Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10651 - 10700 OF 15598 RESULTS

October 4, 2005

Achieving door-to-balloon times that meet quality guidelines: How do successful hospitals do it?

Journal of the American College of Cardiology, ISSN: 07351097

Elizabeth H. Bradley; Sarah A. Roumanis; Martha J. Radford; Tashonna R. Webster; Robert L. McNamara; Jennifer A. Mattera; Barbara A. Barton; David N. Berg; Edward L. Portnay; Harry Moscovitz; Janet Parkosewich; Eric S. Holmboe; Martha Blaney; Harlan M. Krumholz

October 1, 2005

Pathogen recognition: TLRs throw us a curve

Immunity, ISSN: 10747613

Peter Kirk; J.Fernando Bazan

October 1, 2005

Population pharmacokinetics of trastuzumab in patients with HER2+ metastatic breast cancer

Cancer Chemotherapy and Pharmacology, ISSN: 03445704

Rene Bruno; Carla Washington; Jian-Feng Lu; Lieberman; Ludger Banken; Pam Klein

October 1, 2005

The septin-binding protein anillin is overexpressed in diverse human tumors

Clinical Cancer Research, ISSN: 10780432

Peter A. Hall; Christopher B. Todd; Paula L. Hyland; Simon S. McDade; Grabsch; Mit Dattani; Kenneth J. Hillan; S. E. Hilary Russell

October 1, 2005

The external RNA controls consortium: A progress report

Nature Methods, ISSN: 15487091 15491676

Shawn C. Baker; Steven R. Bauer; Richard P. Beyer; James D. Brenton; Bud Bromley; John Burrill; Helen Causton; Michael P. Conley; Rosalie Elespuru; Michael Fero; Carole Foy; James Fuscoe; Xiaolian Gao; David Lee Gerhold; Patrick Gilles; Federico Goodsaid; Xu Guo; Joe Hackett; Richard D. Hockett; Pranvera Ikonomi; Rafael A. Irizarry; Ernest S. Kawasaki; Tamma Kaysser-Kranich; Kathleen Kerr; Gretchen Kiser; Walter H. Koch; Kathy Y. Lee; Chunmei Liu; Z. Lewis Liu; Anne Lucas; Chitra F. Manohar; Garry Miyada; Zora Modrusan; Helen Parkes; Raj K. Puri; Laura Reid; Thomas B. Ryder; Marc Salit; Raymond R. Samaha; Uwe Scherf; Timothy J. Sendera; Robert A. Setterquist; Leming Shi; Richard Shippy; Jesus V. Soriano; Elizabeth A. Wagar; Janet A. Warrington; Mickey Williams; Frederike Wilmer; Mike Wilson; Paul K. Wolber; Xiaoning Wu; Renata Zadro

October 1, 2005

TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice

Immunology and Cell Biology, ISSN: 08189641

Erika Cretney; Jonathan L. McQualter; Nobuhiko Kayagaki; Hideo Yagita; Claude C.A. Bernard; Iqbal S. Grewal; Avi Ashkenazi; Mark J. Smyth

September 23, 2005

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

Cell, ISSN: 00928674

Sophie Pattingre; Amina Tassa; Xueping Qu; Rita Garuti; Huan Liang Xiao; Noboru Mizushima; Milton Packer; Michael D. Schneider; Beth Levine

September 21, 2005

Inhibitory effects of interferon-γ on myocardial hypertrophy

Cytokine, ISSN: 10434666

Hongkui Jin; Wei Li; Renhui Yang; Annie Ogasawara; Hsienwie Lu; Nicholas F. Paoni

September 19, 2005

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae

Journal of Experimental Medicine, ISSN: 00221007

Kyle I. Happel; Patricia J. Dubin; Mingquan Zheng; Nico Ghilardi; Christie Lockhart; Lee J. Quinton; Anthony R. Odden; Judd E. Shellito; Gregory J. Bagby; Steve Nelson; Jay K. Kolls

September 15, 2005

Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40

Cancer Research, ISSN: 00085472

Che-Leung Law; Kristine A. Gordon; John Collier; Kerry Klussman; Julie A. McEarchern; Charles G. Cerveny; Bruce J. Mixan; Wyne P. Lee; Zhonghau Lin; Patricia A. Valdez; Alan Wahl; Iqbal S. Grewal

September 15, 2005

Novel method of generating prostate-specific Cre-loxP gene switching via intraductal delivery of adenovirus

