Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3951 - 4000 OF 15657 RESULTS

November 1, 2018

Multiproduct resin reuse for clinical and commercial manufacturing - Methodology and acceptance criteria

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Rizwan Sharnez; Steve Doares; Shane Manning; Krunal Mehta; Ekta Mahajan; Angela To; William Daniels; Judy Glynn; Sagar Dhamane; Xiaona Wen; Yunjuan Wang; Pankaj Gour; Constanze Guenther; Derek Foley; Ronan Hayes; Adam Mott; Sunil Prabhu; Dawn Tavalsky; Michael Hendershot; David Haas; Ashley Hesslein; Norbert Schuelke; Hendri Tjandra

November 1, 2018

Safety and clinical activity of atezolizumab in head and neck cancer: Results from a phase I trial

Annals of Oncology, ISSN: 15698041 09237534

A. Dimitrios Colevas; Rastilav Bahleda; Fadi S. Braiteh; Ani Balmanoukian; Brana; Chau; Indrani Sarkar; Luciana L. Molinero; William Grossman; Fairooz F. Kabbinavar; Marcella Fassò; Carol O’Hear; John D. Powderly

November 1, 2018

Systemic Safety in Ranibizumab-Treated Patients with Neovascular Age-Related Macular Degeneration: A Patient-Level Pooled Analysis

Kidney International Reports, ISSN: 24686530

Marco A. Zarbin; Steve Francom; Susanna M. Grzeschik; Lisa Tuomi; Zdenka Haskova; Wayne Macfadden; Philippe Margaron; Howard Snow; Alan Cruess; Giovanni Staurenghi; Cornelia Dunger-Baldauf

November 1, 2018

IMpower133: Primary efficacy and safety + CNS-related adverse events in a phase I/III study of first-line (1L) atezolizumab + carboplatin + etoposide in extensive-stage SCLC (ES-SCLC)

Annals of Oncology, ISSN: 15698041

Tony SK Mok; Martin Reck; Leora Horn; Lam; David S. Shames; Liu; Fairooz F. Kabbinavar; Lin; Alan Sandler; Stephen V. Liu

November 1, 2018

A method for manual and automated multiplex RNAscope in situ hybridization and immunocytochemistry on cytospin samples

PLoS ONE, ISSN: 19326203

Sara M. Chan; Audrey Filézac de L’Etang; Linda Rangell; Patrick Caplazi; John Lowe; Valentina Romeo

November 1, 2018

Lymphocytes are a major source of circulating soluble dipeptidyl peptidase 4

Clinical and Experimental Immunology, ISSN: 13652249 00099104

Armanda Casrouge; Sauer; Rosa Barreira da Silva; Tejera-Alhambra; Sánchez-Ramón; Cancrini; Molly A. Ingersoll; Aiuti; Matthew L. Albert

November 1, 2018

Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine

Pharmaceutical Research, ISSN: 1573904X 07248741

Michelle Z. Dion; Danielle L. Leiske; Vikas Sharma; Christina L. Zuch de Zafra; Cleo M. Salisbury

November 1, 2018

CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts

Alzheimer's and Dementia, ISSN: 15525279 15525260

Oskar Hansson; John P. Seibyl; Erik Stomrud; Henrik Zetterberg; John Q. Trojanowski; Tobias Bittner; Valeria Lifke; Veronika Corradini; Udo Eichenlaub; Richard Batrla; Katharina Buck; Katharina Zink; Christina Rabe; Kaj Blennow; Leslie Shaw

October 30, 2018

Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Kim Newton; Dugger; Arundhati Sengupta Ghosh; Ron Ferrando; Felix Chu; Janet Tao; Wendy Lam; Susan Haller; Sara M. Chan; Susan Sa; Debra Dunlap; Jeffrey Eastham-Anderson; Hai Ngu; Jeffrey Hung; French; Webster; Brad Bolon; Jinfeng Liu; Rohit Reja; Sarah K. Kummerfeld; Ying-Jiun Chen; Zora Modrusan; Joe Lewcock; Vishva M. Dixit

