; Song Ren; Chee Ng
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Evaluation of erlotinib in advanced non-small cell lung cancer: Impact on the budget of a U.S. health insurance plan
Journal of Managed Care Pharmacy, ISSN: 10834087
Scott D. Ramsey; Lauren Clarke; Tripthi V. Kamath; Deborah Lubeck
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Is tobacco use a problem among deaf college students?
American Annals of the Deaf, ISSN: 0002726X
Barbara A. Berman; Coen A. Bernaards; Elizabeth A. Eckhardt; Heidi B. Kleiger; Lauren Maucere; Leanne Streja; Glenn Wong; Shari Barkin; Roshan Bastani
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Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
ACS Chemical Biology, ISSN: 15548937
Zobel; Lan Wang; Eugene Varfolomeev; Matthew C Franklin; Linda O. Elliott; Heidi J. A. Wallweber; David C Okawa; Flygare; Domagoj Vucic; Wayne J. Fairbrother; Deshayes
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Regulation of ERK3/MAPK6 expression by BRAF
International Journal of Oncology, ISSN: 17912423 10196439
Klaus P. Hoeflich; Mike Eby; William F. Forrest; Daniel C. Gray; Janet Y. Tien; Howard M. Stern; Lesley J. Murray; David P. Davis; Zora Modrusan; Somasekar Seshagiri
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Targeted therapies in solid tumors: Monoclonal antibodies and small molecules
Human Antibodies, ISSN: 10932607
Louis M. Weiner; Hossein Borghaei
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Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Aditya A. Wakankar; Ronald T. Borchardt
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Paracrine VEGF/VE-cadherin action on ovarian cancer permeability
Experimental Biology and Medicine, ISSN: 15353699 15353702
Limin Hu; Napoleone Ferrara; Robert B. Jaffe
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Longitudinal differences in psychological outcomes for Men with erectile dysfunction: Results from ExCEED™
Journal of Sexual Medicine, ISSN: 17436109 17436095
David M. Latini; David F. Penson; Katrine L. Wallace; Deborah Lubeck; Tom F. Lue
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Clinical and psychosocial characteristics of men with erectile dysfunction: Baseline data from ExCEED™
Journal of Sexual Medicine, ISSN: 17436109 17436095
David M. Latini; David F. Penson; Katrine L. Wallace; Deborah Lubeck; Tom F. Lue
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Synthetic therapeutic antibodies
Nature Chemical Biology, ISSN: 15524469 15524450
Sachdev S. Sidhu; Frederic A. Fellouse
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Nontraditional roles for certified pharmacy technicians in a pharmaceutical company
Journal of the American Pharmacists Association, ISSN: 15443450 15443191
Stacey M. Fung; Christine Gilmour; David McCracken; Korban Shane; Gary Matsuura
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Large-scale trends in the evolution of gene structures within 11 animal genomes
PLoS Computational Biology, ISSN: 15537358 1553734X
Mark Yandell; Chris J. Mungall; Chris Smith; Simon Prochnik; Joshua S. Kaminker; George Hartzell; Suzanna E. Lewis; Gerald M. Rubin
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TGF-β regulates the mechanical properties and composition of bone matrix
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Guive Balooch; Mehdi Balooch; Ravi K. Nalla; Stephen Schilling; Ellen H. Filvaroff; Grayson W. Marshall; Sally J. Marshall; Robert O. Ritchie; Rik Derynck; Tamara Alliston
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Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Michelle A. Lowes; Francesca Chamian; Maria V. Abello; Judilyn Fuentes-Duculan; Shao-Lee Lin; Rachel Nussbaum; Inna Novitskaya; Henrietta Carbonaro; Irma Cardinale; Toyoko Kikuchi; Patricia Gilleaudeau; Mary Sullivan-Whalen; Knut Wittkowski; Kim Papp; Marvin Garovoy; Wolfgang Dummer; Ralph M. Steinman; James G. Krueger
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Identification of the minimal protein domain required for priming activity of munc13-1