Prostate, ISSN: 02704137

Ching Ching Leow; Xi-De Wang; Gao

September 15, 2005

A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging

Biochemical Journal, ISSN: 02646021

Stanley W. Botchway; Ignasi Barba; Randolf Jordan; Rebecca Harmston; Peter M. Haggie; Simon P. Williams; Alexandra M. Fulton; Anthony W. Parker; Kevin M. Brindle

September 13, 2005

Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Roland H. Friedel; Andrew Plump; Lu; Kerri Spilker; Christine Jolicoeur; Karen G. Wong; Tadmiri R. Venkatesh; Avraham Yaron; Mary Hynes; Bin Chen; Ami Okada; Susan K. McConnell; Helen Rayburn; Marc Tessier-Lavigne

September 1, 2005

Mutations increasing exposure of a receptor binding site epitope in the soluble and oligomeric forms of the caprine arthritis-encephalitis lentivirus envelope glycoprotein

Virology, ISSN: 00426822

Isidro Hötzel; William P. Cheevers

September 1, 2005

NMR methods for studying the structure and dynamics of RNA

ChemBioChem, ISSN: 14394227

Michael P. Latham; Darin J. Brown; Scott A. McCallum; Arthur Pardi

September 1, 2005

Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis

Protein Science, ISSN: 09618368 1469896X

Gábor Pál; Shun-Yin Fong; Anthony A. Kossiakoff; Sachdev S. Sidhu

September 1, 2005

Separation of genomic DNA from plasmid DNA by selective renaturation with immobilized metal affinity capture

Biotechnology Progress, ISSN: 87567938

Tony Cano; Jason C. Murphy; George E. Fox; Richard C. Willson

September 1, 2005

Alcohol as a risk factor for plaque-type psoriasis

Cutis, ISSN: 00114162

Shahrad M. Behnam; Shahdad E. Behnam; John Y. Koo

September 1, 2005

Partial remission of psoriasis following rituximab therapy for non-hodgkin lymphoma

Cutis, ISSN: 00114162

Fiza Singh; Jeffrey M. Weinberg

September 1, 2005

Technical report # 39: Cold chain guidance for medicinal products: Maintaining the quality of temperature-sensitive medicinal products through the transportation environment

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440

Rafik H. Bishara; Jim Antonopoulos; Mari Bakken; Daniel Colton; Laura Fontan; Derrick Gallagher; Paul Harber; Kelly Klien; Chris Landauer; Teresa Lucas; Sarvang Mishra; Kevin O'Donnell; Oumer Salim; Jeff Seeley; Bob Seevers; Edward G. Smith; Douglas Staruk; Donald Wilson

September 1, 2005

Effect of statin use within the first 24 hours of admission for acute myocardial infarction on early morbidity and mortality

American Journal of Cardiology, ISSN: 00029149

Gregg C. Fonarow; R. Scott Wright; Frederick A. Spencer; Paul D. Fredrick; Wei Dong; Nathan R. Every; William J. French

September 1, 2005

Recombinant tissue plasminogen activator for minor strokes: The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study experience

Annals of Emergency Medicine, ISSN: 01960644

Steven R. Levine; Joseph P. Broderick; Thomas Brott; Thomas DeGraba; Susan C. Fagan; Michael R. Frankel; James C. Grotta; E. Clarke Haley Jr.; Scott Hamilton; Thomas Kwiatkowski; Christopher A. Lewandowski; Yan Lin; Richard Libman; Mei Lu; Patrick Lyden; John R. Marler; Lewis Morgenstern; Suresh Patel; Corsee Sanders; Barbara C. Tilley

September 1, 2005

Portfolio management by late-phase design

Good Clinical Practice Journal, ISSN: 13500961

Susan Morris; Elizabeth Tschosik

September 1, 2005

Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab

Breast Cancer Research and Treatment, ISSN: 01676806

Noel Dybdal; Grazyna Leiberman; Steven M. Anderson; Bryan McCune; Alex Bajamonde; Robert L. Cohen; Robert Mass; Corsee Sanders; Michael F. Press

September 1, 2005

Protein-interaction mapping in search of effective drug targets

BioEssays, ISSN: 02659247

Amitabha Chaudhuri; John Chant

September 1, 2005

Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab

Journal of Surgical Oncology, ISSN: 00224790

Frank A. Scappaticci; Louis Fehrenbacher; Cartwright; John Hainsworth; William Heim; Jordan Berlin; Fairooz F. Kabbinavar; Novotny; Somnath Sarkar; Herbert Hurwitz

