Genentech: Publications

January 1, 2004

Discovery of novel PTP1b inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Denise A. Ockey; Thomas Gadek

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January 1, 2004

Bivalent antibody phage display mimics natural immunoglobulin

Journal of Immunological Methods, ISSN: 00221759

Chingwei V. Lee; Sachdev S. Sidhu; Fuh

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January 1, 2004

Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis

Nature Medicine, ISSN: 10788956

Scott T. Avecilla; Koichi Hattori; Beate Heissig; Rafael Tejada; Fang Liao; Koji Shido; David K. Jin; Sergio Dias; Fan Zhang; Travis E. Hartman; Neil R. Hackett; Crystal; Larry Witte; Daniel J. Hicklin; Peter Bohlen; Dan L. Eaton; David Lyden; Frederic J. De Sauvage; Shahin Rafii

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January 1, 2004

Neutralizing VEGF Bioactivity with a Soluble Chimeric VEGF-Receptor Protein flt(I-3) IgG Inhibits Testosterone-Stimulated Prostate Growth in Castrated Mice

Prostate, ISSN: 02704137

Ingela Franck Lissbrant; Peter Hammarsten; Erik Lissbrant; Napoleone Ferrara; Stina Häggström Rudolfsson; Anders Bergh

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January 1, 2004

Ureagenesis: Evidence for a lack of hepatic regulation of acid-base equilibrium in humans

American Journal of Physiology - Renal Physiology, ISSN: 03636127

Markus Hosch; Juergen Muser; Henry N. Hulter; Reto Krapf

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January 1, 2004

Maintaining change control in part 11 - Compliant systems - A quality systems approach

American Pharmaceutical Review, ISSN: 10998012

Peter Bland

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January 1, 2004

APC-Independent Activation of NK Cells by the Toll-Like Receptor 3 Agonist Double-Stranded RNA

Journal of Immunology, ISSN: 00221767

Kerstin N. Schmidt; Beatrice Leung; Mandy Kwong; Kol A. Zarember; Sanjeev Satyal; Tony A. Navas; Fay Wang; Godowski

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January 1, 2004

Design and baseline characteristics of The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study: A large cohort of patients with severe or difficult-to-treat asthma

Annals of Allergy, Asthma and Immunology, ISSN: 10811206

Chantal M. Dolan; Kyle Fraher; Eugene R. Bleecker; Larry Borish; Bradley E. Chipps; Mary Lou Hayden; Weiss; Zheng; Charles A. Johnson; Sally E. Wenzel

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January 1, 2004

Editorial introductions

Current Opinion in Nephrology and Hypertension, ISSN: 10624821

Barry M. Brenner; Marc R. Hammerman; Matthew R. Weir; Ronald C. Blantz; Pierre M. Ronco

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January 1, 2004

Single lead ST-segment recovery: A simple, reliable measure of successful fibrinolysis after acute myocardial infarction

American Heart Journal, ISSN: 00028703

Mushabbar A. Syed; Steven Borzak; Abed Asfour; Madhavi Gunda; Omar Obeidat; Sabina A. Murphy; Raymond J. Gibbons; Steven G. Gourlay; Hal V. Barron; W.Douglas Weaver; Michael Hudson

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January 1, 2004

Treatment of Pulmonary Arterial Hypertension with Sildenafil

Hospital Pharmacy, ISSN: 00185787

Stacey M. Fung; Mary J. Ferrill

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January 1, 2004

Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor

Thrombosis and Haemostasis, ISSN: 03406245

Sabine Raab; Heike Beck; Andreas Gaumann; Ali Yüce; Hans-Peter Gerber; Karl Plate; Hans-Peter Hammes; Napoleone Ferrara; Georg Breier

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January 1, 2004

Reflections on Rice's formulae for level crossings - History, extensions and use

Australian and New Zealand Journal of Statistics, ISSN: 13691473

Leadbetter; Spaniolo

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January 1, 2004

Evaluation of procedures for amplification of small-size samples for hybridization on microarrays

Genomics, ISSN: 08887543

Sandra Klur; Toy; Mickey P. Williams; Ulrich Certa

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January 1, 2004

The HER receptor family: A rich target for therapeutic development

International Journal of Radiation Oncology Biology Physics, ISSN: 03603016

Robert Mass

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January 1, 2004

Quantification of Tumor Tissue Populations by Multispectral Analysis

Magnetic Resonance in Medicine, ISSN: 07403194

Richard A. D. Carano; Adrienne L. Ross; Ross; Simon P. Williams; Koeppen; Ralph H. Schwall; Nicholas Van Bruggen

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January 1, 2004

Substrate capacity consideration in developing kinase assays

Assay and Drug Development Technologies, ISSN: 1540658X

Laura DeForge; Andrea G. Cochan; Sherry Yeh; Brian S. Robinson; Karen L Billeci; Wai Lee T. Tong

