Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4151 - 4200 OF 15583 RESULTS

Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN: 15244636 10795642
Lars La Cour Poulsen; Reidunn Jetne Edelmann; Stig Krüger; Rodrigo Diéguez-Hurtado; Akshay Shah; Tor Espen Stav-Noraas; Anastasia Renzi; Monika Szymanska; Junbai Wang; Manuel Ehling; Rui Benedito; Monika Kasprzycka; Espen Bækkevold; Olav Sundnes; Kim S. Midwood; Helge Scott; Philippe Collas; Christian W. Siebel; Ralf H. Adams; Guttorm Haraldsen; Eirik Sundlisæter; Johanna Hol
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Use of Severity Grades to Characterize Histopathologic Changes
Toxicologic Pathology, ISSN: 15331601 01926233
Kenneth A. Schafer; John Eighmy; James D. Fikes; Wendy Halpern; Renee R. Hukkanen; Gerald G. Long; Emily K. Meseck; Daniel J. Patrick; Michael S. Thibodeau; Charles E. Wood; Sabine Francke
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Omalizumab response in patients with chronic idiopathic urticaria: Insights from the XTEND-CIU study
Journal of the American Academy of Dermatology, ISSN: 10976787 01909622
Thomas B. Casale; Patrick H. Win; Jonathan A. Bernstein; Karin Rosén; Michael Holden; Ahmar Iqbal; Benjamin L. Trzaskoma; Ming Yang; Evgeniya Antonova; Thomas R. Murphy; Mark D. Scarupa; Howard Sofen; Allen P. Kaplan
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Comparing Mechanistic and Preclinical Predictions of Volume of Distribution on a Large Set of Drugs
Pharmaceutical Research, ISSN: 1573904X 07248741
Rosa Chan; Tom De Bruyn; Matthew Wright; Broccatelli
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The GluN2B subunit represents a major functional determinant of NMDA receptors in human induced pluripotent stem cell-derived cortical neurons
Stem Cell Research, ISSN: 18767753 18735061
Ioana Neagoe; Chang Liu; Alexander Stumpf; Yanmei Lu; Dongping He; Ross Francis; Jun Chen; Paul Reynen; Moulay Hicham Alaoui-Ismaili; Hirokazu Fukui
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Prediction of the Pharmacokinetics of Pravastatin as an OATP Substrate Using Plateable Human Hepatocytes With Human Plasma Data and PBPK Modeling
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Jialin Mao; Utkarsh Doshi; Matthew Wright; Cornelis E. Hop; Albert P. Li; Yuan Chen
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Multi-site N-Glycan mapping study 2: UHPLC
Electrophoresis, ISSN: 15222683 01730835
Ákos Szekrényes; Park; Eoin Cosgrave; Aled Jones; Ted Haxo; Michael Kimzey; Shiva Pourkaveh; Zoltán Szabó; Zoran Sosic; Peng Feng; Preeti Sejwal; Kelsey Dent; David A. Michels; Gordon Freckleton; Jun Qian; Catherine Lancaster; Toni Duffy; Melissa Schwartz; Jiann-Kae Luo; Jonathan van Dyck; Pui-King Leung; Marcell Olajos; Ronald Kowle; Kai Gao; Wenbo Wang; Jo Wegstein; Samnang Tep; Apolka Domokos; Csaba Váradi; András Guttman
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Barcoded sequencing workflow for high throughput digitization of hybridoma antibody variable domain sequences
Journal of Immunological Methods, ISSN: 18727905 00221759
Yongmei Chen; Si Hyun Kim; Yonglei Shang; Joseph Guillory; Stinson; Qing Zhang; Isidro Hötzel; Kam Hon Hoi
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gPKPDSim: a SimBiology®-based GUI application for PKPD modeling in drug development
Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 15738744 1567567X
Iraj Hosseini; Anita Gajjala; Daniela Bumbaca Yadav; Siddharth Sukumaran; Ramanujan; Ricardo Paxson; Kapil Gadkar
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Impurity investigations by phases of drug and product development
TrAC - Trends in Analytical Chemistry, ISSN: 18793142 01659936
Bernard A. Olsen; Alavattam Sreedhara; Steven W. Baertschi
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Reactive impurities in large and small molecule pharmaceutical excipients – A review
TrAC - Trends in Analytical Chemistry, ISSN: 18793142 01659936
Kelly Zhang; Jackson D. Pellett; Ajit S. Narang; Y. John Wang; Taylor Zhang
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Adjuvant vemurafenib in resected, BRAFV600 mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
