Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 13401 - 13450 OF 15613 RESULTS

Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Brian D. Bennett; Francis C. Zeigler; Qimin Gu; Brian M. Fendly; Goddard; Nancy Gillett; William Matthews
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Mice from a genetically resistant background lacking the interferon γ receptor are susceptible to infection with leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response
Journal of Experimental Medicine, ISSN: 15409538 00221007
Kristin Swihart; Ulrich Fruth; Nathalie Messmer; Katharina Hug; Reza Behin; Sui Huang; Giuseppe Del Giudice; Michel Aguet; Jacques A. Louis
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The use of laser diffraction for the evaluation of the aerosol clouds generated by medical nebulizers
International Journal of Pharmaceutics, ISSN: 03785173
Clark
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Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Thomas K. Morrissey; Allan D. O. Levi; Andrew Nuijens; Mark X. Sliwkowski; Richard P. Bunge
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Development of anti-p185HER2 immunoliposomes for cancer therapy
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Park; Hong; Paul J. Carter; Asgari; Guo; Gilbert-Andre Keller; Wirth; Shalaby; Claire Kotts; William I. Wood; Papahadjopoulos; Benz
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Characterization of the hormone binding site of natriuretic peptide receptor-C
FEBS Letters, ISSN: 00145793
Alfred M Engel; David G Lowe
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Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin
Blood, ISSN: 00064971
Austin L. Gurney; Wun-Jing Kuang; Xie; Malloy; Dan L. Eaton; Frederic J. De Sauvage
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Development of a Humanized Disulfide-stabilized Anti-p185HER2 Fv-β-Lactamase Fusion Protein for Activation of a Cephalosporin Doxorubicin Prodrug
Cancer Research, ISSN: 15387445 00085472
Maria L. Rodrigues; Presta; Claire Kotts; Wirth; Joyce Mordenti; Gary Osaka; Wai Lee T. Wong; Andrew Nuijens; Brent Blackburn; Paul J. Carter
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Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus
Nature, ISSN: 00280836
Betty A. Maddux; Paolo Sbraccia; Shinobu Kumakura; Shlomo Sasson; Jack Youngren; Alexander Fisher; Steven A. Spencer; Andrew Grupe; William J. Henzel; Stewart; Gerald M. Reaven; Ira D. Goldfine
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Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Diane Pennica; King; Kenneth J. Shaw; Luis; Janette Rullamas; Shiuh-Ming Luoh; Darbonne; Deborah S. Knutzon; Randy Yen; Kenneth R. Chien; Baker; William I. Wood
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Effects of growth hormone in rats with postinfarction left ventricular dysfunction
Cardiovascular Drugs and Therapy, ISSN: 09203206 15737241
Renhui Yang; Bunting; Nancy Gillett; Ross Clark; Hongkui Jin
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Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: Identification of a novel in vivo role for p75
Journal of Experimental Medicine, ISSN: 15409538 00221007
Kathleen C. Sheehan; J. Keith Pinckard; Cora D. Arthur; Louis P. Dehner; David V. Goeddel; Schreiber
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Apoptosis in CHO cell batch cultures: examination by flow cytometry
Cytotechnology, ISSN: 09209069 15730778
Alison Moore; Christopher J. Donahue; Jeff Hooley; Diana L. Stocks; Kenneth D. Bauer; Mather
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Bispecific HER2 × CD3 Antibodies Enhance T-Cell Cytotoxicity in Vitro and Localize to HER2-Overexpressing Xenografts in Nude Mice
Clinical Immunology and Immunopathology, ISSN: 00901229
Shalaby; Paul J. Carter; Daniel A. Maneval; Giltinan; Claire Kotts
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Nerve growth factor levels in cultured human skin cells: effect of gestation and viral transformation
Neuroscience Letters, ISSN: 03043940
Anand; Foley; Navsaria; Sinicropi; Williams-Chestnut; Leigh
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Mesencephalic dopaminergic neurons protected by gdnf from axotomy-induced degeneration in the adult brain
Nature, ISSN: 00280836
Klaus D. Beck; Janet Valverde; Alexi; Kris Poulsen; Moffat; Richard L. Vandlen; Rosenthal; Franz Hefti
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Monoclonal antibodies that block the activity of leukocyte function-associated antigen 1 recognize three discrete epitopes in the inserted domain of CD11a
Journal of Biological Chemistry, ISSN: 00219258
Mark Champe; Bradley W. McIntyre; Berman