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January 1, 2004

Raman Spectroscopic Characterization of Drying-Induced Structural Changes in a Therapeutic Antibody: Correlating Structural Changes with Long-Term Stability

Journal of Pharmaceutical Sciences, ISSN: 00223549

Samir Sane; Wong; Chung C. Hsu

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January 1, 2004

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

Cancer Cell, ISSN: 15356108

Matthew C Franklin; Kendall Carey; Vajdos; Daniel J. Leahy; De Vos; Mark X. Sliwkowski

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January 1, 2004

The discovery of receptor tyrosine kinases: Targets for cancer therapy

Nature Reviews Cancer, ISSN: 1474175X

Andreas Gschwind; Oliver M. Fischer; Axel Ullrich

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January 1, 2004

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

Nature Reviews Drug Discovery, ISSN: 14741776

Napoleone Ferrara; Kenneth J. Hillan; Hans-Peter Gerber; Novotny

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January 1, 2004

Hydrophobic vancomycin derivatives with improved ADME properties: Discovery of telavancin (TD-6424)

Journal of Antibiotics, ISSN: 00218820

Michael R. Leadbetter; Stacy M. Adams; Bettina Bazzini; Paul R. Fatheree; Dane E. Karr; Kevin M. Krause; Bernice M.T. Lam; Martin S. Linsell; Matthew B. Nodwell; John Pace; Kelly Quast; Jeng-Pyng Shaw; Elizabeth Soriano; Sean Trapp; Jenny D. Villena; Terry X. Wu; Burton G. Christensen; J. Kevin Judice

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January 1, 2004

EG-VEGF: A novel mediator of endocrine-specific angiogenesis, endothelial phenotype, and function

Annals of the New York Academy of Sciences, ISSN: 00778923

Jennifer Lecouter; Rui Lin; Napoleone Ferrara

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January 1, 2004

Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products

Journal of Immunological Methods, ISSN: 00221759

Mire-Sluis; Yu Chen Barrett; Viswanath Devanarayan; Koren; Hank Liu; Mauricio Maia; Thomas Parish; George Scott; Gopi Shankar; Elizabeth Shores; Steven J. Swanson; Gary Taniguchi; Daniel Wierda; Linda A. Zuckerman

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January 1, 2004

Benzyl alcohol-induced destabilization of interferon-γ: A study by hydrogen-deuterium isotope exchange

Journal of Pharmaceutical Sciences, ISSN: 00223549

Scott A. Tobler; Bryan W. Holmes; Cromwell; Erik J. Fernandez

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January 1, 2004

Challenges in the development of high protein concentration formulations

Journal of Pharmaceutical Sciences, ISSN: 00223549

Steven J. Shire; Shahrokh; Jun Liu

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January 1, 2004

Thrombolysis for lower extremity deep venous thrombosis

Techniques in Vascular and Interventional Radiology, ISSN: 10892516

Charles P. Semba; Mahmood K Razavi; Stephen T. Kee; Daniel Y. Sze; Michael D. Dake

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January 1, 2004

Phage display-derived ligands provide structural insight into insulin-like growth factor I function

Spectroscopy, ISSN: 07124813

Nicholas J. Skelton; Schaffer; Deshayes; Tamas Blandl; Steven T. Runyon; Nakamura; Sachdev S. Sidhu

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January 1, 2004

The Sema domain of Met is necessary for receptor dimerization and activation

Cancer Cell, ISSN: 15356108

Monica Kong-Beltran; Jennifer Stamos; Dineli Wickramasinghe

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January 1, 2004

Neonatal hypoglycemia in a growth hormone registry: Incidence and pathogenesis

Journal of Pediatric Endocrinology and Metabolism, ISSN: 0334018X

Jennifer J. Bell; Gilbert P. August; Sandra L. Blethen; Joyce Baptista

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January 1, 2004

Targeting death receptors in cancer with Apo2L/TRAIL

Current Opinion in Pharmacology, ISSN: 14714892

Kelley; Avi Ashkenazi

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January 1, 2004

Structure-based models of cadherin-mediated cell adhesion: The evolution continues

Cellular and Molecular Life Sciences, ISSN: 1420682X

Alexander W. Koch; Manzur; Shan

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January 1, 2004

Bioprocess equipment: Characterization of energy dissipation rate and its potential to damage cells

Biotechnology Progress, ISSN: 87567938

Mike Mollet; Ningning Ma; Yang Zhao; Robert Brodkey; Ron Taticek; Jeffrey J. Chalmers

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January 1, 2004

WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair

American Journal of Pathology, ISSN: 00029440

French; Raji J. Kaul; Aloma L. D'Souza; Crowley; Bao; Gretchen D. Frantz; Ellen H. Filvaroff; Luc Desnoyers