October 25, 2018

GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Shumei Wang; Vickie Tsui; Terry Crawford; James E. Audia; Burdick; Beresini; Alexandre Côté; Richard T Cummings; Martin Duplessis; E. Megan Flynn; Michael C. Hewitt; Hon-Ren Huang; Hariharan Jayaram; Ying Jiang; Shivangi Joshi; Jeremy Murray; Christopher G. Nasveschuk; Eneida Pardo; Florence Poy; F. Anthony Romero; Yong Tang; Alexander M. Taylor; Jian Wang; Zhaowu Xu; Laura E. Zawadzke; Xiaoyu Zhu; Brian K Albrecht; Steven Magnuson; Steve Bellon; Andrea G Cochran

October 25, 2018

Kinase Inhibitors for the Treatment of Immunological Disorders: Recent Advances

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Marian C. Bryan; Naomi S. Rajapaksa

October 23, 2018

Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1)

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Marcin Kowanetz; Wei Zou; Scott Gettinger; Koeppen; Mark Kockx; Schmid; Edward E. Kadel III; Ignacio I. Wistuba; Jamie E. Chaft; Naiyer A. Rizvi; David Spigel; Alexander Spira; Fred R. Hirsch; Victor Cohen; Dustin Smith; Zachary Boyd; Natasha Miley; Susan Flynn; Vincent Leveque; David S. Shames; Ballinger; Mocci; Geetha Shankar; Roel Funke; Garret M. Hampton; Alan Sandler; Lukas Amler; Ira Mellman; Daniel S. Chen; Priti Hegde

October 19, 2018

Evaluating the Impact of a Decade of Funding from the Green Chemistry Institute Pharmaceutical Roundtable

Organic Process Research and Development, ISSN: 1520586X 10836160

Stefan G. Koenig; David Leahy; Andrew S. Wells

October 18, 2018

A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition

Nature, ISSN: 14764687 00280836

Brian Biehs; Gerrit J. P. Dijkgraaf; Robert Piskol; Bruno Alicke; Soufiane Boumahdi; Franklin V. Peale Jr.; Stephen Gould; Frederic J. De Sauvage

October 17, 2018

Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3

Science Translational Medicine, ISSN: 19466242 19466234

Dionysos S. Slaga; Diego Ellerman; T. Noelle Lombana; Rajesh Vij; Ji Li; Maria Hristopoulos; Robyn Clark; Jennifer A. Johnston; Amy Shelton; Elaine Mai; Kapil Gadkar; Amy Lo; James T. Koerber; Klara Totpal; Prell; Genee Y. Lee; Christoph Spiess; Teemu T. Junttila

October 15, 2018

Conventional wastewater treatment and reuse site practices modify bacterial community structure but do not eliminate some opportunistic pathogens in reclaimed water

Science of the Total Environment, ISSN: 18791026 00489697

Prachi Kulkarni; Nathan D. Olson; Joseph N. Paulson; Mihai Pop; Cynthia Maddox; Emma Claye; Rachel E. Rosenberg Goldstein; Manan Sharma; Shawn G. Gibbs; Emmanuel F. Mongodin; Amy R. Sapkota

October 15, 2018

Chemotherapy combines effectively with Anti-PD-L1 treatment and can augment antitumor responses

Journal of Immunology, ISSN: 15506606 00221767

Rafael Cubas; Marina Moskalenko; Jeanne Cheung; Michelle Yang; Erin McNamara; Huizhong Xiong; Sabine Hoves; Carola H. Ries; Kim; Stephen Gould

October 8, 2018

Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors

Cancer Cell, ISSN: 18783686 15356108

Ivana Yen; Frances Shanahan; Mark Merchant; Christine Orr; Thomas Hunsaker; Matthew Durk; Hank La; Xiaolin Zhang; Scott E. Martin; Eva Lin; John Chan; Yihong Yu; Dhara Amin; Richard M. Neve; Amy Gustafson; Avinashnarayan Venkatanarayan; Scott A. Foster; Joachim Rudolph; Christiaan N. Klijn; Shiva Malek