September 1, 2005

Bioanalytical method validation for macromolecules in support of pharmacokinetic studies

Pharmaceutical Research, ISSN: 07248741 1573904X

JoMarie Smolec; Binodh DeSilva; Wendell Smith; Russell Weiner; Marian Kelly; Ben Lee; Masood Khan; Richard Tacey; Howard Hill; Abbie Celniker; Vinod Shah; Ronald Bowsher; Mire-Sluis; John W. A. Findlay; Mary Saltarelli; Quarmby; David Lansky; Robert Dillard; Martin Ullmann; Steve Keller; H. Thomas Karnes

August 18, 2005

ERM is required for transcriptional control of the spermatogonial stem cell niche

Nature, ISSN: 00280836

Chen Chen; Wenjun Ouyang; Vadim Grigura; Qing Zhou; Kay Carnes; Hyunjung J. Lim; Guang-Quan Zhao; Silvia Arber; Natasza Kurpios; Theresa L. Murphy; Alec M. Cheng; John A. Hassell; Varadaraj Chandrashekar; Marie-Claude Hofmann; Rex A. Hess; Kenneth M. Murphy

August 18, 2005

Sex and racial differences in the management of acute myocardial infarction, 1994 through 2002

New England Journal of Medicine, ISSN: 00284793

Viola Vaccarino; Saif S. Rathore; Nanette K. Wenger; Paul D. Frederick; Jerome L. Abramson; Hal V. Barron; Ajay Manhapra; Susmita Mallik; Harlan M. Krumholz

August 17, 2005

Relationship between time of day, day of week, timeliness of reperfusion, and in-hospital mortality for patients with acute ST-segment elevation myocardial infarction

JAMA - Journal of the American Medical Association, ISSN: 00987484

David J. Magid; Yongfei Wang; Jeph Herrin; Robert L. McNamara; Elizabeth H. Bradley; Jeptha P. Curtis; Charles V. Pollack Jr.; William J. French; Martha Blaney; Harlan M. Krumholz

August 17, 2005

Relationship between time of day, day of week, timeliness of reperfusion, and in-hospital mortality for patients with acute ST-segment elevation myocardial infarction

JAMA - Journal of the American Medical Association, ISSN: 15383598 00987484

David J. Magid; Yongfei Wang; Jeph Herrin; Robert L. McNamara; Elizabeth H. Bradley; Jeptha P. Curtis; Charles V. Pollack Jr.; William J. French; Martha Blaney; Harlan M. Krumholz

August 15, 2005

APC-independent NK cell activation [1] (multiple letters)

Journal of Immunology, ISSN: 00221767

Zhongjun Dong; Zhigang Tian; Kerstin N. Schmidt; Beatrice Leung; Mandy Kwong; Kol A. Zarember; Sanjeev Satyal; Tony A. Navas; Fay Wang; Godowski

August 15, 2005

Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers

Biochemical Journal, ISSN: 02646021

Sylvia Herter; Derek E. Piper; Wade Aaron; Timothy Gabriele; Cutler; Ping Cao; Ami S. Bhatt; Youngchool Choe; Charles S. Craik; Nigel Walker; David Meininger; Timothy Hoey; Richard J. Austin

August 15, 2005

Unambiguous assignment of intramolecular chemical cross-links in modified mammalian membrane proteins by Fourier transform-tandem mass spectrometry

Analytical Chemistry, ISSN: 00032700

Petr Novak; William E. Haskins; Marites J. Ayson; Richard B. Jacobsen; Joseph S. Schoeniger; Michael D. Leavell; Malin M. Young; Gary H. Kruppa

August 5, 2005

Phosphorylation of FADD at serine 194 by CKIα regulates its nonapoptotic activities

Molecular Cell, ISSN: 10972765

Elizabeth C. Alappat; Christine Feig; Benjamin Boyerinas; Jörg Volkland; Martin Samuels; Andrea E. Murmann; Andrew Thorburn; Vincent J. Kidd; Clive A. Slaughter; Stephanie L. Osborn; Astar Winoto; Wei-Jen Tang; Marcus E. Peter

