Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10951 - 11000 OF 15805 RESULTS

Population pharmacokinetics or efalizumab (humanized monoclonal anti-CD11a antibody) following long-term subcutaneous weekly dosing in psoriasis subjects
Journal of Clinical Pharmacology, ISSN: 00912700
Sun; Jian-Feng Lu; Amita Joshi; Peter Compton; Paul Kwon; Rene Bruno
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Defining molecular targets for drug design: Synergism between academia and industry
Journal of Pediatric Gastroenterology and Nutrition, ISSN: 02772116
Andrew A. Chan
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Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: A conference report
Pharmaceutical Research, ISSN: 07248741
Jean W. Lee; Russell Weiner; Jeff M. Sailstad; Ronald Bowsher; Dean W. Knuth; Peter J. O'Brien; Jean L. Fourcroy; Rakesh Dixit; Lini Pandite; Robert G. Pietrusko; Holly D. Soares; Quarmby; Ole L. Vesterqvist; David M. Potter; James L. Witliff; Herbert A. Fritche; Timothy O'Leary; Lorah Perlee; Sunil Kadam; John A. Wagner
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Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis
Journal of Molecular Biology, ISSN: 00222836
Gábor Pál; Ultsch; Clark; Bridget Currell; Anthony A. Kossiakoff; Sachdev S. Sidhu
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Identification of a massive reserve of hematopoietic progenitors in mice
Stem Cells and Development, ISSN: 15473287
Hal E. Broxmeyer; Scott Cooper; Lasky; Frederic J. De Sauvage
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Safety and efficacy of intravitreal injection of ranibizumab in combination with verteporfin PDT on experimental choroidal neovascularization in the monkey
Archives of Ophthalmology, ISSN: 00039950
Deeba Husain; Ivana K. Kim; Danny Gauthier; Anne Marie Lane; Miltiadis K. Tsilimbaris; Eric Ezra; Edward Connolly; Norman Michaud; Evangelos S. Gragoudas; Charles A. O'Neill; Joseph Beyer; Joan W. Miller
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Multiple protein interactions involving proposed extracellular loop domains of the tight junction protein occludin
Molecular Biology of the Cell, ISSN: 10591524
Asma Nusrat; G. Thomas Brown; Jeffrey Tom; Alex Drake; Tam T.T. Bui; Quan; Mrsny
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Coregulator interactions with the thyroid hormone receptor
Molecular and Cellular Proteomics, ISSN: 15359476
Jamie M. R. Moore; R. Kiplin Guy
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Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2
FEBS Letters, ISSN: 00145793
Daniel Kirchhofer; Peek; Michael T. Lipari; Karen L Billeci; Bin Fan; Paul Moran
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Impact of multiple re-use of anion-exchange chromatography media on virus removal
Journal of Chromatography A, ISSN: 00219673
Lenore A Norling; Scott Lute; Rachel Emery; Wynn Khuu; Mark Voisard; Yuan Xu; Qi Chen; Gregory S. Blank; Kurt Brorson
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Cutting edge: Recent immune status determines the source of antigens that drive homeostatic T cell expansion
Journal of Immunology, ISSN: 00221767
William C. Kieper; Amy Troy; J. Theodore Burghardt; Chris Ramsey; Joon Youb Lee; Han-Qing Jiang; Wolfgang Dummer; Hao Shen; John J. Cebra; Charles D. Surh
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IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes
Journal of Immunology, ISSN: 00221767
Katia Boniface; François-Xavier Bernard; Martine Garcia; Austin L. Gurney; Jean-Claude Lecron; Franck Morel
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A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Alan G. Olivero; Eigenbrot; Richard Goldsmith; Kirk D. Robarge; Dean R. Artis; Flygare; Thomas E. Rawson; Daniel P. Sutherlin; Saloumeh Kadkhodayan; Beresini; Linda O. Elliott; Geralyn G. Deguzman; David W. Banner; Ultsch; Ulla Marzec; Stephen R. Hanson; Refino; Bunting; Daniel Kirchhofer
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Conformational lability in serine protease active sites: Structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B
Journal of Molecular Biology, ISSN: 00222836
Steven Shia; Jennifer Stamos; Daniel Kirchhofer; Bin Fan; Judy Wu; Corpuz; Santell; Lazarus; Eigenbrot
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T cells that cannot respond to TGF-β escape control by CD4+ CD25+ regulatory T cells
Journal of Experimental Medicine, ISSN: 00221007
Linda Fahlén; Simon Read; Leonid Gorelik; Stephen D. Hurst; Coffman; Richard A. Flavell; Fiona Powrie
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The mitochondrial inner membrane protein mitofilin controls cristae morphology
Molecular Biology of the Cell, ISSN: 10591524