The Lancet Oncology, ISSN: 14745488 14702045
Michele Maio; Karl Lewis; Lev Demidov; Mario Mandala; Igor Bondarenko; Paolo A. Ascierto; Christopher Herbert; Andrzej Mackiewicz; Piotr Rutkowski; Alexander Guminski; Grant R. Goodman; Brian Simmons; Chenglin Ye; Yibing Yan; Dirk Schadendorf; Gabriela Cinat; Luis Enrique Fein; Michael Brown; Andrew Haydon; Adnan Khattak; Catriona McNeil; Phillip Parente; Jeremy Power; Rachel Roberts-Thomson; Shahneen Sandhu; Craig Underhill; Suresh Varma; Thomas Berger; Ahmad Awada; Nathalie Blockx; Veronique Buyse; Jeroen Mebis; Fábio André Franke; Sérgio Jobim de Azevedo; Nicolas Silva Lazaretti; Rahima Jamal; Catalin Mihalcioiu; Teresa Petrella; Kerry Savage; Xinni Song; Ralph Wong; Nina Dabelic; Stjepko Plestina; Zeljko Vojnovic; Petr Arenberger; Ivo Kocak; Ivana Krajsova; Eugen Kubala; Melichar; Yvetta Vantuchova; Kadri Putnik; Brigitte Dréno; Caroline Dutriaux; Jean-Jacques Grob; Pascal Joly; Jean-Philippe Lacour; Nicolas Meyer; Laurent Mortier; Luc Thomas; Michael Fluck; Thilo Gambichler; Jessica Hassel; Axel Hauschild; Paul Donnellan; John McCaffrey; Derek Power; Samuel Ariad; Gil Bar-Sela; Daniel Hendler; Ilan Ron; Jacob Schachter; Alfredo Berruti; Luca Bianchi; Vanna Chiarion Sileni; Francesco Cognetti; Riccardo Danielli; Anna Maria Di Giacomo; Luca Gianni; Aron Goldhirsch; Michele Guida; Paolo Marchetti; Paola Queirolo; Armando Santoro; Ellen Kapiteijn; Paula Ferreira; Georgy Gafton; Yulia Makarova; Zoran Andric; Nada Babovic; Darjana Jovanovic; Lidija Kandolf Sekulovic; Graham Cohen; Lydia Dreosti; Daniel Vorobiof; Maria Teresa Curiel Garcia; Roberto Diaz Beveridge; Margarita Majem; Ivan Marquez Rodas; Jose-M Puliats Rodriguez; Antonio Rueda Dominguez; Marianne Maroti; Karin Papworth; Olivier Michielin; Ewan Brown; Pippa G. Corrie; Mark Harries; Satish Kumar; Agustin Martin-Clavijo; Mark R. Middleton; Poulam Patel; Toby Talbot; Sanjiv Agarwala; Paul B. Chapman; Robert Conry; Gary Doolittle; Tara Gangadhar; Sigrun Hallmeyer; Omid Hamid; Leonel Hernandez-Aya; Douglas B. Johnson; Frederic Kass; Tatjana Kolevska; Scott Lunin; April Salama; Branimir I. Sikic; Bradley Somer; David Spigel; Eric Whitman
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Venetoclax-rituximab in relapsed or refractory chronic lymphocytic leukemia
New England Journal of Medicine, ISSN: 15334406 00284793
John F. Seymour; Thomas J. Kipps; Barbara Eichhorst; Hillmen; D'Rozario; Sarit E. Assouline; Carolyn J. Owen; John Gerecitano; Tadeusz Robak; Javier De La Serna; Jaeger; Guillaume Cartron; Marco Montillo; Rod A. Humerickhouse; Elizabeth A. Punnoose; Li; Michelle Boyer; Kathryn Humphrey; Mehrdad Mobasher; Kater
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Structure and Relaxation in Solutions of Monoclonal Antibodies
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Gang Wang; Zsigmond Varga; Jennifer Hofmann; Isidro E. Zarraga; James W. Swan
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Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
James J. Crawford; Adam R. Johnson; Misner; Lisa D. Belmont; Georgette M. Castanedo; Regina Choy; Melis Coraggio; Liming Dong; Eigenbrot; Rebecca Erickson; Nico Ghilardi; Jonathan Hau; Arna Katewa; Pawan Bir Kohli; Wendy Lee; Joseph W. Lubach; Brent Mckenzie; Daniel F. Ortwine; Leah Schutt; Suzanne Tay; Binqing Wei; Karin Reif; Lichuan Liu; Harvey Wong; Wendy B. Young
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Targeting the hippo pathway and cancer through the TEAD family of transcription factors
Cancers, ISSN: 20726694
Jeffrey K. Holden; Christian N. Cunningham
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Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation-positive melanoma
British Journal of Cancer, ISSN: 15321827 00070920
Brigitte Dréno; Paolo A. Ascierto; Victoria Atkinson; Gabriella Liszkay; Michele Maio; Mario Mandala; Lev Demidov; Daniil Stroyakovskiy; Luc Thomas; Luis De La Cruz-Merino; Caroline Dutriaux; Claus Garbe; Karen Bartley; Thomas Karagiannis; Ilsung Chang; Isabelle Rooney; Daniel Koralek; James Larkin; McArthur; Antoni Ribas