Current Biology, ISSN: 09609822
David R. Stevens; Zheng-Xing Wu; Ulf Matti; Harald Junge; Claudia Schirra; Ute Becherer; Sonja M. Wojcik; Nils Brose; Jens Rettig
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Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients
Clinical Cancer Research, ISSN: 10780432
Robert Yauch; Thomas Januario; Eberhard; Guy Cavet; Wenjing Zhu; Ling Fu; Thinh Q. Pham; Robert Soriano; Stinson; Somasekar Seshagiri; Zora Modrusan; Chin-Yu Lin; Vincent O'Neill; Lukas Amler
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Angiogenesis as a therapeutic target
Nature, ISSN: 00280836 14764679
Napoleone Ferrara; Robert S. Kerbel
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MORT1/FADD is involved in liver regeneration
World Journal of Gastroenterology, ISSN: 10079327
Marcus Schuchmann; Felix Rückert; Jose F. Garcia-Lazaro; Andrea Karg; Jürgen Burg; Natalia Knorr; Jürgen Siebler; Eugene Varfolomeev; David Wallach; Wolfgang Schreiber; Ansgar W. Lohse; Peter R. Galle
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Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Cary D. Austin; Xiaohui Wen; Lewis Gazzard; Nelson; Richard H. Scheller; Suzie J. Scales
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Interspecies exchange mutagenesis of the first epidermal growth factor-like domain of human factor VII
Journal of Thrombosis and Haemostasis, ISSN: 15387933 15387836
Williamson; Pyke; Sampath Sridhara; Robert F. Kelley; Morris A. Blajchman; Bryan J. Clarke
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Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eugene Varfolomeev; Heather Maecker; Darcie Sharp; David Lawrence; Renz; Domagoj Vucic; Avi Ashkenazi
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A smooth operator for LPS responses
Nature Immunology, ISSN: 15292908 15292916
Godowski
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P63 is an essential proapoptotic protein during neural development
Neuron, ISSN: 08966273
W. Bradley Jacobs; Gregory Govoni; Daniel Ho; Jasvinder K. Atwal; Fanie Barnabe-Heider; William M. Keyes; Alea A. Mills; Freda D. Miller; David R. Kaplan
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TWEAK attenuates the transition from innate to adaptive immunity
Cell, ISSN: 00928674
Heather Maecker; Eugene Varfolomeev; Frank C. Kischkel; David Lawrence; Heidi LeBlanc; Wyne P. Lee; Stephen D. Hurst; Dimitry Danilenko; Jun Li; Ellen H. Filvaroff; Becky Yang; Dylan Daniel; Avi Ashkenazi
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Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
Journal of Clinical Oncology, ISSN: 0732183X
David B. Agus; Michael S. Gordon; Charles Taylor; Ronald B. Natale; Beth Karlan; David Mendelson; Michael F. Press; David E. Allison; Mark X. Sliwkowski; Grade Lieberman; Stephen Kelsey; Gwendolyn Fyfe
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Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
Journal of Clinical Oncology, ISSN: 0732183X
Eberhard; Bruce E. Johnson; Lukas Amler; Goddard; Sherry Heldens; Roy S. Herbst; William Ince; Pasi A. Jänne; Thomas Januario; David H. Johnson; Pam Klein; Vincent A. Miller; Michael Ostland; David A. Ramies; Dragan Sebisanovic; Stinson; Zhang; Somasekar Seshagiri; Kenneth J. Hillan
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UV microscopy at 280 nm is effective in screening for the growth of protein microcrystals
Journal of Applied Crystallography, ISSN: 00218898 16005767
Christopher S. Lunde; Shahab Rouhani; Jonathan P. Remis; Steven E. Ruzin; James A. Ernst; Robert M. Glaeser
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Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
Journal of Clinical Oncology, ISSN: 0732183X
Kathy Miller; Linnea I. Chap; Frankie Ann Holmes; Melody A. Cobleigh; P. Kelly Marcom; Louis Fehrenbacher; Maura N. Dickler; Beth A. Overmoyer; Reimann; Amy Sing; Virginia K. Langmuir; Hope S. Rugo
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