George B. John; Yonglei Shang; Li Li; Christian Renken; Carmen A. Mannella; Jeanne M. L. Selker; Linda Rangell; Michael J. Bennett; Jiping Zha
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Effect of copper sulfate on performance of a serum-free CHO cell culture process and the level of free thiol in the recombinant antibody expressed
Biotechnology Progress, ISSN: 87567938
Wendy B. Chaderjian; Chin; Reed J. Harris; Etcheverry
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αvβ3 antagonists based on a central benzoic acid scaffold
Polish Journal of Chemistry, ISSN: 01375083
Will; Breipohl; Gourvest; Ruxer; Doucet; Auberval; Roland Baron; Gaillard; Thomas Gadek; Knolle; Stilz; Peyman
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1H, 13C, and 15N resonance assignments of SAP18 [1]
Journal of Biomolecular NMR, ISSN: 09252738
Scott A. McCallum; Jianping Yin; Wayne J. Fairbrother
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Pharmacokinetics and pharmacodynamics of multiple weekly subcutaneous efalizumab doses in patients with plaque psoriasis
Journal of Clinical Pharmacology, ISSN: 00912700
Deborah L. Mortensen; Patricia Walicke; Xiaolin Wang; Paul Kwon; Peter Kuebler; Alice Gottlieb; James G. Krueger; Craig Leonardi; Bruce Miller; Amita Joshi
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CD4+ T cell-mediated antigen-specific immunotherapy in a mouse model of cervical cancer
Cancer Research, ISSN: 00085472
Dylan Daniel; Christopher Chiu; Enrico Giraudo; Masahiro Inoue; Lee A. Mizzen; N. Randall Chu; Douglas Hanahan
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Efficacy of trastuzumab
Cancer Research, ISSN: 00085472
Charles L. Vogel; Josina C. Reddy; Leonard M. Reyno
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Mass spectrometric contributions to the practice of phosphorylation site mapping through 2003
Molecular and Cellular Proteomics, ISSN: 15359476
Kelly M. Loyet; Stults; David Arnott
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Vascular endothelial growth factor D is dispensable for development of the lymphatic system
Molecular and Cellular Biology, ISSN: 02707306
Megan E. Baldwin; Michael M. Halford; Sally Roufail; Richard A. Williams; Margaret L. Hibbs; Dianne Grail; Hajime Kubo; Steven A. Stacker; Marc G. Achen
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Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback
Development (Cambridge), ISSN: 09501991
Yoh-Suke Mukouyama; Hans-Peter Gerber; Napoleone Ferrara; Chenghua Gu; David J. Anderson
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Proteomic profiling of surface proteins on Th1 and Th2 Cells
Journal of Proteome Research, ISSN: 15353893
Kelly M. Loyet; Wenjun Ouyang; Dan L. Eaton; Stults
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Structures of APRIL-receptor complexes: Like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding
Journal of Biological Chemistry, ISSN: 00219258
Sarah G. Hymowitz; Darshana Patel; Heidi J. A. Wallweber; Steven T. Runyon; Minhong Yan; Jianping Yin; Stephanie K. Shriver; Nathaniel C. Gordon; Borlan Pan; Nicholas J. Skelton; Robert F. Kelley; Melissa A. Starovasnik
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A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer
Journal of Translational Medicine, ISSN: 14795876 14795876
Michael A. Morse; Jennifer Garst; Takuya Osada; Shubi Khan; Amy Hobeika; Timothy M. Clay; Nancy Valente; Revati Shreeniwas; Mary Ann Sutton; Alain Delcayre; Di-Hwei Hsu; Jean-Bernard Le Pecq; H. Kim Lyerly
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Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels
Journal of Biological Chemistry, ISSN: 00219258
Anne-Laure Perraud; Christina L. Takanishi; Betty Shen; Shin Kang; Megan K. Smith; Carsten Schmitz; Heather M. Knowles; Dana Ferraris; Weixing Li; Jie Zhang; Barry L. Stoddard; Andrew M. Scharenberg
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Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins
Neuron, ISSN: 08966273
Avraham Yaron; Pei-Hsin Huang; Hwai-Jong Cheng; Marc Tessier-Lavigne
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Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function
Journal of Neuroscience, ISSN: 02706474
Bettina Holtmann; Stefan Wiese; Mohtashem Samsam; Katja Grohmann; Diane Pennica; Rudolf Martini; Michael Sendtner
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Semi-parametric and non-parametric methods for clinical trials with incomplete data
Statistics in Medicine, ISSN: 02776715
O'Brien; David Zhang; Kent R. Bailey
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Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
Cancer Research, ISSN: 00085472
Hans-Peter Gerber; Napoleone Ferrara
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Characterization of alteplase (tPA) following delivery through the AngioJet rheolytic catheter
