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Publications

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DISPLAYING 3001 - 3050 OF 15169 RESULTS

Design and evaluation of highly selective human immunoproteasome inhibitors reveal a compensatory process that preserves immune cell viability
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Ena Ladi; Christine Everett; Craig E. Stivala; Blake E. Daniels; Matthew Durk; Seth F. Harris; Malcolm P. Huestis; Hans E. Purkey; Steven T. Staben; Martin Augustin; Michael Blaesse; Stefan Steinbacher; Celine Eidenschenk; Rajita Pappu; Michael Siu
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MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Du; Jack Bevers; Ryan Cook; T. Noelle Lombana; Kamalakannan Rajasekaran; Marissa L. Matsumoto; Christoph Spiess; Kim; Zhengmao Ye
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Healthcare costs among patients with hemophilia A treated with factor replacement or bypassing agents
Current Medical Research and Opinion, ISSN: 14734877 03007995
Jason P. Swindle; Yaping Xu; Yunming Mu; Paul G. Solari
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Palladium-catalyzed α,β-dehydrogenation of acyclic ester equivalents promoted by a novel electron deficient phosphinooxazoline ligand
Tetrahedron, ISSN: 14645416 00404020
Tyler J. Fulton; Brenda Wu; Eric J. Alexy; Haiming Zhang; Brian M. Stoltz
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Functions and regulation of T cell-derived interleukin-10
Seminars in Immunology, ISSN: 10963618 10445323
Christian Neumann; Alexander Scheffold; Sascha Rutz
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Impact of consensus molecular subtype on survival in patients with metastatic colorectal cancer: Results from CALGB/SWOG 80405 (Alliance)
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Heinz-Josef Lenz; Fang-Shu Ou; Alan P. Venook; Hochster; Donna Niedzwiecki; Richard M. Goldberg; Robert J. Mayer; Monica M. Bertagnolli; Charles D. Blanke; Tyler J. Zemla; Xueping Qu; Pratyaksha Wirapati; Sabine Tejpar; Federico Innocenti; Omar Kabbarah
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FAIRLANE, a double-blind placebo-controlled randomized phase II trial of neoadjuvant ipatasertib plus paclitaxel for early triple-negative breast cancer
Annals of Oncology, ISSN: 15698041 09237534
Oliveira; Saura; Nuciforo; Calvo; Andersen; Passos-Coelho; Gil Gil; Bermejo; Debra Patt; Eva Ciruelos; Lorena de la Peña; Xu; Matthew Wongchenko; Shi; Stina M. Singel; Isakoff
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Prognostic impact of natural killer cell count in follicular lymphoma and diffuse large b-cell lymphoma patients treated with immunochemotherapy
Clinical Cancer Research, ISSN: 15573265 10780432
Magdalena Klanova; Mikkel Z. Oestergaard; Marek Trneny; Wolfgang Hiddemann; Robert Marcus; Laurie H. Sehn; Umberto Vitolo; Alexandra Bazeos; Valentin Goede; Harald Zeuner; Andrea Knapp; Deniz Sahin; Nathalie Spielewoy; Christopher R. Bolen; Andres Cardona; Christian Klein; Jeffrey M. Venstrom; Tina Nielsen; Guenter Fingerle-Rowson
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CBP/p300 drives the differentiation of regulatory T cells through transcriptional and non-transcriptional mechanisms
Cancer Research, ISSN: 15387445 00085472
Joseph Castillo; Esther Wu; Christopher Lowe; Shrividhya Srinivasan; Mccord; Marie-Claire Wagle; Sangeeta Jayakar; Melissa Gonzalez Edick; Jeffrey Eastham-Anderson; Bonnie Liu; Katherine E. Hutchinson; Wendell Jones; Matthew P. Stokes; Somayeh S. Tarighat; Thomas Holcomb; Andrew Glibicky; F. Anthony Romero; Steven Magnuson; Shih-Min A. Huang; Vicki Plaks; Jennifer M. Giltnane; Lackner; Zineb Mounir
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Bromodomains: a new target class for drug development
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Andrea G Cochran; Andrew R. Conery; Robert J. Sims