October 6, 2018

Quality assessment and interference detection in targeted mass spectrometry data using machine learning 03 Chemical Sciences 0301 Analytical Chemistry

Clinical Proteomics, ISSN: 15590275 15426416

Shadi Toghi Eshghi; Paul Auger; W Rodney Mathews

October 5, 2018

Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin

Journal of Organic Chemistry, ISSN: 15206904 00223263

Scott Savage; Andrew McClory; Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Colin Masui; Sarah J. Robinson; Chong Han; Christoph Ochs; Pankaj D. Rege; Francis Gosselin

October 3, 2018

Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole

Xenobiotica, ISSN: 13665928 00498254

Molly Lin; Justin Ly; Ryan Takahashi; John Chen; Alan Deese; Sarah J. Robinson; Aleksandr Kolesnikov; Susan C. Wong; Xiaojing Wang; Jae H. Chang

October 3, 2018

Cost-effectiveness of obinutuzumab plus bendamustine followed by obinutuzumab monotherapy for the treatment of follicular lymphoma patients who relapse after or are refractory to a rituximab-containing regimen in the US

Journal of Medical Economics, ISSN: 1941837X 13696998

Gregory F. Guzauskas; Anthony Masaquel; Carolina Reyes; Coen A. Bernaards; Tania Krivasi; David L. Veenstra

October 3, 2018

Characterization of in vivo biotransformations for trastuzumab emtansine by high-resolution accurate-mass mass spectrometry

mAbs, ISSN: 19420870 19420862

Jintang He; Shang-Fan Yu; Sharon Fong Yee; Surinder Kaur; Keyang Xu

October 3, 2018

Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model

mAbs, ISSN: 19420870 19420862

Shun xin Wang-Lin; Chenguang Zhou; Amrita Kamath; Kyu Hong; Neelima Koppada; Ola M. Saad; Montserrat Carrasco-Triguero; S. Cyrus Khojasteh; Rong Deng

October 3, 2018

Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid

mAbs, ISSN: 19420870 19420862

Rina Fong; Kimberly K. Kajihara; Matthew Chen; Isidro Hötzel; Sanjeev Mariathasan; Wouter L. W. Hazenbos; Patrick J. Lupardus

October 3, 2018

High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants

mAbs, ISSN: 19420870 19420862

Danielle DiCara; Nisana Andersen; Ruby Chan; James A. Ernst; Gai Ayalon; Greg A. Lazar; Nick Agard; Amy Hilderbrand; Isidro Hötzel

October 2, 2018

The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function

Cell Reports, ISSN: 22111247

Sairy Hernandez; Jing Qing; Rebecca Hong Thibodeau; Xiangnan Du; Summer Park; Hyang-Mi Lee; Min Xu; Soyoung Oh; Armando Navarro; Merone Roose-Girma; Robert J. Newman; Søren Warming; Michelle Nannini; Deepak Sampath; Kim; Jane L. Grogan; Ira Mellman

October 1, 2018

Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics

Seminars in Cancer Biology, ISSN: 10963650 1044579X

Priti Hegde; Jeffery J. Wallin; Christoph Mancao

October 1, 2018

Efficacy of Ranibizumab in Eyes with Diabetic Macular Edema and Macular Nonperfusion in RIDE and RISE

Ophthalmology, ISSN: 15494713 01616420

Rahul K. Reddy; Dante Joseph Pieramici; Shamika Gune; Avanti Ghanekar; Na Lu; Carlos Quezada-Ruiz; Caroline R. Baumal

October 1, 2018

High Intracellular Seed Train BiP Levels Correlate With Poor Production Culture Performance in CHO Cells

Biotechnology Journal, ISSN: 18607314 18606768

Meg Tung; Danming Tang; Szu-Han Wang; Dejin Zhan; Karen Kiplinger; Shu Pan; Yifeng Jing; Amy Shen; Patrick Ahyow; Snedecor; Martin Gawlitzek; Shahram Misaghi

October 1, 2018

Applying a weight of evidence approach to the evaluation of developmental toxicity of biopharmaceuticals

Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300

Meredith Rocca; LaRonda L. Morford; Diann Blanset; Wendy Halpern; Joy A. Cavagnaro; Christopher J. Bowman

October 1, 2018

Buffer exchange path influences the stability and viscosity upon storage of a high concentration protein

European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411

Mary E. Krause; Ajit S. Narang; Gregory Barker; Sibylle Herzer; Smeet Deshmukh; Wenkui Lan; Daniel Fichana; John M. Wasylyk; Bahar Demirdirek; Limin Zhang; John Fiske; Matthew McGann; Monica L. Adams; Rajesh B. Gandhi

October 1, 2018

Development and validation of a novel semi-homogenous clinical assay for quantitation of Ranibizumab in human serum

Journal of Immunological Methods, ISSN: 18727905 00221759

John Lowe; Eric Wakshull; Theresa Shek; Anan Chuntharapai; Rebecca Elliott; Jeriza Rusit; Mauricio Maia

October 1, 2018

Investigation of Metal-Catalyzed Antibody Carbonylation With an Improved Protein Carbonylation Assay

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yi Yang; Anna Mah; Inn H. Yuk; Parbir Grewal; Abigail F.J. Pynn; Will Cole; Di Gao; Fan Zhang; Jia Chen; Lynn Gennaro; Christian Schöneich

October 1, 2018

An automated mapping method for Nissl-stained mouse brain histologic sections

Journal of Neuroscience Methods, ISSN: 1872678X 01650270

Smadar Shiffman; Sayantani Basak; Cleopatra Kozlowski; Reina N. Fuji

October 1, 2018

Modeled Prognostic Subgroups for Survival and Treatment Outcomes in BRAF V600-Mutated Metastatic Melanoma: Pooled Analysis of 4 Randomized Clinical Trials

JAMA Oncology, ISSN: 23742445 23742437

Axel Hauschild; James Larkin; Antoni Ribas; Brigitte Dréno; Keith Flaherty; Paolo A. Ascierto; Karl Lewis; Edward McKenna; Qian Zhu; Yong Mun; McArthur

October 1, 2018

Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process

Molecular Pharmaceutics, ISSN: 15438392 15438384

Ankai Xu; Hok Seon Kim; Samarkand Estee; Sharon Viajar; William J. Galush; Avinash Gill; Isidro Hötzel; Greg A. Lazar; Paul McDonald; Nisana Andersen; Christoph Spiess

October 1, 2018

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

Nature Cell Biology, ISSN: 14764679 14657392

Kristiaan J. Lenos; Daniël M. Miedema; Sophie C. Lodestijn; Lisanne E. Nijman; Tom van den Bosch; Xavier Romero Ros; Filipe C. Lourenço; Maria C. Lecca; Maartje van der Heijden; Sanne M. van Neerven; Anita van Oort; Nicolas Leveille; Ronja S. Adam; Felipe de Sousa e Melo; Joy Otten; Patrick Veerman; Guillaume Hypolite; Lianne Koens; Scott K. Lyons; Stassi; Douglas J. Winton; Jan Paul Medema; Edward Morrissey; Maarten F. Bijlsma; Louis Vermeulen

October 1, 2018

Using pH Gradient Dissolution with In-Situ Flux Measurement to Evaluate Bioavailability and DDI for Formulated Poorly Soluble Drug Products

AAPS PharmSciTech, ISSN: 15309932

Jane Li; Konstantin Tsinman; Oksana Tsinman; Larry Wigman

October 1, 2018

Humoral immunity goes hormonal: Studies of mice demonstrate a link between the female hormone estrogen and protection against bacteremia and sepsis through the induction of natural antibodies to eshcerichia coli

Nature Immunology, ISSN: 15292916 15292908

Joseph Chavarria-Smith; Wouter L. W. Hazenbos; Menno van Lookeren Campagne

October 1, 2018

Anatomy and physiology of the digestive tract of drosophila melanogaster

Genetics, ISSN: 19432631 00166731

Irene Miguel-Aliaga; Heinrich Jasper; Bruno Lemaitre

October 1, 2018

Serum periostin as a biomarker in eosinophilic granulomatosis with polyangiitis

PLoS ONE, ISSN: 19326203

Rennie L. Rhee; Cecile Holweg; Kit Wong; David Cuthbertson; Simon Carette; Nader A. Khalidi; Curry L. Koening; Langford; Carol A. McAlear; Paul A. Monach; Larry W. Moreland; Christian Pagnoux; Seo; Specks; Antoine G. Sreih; Steven R. Ytterberg; Peter A. Merkel

