Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10851 - 10900 OF 15612 RESULTS

Activity-dependent internalization of smoothened mediated by β-Arrestin 2 and GRK2
Science, ISSN: 00368075
Wei Chen; Xiu-Rong Ren; Nelson; Larry S. Barak; James K. Chen; Philip A. Beachy; Frederic J. De Sauvage; Robert J. Lefkowitz
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Structural basis and therapeutic implication of the interaction of CCN proteins with glycoconjugates
Current Pharmaceutical Design, ISSN: 13816128
Luc Desnoyers
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Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL
Cancer Research, ISSN: 00085472
Rajani Ravi; Ajay J. Jain; Richard D. Schulick; Vui Pham; Traci S. Prouser; Heather Allen; Elizabeth Garrett Mayer; Hua Yu; Drew M. Pardoll; Avi Ashkenazi; Atul Bedi
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Integrin α4β1 function is required for cell survival in developing retina
Developmental Biology, ISSN: 00121606
Sergiu T. Leu; Susan A.L. Jacques; Kevin L. Wingerd; Sherry T. Hikita; Erin C. Tolhurst; Jan L. Pring; Derek Wiswell; Lisa Kinney; Nichol L. Goodman; Jackson; Dennis O. Clegg
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IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice
Journal of Immunology, ISSN: 00221767
John E. Pearl; Shabaana A. Khader; Alejandra Solache; Leigh Gilmartin; Nico Ghilardi; Frederic J. De Sauvage; Andrea M. Cooper
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Roles of active site tryptophans in substrate binding and catalysis by α-1,3 galactosyltransferase
Glycobiology, ISSN: 09596658
Yingnan Zhang; Ashlesha Deshpande; Zhihong Xie; Ramanathan Natesh; K. Ravi Acharya; Keith Brew
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Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
Journal of Clinical Oncology, ISSN: 0732183X
David H. Johnson; Louis Fehrenbacher; Novotny; Roy S. Herbst; John J. Nemunaitis; David M. Jablons; Corey Langer; Russell F. DeVore III; Jacques Gaudreault; Lisa A. Damico; Holmgren; Fairooz F. Kabbinavar
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Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro
Angiogenesis, ISSN: 09696970
Yaning Wang; David T.W. Fei; Vanderlaan; An Song
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Competency-based benchmarking: Revolutionizing biopharmaceutical product launches
Benchmarking, ISSN: 14635771
Mark J. Ahn; Daniel Dornbusch
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Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin
Molecular Biology of the Cell, ISSN: 10591524
Cary D. Austin; Ann De Mazière; Paul Pisacane; Suzanne Van Dijk; Eigenbrot; Mark X. Sliwkowski; Judith Klumperman; Richard H. Scheller
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The endo-lysosomal sorting machinery interacts with the intermediate filament cytoskeleton
Molecular Biology of the Cell, ISSN: 10591524
Melanie L. Styers; Gloria Salazar; Rachal Love; Andrew A. Peden; Andrew P. Kowalczyk; Victor Faundez
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The burden of illness associated with psoriasis: Cost of treatment with systemic therapy and phototherapy in the US
Current Medical Research and Opinion, ISSN: 03007995
William H. Crown; Bresnahan; Lucinda S. Orsini; Sean Kennedy; Craig Leonardi
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Development of a PCR method for mycoplasma testing of Chinese hamster ovary cell cultures used in the manufacture of recombinant therapeutic proteins
Biologicals, ISSN: 10451056
Joyce A. Eldering; Chantal Felten; Connie A. Veilleux; Barbara J. Potts
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Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression
Journal of Clinical Oncology, ISSN: 0732183X
Debasish Tripathy; Dennis J. Slamon; Melody A. Cobleigh; Andrew Arnold; Mansoor Saleh; Joanne E. Mortimer; Maureen Murphy; Stanford J. Stewart
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Transcriptional-based screens for pathway-specific, high-throughput target discovery in endothelial cells
Journal of Biomolecular Screening, ISSN: 10870571
Robert Yauch; Edward E. Kadel III; Cory Nicholas; Selwyna Tetangco; Douglas O. Clary
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Effect of anti-TGF-Β antibodies in syngeneic mouse models of metastasis
Journal of Musculoskeletal Neuronal Interactions, ISSN: 11087161
Richard A. D. Carano; Li; Bao; Li; Berry; Ross; Joe Kowalski; French; Dugger; Ralph H. Schwall; Wang; David T.W. Fei; Sarah L. Moseley; Ellen H. Filvaroff
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Visualization tool for a terrain-based genetic algorithm
Proceedings - International Conference on Tools with Artificial Intelligence, ICTAI, ISSN: 10823409
V. Scott Gordon; James Thein