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Long-Term Safety of Rituximab in Patients With Rheumatoid Arthritis: Results of a Five-Year Observational Study
Arthritis Care and Research, ISSN: 21514658 2151464X
Kevin L. Winthrop; Saag; Matthew Cascino; Jinglan Pei; Ani John; Angelika Jahreis; Tmirah Haselkorn; Daniel E. Furst
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Efficacious dose of metformin for breast cancer therapy is determined by cation transporter expression in tumours
British Journal of Pharmacology, ISSN: 14765381 00071188
Hao Cai; Ruth S. Everett; Dhiren R. Thakker
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Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Shuguang Ma; Julia Suchomel; Evelyn Yanez; Edward Yost; Xiaorong Liang; Rui Zhu; Hoa Le; Nicholas Siebers; Lori Joas; Roland Morley; Stephanie Royer-Joo; Andrea Pirzkall; Laurent Salphati; Joseph A. Ware; Kari M. Morrissey
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Protein conjugates and fusion proteins as ocular therapeutics
Drug Discovery Today, ISSN: 18785832 13596446
Shrenik C. Mehta; Robert F. Kelley; Devin B. Tesar
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Hydrogels for sustained delivery of biologics to the back of the eye
Drug Discovery Today, ISSN: 18785832 13596446
Debby P. Chang; Kinam Park; Amin Famili
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The safety evaluation of long-acting ocular delivery systems
Drug Discovery Today, ISSN: 18785832 13596446
Evan A Thackaberry; Florence Lorget; Cindy A. Farman; Vlad Bantseev
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Safety, clinical activity and biomarker assessments of atezolizumab from a Phase I study in advanced/recurrent ovarian and uterine cancers
Gynecologic Oncology, ISSN: 10956859 00908258
Joyce F. Liu; Michael S. Gordon; Jennifer Veneris; Fadi S. Braiteh; Ani Balmanoukian; Joseph Paul Eder; Ana Oaknin; Hamilton; Wang; Indrani Sarkar; Luciana L. Molinero; Marcella Fassò; Carol E. O'Hear; Yvonne G. Lin; Leisha A. Emens
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The Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration: Results from the Randomized Phase 2 Ladder Clinical Trial
Ophthalmology, ISSN: 15494713 01616420
Peter A. Campochiaro; Dennis Marcus; Carl C. Awh; Carl D. Regillo; Anthony P. Adamis; Vlad Bantseev; Yawen Chiang; Jason S. Ehrlich; Signe Erickson; William D. Hanley; Joshua Horvath; Katie F. Maass; Natasha Singh; Fan Tang; Giulio Barteselli
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Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: An interventional open-label study
Thorax, ISSN: 14683296 00406376
John Busby; Cecile Holweg; Akiko Chai; Peter Bradding; Fang Cai; Rekha Chaudhuri; Adel Mansur; James Lordan; Matthews; Andrew Menzies-Gow; Robert Niven; Tracy Staton; Liam G. Heaney
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Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid
Annals of Neurology, ISSN: 15318249 03645134
Ting Yang; Yifan Dang; Beth Ostaszewski; David Mengel; Verena Steffen; Christina Rabe; Tobias Bittner; Dominic M. Walsh; Dennis J. Selkoe
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Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: An interventional open-label study
Thorax, ISSN: 14683296 00406376
John Busby; Cecile Holweg; Akiko Chai; Peter Bradding; Fang Cai; Rekha Chaudhuri; Adel Mansur; James Lordan; John Matthews; Andrew Menzies-Gow; Robert Niven; Tracy Staton; Liam G. Heaney
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Pharmacokinetics of the BCL-2 Inhibitor Venetoclax in Subjects with Hepatic Impairment
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Ahmed Hamed Salem; Nimita Dave; Thomas Marbury; Beibei Hu; Dale Miles; Suresh K. Agarwal; Orlando F. Bueno; Rajeev M. Menon
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Protein conjugates and fusion proteins as ocular therapeutics
