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Publications

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DISPLAYING 4601 - 4650 OF 15657 RESULTS

Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates
Bioconjugate Chemistry, ISSN: 15204812 10431802
Jack D. Sadowsky; Thomas H. Pillow; Jinhua Chen; Fang Fan; Changrong He; Yanli Wang; Gang Yan; Hui Yao; Zijin Xu; Shanique Martin; Donglu Zhang; Phillip Chu; Josefa Dela Cruz Chuh; Aimee O'Donohue; Guangmin Li; Geoffrey Del Rosario; Jintang He; Luna Liu; Carl Ng; Dian Su; Gail L. Phillips; Katherine R. Kozak; Shang-Fan Yu; Keyang Xu; Douglas Leipold; John Wai
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Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease
Science Translational Medicine, ISSN: 19466242 19466234
Claire E. Le Pichon; William J. Meilandt; Sara L. Dominguez; Hilda Solanoy; Han Lin; Hai Ngu; Alvin Gogineni; Arundhati Sengupta Ghosh; Zhiyu Jiang; Seung-Hye Lee; Janice Maloney; Vineela D. Gandham; Christine D. Pozniak; Bei Wang; Sebum Lee; Michael Siu; Snahel Patel; Zora Modrusan; Xingrong Liu; York Rudhard; Miriam Baca; Amy Gustafson; Joshua S. Kaminker; Richard A. D. Carano; Eric J. Huang; Oded Foreman; Robby M. Weimer; Kimberly Scearce-Levie; Joe Lewcock
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The Ox40/Ox40 ligand pathway promotes pathogenic Th cell responses, plasmablast accumulation, and lupus nephritis in NZB/W F1 mice
Journal of Immunology, ISSN: 15506606 00221767
Jonathan Sitrin; Eric Suto; Arthur Wuster; Jeffrey Eastham-Anderson; Kim; Cary D. Austin; Wyne P. Lee; Timothy W. Behrens
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Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure
Cancer Cell, ISSN: 18783686 15356108
Gulfem D. Guler; Charles Tindell; Pitti; Catherine Wilson; Katrina Nichols; Tommy K. Cheung; Hyo-Jin Kim; Matthew Wongchenko; Yibing Yan; Benjamin Haley; Trinna L. Cuellar; Webster; Navneet Alag; Ganapati V. Hegde; Erica L. Jackson; Tracy Leah Nance; Paul Garrett Giresi; Kuan-Bei Chen; Jinfeng Liu; Suchit Jhunjhunwala; Jeffrey Settleman; Jean-Philippe Stephan; David Arnott; Marie Classon
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Effectiveness outcomes and health related quality of life impact of disease progression in patients with advanced nonsquamous NSCLC treated in real-world community oncology settings: Results from a prospective medical record registry study
Health and Quality of Life Outcomes, ISSN: 14777525
Mark S. Walker; Wong; Arliene Ravelo; Paul J. E. Miller; Lee S. Schwartzberg
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Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-Carbon Olefins via Enol Tosylation and Suzuki-Miyaura Coupling
Journal of the American Chemical Society, ISSN: 15205126 00027863
Beryl X. Li; Diane N. Le; Kyle A. Mack; Andrew McClory; Ngiap-Kie Lim; Theresa Cravillion; Scott Savage; Chong Han; David B. Collum; Haiming Zhang; Francis Gosselin
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Introduction of Trifluoroethylamine as Amide Isostere by C-H Functionalization of Heteroarenes
Organic Letters, ISSN: 15237052 15237060
Marie-Gabrielle Braun; Georgette M. Castanedo; Ling Qin; Patrick Salvo; Samir Z. Zard
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Corrigendum to “Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics” [Regul. Toxicol. Pharmacol. (2017) 221–230](S0273230017300727)(10.1016/j.yrtph.2017.03.013)
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Christina de Zafra; Vito G. Sasseville; Steven Matsumoto; Christian Freichel; Milton; Timothy K. MacLachlan; Cindy A. Farman; Iona Raymond; Swati Gupta; Ronald Newton; Elke-Astrid Atzpodien; Evan A Thackaberry
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Thaw-and-use target cells pre-labeled with calcein AM for antibody-dependent cell-mediated cytotoxicity assays
Journal of Immunological Methods, ISSN: 18727905 00221759
Shan Chung; Van Nguyen; Yuwen L. Lin; Lynn Kamen; An Song
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Preparation and evaluation of L- and D-5-[18F]fluorotryptophan as PET imaging probes for indoleamine and tryptophan 2,3-dioxygenases
Nuclear Medicine and Biology, ISSN: 18729614 09698051