October 1, 2018

Pertuzumab plus trastuzumab and chemotherapy for HER2-positive metastatic gastric or gastro-oesophageal junction cancer (JACOB): final analysis of a double-blind, randomised, placebo-controlled phase 3 study

The Lancet Oncology, ISSN: 14745488 14702045

Tabernero; Paulo M. Hoff; Lin Shen; Atsushi Ohtsu; Manish A. Shah; Karen Cheng; Chunyan Song; Haiyan Wu; Jennifer Eng-Wong; Katherine Kim; Yoon-Koo Kang

October 1, 2018

Evaluation of no evidence of progression or active disease (NEPAD) in patients with primary progressive multiple sclerosis in the ORATORIO trial

Annals of Neurology, ISSN: 15318249 03645134

Wolinsky; Montalban; Stephen L. Hauser; Giovannoni; Patrick Vermersch; Corrado Bernasconi; Gurpreet Deol-Bhullar; Hideki Garren; Peter Chin; Belachew; Ludwig Kappos

October 1, 2018

Humoral immunity goes hormonal: Studies of mice demonstrate a link between the female hormone estrogen and protection against bacteremia and sepsis through the induction of natural antibodies to eshcerichia coli

Nature Immunology, ISSN: 15292916 15292908

Joseph Chavarria-Smith; Wouter L. W. Hazenbos; Menno van Lookeren Campagne

October 1, 2018

Ranibizumab Induces Regression of Diabetic Retinopathy in Most Patients at High Risk of Progression to Proliferative Diabetic Retinopathy

Kidney International Reports, ISSN: 24686530

Charles C. Wykoff; David Eichenbaum; Daniel B. Roth; Lauren Hill; Anne E. Fung; Zdenka Haskova

October 1, 2018

Identification of biological axes associated with stage II/III CRC recurrence risk and outcome after adjuvant therapy revealed a T-effector-independent prognostic role for granzyme B

Annals of Oncology, ISSN: 15698041

Meghna Das Thakur; Akshata R. Udyavar; Thomas Sandmann; Li; Bosch; William E. O'Gorman; Li; Amelia Au-Yeung; Chikara Takahashi; Richard Bourgon; Daemen; Priti Hegde; Carlos Bais

October 1, 2018

Molecular correlates differentiate response to atezolizumab (atezo) + bevacizumab (bev) vs sunitinib (sun): Results from a phase III study (IMmotion151) in untreated metastatic renal cell carcinoma (mRCC)

Annals of Oncology, ISSN: 15698041

Brian I Rini; Mahrukh Huseni; Michael B. Atkins; David McDermott; Thomas Powles; Bernard Escudier; Romain Banchereau; L-F Liu; Ning Leng; Fan; Doss; Sam C. Nalle; Carroll; Li; Christina Schiff; Marjorie Green; Robert J. Motzer

October 1, 2018

Clinical and analytical validation of an FDA approved comprehensive genomic profiling (CGP) assay incorporating multiple companion diagnostics for targeted and immunotherapies

Annals of Oncology, ISSN: 15698041

Li; James X. Sun; Skoletsky; Milbury; Burns; W-K Yip; Dewal; He; Tuesdell; Peters; Erica Schleifman; Johannes Noé; Jenkins; Elvin; Geoff A. Otto; Doron Lipson; Jeffrey S. Ross; Vincent A. Miller; Doherty; Vietz

October 1, 2018

Dissecting gastric cancer biology and how and when to use immunotherapy

Annals of Oncology, ISSN: 15698041

Meghna Das Thakur; Kwame Okrah; David S. Shames; Priti Hegde; Carlos Bais

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