Drug Discovery Today, ISSN: 18785832 13596446
Shrenik Mehta; Robert F. Kelley; Devin B. Tesar
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Classification and Diagnosis of Bioprocess Cell Growth Productions Using Early-Stage Data
Industrial and Engineering Chemistry Research, ISSN: 15205045 08885885
Yuan Jin; Joe Qin; Qiang Huang; Victor Saucedo; Zheng Li; Angela Meier; Siddhartha Kundu; Bri Lehr; Salim Charaniya
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Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Laurel M. Pegram; Jennifer C. Liddle; Yao Xiao; Maria Hoh; Johannes Rudolph; Dylan B. Iverson; Guy Vigers; Darin Smith; Hailong Zhang; Weiru Wang; John Moffat; Natalie G. Ahn
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The Importance of Molecular Immune Investigation in Therapeutic Clinical Development for Biomarker Assessment
Journal of Crohn's and Colitis, ISSN: 18764479 18739946
Christopher A. Lamb; John C. Mansfield; John A. Kirby; Mary E. Keir
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Discovery of clinical candidate (1 R,4 r)-4-((R)-2-((S)-6-Fluoro-5 H-imidazo[5,1-A[isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a potent and selective inhibitor of indoleamine 2,3-dioxygenase 1
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Sanjeev Kumar; Jesse P. Waldo; Firoz A. Jaipuri; Agnieszka Marcinowicz; Clarissa Van Allen; James Adams; Tanay Kesharwani; Xiaoxia Zhang; Richard Metz; Angela Oh; Seth F. Harris; Mario R. Mautino
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TAZ is required for lung alveolar epithelial cell differentiation after injury
JCI insight, ISSN: 23793708
Tianhe Sun; Zhiyu Huang; Hua Zhang; Clara Posner; Guiquan Jia; Thirumalai R. Ramalingam; Min Xu; Hans D. Brightbill; Jackson G. Egen; Anwesha Dey; Joseph R. Arron
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SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
Neuron, ISSN: 10974199 08966273
Koopmans; Pim van Nierop; Andres-Alonso; Andrea Byrnes; Tony Cijsouw; Marcelo P. Coba; L. Niels Cornelisse; Ryan J. Farrell; Hana Goldschmidt; Daniel P. Howrigan; Natasha K. Hussain; Cordelia Imig; Arthur P.H. de Jong; Hwajin Jung; Mahdokht Kohansalnodehi; Barbara Kramarz; Noa Lipstein; Ruth C. Lovering; Harold MacGillavry; Vittoria Mariano; Huaiyu Mi; Momchil Ninov; Osumi-Sutherland; Rainer Pielot; Karl-Heinz Smalla; Haiming Tang; Katherine Tashman; Ruud F.G. Toonen; Chiara Verpelli; Rita Reig-Viader; Watanabe; Jan van Weering; Tilmann Achsel; Ghazaleh Ashrafi; Asi; Tyler C. Brown; Pietro De Camilli; Marc Feuermann; Rebecca E. Foulger; Pascale Gaudet; Anoushka Joglekar; Alexandros Kanellopoulos; Robert C. Malenka; Roger A. Nicoll; Camila Pulido; de Juan-Sanz; Morgan Sheng; Thomas C. Südhof; Hagen U. Tilgner; Claudia Bagni; Àlex Bayés; Thomas Biederer; Nils Brose; John Jia En Chua; Daniela C. Dieterich; Eckart D. Gundelfinger; Casper C Hoogenraad; Richard Huganir; Reinhard Jahn; Pascal S. Kaeser; Eunjoon Kim; Michael R. Kreutz; Peter S. McPherson; Neale; Vincent O'Connor; Danielle Posthuma; Timothy A. Ryan; Sala; Guoping Feng; Steven E. Hyman; Paul D. Thomas; August B. Smit; Matthijs Verhage
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A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages
Immunity, ISSN: 10974180 10747613
Matthew B. Buechler; Ki-Wook Kim; Emily J. Onufer; Jesse W. Williams; Christine C. Little; Claudia X. Dominguez; Qingling Li; Wendy N. Sandoval; Jonathan Cooper; Charles Harris; Melissa Junttila; Gwendalyn J. Randolph; Shannon J. Turley
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Robust network inference using response logic
Bioinformatics, ISSN: 14602059 13674803
Torsten Gross; Matthew Wongchenko; Yibing Yan; Nils Blüthgen
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IL-17A is associated with the breakdown of the blood-brain barrier in relapsing-remitting multiple sclerosis