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Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in β3-integrin-deficient mice
Cancer Research, ISSN: 00085472
Andrew R. Reynolds; Louise E. Reynolds; Tobi Nagel; Julie C. Lively; Stephen D. Robinson; Daniel J. Hicklin; Bodary; Kairbaan M. Hodivala-Dilke
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Evaluation of a surrogate antibody for preclinical safety testing of an anti-CD11a monoclonal antibody
Regulatory Toxicology and Pharmacology, ISSN: 02732300
Janet Clarke; Will Leach; Susanne Pippig; Amita Joshi; Benjamin Wu; Robert House; Joseph Beyer
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Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Jennifer Lecouter; Constance Zlot; Max L. Tejada; Franklin V. Peale Jr.; Napoleone Ferrara
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Impurity effects on the crystallization kinetics of ampicillin
Industrial and Engineering Chemistry Research, ISSN: 08885885
Ottens; Lebreton; Zomerdijk; Rijkers; Bruinsma; Van Der Wielen
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Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival
Journal of Biological Chemistry, ISSN: 00219258
Beatrix Schäfer; Beatrice Marg; Andreas Gschwind; Axel Ullrich
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The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Nature, ISSN: 00280836
Xiaowel Lu; Ferdinand Le Noble; Li Yuan; Quingjan Jiang; Benjamin De Lafarge; Daisuke Sugiyama; Christiane Bréant; Filip Claes; Frederik De Smet; Jean-Léon Thomas; Monica Autiero; Peter Carmeliet; Marc Tessier-Lavigne; Anne Eichmann
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The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity
Journal of Immunology, ISSN: 00221767
David Artis; Alejandro V. Villarino; Michael Silverman; Weimian He; Elizabeth M. Thornton; Sharon Mu; Shamin Summer; Todd M. Covey; Elaine Huang; Hiroki Yoshida; Gary Koretzky; Michael Goldschmidt; Gary D. Wu; Frederic J. De Sauvage; Hugh R. P. Miller; Christiaan J. M. Saris; Phillip Scott; Christopher A. Hunter
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Current immunomodulatory therapies for multiple sclerosis
Formulary, ISSN: 1082801X
Craig H. Smith
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Pharmacokinetics of novel dipeptide ester prodrugs of acyclovir after oral administration: Intestinal absorption and liver metabolism
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565
Banmeet S. Anand; Suresh Katragadda; Ashim K. Mitra
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Simple quantitative live cell and anti-idiotypic antibody based ELISA for humanized antibody directed to cell surface protein CD20
Journal of Immunological Methods, ISSN: 00221759
Kyu Hong; Presta; Yanmei Lu; Ashley Penn; Adams; Anan Chuntharapai; Yang; Wai Lee T. Wong; Meng
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Efficacy of PUVA phototherapy compared with biologics
Cosmetic Dermatology, ISSN: 10413766
John Y. Koo; Rachel Wenner
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Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53
Molecular and Cellular Biology, ISSN: 02707306
David Dornan; Mirjam Eckert; Maura Wallace; Harumi Shimizu; Eleanor Ramsay; Ted R. Hupp; Kathryn L. Ball
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A new suite of automated bioreactors at Genentech: A case study employing standards, guidelines, and software: From requirements to validation
Pharmaceutical Engineering, ISSN: 02738139
Ronald E. Menéndez
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Novel biologic agents for multiple sclerosis and their impact on managed care
Formulary, ISSN: 1082801X
Schumarry H. Chao; Craig H. Smith
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The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis
Critical Care Medicine, ISSN: 00903493
Derek C. Angus; Pierre-Francois Laterre; Jeffrey D. Helterbrand; E. Wesley Ely; Daniel E. Ball; Rekha Garg; Lisa A. Weissfeld; Gordon R. Bernard
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Detection and in vitro and in vivo characterization of porcine circovirus DNA from a porcine-derived commercial pepsin product
Journal of General Virology, ISSN: 00221317
Fenaux; Opriessnig; Halbur; Yuan Xu; Barbara J. Potts; Meng
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Tissue distribution, stability, and pharmacokinetics of APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in human colon carcinoma COLO205 tumor-bearing nude mice
Drug Metabolism and Disposition, ISSN: 00909556
Hong Xiang; Cindy B. Nguyen; Kelley; Noel Dybdal; Escandon
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Vascular endothelial growth factor-induced nitric oxide-and PGI 2-dependent relaxation in human internal mammary arteries: A comparative study with KDR and Flt-1 selective mutants