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January 1, 2004

Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesis

Annals of Allergy, Asthma and Immunology, ISSN: 10811206

Jonathan Corren; David Diaz-Sanchez; Andrew Saxon; Yamo Deniz; Reimann; Sinclair; Teresa Davancaze; Daniel C. Adelman

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January 1, 2004

Inhibitors of tissue factor•factor VIIa for anticoagulant therapy

Current Medicinal Chemistry, ISSN: 09298673

Lazarus; Alan G. Olivero; Eigenbrot; Daniel Kirchhofer

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January 1, 2004

Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal

Cytotherapy, ISSN: 14653249

Judy C. Young; Wu; Hansteen; Du; Sambucetti; Remiszewski; O'Farrell; Hill; Lavau; Lesley J. Murray

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January 1, 2004

Quantitative structure-pharmacokinetic parameters relationships (QSPKR) analysis of antimicrobial agents in humans using simulated annealing k-nearest-neighbor and partial least-square analysis methods

Journal of Pharmaceutical Sciences, ISSN: 00223549

Chee Ng; Yun-De Xiao; Wendy Putnam; Bert L. Lum; Alexander Tropsha

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January 1, 2004

Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis

Cancer Cell, ISSN: 15356108

Nan Tang; Lianchun Wang; Jeffrey Esko; Frank J. Giordano; Yan Huang; Hans-Peter Gerber; Napoleone Ferrara; Randall S. Johnson

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January 1, 2004

Quality assurance practices for pharmaceutical industry-based drug information departments: A review and case study

Drug Information Journal, ISSN: 00928615

Stacey M. Fung; Joyce Serrano Martin

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January 1, 2004

Effect of cardiac dysfunction of treatment outcomes in women receiving trastuzumab for HER2-overexpressing metastatic breast cancer

Clinical Breast Cancer, ISSN: 15268209

Debasish Tripathy; Andrew Seidman; Deborah Keefe; Clifford Hudis; Virginia Paton; Lieberman

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January 1, 2004

Quantification of bone lesions in rheumatoid arthritis by MRI multispectral tissue class transition analysis

Seminars in Musculoskeletal Radiology, ISSN: 1098898X 10897860

Richard A. D. Carano; John A. Lynch

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January 1, 2004

Ureagenesis: Evidence for a lack of hepatic regulation of acid-base equilibrium in humans

American Journal of Physiology - Renal Physiology, ISSN: 15221466 1931857X

Markus Hosch; Juergen Muser; Henry N. Hulter; Reto Krapf

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December 22, 2003

Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz

Journal of Cell Biology, ISSN: 00219525

James E. Wilhelm; Meredith Hilton; Quinlan Amos; William J. Henzel

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December 20, 2003

Application of Multivirus Spike Approach for Viral Clearance Evaluation

Biotechnology and Bioengineering, ISSN: 00063592

Christine Valera; Janice W. Chen; Yuan Xu

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December 17, 2003

Efalizumab for Patients with Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial

JAMA - Journal of the American Medical Association, ISSN: 00987484

Kenneth B. Gordon; Kim Papp; Tiffani K. Hamilton; Patricia Walicke; Wolfgang Dummer; Nicole F. Li; Bresnahan; Alan Menter

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December 15, 2003

Activation of Toll-Like Receptor 2 on Human Tracheobronchial Epithelial Cells Induces the Antimicrobial Peptide Human β Defensin-2

Journal of Immunology, ISSN: 00221767

Cheryl J. Hertz; Qi Wu; Edith Martin Porter; Yan J. Zhang; Karl-Heinz Weismüller; Godowski; Tomas Ganz; Scott H. Randell; Robert L. Modlin

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December 12, 2003

Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling

Science, ISSN: 00368075

Anna I. Lyuksyutova; Chin-Chun Lu; Nancy Milanesio; Leslie A. King; Nini Guo; Yanshu Wang; Jeremy Nathans; Marc Tessier-Lavigne; Yimin Zou

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December 9, 2003

IL-27 regulates IL-12 responsiveness of naïve CD4+ T cells through Stat1-dependent and -independent mechanisms

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Sophie Lucas; Nico Ghilardi; Ji Li; Frederic J. De Sauvage

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December 4, 2003

IGF-I Receptor Mutations Resulting in Intrauterine and Postnatal Growth Retardation

New England Journal of Medicine, ISSN: 00284793

M. Jennifer Abuzzahab; Anke Schneider; Goddard; Florin Grigorescu; Corinne Lautier; Eberhard Keller; Wieland Kiess; Jürgen Klammt; Jürgen Kratzsch; Doreen Osgood; Roland Pfäffle; Klemens Raile; Berthold Seidel; Robert J. Smith; Chernausek

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