Genentech: Publications

January 1, 2018

Risk mitigation in preventing adventitious agent contamination of mammalian cell cultures

Advances in Biochemical Engineering/Biotechnology, ISSN: 07246145

Masaru Shiratori; Robert Kiss

January 1, 2018

A different perspective: How much innovation is really needed for monoclonal antibody production using mammalian cell technology?

Advances in Biochemical Engineering/Biotechnology, ISSN: 07246145

Kelley; Robert Kiss; Mike Laird

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January 1, 2018

A phase 2 randomized trial of crenezumab in mild to moderate Alzheimer disease

Neurology, ISSN: 1526632X 00283878

Jeffrey L. Cummings; Sharon Cohen; Christopher H. Van Dyck; Mark Brody; Craig Curtis; William Cho; Michael Ward; Michel Friesenhahn; Flavia Brunstein; Angelica Quartino; Lee Honigberg; Reina N. Fuji; David Clayton; Deborah L. Mortensen; Carole Ho; Robert Paul; Christina Rabe

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January 1, 2018

Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes

Science immunology, ISSN: 24709468

Teresita L. Arenzana; Steve Lianoglou; Akiko Seki; Celine Eidenschenk; Tommy K. Cheung; Dhaya Seshasayee; Thijs Hagenbeek; Arivazhagan Sambandam; Rajkumar Noubade; Ivan Peng; Justin Lesch; Jason Devoss; Xiumin Wu; Wyne P. Lee; Patrick Caplazi; Webster; Jinfeng Liu; Victoria Pham; David Arnott; Jennie R. Lill; Zora Modrusan; Anwesha Dey; Sascha Rutz

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January 1, 2018

Discovery and Development of GDC-0994: A Selective and Efficacious Small Molecule Inhibitor of ERK1/2

ACS Symposium Series, ISSN: 19475918 00976156

Xin Linghu; Nicholas Wong; James F. Blake; John J. Gaudino; John Moffat

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January 1, 2018

Optimizing hybrid LC-MS/MS binding conditions is critical: Impact of biotransformation on quantification of trastuzumab

Bioanalysis, ISSN: 17576199 17576180

Luna Liu; Keyang Xu; Jenny Li; Mauricio Maia; Mary Mathieu; Rebecca Elliott; Yang; Ihsan Nijem; Surinder Kaur

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January 1, 2018

Reproducibility of the Measurement of Bulk/Tapped Density of Pharmaceutical Powders Between Pharmaceutical Laboratories

Journal of Pharmaceutical Sciences, ISSN: 00223549

Ilgaz Akseli; Jon Hilden; Jeffrey M. Katz; Ron C. Kelly; Timothy T. Kramer; Chen Mao; Frederick Osei-Yeboah; John C. Strong

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January 1, 2018

Key Green Chemistry research areas from a pharmaceutical manufacturers' perspective revisited

Green Chemistry, ISSN: 14639270 14639262

Marian C. Bryan; Peter Dunn; David Entwistle; Fabrice Gallou; Stefan G. Koenig; John Hayler; Matthew Hickey; Shaun Hughes; Michael E. Kopach; Gerard Moine; Paul Richardson; Frank Roschangar; Alan Steven; Franz J. Weiberth

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January 1, 2018

Utility of pooled cryopreserved human enterocytes as an in vitro model for assessing intestinal clearance and drug-drug interactions

Drug Metabolism Letters, ISSN: 18723128

Susan C. Wong; Utkarsh Doshi; Peter Vuong; Ning Liu; Suzanne Tay; Hoa Le; Mika Kosaka; Jane R. Kenny; Albert P. Li; Zhengyin Yan

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January 1, 2018

Combinations of bevacizumab with cancer immunotherapy

Cancer Journal (United States), ISSN: 1540336X 15289117

Daniel S. Chen; Herbert Hurwitz

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January 1, 2018

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

Journal of Experimental Medicine, ISSN: 15409538 00221007

Bettina L. Lee; Irma B. Stowe; Aaron Gupta; Opher S. Kornfeld; Merone Roose-Girma; Keith R. Anderson; Søren Warming; Juan Zhang; Wyne P. Lee; Nobuhiko Kayagaki