Tang Tang; Herman S. Gill; Annie Ogasawara; Jeff N. Tinianow; Alexander N. Vanderbilt; Simon P. Williams; Georgia Hatzivassiliou; Sharla White; Wendy N. Sandoval; Kevin Dement; Mengling Wong; Jan Marik
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Role of regional absorption and gastrointestinal motility on variability in oral absorption of a model drug
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Ajit S. Narang; Anand Balakrishnan; John Morrison; Jinjiang Li; Jennifer Wang; Huidong Gu; Katrina Taylor; Kenneth Santone; Jon Ehrmann; Sophie Beyer; Xujin Lu; Rod Ketner; Jennifer Pizzano; Tami Orcutt; Eric Shields; Heidi Dulac; Sharon Aborn; Margaret Batchelder; Kimberley Lentz
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Trastuzumab uptake and its relation to efficacy in an animal model of HER2-positive breast cancer brain metastasis
Breast Cancer Research and Treatment, ISSN: 15737217 01676806
Gail L. Phillips; Merry C. Nishimura; Jennifer A. Lacap; Samir Kharbanda; Elaine Mai; Janet Y. Tien; Kim Malesky; Simon P. Williams; Jan Marik; Phillips
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Clinical Pharmacokinetics and Pharmacodynamics of Atezolizumab in Metastatic Urothelial Carcinoma
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Mark Stroh; Helen Winter; Mathilde Marchand; Laurent Claret; Stephen M. Eppler; Jane Ruppel; Oyewale Abidoye; Siew-Leng Teng; Lin; Dayog; Rene Bruno; Jin Y. Jin; Sandhya Girish
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Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
Archives of Toxicology, ISSN: 14320738 03405761
William R. Proctor; Alison J. Foster; Jennifer Vogt; Claire Summers; Brian Middleton; Mark A. Pilling; Daniel Shienson; Monika Kijanska; Simon Ströbel; Jens M. Kelm; Paul Morgan; Simon Messner; Dominic Williams
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Feasibility Assessment of a MALDI FTICR Imaging Approach for the 3D Reconstruction of a Mouse Lung
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
E. Ellen Jones; Cristine Quiason; Stephanie Dale; Sheerin Shahidi-Latham
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A phase 1, randomized, double-blind, placebo-controlled, single-ascending-dose study to investigate the safety, tolerability, and pharmacokinetics of an anti-influenza B virus monoclonal antibody, MHAB5553A, in healthy volunteers
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Jeremy Lim; Michael A. Derby; Yaping Zhang; Rong Deng; Richard Larouche; Malia Anderson; Mauricio Maia; Stephanie Carrier; Isabelle Pelletier; Johanne Girard; Priya Kulkarni; Elizabeth Newton; Jorge A. Tavel
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Multiplexed ion beam imaging analysis for quantitation of protein expresssion in cancer tissue sections
Laboratory Investigation, ISSN: 15300307 00236837
Sandra Rost; Jennifer M. Giltnane; Jennifer M. Bordeaux; Chuck Hitzman; Koeppen; Scot D. Liu
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Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk
Nature Genetics, ISSN: 15461718 10614036
Terence D. Capellini; Hao Chen; Jiaxue Cao; Andrew C. Doxey; Ata M. Kiapour; Michael Schoor; David M. Kingsley
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SeqArray-a storage-efficient high-performance data format for WGS variant calls
Bioinformatics, ISSN: 14602059 13674803
Xiuwen Zheng; Stephanie M. Gogarten; Michael Lawrence; Adrienne Stilp; Matthew P. Conomos; Bruce S. Weir; Cathy C. Laurie; David Levine
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HELOISE: Phase IIIb randomized multicenter study comparing standard-of-care and higher-dose trastuzumab regimens combined with chemotherapy as first-line therapy in patients with human epidermal growth factor receptor 2–positive metastatic gastric or gastroesophageal junction adenocarcinoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Manish A. Shah; Rui-hua Xu; Bang; Paulo M. Hoff; Tianshu Liu; Luis A. Herráez-Baranda; Fan Xia; Amit Garg; Mona Shing; Tabernero
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Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL
Journal of Experimental Medicine, ISSN: 15409538 00221007
Arturo I. Machuca-Parra; Alexander A. Bigger-Allen; Angie V. Sanchez; Anissa Boutabla; Jonathan Cardona-Vélez; Dhanesh Amarnani; Magali Saint-Geniez; Christian W. Siebel; Leo A. Kim; Patricia A. D'Amore; Joseph F. Arboleda-Velasquez