Journal of Endovascular Therapy, ISSN: 15266028
Charles P. Semba; Weck; Mahmood K Razavi; Cindy M. Setum; Thomas W. Patapoff
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The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis
Molecular Biology of the Cell, ISSN: 10591524
Gayle M. Wilson; Andrew B. Fielding; Glenn C. Simon; Xinzi Yu; Paul D. Andrews; Rebecca S. Haines; Andrew M. Frey; Andrew A. Peden; Gwyn W. Gould; Rytis Prekeris
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Review: Clonidine is more effective than placebo for long term smoking cessation, but has side effects
Evidence-Based Medicine, ISSN: 13565524
Steven G. Gourlay; Stead; Neal L. Benowitz; Charles J. Bentz
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Nitration and increased α-synuclein expression associated with dopaminergic neurodegeneration in equine pituitary pars intermedia dysfunction
Journal of Neuroendocrinology, ISSN: 09538194
Dianne McFarlane; Noel Dybdal; Donaldson; Lisa M. Miller; Alastair E. Cribb
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Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration
Investigative Ophthalmology and Visual Science, ISSN: 01460404
Jacques Gaudreault; David T.W. Fei; Jeriza Rusit; Pamela Suboc; Vanessa Shiu
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A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Lino C. Gonzalez Jr.; Kelly M. Loyet; Jill Calemine-Fenaux; Vandana Chauhan; Bernd Wranik; Wenjun Ouyang; Dan L. Eaton
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Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Binhai Zheng; Jasvinder K. Atwal; Carole Ho; Lauren C Case; Xiao-Lin He; Garcia; Oswald Steward; Marc Tessier-Lavigne
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Automated online liquid chromatographic/mass spectrometric metabolic study for prodrug stability
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232
Fran Lai; S. Cyrus Khojasteh
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Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of Death Receptor (DR) 5 than DR4 to apoptosis signaling
Journal of Biological Chemistry, ISSN: 00219258
Robert F. Kelley; Klara Totpal; Stephanie H. Lindstrom; Mary Mathieu; Karen L Billeci; Laura DeForge; Roger Pai; Sarah G. Hymowitz; Avi Ashkenazi
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Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy
Journal of Immunology, ISSN: 00221767
Qian Gong; Qinglin Ou; Shiming Ye; Wyne P. Lee; Jennine Cornelius; Laurie Diehl; Yu Lin Wei; Zhilan Hu; Yanmei Lu; Yongmei Chen; Yan Wu; Meng; Gribling; Zhonghua Lin; Kathy Nguyen; Thanhvien Tran; Yifan Zhang; Hugh Rosen; Flavius Martin; Andrew A. Chan
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Proteomic profiling of recombinant Escherichia coli in high-cell-density fermentations for improved production of an antibody fragment biopharmaceutical
Applied and Environmental Microbiology, ISSN: 00992240
Ilana S. Aldor; Denise C. Krawitz; William F. Forrest; Christina Y. Chen; Julie C. Nishihara; John C. Joly; Kathleen M. Champion
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Alteplase as a catheter locking solution: In vitro evaluation of biochemical stability and antimicrobial properties
Journal of Vascular and Interventional Radiology, ISSN: 10510443
Weck; Samantha Cheung; Hiraoka-Sutow; Thomas W. Patapoff; Charles P. Semba
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Alteplase stability and bioactivity after low-power ultrasonic energy delivery with the OmniSonics resolution system
Journal of Vascular and Interventional Radiology, ISSN: 10510443
John Smikahl; Yeung; Sharon Wang; Charles P. Semba
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The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation
Journal of Allergy and Clinical Immunology, ISSN: 00916749
Stephen Holgate; Thomas B. Casale; Sally E. Wenzel; Jean Bousquet; Yamo Deniz; Colin Reisner
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Industry-based medical communications: Benchmarking survey of quality assurance practices
Drug Information Journal, ISSN: 00928615
S. Justin Hileman; Graham; Joyce Serrano Martin; Barry Grobman
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Are inflammatory cytokines the common link between cancer-associated cachexia and depression?
Journal of Supportive Oncology, ISSN: 15446794
James Illman; Robert Corringham; Don Robinson Jr.; Hugh M. Davis; Jean-Francois Rossi; Cella; Mohit Trikha
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The changing role of thrombolytic therapy in the management of acute deep vein thrombosis
Therapy, ISSN: 14750708
Mahmood K Razavi; Charles P. Semba
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