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January 1, 2018

Optimal management of pigment epithelial detachments in eyes with neovascular age-related macular degeneration

Retina, ISSN: 15392864 0275004X

Arshad M. Khanani; David Eichenbaum; Patricio G. Schlottmann; Lisa Tuomi; David Sarraf

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January 1, 2018

Disorders of the Spleen

Hematopathology: A Volume in the Series: Foundations in Diagnostic Pathology,

Robert S. Ohgami; James Ziai; Daniel A. Arber

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January 1, 2018

Optimization and qualification of the single molecule array digital immunoassay for IL-12p70 in plasma of cancer patients

Bioanalysis, ISSN: 17576199 17576180

Vinita Gupta; Navdeep Kalia; Mahesh Yadav; Amy Noyes; Jeremy Good; Robert Hendricks; Wenfeng Xu

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January 1, 2018

Interpreting the language of polyubiquitin with linkage-specific antibodies and mass spectrometry

Methods in Molecular Biology, ISSN: 10643745

Marissa L. Matsumoto; Erick R. Castellanos; Yi Jimmy Zeng; Donald S. Kirkpatrick

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January 1, 2018

A validated surrogate analyte LC-MS/MS assay for quantitation of endogenous kynurenine and tryptophan in human plasma

Bioanalysis, ISSN: 17576199 17576180

Dennis Miller; Lei Tan; Dorshorst; Kari M. Morrissey; Sami Mahrus; Dennis Milanowski; McKnight; Stephanie Cape; Brian J. Dean; Xiaorong Liang

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January 1, 2018

Detection of necroptosis by phospho-RIPK3 immunohistochemical labeling

Methods in Molecular Biology, ISSN: 10643745

Webster; Margaret Solon; Susan Haller; Kim Newton

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January 1, 2018

Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab

Nature Medicine, ISSN: 1546170X 10788956

David R. Gandara; Sarah M. Paul; Marcin Kowanetz; Erica Schleifman; Wei Zou; Yan Li; Achim Rittmeyer; Louis Fehrenbacher; Geoff A. Otto; Christine Malboeuf; Daniel S. Lieber; Doron Lipson; Jacob Silterra; Lukas Amler; Todd Riehl; Cummings; Priti Hegde; Alan Sandler; Ballinger; David Fabrizio; Tony Mok; David S. Shames

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January 1, 2018

Real-World Effectiveness of Chemotherapy in Elderly Patients with Metastatic Bladder Cancer in the United States

Bladder Cancer, ISSN: 23523735 23523727

Matthew D. Galsky; Sumanta Kumar Pal; Shih Wen Lin; Sarika Ogale; Marko Zivkovic; Joe Simpson; Christina L. Derleth; Christina Schiff; Guru Sonpavde

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January 1, 2018

Process Variability Source Analysis for a Multi-step Bio-process

Computer Aided Chemical Engineering, ISSN: 15707946

Yuan Jin; Joe Qin; Victor Saucedo; Zheng Li; Angela Meier; Siddhartha Kunda; Salim Charaniya

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January 1, 2018

Elastomer change out - Justification for minimizing the removal of elastomers to prevent cross-contamination in a multiproduct facility

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Michael Parks; Niamh O'Dwyer; Jeremy Bollinger; Alan Johnson; Brian Goss; Ned Wyman; Adeyma Arroyo; Joseph Wood; Derek Willison-Parry

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January 1, 2018

Inspiring process innovation: Via an improved green manufacturing metric: IGAL

Green Chemistry, ISSN: 14639270 14639262

Frank Roschangar; Yanyan Zhou; David J. C. Constable; Juan Colberg; David P. Dickson; Peter Dunn; Martin D. Eastgate; Fabrice Gallou; John Hayler; Stefan G. Koenig; Michael E. Kopach; David Leahy; Ingrid Mergelsberg; Ulrich Scholz; Austin G. Smith; Manuel Henry; Jason Mulder; Jörg Brandenburg; Juan R. Dehli; Daniel R. Fandrick; Keith R. Fandrick; Frieder Gnad-Badouin; Georg Zerban; Klaus Groll; Paul T. Anastas; Roger A. Sheldon; Chris H. Senanayake