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Evaluation of the toxicity of intravitreally injected PLGA microspheres and rods in monkeys and rabbits: Effects of depot size on inflammatory response
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Evan A Thackaberry; Cindy A. Farman; Fiona Zhong; Florence Lorget; Karin Staflin; Angelique Cercillieux; Paul Miller; Chris Schuetz; Debby P. Chang; Amin Famili; Daugherty; Karthikan Rajagopal; Vlad Bantseev
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Overcoming disease-specific matrix effect in a clinical pharmacokinetic assay using a microfluidic immunoassay technology
Bioanalysis, ISSN: 17576199 17576180
Kathi Williams; Erickson; Saloumeh Kadkhodayan Fischer
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SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans
Nature Medicine, ISSN: 1546170X 10788956
Emma Kaitlynn Allen; Adrienne G. Randolph; Tushar Bhangale; Pranay Dogra; Maikke B. Ohlson; Christine M. Oshansky; Anthony E. Zamora; John P. Shannon; David Finkelstein; Amy Dressen; John DeVincenzo; Miguela Caniza; Ben Youngblood; Carrie M. Rosenberger; Paul G. Thomas
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Cumulative oral corticosteroid use increases risk of glucocorticoid-related adverse events in patients with newly diagnosed pemphigus
Journal of the American Academy of Dermatology, ISSN: 10976787 01909622
David Wormser; Chen; Paul Brunetta; Diana Sun; Michael S. Broder; Eunice Chang; Sheila R. Reddy
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Application and methodology of the non-destructive19F time-domain NMR technique to measure the content in fluorine-containing drug products
Journal of Visualized Experiments, ISSN: 1940087X
Maria Victoria Silva Elipe; Lan Li; Karthik Nagapudi; Alan M. Kook; Carlos Cobas; Isaac Iglesias; Chen Peng
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Voltage-gated sodium channels viewed through a structural biology lens
Current Opinion in Structural Biology, ISSN: 1879033X 0959440X
Thomas Clairfeuille; Hui Xu; Christopher M. Koth; Jian Payandeh
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Opportunities and challenges in phenotypic drug discovery: An industry perspective
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
John Moffat; Fabien Vincent; Jonathan A. Lee; Jörg Eder; Marco Prunotto
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Inorganic and Organic Ions
Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques,
Xiaodong Liu; Christopher A. Pohl; Kelly Zhang
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Trial of tocilizumab in giant-cell arteritis
New England Journal of Medicine, ISSN: 15334406 00284793
John H. Stone; Katie Tuckwell; Sophie Dimonaco; Micki Klearman; Aringer; Daniel Blockmans; Elisabeth Brouwer; Maria C. Cid; Bhaskar Dasgupta; Juergen Rech; Carlo Salvarani; Schett; Schulze-Koops; Spiera; Sebastian Unizony; Neil Collinson
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Sustainable Practices in Medicinal Chemistry Part 2: Green by Design
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Ignacio Aliagas; Raphaëlle Berger; Kristin Goldberg; Rachel T. Nishimura; John Reilly; Paul Richardson; Daniel Richter; Edward C. Sherer; Brian A. Sparling; Marian C. Bryan
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Structural insights into lipoprotein N-acylation by Escherichia coli apolipoprotein N-acyltransferase
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Cameron Noland; Michele D. Kattke; Jingyu Diao; Susan L. Gloor; Homer Pantua; Mike Reichelt; Anand K. Katakam; Donghong Yan; Jing Kang; Inna Zilberleyb; Min Xu; Sharookh B. Kapadia; Jeremy Murray
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Identifying and mitigating batch effects in whole genome sequencing data
BMC Bioinformatics, ISSN: 14712105
Jennifer A. Tom; Jens Reeder; William F. Forrest; Robert R. Graham; Julie Hunkapiller; Timothy W. Behrens; Tushar Bhangale
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TFH-derived dopamine accelerates productive synapses in germinal centres
Nature, ISSN: 14764687 00280836
