Genentech: Publications

March 24, 2001

The structure and activity of a monomeric interferon-γ:α-chain receptor signaling complex

Structure, ISSN: 09692126

Michael Randal; Anthony A. Kossiakoff

March 20, 2001

Transplantation of a fetus with paternal Thy-1+ CD34+ cells for chronic granulomatous disease

Bone Marrow Transplantation, ISSN: 02683369

Muench; Julie Rae; Bárcena; Leemhuis; Farrell; Humeau; Maxwell-Wiggins; Capper; Mychaliska; Albanese; Martin; Tsukamoto; John T. Curnutte; Harrison

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March 17, 2001

Overexpression of HER2/neu in solid tumours: An immunohistochemical survey

Histopathology, ISSN: 03090167

Koeppen; Wright; Burt; Philip Quirke; McNicol; Noel Dybdal; Mark X. Sliwkowski; Kenneth J. Hillan

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March 15, 2001

Use of chemotherapy plus a monoclonal antibody against her2 for metastatic breast cancer that overexpresses HER2

New England Journal of Medicine, ISSN: 00284793

Dennis J. Slamon; Brian R. Leyland-Jones; Steven Shak; Henry J. Fuchs; Virginia Paton; Alex Bajamonde; Thomas R. Fleming; Wolfgang Eiermann; Janet Wolter; Pegram; Baselga; Norton

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March 10, 2001

Identification of multiple sources of charge heterogeneity in a recombinant antibody

Journal of Chromatography B: Biomedical Sciences and Applications, ISSN: 13872273

Reed J. Harris; Bruce Kabakoff; Frank D. Macchi; Felicity J. Shen; Kwong; Andya; Steven J. Shire; Nancy Bjork; Klara Totpal; Chen

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March 10, 2001

Recombinant human thrombopoietin (rhTPO) after autologous bone marrow transplantation: A phase I pharmacokinetic and pharmacodynamic study

Bone Marrow Transplantation, ISSN: 02683369

Wolff; Herzig; Joseph P. Lynch; Ericson; Greer; Stein; Goodman; Benyunes; Ashby; Jones Jr.; Fay

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March 2, 2001

High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR

Journal of Biological Chemistry, ISSN: 00219258

Robert L. Shields; Angela K. Namenuk; Kyu Hong; Meng; Julie Rae; Briggs; Dong Xie; Lai; Andrew Stadlen; Betty Li; Judy Fox; Presta

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March 1, 2001

One product, one process, one set of specifications: A proven quality paradigm for the safety and efficacy of biologic drugs

Pharmaceutical Technology North America, ISSN: 15342131

Copmann; Gregory Davis; Robert L. Garnick; John Landis; Lubiniecki; Tobias Massa; Gene Murano; Kenneth Seamon; Diane Zezza

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March 1, 2001

Death or nonfatal stroke in patients with acute myocardial infarction treated with tissue plasminogen activator

American Journal of Cardiology, ISSN: 00029149

Brad G. Angeja; Amy Chen Rundle; Jerry H. Gurwitz; Joel M. Gore; Hal V. Barron

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February 27, 2001

Effect of selective or combined inhibition of integrins αIIbβ3 and αvβ3 thrombosis and neointima after oversized porcine coronary angioplasty

Circulation, ISSN: 00097322

Chico; Janet Chamberlain; Gunn; Arnold; Sherron L. Bullens; Thomas Gadek; Sheila E. Francis; Bunting; Horton; Lynda Shepherd; Michael T. Lipari; Quan; Knolle; Stilz; Peyman; Crossman

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February 22, 2001

Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia

Journal of the American College of Cardiology, ISSN: 07351097

Kaori Sato; Tiangen Wu; Roger J Laham; Robert B Johnson; Pamela Douglas; Jianyi Li; Frank W Sellke; Bunting; Michael Simons; Mark J Post

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February 16, 2001

Vascular Endothelial Growth Factor KDR Receptor Signaling Potentiates Tumor Necrosis Factor-induced Tissue Factor Expression in Endothelial Cells

Journal of Biological Chemistry, ISSN: 00219258

Shen; David Y. Lee; Karen M. Cortopassi; Lisa A. Damico; Zioncheck

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February 15, 2001

Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons

Journal of Neuroscience, ISSN: 02706474

Ronald W. Oppenheim; Stefan Wiese; David Prevette; Armanini; Siwei Wang; Lucien J. Houenou; Bettina Holtmann; Rudolf Götz; Diane Pennica; Michael Sendtner

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February 13, 2001

Elimination pathways of [14C]losoxantrone in four cancer patients

Drug Metabolism and Disposition, ISSN: 00909556

Amita Joshi; Pieniaszek H.J.; Vokes; Nicholas J. Vogelzang; Davidson; Richards; Chai; Finizio; Ratain

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February 13, 2001

Vascular endothelial growth factor-mediated endothelium- dependent relaxation is blunted in spontaneously hypertensive rats

Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565

Ming-Hui Liu; Hongkui Jin; H. Storm Floten; Qin Yang; Anthony P. C. Yim; Anthony Furnary; Zioncheck; Bunting; Guo-Wei He

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February 6, 2001

Effects of early angiotensin-converting enzyme inhibition on cardiac gene expression after acute myocardial infarction

Circulation, ISSN: 00097322

Hongkui Jin; Renhui Yang; Tarif A. Awad; Fay Wang; Wei Li; Simon P. Williams; Annie Ogasawara; Brian Shimada; P. Mickey Williams; Gianfranco De Feo; Nicholas F. Paoni

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February 2, 2001

Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2): A reassessment using novel receptor-specific vascular endothelial growth factor mutants

Journal of Biological Chemistry, ISSN: 00219258

Hendrik Gille; Joe Kowalski; Bing Li; Jennifer Lecouter; Moffat; Zioncheck; Nicolas Pelletier; Napoleone Ferrara

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February 1, 2001

Untangling the ErbB signalling network

Nature Reviews Molecular Cell Biology, ISSN: 14710072

Yarden; Mark X. Sliwkowski

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February 1, 2001

Bispecific human IgG by design

Journal of Immunological Methods, ISSN: 00221759

Paul J. Carter

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January 31, 2001

A minimal peptide scaffold for β-turn display: Optimizing a strand position in disulfide-cyclized β-hairpins

Journal of the American Chemical Society, ISSN: 00027863

Andrea G Cochran; Tong; Melissa A. Starovasnik; Park; Robert S. McDowell; Theaker; Nicholas J. Skelton

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January 23, 2001

The tissue factor region that interacts with factor Xa in the activation of factor VII

Biochemistry, ISSN: 00062960

Daniel Kirchhofer; Eigenbrot; Michael T. Lipari; Paul Moran; Peek; Robert F. Kelley

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January 20, 2001

Engraftment of autologous retrovirally transduced hepatocytes after intraportal transplantation into nonhuman primates: Implication for ex vivo gene therapy

Human Gene Therapy, ISSN: 10430342

Andreoletti; Nathalie Loux; Corinne Vons; Tuan Huy Nguyen; Lorand; Mahieu; Simon; Di Rico; Vingert; Chapman; Pascale Briand; Ralph H. Schwall; Hamza; Capron; Bargy; Dominique Franco; Anne Weber

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January 15, 2001

Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: Contrast with the unique cold-induced mitochondrial carrier CGI-69

Biochemical Journal, ISSN: 02646021

Yu; Lewin; Zhong; Brush; Peter Schow; Steve Sherwood; Pan; Adams

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January 12, 2001

IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1

Journal of Biological Chemistry, ISSN: 00219258

James Lee; Ho; Maruoka; Corpuz; Daryl T. Baldwin; Foster; Goddard; Yansura; Richard L. Vandlen; William I. Wood; Austin L. Gurney

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January 12, 2001

The RelA(p65) subunit of NF-κB is essential for inhibiting double-stranded RNA-incluced cytotoxicity

Journal of Biological Chemistry, ISSN: 00219258

Ming Li; Wendy Shillinglaw; William J. Henzel; Amer A. Beg

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January 12, 2001

Membrane ion-exchange chromatography for process-scale antibody purification

Journal of Chromatography A, ISSN: 00219673

Knudsen; Fahrner; Yuan Xu; Lenore A Norling; Gregory S. Blank

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January 7, 2001

IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp

Cytokine, ISSN: 10434666

Pan; Risser; Mao; Daryl T. Baldwin; Zhong; Ellen H. Filvaroff; Yansura; Lhney Lewis; Eigenbrot; William J. Henzel; Richard L. Vandlen

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January 1, 2001

Similarity of the Escherichia coli proteome upon completion of different biopharmaceutical fermentation processes

Proteomics, ISSN: 16159853

Kathleen M. Champion; Julie C. Nishihara; John C. Joly; David Arnott

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January 1, 2001

A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

Journal of Pharmaceutical Sciences, ISSN: 00223549

Cleland; Lam; Brent Kendrick; Yang; Tzung-Horng Yang; David E. Overcashier; Brooks; Chung C. Hsu; John F. Carpenter

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January 1, 2001

Tissue microarray (TMA) technology: Miniaturized pathology archives for high-throughput in situ studies

Journal of Pathology, ISSN: 00223417

Franklin V. Peale Jr.; Mary E. Gerritsen

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January 1, 2001

Mutations altering leaf morphology in tomato

International Journal of Plant Sciences, ISSN: 10585893

Sharon Kessler; Minsung Kim; Thinh Q. Pham; Natalie Weber; Neelima Sinha

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January 1, 2001

Regulation of the association between PSTPIP and CD2 in murine T cells

Experimental and Molecular Pathology, ISSN: 00144800

Yalai Bai; Yaozhong Ding; Yalai Bai; Yaozhong Ding; Jonathan S. Bromberg; Spencer; Lasky