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January 1, 2018

Applications of genetics, genomics and bioinformatics in drug discovery

Pacific Symposium on Biocomputing, 2018, ISSN: 23356936 23356928

Richard Bourgon; Frederick E. Dewey; Zhengyan Kan; Shuyu D. Li

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January 1, 2018

The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort

Alzheimer's and Dementia: Translational Research and Clinical Interventions, ISSN: 23528737

Pierre N. Tariot; Francisco Lopera; Jessica B. Langbaum; Ronald G. Thomas; Suzanne Hendrix; Lon S. Schneider; Silvia Rios-Romenets; Margarita Giraldo; Natalia Acosta; Carlos Tobon; Claudia Ramos; Alejandro Espinosa; William Cho; Michael Ward; David Clayton; Michel Friesenhahn; Howard M. Mackey; Lee Honigberg; Sandra M. Sanabria-Bohorquez; Kewei Chen; Trisha Walsh; Carolyn Langlois; Eric M. Reiman

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January 1, 2018

Selective ligands and drug discovery targeting the voltage-gated sodium channel nav1.7

Handbook of Experimental Pharmacology, ISSN: 18650325 01712004

Jian Payandeh; David Hackos

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January 1, 2018

Immune-modified response evaluation criteria in solid tumors (imrecist): Refining guidelines to assess the clinical benefit of cancer immunotherapy

Journal of Clinical Oncology, ISSN: 15277755 0732183X

F. Stephen Hodi; Ballinger; Benjamin Lyons; Jean-Charles Soria; Mizuki Nishino; Tabernero; Thomas Powles; David Smith; Axel Hoos; Chris McKenna; Ulrich Beyer; Ina Rhee; Gregg D. Fine; Nathan Winslow; Daniel S. Chen; Jedd D Wolchok

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January 1, 2018

Status and future of 3D cell culture in toxicity testing

Methods in Pharmacology and Toxicology, ISSN: 19406053 15572153

Monicah A. Otieno; Jinping Gan; William R. Proctor

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January 1, 2018

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: Study protocol for a randomised trial

Trials, ISSN: 17456215

Catherine E. Hanratty; Matthews; Joseph R. Arron; David F. Choy; Ian D. Pavord; Peter Bradding; Chris E. Brightling; Rekha Chaudhuri; Douglas Cowan; Ratko Djukanovic; Nicola Gallagher; Stephen J. Fowler; Tim Hardman; Timothy Harrison; Cécile T.J. Holweg; Peter Howarth; James Lordan; Adel Mansur; Andrew Menzies-Gow; Mosesova; Robert Niven; Douglas S. Robinson; Dominick E. Shaw; Samantha Walker; Ashley Woodcock; Liam G. Heaney; Ian Adcock; Boriello; Matthew Catley; Kian Fan Chung; Richard W. Costello; Sebastian Johnston; Frank Keane; Richard May; Lisa Pierre; Dirk Smith; Chris Stevenson; Val Hudson; David Supple; Gainsborough; Horn

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January 1, 2018

First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL

Oncotarget, ISSN: 19492553

John C. Byrd; Stephen Smith; Nina D. Wagner-Johnston; Jeff P. Sharman; Chen; Ranjana H. Advani; Bradley Augustson; Paula Marlton; S. Renee Commerford; Kwame Okrah; Lichuan Liu; Elaine R. Murray; Elicia M. Penuel; Ashley F. Ward; Ian W. Flinn

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January 1, 2018

Nonclinical safety assessment of anti-factor d: Key strategies and challenges for the nonclinical development of intravitreal biologics

Journal of Ocular Pharmacology and Therapeutics, ISSN: 15577732 10807683

Vlad Bantseev; Rebecca Erickson; Douglas Leipold; Caroline Amaya; Paul Miller; Helen Booler; Evan A Thackaberry