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An Efficient Through-Process for Chk1 Kinase Inhibitor GDC-0575
Organic Process Research and Development, ISSN: 1520586X 10836160
Chong Han; Keena L. Green; Kathrin Oehring; Arthur Meili; Eugen Pfeifer; Michelangelo Scalone; Francis Gosselin
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A Decade of Click Chemistry in Protein Palmitoylation: Impact on Discovery and New Biology
Cell Chemical Biology, ISSN: 24519448 24519456
Xinxin Gao; Rami N. Hannoush
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Accuracy Comparison of Generalized Born Models in the Calculation of Electrostatic Binding Free Energies
Journal of Chemical Theory and Computation, ISSN: 15499626 15499618
Saeed Izadi; Robert C. Harris; Marcia O. Fenley; Alexey V. Onufriev
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Erratum: Results from the phase III randomized trial of onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIB or IV non-small-cell lung cancer: METLung (Journal of Clinical Oncology (2017) DOI: 10.1200/JCO.2016.69.2160)
Journal of Clinical Oncology, ISSN: 15277755 0732183X
David Spigel; Martin J. Edelman; Kenneth O'Byrne; Luis Paz-Ares; Mocci; See Phan; David S. Shames; Dustin Smith; Virginia Paton; Tony Mok
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In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies
Journal of Controlled Release, ISSN: 18734995 01683659
Hanne Kinnunen Bown; Catherine Bonn; Stefan T. Yohe; Daniela Bumbaca; Thomas W. Patapoff; Daugherty; Mrsny
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CisTEM, user-friendly software for single-particle image processing
eLife, ISSN: 2050084X
Timothy Grant; Alexis Rohou; Nikolaus Grigorieff
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Determination of Fragility in Organic Small Molecular Glass Forming Liquids: Comparison of Calorimetric and Spectroscopic Data and Commentary on Pharmaceutical Importance
Molecular Pharmaceutics, ISSN: 15438392 15438384
Paroma Chakravarty; Keyur Pandya; Karthik Nagapudi
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In Situ Salt Formation during Melt Extrusion for Improved Chemical Stability and Dissolution Performance of a Meloxicam-Copovidone Amorphous Solid Dispersion
Molecular Pharmaceutics, ISSN: 15438392 15438384
Abbe Haser; Tu Cao; Joseph W. Lubach; Feng Zhang
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Maximum reading speed in patients with geographic atrophy secondary to age-related macular degeneration
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Rohit Varma; Eric H. Souied; Adnan Tufail; Elizabeth Tschosik; Daniela Ferrara; Jiameng Zhang; David Silverman; Chantal M. Dolan; Neil M. Bressler
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Vemurafenib for BRAF V600-mutant erdheim-chester disease and langerhans cell histiocytosis analysis of data from the histology-independent, phase 2, open-label VE-BASKET study
JAMA Oncology, ISSN: 23742445 23742437
Eli L. Diamond; Vivek Subbiah; Albert Craig Lockhart; Jean-Yves Blay; Igor Puzanov; Chau; Noopur S. Raje; Jurgen Wolf; Joseph P. Erinjeri; Jean Torrisi; Mario E. Lacouture; Elena Elez; Ferran Martínez-Valle; Benjamin Durham; Maria E. Arcila; Gary A. Ulaner; Omar Abdel-Wahab; Bethany Pitcher; Makrutzki; Todd Riehl; Baselga; David Hyman
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A risk index and data display for process performance in the pharmaceutical industry
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Bert Gunter; Daniel A. Coleman; Aaron Goerke; Theo Koulis; Jens Lamerz; Yiming Peng
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Homozygous ksr1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of ras-driven pancreatic cancer
PLoS ONE, ISSN: 19326203
Elizabeth A. Germino; Joseph P. Miller; Laurie Diehl; Carter J. Swanson; Durinck; Zora Modrusan; Jeffrey H. Miner; Andrey S. Shaw
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Mechanistic investigation on grinding-induced subvisible particle formation during mixing and filling of monoclonal antibody formulations