Journal of Neuroimmunology, ISSN: 18728421 01655728
A F. Setiadi; Abbas Alexander; Surinc Er Jeet; Kit Wong; Antje Bischof; Ivan Peng; James Lee; Meire C. Bremer; Erica L. Eggers; Jason Devoss; Tracy Staton; Ann E. Herman; H. -Christian von Büdingen; Michael J. Townsend
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Discovery and development of venetoclax, a selective antagonist of BCL-2
Successful Drug Discovery,
Wayne J. Fairbrother; Joel D. Leverson; Deepak Sampath; Andrew J. Souers
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Ocrelizumab: A new generation of anti-CD20 mAb for treatment of multiple sclerosis
Successful Drug Discovery,
Andrew A. Chan; Paul Brunetta; Peter Chin
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Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Marian C. Bryan; Joy Drobnick; Alberto Gobbi; Aleksandr Kolesnikov; Yongsheng Chen; Naomi S. Rajapaksa; Chudi O. Ndubaku; Jianwen A. Feng; Willy Chang; Ross Francis; Christine Yu; Edna F. Choo; Kevin Dement; Yingqing Ran; Le An; Claire Emson; Zhiyu Huang; Swathi Sujatha-Bhaskar; Hans D. Brightbill; Antonio G. DiPasquale; Jonathan M. Maher; John Wai; Brent Mckenzie; Patrick J. Lupardus; Ali A. Zarrin; James R. Kiefer
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An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans
mAbs, ISSN: 19420870 19420862
Shan Chung; Van Nguyen; Yuwen L. Lin; Julien Lafrance-Vanasse; Suzie J. Scales; Kevin Lin; Rong Deng; Kathi Williams; Gizette Sperinde; Juan Jenny Li; Kai Zheng; Siddharth Sukumaran; Devin B. Tesar; James A. Ernst; Saloumeh Kadkhodayan Fischer; Greg A. Lazar; Saileta Prabhu; An Song
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trackr: A Framework for Enhancing Discoverability and Reproducibility of Data Visualizations and Other Artifacts in R
Journal of Computational and Graphical Statistics, ISSN: 15372715 10618600
Gabriel Becker; Sara E. Moore; Michael Lawrence
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Scina: Semi-supervised analysis of single cells in silico
Genes, ISSN: 20734425
Ze Zhang; Danni Luo; Xue Zhong; Jin Huk Choi; Yuanqing Ma; Stacy Wang; Elena Mahrt; Wei Guo; Eric Stawiski; Zora Modrusan; Somasekar Seshagiri; Payal Kapur; Gary C. Hon; James Brugarolas; Tao Wang
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Phase Ib study of atezolizumab combined with cobimetinib in patients with solid tumors
Annals of Oncology, ISSN: 15698041 09237534
Matthew D. Hellmann; Kim; Lee; Goh; Miller; Do-Youn Oh; Rahima Jamal; Chee; Laura Q.M. Chow; Gainor; Jayesh Desai; Benjamin Solomon; Meghna Das Thakur; Bethany Pitcher; Paul Foster; Genevive Hernandez; Matthew Wongchenko; Edward Cha; Bang; Siu; Bendell
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Variance component analysis of circulating miR-122 in serum from healthy human volunteers
PLoS ONE, ISSN: 19326203
Jennifer Vogt; Daniel Sheinson; Paula Katavolos; Hiroko Irimagawa; Min Tseng; Kathila R. Alatsis; William R. Proctor
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Rapid characterization of formulated pharmaceuticals using fast MAS 1H solid-state NMR spectroscopy
Molecular Pharmaceutics, ISSN: 15438392 15438384
David A. Hirsh; Anuradha V. Wijesekara; Scott L. Carnahan; Ivan Hung; Joseph W. Lubach; Karthik Nagapudi; Aaron J. Rossini
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Pharmacokinetics and biodistribution of a [89Zr]Zr-DFO-MSTP2109A Anti-STEAP1 antibody in metastatic castration-resistant prostate cancer patients
Molecular Pharmaceutics, ISSN: 15438392 15438384
Joseph A. O'Donoghue; Daniel C. Danila; Neeta Pandit-Taskar; Volkan Beylergil; Sarah M. Cheal; Stephen E. Fleming; Josef J. Fox; Shutian Ruan; Pat B. Zanzonico; Govind Ragupathi; Serge K. Lyashchenko; Simon P. Williams; Scher; Bernard M. Fine; John L. Humm; Steven M. Larson; Michael J. Morris; Jorge A. Carrasquillo