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January 1, 2001

First-line, single-agent Herceptin® (trastuzumab) in metastatic breast cancer: A preliminary report

European Journal of Cancer, ISSN: 09598049

Charles L. Vogel; Melody A. Cobleigh; Debasish Tripathy; John C. Gutheil; Lyndsay N. Harris; Louis Fehrenbacher; Dennis J. Slamon; Maureen Murphy; Novotny; Michael Burchmore; Shak; Stanford J. Stewart

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January 1, 2001

Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo

American Journal of Pathology, ISSN: 00029440

Xiaohua Xin; Suya Yang; Gladys S. Ingle; Constance Zlot; Linda Rangell; Joe Kowalski; Ralph H. Schwall; Napoleone Ferrara; Mary E. Gerritsen

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January 1, 2001

A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

Journal of Pharmaceutical Sciences, ISSN: 00223549

Cleland; Lam; Brent Kendrick; Yang; Tzung-Horng Yang; David E. Overcashier; Brooks; Chung C. Hsu; John F. Carpenter

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January 1, 2001

Distribution and localization of CMP-N-acetylneuraminic acid hydroxylase and N-glycolylneuraminic acid-containing glycoconjugates in porcine lymph node and peripheral blood lymphocytes

European Journal of Cell Biology, ISSN: 01719335

Yanina N. Malykh; Brigitte Krisch; Lee Shaw; Warner; Sinicropi; Roanne Smith; Joseph Chang; Roland Schauer

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January 1, 2001

Validating the sanitization of chromatographic resins: A sample case study

BioPharm, ISSN: 10408304

Hiraoka-Sutow; Broughton

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January 1, 2001

The external granule layer of the developing chick cerebellum generates granule cells and cells of the isthmus and rostral hindbrain

Journal of Neuroscience, ISSN: 02706474

John C. Lin; Li Cai; Constance L. Cepko

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January 1, 2001

An improved method for the extraction of SV40 DNA for real-time quantitative PCR assay

American Biotechnology Laboratory, ISSN: 07493223

Shi; Yuan Xu

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January 1, 2001

Migrating, archiving, and reconstructing electronic records in a regulatory environment

Drug Information Journal, ISSN: 00928615

Woodrum

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January 1, 2001

Capillary Electrophoresis as a Routine Analytical Tool in Pharmaceutical Analysis

LC-GC Europe, ISSN: 14716577

Kevin D. Altria; Chen; Lilian Clohs

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January 1, 2001

Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus

Developmental Biology, ISSN: 00121606

Jian Zhang; Rosenthal; Frederic J. De Sauvage; Ramesh A. Shivdasani

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January 1, 2001

Metal-catalyzed oxidation of human growth hormone: Modulation by solvent-induced changes of protein conformation

Journal of Pharmaceutical Sciences, ISSN: 00223549

Susan W. Hovorka; Jinyang Hong; Cleland; Christian Schöneich

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January 1, 2001

Determination of a weight-adjusted dose of TNK-tissue plasminogen activator

American Heart Journal, ISSN: 00028703

Wang-Clow; Fox; Christopher P. Cannon; C.Michael Gibson; Berioli; Bluhmki; Danays; Eugene Braunwald; Frans Van De Werf; David Stump

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January 1, 2001

Characterization of EDTA-soluble polysaccharides from the scape of Musa paradisiaca (banana)

Biotechnology and Applied Biochemistry, ISSN: 08854513

T. Shantha Raju; Jagadish; Anjaneyalu

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January 1, 2001

Binding protein-3-selective insulin-like growth factor I variants: Engineering, biodistributions, and clearance

Endocrinology, ISSN: 00137227

Yves Dubaquié; Deborah L. Mortensen; Anthony Intintoli; Deborah A. Hogue; Nakamura; Rancatore; Philip M. Lester; Michael D Sadick; Ellen H. Filvaroff; Fielder; Henry B. Lowman

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January 1, 2001

Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin

Experimental Neurology, ISSN: 00144886

John F. Hamilton; Paul F. Morrison; Michael Y. Chen; Judith Harvey-White; Rosario S. Pernaute; Phillips; Edward Oldfield; Krys S. Bankiewicz

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January 1, 2001

Effect of NGF and neurotrophin-3 treatment on experimental diabetic autonomic neuropathy

Journal of Neuropathology and Experimental Neurology, ISSN: 00223069

Robert E. Schmidt; Denise A. Dorsey; Lucie N. Beaudet; Curtis A. Parvin; Escandon

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January 1, 2001

Power consumption profiles in high-shear wet granulation. II: Predicting the overwetting point from a spreading energy

Journal of Pharmaceutical Sciences, ISSN: 00223549

Cleland; Lam; Brent Kendrick; Yang; Tzung-Horng Yang; David E. Overcashier; Brooks; Chung C. Hsu; John F. Carpenter

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January 1, 2001

Assays for human DNase I activity in biological matrices.

Methods in Molecular Biology, ISSN: 10643745

Sinicropi; Lazarus

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