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Control of neuronal diversity by the floor plate: Contact-mediated induction of midbrain dopaminergic neurons
Cell, ISSN: 00928674
Mary Hynes; Kris Poulsen; Marc Tessier-Lavigne; Rosenthal
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Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation
Neuron, ISSN: 08966273
Winslow; Paul Moran; Janet Valverde; Shih; Jean Q. Yuan; Suzy C. Wong; Siao Ping Tsai; Goddard; William J. Henzel; Franz Hefti; Klaus D. Beck; Caras
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Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA
Science, ISSN: 00368075
Olivier Cases; Isabelle Seif; Joseph Grimsby; Patricia Gaspar; Kevin Chen; Sandrine Pournin; Ulrike Müller; Michel Aguet; Charles Babinet; Jean Chen Shih; Edward De Maeyer
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Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families
American Journal of Human Genetics, ISSN: 00029297
Friedman; Szabo; Elizabeth A. Ostermeyer; Patrick Dowd; Lesley Butler; Tari Park; Ming K. Lee; Ellen L. Goode; Sarah E. Rowell; Mary-Claire King
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X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp
Journal of Molecular Biology, ISSN: 00222836
Axel J. Scheidig; Sybille M. Franken; John E.T. Corrie; Gordon P. Reid; Alfred Wittinghofer; Emil F. Pai; Roger S. Goody
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Dissection of the Extracellular Human Interferon γ Receptor α-Chain into two Immunoglobulin-like Domains. Production in an Escherichia coli Thioredoxin Gene Fusion Expression System and Recognition by Neutralizing Antibodies
Biochemistry, ISSN: 15204995 00062960
Geoffrey Williams; Nicole Ruegg; Ashley Birch; Christoph Weber; Klaus Hofstädter; John A. Robinson; Michel Aguet; Gianni Garotta; Daniel Schlatter; Walter Huber
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Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase
EMBO Journal, ISSN: 02614189
Yi-Li Yang; Luiz F. L. Reis; Jovan Paylovic; Sano Aguzzi; Reinhold Schäfer; Aseem Kumar; Bryan R. G. Williams; Michel Aguet; Charles Weissmann
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Structure-Based Design from Flexible Ligands
Annual Reports in Medicinal Chemistry, ISSN: 00657743
Robert S. McDowell; Dean R. Artis
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Analysis of the Factor Vila Binding Site on Human Tissue Factor: Effects of Tissue Factor Mutations on the Kinetics and Thermodynamics of Binding
Biochemistry, ISSN: 15204995 00062960
Robert F. Kelley; Kimberly E. Costas; Mark P. O'Connell; Lazarus
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Anti-IgE therapy
Current Opinion in Immunology, ISSN: 09527915
Paula Jardieu
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Cloning of the Murine Counterpart of the Tumor-Associated Antigen H-L6: Epitope Mapping of the Human and Murine L6 Antigens
Biochemistry, ISSN: 15204995 00062960
Caroline P. Edwards; Andrew G. Farr; John S. Marken; Andrew Nelson; Jürgen Bajorath; Karl Erik Hellstrom; Ingegerd Hellstrom; Alejandro Aruffo
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Structural and functional epitopes in the growth hormone receptor complex: Can information from large molecules lead to the design of small molecule mimetics?
Nature Biotechnology, ISSN: 0733222X
James A. Wells
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Exploring the Role of the Solvent in the Denaturation of a Protein: A Molecular Dynamics Study of the DNA Binding Domain of the 434 Repressor
Biochemistry, ISSN: 15204995 00062960
Celia A. Schiffer; Volker Dötsch; Kurt Wüthrich; Wilfred F. Van Gunsteren
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The unexpected presence of hydroxylysine in non-collagenous proteins
Techniques in Protein Chemistry, ISSN: 10808914
Michael S. Molony; Wu; Lene K. Keyt; Reed J. Harris
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Ligand Binding to the Tissue-Type Plasminogen Activator Kringle 2 Domain: Structural Characterization by 1H-NMR
Biochemistry, ISSN: 15204995 00062960
In-Ja L. Byeon; Robert F. Kelley; Michael G. Mulkerrin; Seong Soo A. An; Miguel Llinás
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Characterization of Complex Formation by Humanized Anti-IgE Monoclonal Antibody and Monoclonal Human IgE
Biochemistry, ISSN: 15204995 00062960
Jun Liu; Philip M. Lester; Stuart E. Builder; Steven J. Shire
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Time course of increased cellular proliferation collateral arteries after administration of vascular endothelial growth factor in a rabbit model of lower limb vascular insufficiency
American Journal of Pathology, ISSN: 00029440