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Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins
eLife, ISSN: 2050084X
Junghyun Lim; Hyunjoo Park; Jason Heisler; Timurs Maculins; Merone Roose-Girma; Min Xu; Brent Mckenzie; Menno Van Lookeren Campagne; Kim Newton; Aditya Murthy
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An IQ Consortium Perspective on The Scientific Committee on Health, Environmental and Emerging Risks Final Opinion on the Need for Nonhuman Primates in Biomedical Research, Production and Testing of Products and Devices (Update 2017)
Toxicologic Pathology, ISSN: 15331601 01926233
Khary Adams; Donna Clemons; Lynn Collura Impelluso; Donna W. Lee; Sean Maguire; Alexis Myers; Christopher Petursson; Robert J. Schulingkamp; Kevin Trouba; Matthew Wright
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Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
Nature Methods, ISSN: 15487105 15487091
Glenn R. Masson; John E. Burke; Natalie G. Ahn; Ganesh Srinivasan Anand; Christoph H. Borchers; Sébastien Brier; George M. Bou-Assaf; John R. Engen; S. Walter Englander; Johan Faber; Rachel Garlish; Patrick Griffin; Michael L. Gross; Miklos Guttman; Yoshitomo Hamuro; Albert J.R. Heck; Damian Houde; Roxana E. Iacob; Thomas J. D. Jørgensen; Igor A. Kaltashov; Judith P. Klinman; Lars Konermann; Petr Man; Leland Mayne; Bruce D. Pascal; Dana Reichmann; J. Mark Skehel; Joost Snijder; Timothy S. Strutzenberg; Eric S. Underbakke; Cornelia Wagner; Thomas E. Wales; Benjamin T. Walters; David D. Weis; Derek J. Wilson; Patrick L. Wintrode; Zhongqi Zhang; Jie Zheng; David C. Schriemer; Kasper D. Rand
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Pirfenidone in patients with idiopathic pulmonary fibrosis and more advanced lung function impairment
Respiratory Medicine, ISSN: 15323064 09546111
Steven D Nathan; Ulrich Costabel; Carlo Albera; Jürgen Behr; Wim Wuyts; Klaus-Uwe Kirchgaessler; John L. Stauffer; Elizabeth A. Morgenthien; Willis Chou; Susan L. Limb; Paul W. Noble
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Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial
The Lancet Oncology, ISSN: 14745488 14702045
Howard West; Michael McCleod; Maen Hussein; Alessandro Morabito; Achim Rittmeyer; Henry J Conter; Hans-Georg Kopp; Davey B Daniel; Steven McCune; Tarek Mekhail; Alona Zer; Niels Reinmuth; Ahad Sadiq; Alan Sandler; Wei Lin; Tania Ochi Lohmann; Venice Archer; Lijia Wang; Marcin Kowanetz; Federico Cappuzzo
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Polatuzumab vedotin in combination with immunochemotherapy in patients with previously untreated diffuse large B-cell lymphoma: an open-label, non-randomised, phase 1b–2 study
The Lancet Oncology, ISSN: 14745488 14702045
Herve Tilly; Morschhauser; Nancy L. Bartlett; Amitkumar Mehta; Gilles Salles; Corinne Haioun; Javier Munoz; Chen; Kathryn S. Kolibaba; Dan Lu; Mark Yan; Elicia M. Penuel; Jamie Hirata; Calvin Lee; Jeff P. Sharman
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Prognostic risk score for patients with relapsed or refractory chronic lymphocytic leukaemia treated with targeted therapies or chemoimmunotherapy: a retrospective, pooled cohort study with external validations
The Lancet Haematology, ISSN: 23523026
Jacob D Soumerai; Ai Ni; Mohamed Darif; Anil Londhe; Guan Xing; Yong Mun; Neil E Kay; Tait D Shanafelt; Kari G Rabe; John C. Byrd; Chanan-Khan; Richard Furman; Hillmen; Jeffrey Jones; John F. Seymour; Jeff P. Sharman; Lucille Ferrante; Mehrdad Mobasher; Thomas Stark; Vijay Reddy; Lyndah K Dreiling; Pankaj Bhargava; Angela Howes; Danelle F James; Zelenetz
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ISPOR, the FDA, and the Evolving Regulatory Science of Medical Device Products
Value in Health, ISSN: 15244733 10983015
Tyler O'Neill; Rebecca Miksad; Danelle Miller; Lesley Maloney; Ani John; Carolyn Hiller; John Hornberger
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