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January 1, 2018

Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial–mesenchymal transition

EMBO Reports, ISSN: 14693178 1469221X

Dan Du; Yoko Katsuno; Dominique Meyer; Erine H Budi; Si-Han Chen; Koeppen; Hongjun Wang; Rosemary J Akhurst; Rik Derynck

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January 1, 2018

Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii

PLoS Pathogens, ISSN: 15537374 15537366

Nicole D. Marino; Michael W. Panas; Magdalena Franco; Terence C. Theisen; Adit Naor; Suchita Rastogi; Kerry R. Buchholz; Hernan A. Lorenzi; John C. Boothroyd

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January 1, 2018

The Integumentary System

Fundamentals of Toxicologic Pathology: Third Edition,

Kelly L. Diegel; Dimitry Danilenko; Zbigniew W. Wojcinski

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January 1, 2018

Prevalence and clinical association of gene mutations through multiplex mutation testing in patients with NSCLC: Results from the ETOP Lungscape Project

Annals of Oncology, ISSN: 15698041 09237534

Keith M. Kerr; Urania Dafni; Katja Schulze; Erik Thunnissen; Lukas Bubendorf; Hager; Stephen P. Finn; Biernat; Vliegen; Losa; Antonio Marchetti; Richard Cheney; Arne Warth; Ernst Jan M. Speel; Blackhall; Kim Monkhorst; Jantus Lewintre; Verena Tischler; Clark; Bertran-Alamillo; Meldgaard; Gately; Wrona; Vandenberghe; Enriqueta Felip; De Luca; Spasenija Savic; Muley; Smit; Anne-Marie C. Dingemans; Priest; Baas; Carlos Camps; Weder; Polydoropoulou; Thomas R. Geiger; Roswitha Kammler; Teiko Sumiyoshi; Molina; David S. Shames; Rolf A Stahel; Solange Peters; Boss

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January 1, 2018

Detection of PD-L1 in circulating tumor cells and white blood cells from patients with advanced non-small-cell lung cancer

Annals of Oncology, ISSN: 15698041 09237534

Marius Ilie; Edith Szafer-Glusman; Véronique Hofman; Chamorey; Salomé Lalvée; Eric Selva; Leroy; Charles-Hugo Marquette; Marcin Kowanetz; Priti Hedge; Elizabeth A. Punnoose; Paul Hofman

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January 1, 2018

A solid-phase approach for the synthesis of α-Aminoboronic acid peptides

RSC Advances, ISSN: 20462069

Blake E. Daniels; Craig E. Stivala

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January 1, 2018

CD8+ T cell infiltration in breast and colon cancer: A histologic and statistical analysis

PLoS ONE, ISSN: 19326203

James Ziai; Houston N. Gilbert; Oded Foreman; Jeffrey Eastham-Anderson; Felix Chu; Mahrukh Huseni; Kim

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January 1, 2018

Opposing roles of dendritic cell subsets in experimental GN

Journal of the American Society of Nephrology, ISSN: 15333450 10466673

Sebastian Brähler; Bernd H. Zinselmeyer; Saravanan Raju; Maximilian Nitschke; Hani Suleiman; Brian T. Saunders; Michael W. Johnson; Alexander M.C. Böhner; Susanne F. Viehmann; Derek J. Theisen; Nicole M. Kretzer; Carlos G. Briseño; Konstantin Zaitsev; Olga Ornatsky; Qing Chang; Javier A. Carrero; Jeffrey B. Kopp; Maxim N. Artyomov; Christian Kurts; Kenneth M. Murphy; Jeffrey H. Miner; Andrey S. Shaw

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January 1, 2018

Cardiovascular effects of renal distal tubule deletion of the fgf receptor 1 gene

Journal of the American Society of Nephrology, ISSN: 15333450 10466673

Xiaobin Han; Ross; Ganesh Kolumam; Min Pi; Junichiro Sonoda; Gwendalyn King; Darryl Quarles

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January 1, 2018

Molecular and Histopathological Characterization of the Tumor Immune Microenvironment in Advanced Stage of Malignant Pleural Mesothelioma