August 1, 2005

Unraveling TACIt functions

Nature Genetics, ISSN: 10614036

Flavius Martin; Vishva M. Dixit

August 1, 2005

Safety and tolerability of omalizumab (Xolair®), a recombinant humanized monoclonal anti-IgE antibody

Clinical Reviews in Allergy and Immunology, ISSN: 10800549

Yamo Deniz; Niroo Gupta

August 1, 2005

Loss of the serine/threonine kinase Fused results in postnatal growth defects and lethality due to progressive hydrocephalus

Molecular and Cellular Biology, ISSN: 02707306

Mark Merchant; Marie Evangelista; Shiuh-Ming Luoh; Gretchen D. Frantz; Sreedevi Chalasani; Richard A. D. Carano; Marjie Van Hoy; Julio Ramirez; Annie Ogasawara; Leanne McFarland; Ellen H. Filvaroff; French; Frederic J. De Sauvage

August 1, 2005

Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)

Journal of Pathology, ISSN: 00223417

Laura A. Strickland; Adrian M. Jubb; Hongo; Fiona Zhong; Jennifer Burwick; Ling Fu; Gretchen D. Frantz; Koeppen

August 1, 2005

Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A

Journal of Cell Biology, ISSN: 00219525

Parker L. Andersen; Honglin Zhou; Landon Pastushok; Trevor Moraes; Sean McKenna; Barry Ziola; Michael J. Ellison; Vishva M. Dixit; Wei Xiao

July 29, 2005

Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy

Biochemical and Biophysical Research Communications, ISSN: 0006291X

Napoleone Ferrara; Kenneth J. Hillan; Novotny

July 25, 2005

Quality of care by classification of myocardial infarction. Treatment patterns for ST-segment elevation vs non-ST-segment elevation myocardial infarction

Archives of Internal Medicine, ISSN: 00039926

Matthew T. Roe; Lori Parsons; Charles V. Pollack Jr.; John G. Canto; Hal V. Barron; Nathan R. Every; William J. Rogers; Eric D. Peterson

July 15, 2005

EphB2 is a prognostic factor in colorectal cancer

Clinical Cancer Research, ISSN: 10780432

Adrian M. Jubb; Fiona Zhong; Sheila Bheddah; Grabsch; Gretchen D. Frantz; Wolfram Mueller; Kavi; Philip Quirke; Paul G. Polakis; Koeppen

July 15, 2005

IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-γ responses if IL-12p70 is available

Journal of Immunology, ISSN: 00221767

Shabaana A. Khader; John E. Pearl; Kaori Sakamoto; Leigh Gilmartin; Guy Bell; Dawn M. Jelley-Gibbs; Nico Ghilardi; Frederic J. De Sauvage; Andrea M. Cooper

July 14, 2005

Common mechanisms of nerve and blood vessel wiring

Nature, ISSN: 00280836

Peter Carmeliet; Marc Tessier-Lavigne

July 13, 2005

Perceptions of positive meaning and vulnerability following breast cancer: Predictors and outcomes among long-term breast cancer survivors

Annals of Behavioral Medicine, ISSN: 08836612

Julienne E. Bower; Beth E. Meyerowitz; Katherine A. Desmond; Coen A. Bernaards; Julia H. Rowland; Patricia A. Ganz

July 1, 2005

Vertebrate GLD2 poly(A) polymerases in the germline and the brain

RNA, ISSN: 13558382

Labib Rouhana; Liaoteng Wang; Natascha Buter; Eun Kwak Jae; Craig A. Schiltz; Gonzalez; Ann E. Kelley; Charles F. Landry; Marvin Wickens

July 1, 2005

Population pharmacokinetics of rituximab (anti-CD20 monoclonal antibody) in rheumatoid arthritis patients during a phase II clinical trial

Journal of Clinical Pharmacology, ISSN: 00912700

Chee Ng; Rene Bruno; Dan Combs; Brian E. Davies

July 1, 2005

Pharmacokinetic-pharmacodynamic-efficacy analysis of efalizumab in patients with moderate to severe psoriasis

Pharmaceutical Research, ISSN: 07248741 1573904X

Chee Ng; Amita Joshi; Russell L Dedrick; Marvin Garovoy; Bauer

July 1, 2005

Transcriptional regulatory networks activated by PI3K and ERK transduced growth signals in human glioblastoma cells

Journal of Computer Science and Technology, ISSN: 10009000

Matthias Peter; Zhi-Ping Weng; Ulla Hansen

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