Satoshi Takeshita; Susan T. Rossow; Marianne Kearney; Lu P. Zheng; Christophe Bauters; Bunting; Napoleone Ferrara; James F. Symes; Jeffrey M. Isner
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Correlation of cleavage techniques with side-reactions following solid-phase peptide synthesis
Techniques in Protein Chemistry, ISSN: 10808914
Gregg B. Fields; Ruth H. Angeletti; Lynda F. Bonewald; William T. Moore; Alan J. Smith; Stults; Lynn C. Williams
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Development of antimalaria immunity in mice lacking IFN-γ receptor
Journal of Immunology, ISSN: 00221767
Moriya Tsuji; Yasushi Miyahira; Ruth S. Nussenzweig; Michel Aguet; Reichel; Fidel Zavala
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In vitro characterization of four novel classes of growth hormone-releasing peptide
Endocrinology, ISSN: 19457170 00137227
Kathleen A. Elias; Gladys S. Ingle; Burnier; R. Glenn Hammonds; Robert S. Mc dowell; Thomas E. Rawson; Todd C. Somers; Mark S. Stanley; Cronin
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Designing Subtilisin BPN’ To Cleave Substrates Containing Dibasic Residues
Biochemistry, ISSN: 15204995 00062960
Ballinger; Jeffrey Torn; James A. Wells
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Neurotrophin‐4/5, brain‐derived neurotrophic factor, and neurotrophin‐3 promote survival of cultured vestibular ganglion neurons and protect them against neurotoxicity of ototoxins
Journal of Neurobiology, ISSN: 10974695 00223034
Lisa Zheng; Randall R. Stewart; Gao
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Enzymatic Cyclization of Linear Peptide Esters Using Subtiligase
Journal of the American Chemical Society, ISSN: 15205126 00027863
Jackson; Burnier; James A. Wells
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Cloning, sequencing, and expression of a 24-kDa Ca2+-binding protein activating photoreceptor guanylyl cyclase
Journal of Biological Chemistry, ISSN: 00219258
Alexander M. Dizhoor; Elena V. Olshevskaya; William J. Henzel; Susan C. Wong; Stults; Irina Ankoudinova; James B. Hurley
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The Regulation of Blood Vessel Growth by Vascular Endothelial Growth Factor
Annals of the New York Academy of Sciences, ISSN: 17496632 00778923
Napoleone Ferrara; Heinsohn; Walder; Bunting; G. Roger Thomas
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Binding and cross-linking of 32p-labeled human relaxin to human uterine cells and primary rat atrial cardiomyocytes
Endocrinology, ISSN: 19457170 00137227
Phyllis L. Osheroff; King
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Immunohistochemical Visualization of Brain‐derived Neurotrophic Factor in the Rat Brain
European Journal of Neuroscience, ISSN: 14609568 0953816X
Dugich-Djordjevic; Christine Peterson; Fujio Isono; Fukuichi Ohsawa; Hans R. Widmer; Denton; Bennett; Franz Hefti
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Engineering high affinity humanized anti‐p185HER2/anti‐CD3 bispecific F(ab′)2 for efficient lysis of p185HER2 overexpressing tumor cells
International Journal of Cancer, ISSN: 10970215 00207136
Zhu; Gail D. Lewis; Paul J. Carter
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Induction of midbrain dopaminergic neurons by Sonic hedgehog
Neuron, ISSN: 08966273
Mary Hynes; Jeffery A. Porter; Chin Chiang; David Chang; Marc Tessier-Lavigne; Philip A. Beachy; Rosenthal
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Stabilization of Type-I β-Turn Conformations in Peptides Containing the NPNA-Repeat Motif of the Plasmodium falciparum Circumsporozoite Protein by Substituting Proline for (S)-α-Methylproline
Journal of the American Chemical Society, ISSN: 15205126 00027863
Christian Bisang; Christoph Weber; Janice Inglis; Wilfred F. Van Gunsteren; Celia A. Schiffer; Ilian Jelesarov; Hans R. Bosshard; John A. Robinson
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Affinity Purification and Microcharacterization of Recombinant DNA-Derived Human Growth Hormone Isolated from an in Vivo Model
Analytical Chemistry, ISSN: 15206882 00032700
John E. Battersby; Venkat R. Mtikku; Rose G. Clark; William S. Hancock
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Neurotrophin‐3 reverses experimental cisplatin‐induced peripheral sensory neuropathy
Annals of Neurology, ISSN: 15318249 03645134
Gao; Noel Dybdal; Natasha Shinsky; Amy Murnane; Charles H. Schmelzer; Mark Siegel; Gilbert-Andre Keller; Franz Hefti; Phillips; Winslow
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Structure of the growth hormone-receptor complex and mechanism of receptor signaling.
Journal of Nuclear Medicine, ISSN: 01615505
Anthony A. Kossiakoff
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