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Benson Gikanga; Ada Hui; Maa
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Pertuzumab, trastuzumab, and standard anthracycline- and taxane-based chemotherapy for the neoadjuvant treatment of patients with HER2-positive localized breast cancer (BERENICE): A phase II, open-label, multicenter, multinational cardiac safety study
Annals of Oncology, ISSN: 15698041 09237534
Sandra M. Swain; Michael S. Ewer; Giuseppe Viale; Delaloge; Jean-Marc Ferrero; Verrill; Ramon Colomer; Vieira; Werner; Hannah Douthwaite; Bradley; Waldron-Lynch; Astrid Kiermaier; Jennifer Eng-Wong; Chau T. Dang
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Quantitative intracerebral microdialysis studies to determine unbound extracellular fluid drug concentrations in discrete areas of the brain
Current Protocols in Pharmacology, ISSN: 19348290 19348282
Matthew Durk
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An anti-gdnf family receptor alpha 1 (gfra1 antibody–drug conjugate for the treatment of hormone receptor–positive breast cancer
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Sunil Bhakta; Lisa Crocker; Chen; Meredith Hazen; Melissa Schutten; Dongwei Li; Coenraad Kuijl; Rachana Ohri; Fiona Zhong; Kirsten Achilles Poon; MaryAnn Go; Eric Cheng; Robert Piskol; Ron Firestein; Aimee Fourie-O'Donohue; Katherine R. Kozak; Helga Raab; Hongo; Deepak Sampath; Dennis; Richard H. Scheller; Paul G. Polakis; Jagath R. Junutula
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Intratumoral payload concentration correlates with the activity of antibody–drug conjugates
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Donglu Zhang; Shang-Fan Yu; S. Cyrus Khojasteh; Yong Ma; Thomas H. Pillow; Jack D. Sadowsky; Dian Su; Katherine R. Kozak; Keyang Xu; Andrew G. Polson; Peter Dragovich; Cornelis E. Hop
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Patient-centered assessment on disease burden, quality of life, and treatment satisfaction associated with acromegaly
Journal of Investigative Medicine, ISSN: 17088267 10815589
Shuqian Liu; Daphne T. Adelman; Yaping Xu; Jillone Sisco; Susan M. Begelman; Susan M. Webb; Xavier Badia; Tina K. Thethi; Vivian Fonseca; Lizheng Shi
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Optimized RNP transfection for highly efficient CRI SPR/Cas9-mediated gene knockout in primary T cells
Journal of Experimental Medicine, ISSN: 15409538 00221007
Akiko Seki; Sascha Rutz
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Measurement and Characterization of Hydrogen-Deuterium Exchange Chemistry Using Relaxation Dispersion NMR Spectroscopy
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Gennady Khirich; Michael J. Holliday; Jasper C. Lin; Aditya Nandy
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A KDM5 inhibitor increases global H3K4 trimethylation occupancy and enhances the biological efficacy of 5-aza-2′-deoxycytidine
Cancer Research, ISSN: 15387445 00085472
Benjamin R. Leadem; Ioannis Kagiampakis; Catherine Wilson; Tommy K. Cheung; David Arnott; Patrick Trojer; Marie Classon; Hariharan Easwaran; Stephen B. Baylin
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Subcutaneous tocilizumab in rheumatoid arthritis: Findings from the common-framework phase 4 study programme TOZURA conducted in 22 countries
Rheumatology, ISSN: 14620332 14620324
Ernest Choy; Roberto Caporali; Ricardo Xavier; Bruno Fautrel; Raimón Sanmarti; Bao; Corrado Bernasconi; Attila Pethö-Schramm
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Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors resource
Nature Immunology, ISSN: 15292916 15292908