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Namrata S. Patil; Luisella Righi; Koeppen; Wei Zou; Stefania Izzo; Federica Grosso; Roberta Libener; Marco Loiacono; Valentina Monica; Consuelo Buttigliero; Silvia Novello; Priti Hegde; Mauro Papotti; Marcin Kowanetz; Giorgio Scagliotti

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January 1, 2018

Reply to hunsberger and memoli, "efficacy analysis in healthy-volunteer influenza challenge trials: Intention to treat"

Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804

Jacqueline McBride; Jeremy Lim; Tracy Burgess; Rong Deng; Michael A. Derby; Mauricio Maia; Priscilla Horn; Omer Siddiqui; Daniel Sheinson; Haiyin Chen-Harris; Elizabeth Newton; Dimitri Fillos; Denise Nazzal; Carrie M. Rosenberger; Maikke B. Ohlson; Rob Lambkin-Williams; Hosnieh Fathi; Harris; Jorge A. Tavela

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January 1, 2018

Patient acceptable symptom state in scleroderma: Results from the tocilizumab compared with placebo trial in active diffuse cutaneous systemic sclerosis

Rheumatology, ISSN: 14620332 14620324

Michael B. Arnold; Dinesh Khanna; Christopher P. Denton; Jacob M. Van Laar; Tracy M. Frech; Marina E. Anderson; Murray Baron; Lorinda Chung; Gerhard Fierlbeck; Santhanam Lakshminarayanan; Yannick Allanore; Gabriela Riemekasten; Virginia D. Steen; Ulf Müller-Ladner; Helen Spotswood; Laura Burke; Jeffrey N. Siegel; Angelika Jahreis; Daniel E. Furst; Janet E. Pope

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January 1, 2018

Type 2 immunity in tissue repair and fibrosis

Nature Reviews Immunology, ISSN: 14741741 14741733

Richard L. Gieseck; Mark S. Wilson; Thomas A. Wynn

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January 1, 2018

Pathology and Pathogenesis of Immune-Mediated Diseases of Animals

Veterinary Pathology, ISSN: 15442217 03009858

Laurie Diehl; David K. Meyerholz; Michael J. Day; Verena K. Affolter

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January 1, 2018

Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition

Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X

Steven Cepa; David M. Potter; Lisa Wong; Leah Schutt; Jacqueline M. Tarrant; Jodie Pang; Xiaolin Zhang; Roxanne Andaya; Laurent Salphati; Yingqing Ran; Le An; Ryan Morgan; Jonathan M. Maher

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January 1, 2018

Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids

Respiratory Medicine, ISSN: 15323064 09546111

Phillip Korenblat; Edwin Kerwin; Igor Leshchenko; Karl Yen; Cécile T.J. Holweg; Judith Anzures-Cabrera; Carmen Martin; Wendy Putnam; Laura Governale; Julie Olsson; Matthews

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January 1, 2018

A View on the Importance of “Multi-Attribute Method” for Measuring Purity of Biopharmaceuticals and Improving Overall Control Strategy

AAPS Journal, ISSN: 15507416

Richard S. Rogers; Michael Abernathy; Douglas D. Richardson; Jason C. Rouse; Justin B. Sperry; Patrick Swann; Jette Wypych; X. Christopher Yu; Li Zang; Rohini Deshpande

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January 1, 2018

A Multi-site In-depth Evaluation of the Quanterix Simoa from a User’s Perspective

AAPS Journal, ISSN: 15507416

Allison Given Chunyk; Alison Joyce; Saloumeh Kadkhodayan Fischer; Mark Dysinger; Alvydas Mikulskis; Andreas Jeromin; Rosemary Lawrence-Henderson; Baker; David Yeung

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January 1, 2018

Solubilization of a Poorly Soluble B-Raf (Rapidly Accelerated Fibrosarcoma) Inhibitor: From Theory to Application

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Linda Bao; Le An; Yingqing Ran

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January 1, 2018

Computational support of medicinal chemistry in industrial settings

Methods in Molecular Biology, ISSN: 10643745

Daniel F. Ortwine

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