Journal of Cardiovascular Pharmacology, ISSN: 01602446
Wei Wei; Hongkui Jin; Zhi-Wu Chen; Zioncheck; Anthony P. C. Yim; Guo-Wei He
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Early withdrawal of statin therapy in patients with non-ST-segment elevation myocardial infarction: National registry of myocardial infarction
Archives of Internal Medicine, ISSN: 00039926
Frederick A. Spencer; Gregg C. Fonarow; Paul D. Frederick; R. Scott Wright; Nathan R. Every; Robert J. Goldberg; Joel M. Gore; Wei Dong; Richard C. Becker; William J. French
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Angiogenesis-dependent and independent phases of intimal hyperplasia
Circulation, ISSN: 00097322
Rohit Khurana; Zhenwu Zhuang; Shalini Bhardwaj; Masahiro Murakami; Ebo De Muinck; Seppo Yla-Herttuala; Napoleone Ferrara; John F. Martin; Ian Zachary; Michael Simons
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COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas
Cancer Research, ISSN: 00085472
David Dornan; Sheila Bheddah; Kim Newton; William Inice; Gretchen D. Frantz; Patrick Dowd; Koeppen; Vishva M. Dixit; French
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The crystal structure of A proliferation-inducing ligand, APRIL
Journal of Molecular Biology, ISSN: 00222836
Heidi J. A. Wallweber; Deanne M. Compaan; Melissa A. Starovasnik; Sarah G. Hymowitz
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Bevacizumab in colorectal cancer [2] (multiple letters)
New England Journal of Medicine, ISSN: 00284793
Guru Sonpavde; Waseem Sharieff; Herbert Hurwitz; Novotny; Fairooz F. Kabbinavar
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Differential requirements for semaphorin 3F and slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections
Journal of Neuroscience, ISSN: 02706474
Jean-François Cloutier; Amar Sahay; Ernie C. Chang; Marc Tessier-Lavigne; Catherine Dulac; Alex L. Kolodkin; David D. Ginty
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GEPIS - Quantitative gene expression profiling in normal and cancer tissues
Bioinformatics, ISSN: 13674803
Yan Zhang; Eberhard; Gretchen D. Frantz; Patrick Dowd; Thomas D Wu; Yan Zhou; Colin K. Watanabe; Shiuh-Ming Luoh; Paul G. Polakis; Kenneth J. Hillan; William I. Wood; Zemin Zhang
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Racial and ethnic differences in time to acute reperfusion therapy for patients hospitalized with myocardial infarction
JAMA - Journal of the American Medical Association, ISSN: 00987484
Elizabeth H. Bradley; Jeph Herrin; Yongfei Wang; Robert L. McNamara; Tashonna R. Webster; David J. Magid; Martha Blaney; Eric D. Peterson; John G. Canto; Charles V. Pollack Jr.; Harlan M. Krumholz
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Selective impairment of TLR-mediated innate immunity in human newborns: Neonatal blood plasma reduces monocyte TNF-α induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848
Journal of Immunology, ISSN: 00221767
Ofer Levy; Kol A. Zarember; Rene M. Roy; Colette Cywes; Godowski; Michael R. Wessels
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Quantification of cortical bone loss and repair for therapeutic evaluation in collagen-induced arthritis, by micro-computed tomography and automated image analysis
Arthritis and Rheumatism, ISSN: 00043591
Kai H. Barck; Wyne P. Lee; Laurie Diehl; Ross; Gribling; Yifan Zhang; Kathy Nguyen; Nicholas Van Bruggen; Stephen D. Hurst; Richard A. D. Carano
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Effect of long-term progestin treatment on endometrial vasculature in normal cycling mice
Contraception, ISSN: 00107824
Girling; Heryanto; Patel; Peter A.W. Rogers
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Capillary regression in vascular endothelial growth factor-deficient skeletal muscle
Physiological Genomics, ISSN: 15312267
Kechun Tang; Ellen C. Breen; Hans-Peter Gerber; Napoleone Ferrara; Peter D. Wagner
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Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae
Molecular Biology of the Cell, ISSN: 10591524
Matthias Versele; Björn Gullbrand; Shulewitz; Victor J. Cid; Shirin Bahmanyar; Raymond E. Chen; Patrick Barth; Tom Alber; Jeremy Thorner
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A pH-sensitive function and phenotype: Evidence that EutH facilitates diffusion of uncharged ethanolamine in Salmonella enterica
Journal of Bacteriology, ISSN: 00219193
Joseph T. Penrod; Christopher C. Mace; John R. Roth
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Suppressor of fused regulates Gli activity through a dual binding mechanism
Molecular and Cellular Biology, ISSN: 02707306
Mark Merchant; Vajdos; Ultsch; Henry R. Maun; K. Ulrich Wendt; Jennifer Cannon; William Desmarais; Lazarus; De Vos; Frederic J. De Sauvage
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