Etienne Patin; Milena Hasan; Jacob Bergstedt; Vincent Rouilly; Valentina Libri; Alejandra Urrutia; Cécile Alanio; Petar Scepanovic; Christian Hammer; Friederike Jönsson; Benoît Beitz; Hélène Quach; Yoong Wearn Lim; Julie Hunkapiller; Magge Zepeda; Cherie Green; Barbara Piasecka; Claire Leloup; Lars Rogge; François Huetz; Isabelle Peguillet; Olivier Lantz; Magnus Fontes; James P. Santo; Stéphanie Thomas; Jacques Fellay; Darragh Duffy; Lluis Quintana-Murci; Matthew L. Albert; Laurent Abel; Andres Alcover; Kalla Astrom; Philippe Bousso; Pierre Bruhns; Ana Cumano; Caroline Demangel; Ludovic Deriano; James P. Di Santo; Françoise Dromer; Gérard Eberl; Jost Enninga; Antonio Freitas; Odile Gelpi; Ivo Gomperts-Boneca; Serge Hercberg; Claude Leclerc; Hugo Mouquet; Sandra Pellegrini; Stanislas Pol; Anavaj Sakuntabhai; Olivier Schwartz; Benno Schwikowski; Spencer Shorte; Vassili Soumelis; Frédéric Tangy; Eric Tartour; Antoine Toubert; Marie-Noëlle Ungeheuer
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Water models for biomolecular simulations
Wiley Interdisciplinary Reviews: Computational Molecular Science, ISSN: 17590884 17590876
Alexey V. Onufriev; Saeed Izadi
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Association between glucocorticoid exposure and healthcare expenditures for potential glucocorticoid-related adverse events in patients with rheumatoid arthritis
Journal of Rheumatology, ISSN: 14992752 0315162X
Jennie Best; Amanda M. Kong; Gregory M. Lenhart; Khaled Sarsour; Marni Stott-Miller; Yong Hwang
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Meta-analysis of the lung microbiota in pulmonary tuberculosis
Tuberculosis, ISSN: 1873281X 14729792
Bo-young Hong; Joseph N. Paulson; O. Colin Stine; George M. Weinstock; Jorge L. Cervantes
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Pediatric Dose Selection and Utility of PBPK in Determining Dose
AAPS Journal, ISSN: 15507416
Ian E. Templeton; Nicholas Steven Jones; Luna Musib
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CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing article
Cell Death and Disease, ISSN: 20414889
Marinella G. Callow; Colin K. Watanabe; Katherine E. Wickliffe; Russell Bainer; Sarah Kummerfield; Julie Weng; Trinna L. Cuellar; Vasantharajan Janakiraman; Chen; Ben Chih; Yuxin Liang; Benjamin Haley; Kim Newton; Michael Costa
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Using Genetically Modified Rodent Models in Drug Development to Explore Target Physiology and Potential Drug Effects
Veterinary Pathology, ISSN: 15442217 03009858
Yu Zhong; Donna M. Dambach; Jonathan M. Maher
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Solid-State NMR Investigation of Drug-Excipient Interactions and Phase Behavior in Indomethacin-Eudragit E Amorphous Solid Dispersions
Pharmaceutical Research, ISSN: 1573904X 07248741
Joseph W. Lubach; Jonathan Hau
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Light-Induced Covalent Buffer Adducts to Histidine in a Model Protein
Pharmaceutical Research, ISSN: 1573904X 07248741
Ming Lei; Quan; Y. John Wang; Kao; Christian Schöneich
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Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis
The Lancet Oncology, ISSN: 14745488 14702045
Jennifer L. McQuade; Carrie R. Daniel; Kenneth R Hess; Carmen Mak; Daniel Y. Wang; Rajat R. Rai; John J. Park; Lauren Haydu; Christine Spencer; Matthew Wongchenko; Stephen Lane; Dung-Yang Lee; Mathilde Kaper; Meredith McKean; Kathryn E. Beckermann; Samuel M. Rubinstein; Isabelle Rooney; Luna Musib; Nageshwar Budha; Jessie Hsu; Theodore S Nowicki; Alexandre Avila; Tomas Haas; Maneka Puligandla; Sandra Lee; Shenying Fang; Jennifer A. Wargo; Jeffrey E Gershenwald; Jeffrey E Lee; Patrick Hwu; Paul B. Chapman; Jeffrey A. Sosman; Dirk Schadendorf; Jean-Jacques Grob; Keith Flaherty; Dana Walker; Yibing Yan; Edward McKenna; Jeffrey J. Legos; Matteo S. Carlino; Antoni Ribas; John M. Kirkwood; Georgina V. Long; Douglas B. Johnson; Alexander M. Menzies; Michael A. Davies
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Cluster-Randomized Trial of a Behavioral Intervention to Incorporate a Treat-to-Target Approach to Care of US Patients With Rheumatoid Arthritis
Arthritis Care and Research, ISSN: 21514658 2151464X
Leslie R. Harrold; Reed; Ani John; Christine J. Barr; Kevin Soe; Robert Magner; Katherine C. Saunders; Eric M. Ruderman; Tmirah Haselkorn; Jeffrey D. Greenberg; Allan Gibofsky; J. Timothy Harrington; Joel M. Kremer
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