Ilenia Papa; David Saliba; Maurilio Ponzoni; Sonia Bustamante; Pablo F. Canete; Paula Gonzalez-Figueroa; Hayley A. McNamara; Salvatore Valvo; Michele A. Grimbaldeston; Rebecca A. Sweet; Harpreet Vohra; Ian A. Cockburn; Michael Meyer-Hermann; Michael L. Dustin; Claudio Doglioni; Carola G. Vinuesa
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Inhibitory effects of trapping agents of sulfur drug reactive intermediates against major human cytochrome P450 isoforms
International Journal of Molecular Sciences, ISSN: 14220067 16616596
Jasleen K. Sodhi; Erlie Marie Delarosa; Jason S Halladay; James Driscoll; Teresa Mulder; Patrick M. Dansette; S. Cyrus Khojasteh
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Transancestral mapping and genetic load in systemic lupus erythematosus
Nature Communications, ISSN: 20411723
Carl D. Langefeld; Hannah C. Ainsworth; Deborah S. Cunninghame Graham; Jennifer A. Kelly; Mary E. Comeau; Miranda C. Marion; Timothy D. Howard; Paula S. Ramos; Jennifer A. Croker; David L. Morris; Johanna K. Sandling; Jonas Carlsson Almlöf; Eduardo M. Acevedo-Vásquez; Graciela S. Alarcõn; Alejandra M. Babini; Vicente Baca; Anders A. Bengtsson; Guillermo A. Berbotto; Marc Bijl; Elizabeth E. Brown; Hermine Brunner; Mario H. Cardiel; Luis Catoggio; Ricard Cervera; Jorge M. Cucho-Venegas; Solbritt Rantapää-Dahlqvist; Sandra D'Alfonso; Berta Martins Da Silva; Inígo De La RúaFigueroa; Andrea Doria; Jeffrey C. Edberg; Emoke Endreffy; Jorge A. Esquivel-Valerio; Fortin; Barry I. Freedman; Johan Frostegård; Mercedes A. Garcýá; Ignacio Garcýá De La Torre; Gary S. Gilkeson; Gladman; Iva Gunnarsson; Joel M. Guthridge; Jennifer L. Huggins; Judith A. James; Cees Kallenberg; Diane L. Kamen; David R. Karp; Kenneth M. Kaufman; Leah C. Kottyan; László Kovács; Helle Laustrup; Bernard R. Lauwerys; Quan-Zhen Li; Marco A. Maradiaga-Ceceną; Javier Martin; W. Joseph McCune; David R. McWilliams; Merrill; Pedro Miranda; José F. Moctezuma; Swapan K. Nath; Timothy B. Niewold; Lorena Orozco; Norberto Ortego-Centeno; Michelle Petri; Christian A. Pineau; Bernardo A. Pons-Estel; Janet E. Pope; Prithvi Raj; Robert P. Kimberly; John D. Reveille; Laurie P. Russell; José M. Sabio; Carlos A. Aguilar-Salinas; Hugo R. Scherbarth; Raffaella Scorza; Michael F. Seldin; Christopher Sjöwall; Elisabet Svenungsson; Susan D. Thompson; Sergio M.A. Toloza; Lennart Truedsson; Teresa Tusié-Luna; Carlos Vasconcelos; Luis M. Vilá; Daniel J. Wallace; Michael H. Weisman; Joan E. Wither; Tushar Bhangale; Jorge R. Oksenberg; John D. Rioux; Peter K. Gregersen; Ann-Christine Syvänen; Lars Rönnblom; Criswell; Chaim O. Jacob; Kathy L. Sivils; Betty P. Tsao; Laura E. Schanberg; Timothy W. Behrens; Earl D. Silverman; Marta E. Alarcón-Riquelme; Robert P. Kimberly; John B. Harley; Edward K. Wakeland; Robert R. Graham; Patrick M. Gaffney; Timothy J. Vyse
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A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain
Neuropharmacology, ISSN: 18737064 00283908
Tzu-Ming Wang; Brandon M. Brown; Lunbin Deng; Benjamin D. Sellers; Patrick J. Lupardus; Heidi J. A. Wallweber; Amy Gustafson; Evera Wong; Matthew Volgraf; Jacob B. Schwarz; David Hackos; Jesse E. Hanson
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GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2)
ACS Medicinal Chemistry Letters, ISSN: 19485875
Terry Crawford; James E. Audia; Steve Bellon; Burdick; Archana Bommi-Reddy; Alexandre Côté; Richard T Cummings; Martin Duplessis; E. Megan Flynn; Michael C. Hewitt; Hon-Ren Huang; Hariharan Jayaram; Ying Jiang; Shivangi Joshi; James R. Kiefer; Jeremy Murray; Christopher G. Nasveschuk; Adrianne Neiss; Eneida Pardo; F. Anthony Romero; Peter Sandy; Robert J. Sims; Yong Tang; Alexander M. Taylor; Vickie Tsui; Jian Wang; Shumei Wang; Yongyun Wang; Zhaowu Xu; Laura E. Zawadzke; Xiaoqin Zhu; Brian K Albrecht; Steven Magnuson; Andrea G Cochran
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Deconvolution of the response to bacillus Calmette-Guérin reveals NF-κB-induced cytokines as autocrine mediators of innate immunity
Frontiers in Immunology, ISSN: 16643224
Aurélie Bisiaux; Jeremy Boussier; Darragh Duffy; Lluis Quintana-Murci; Magnus Fontes; Matthew L. Albert
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Massively parallel nanowell-based single-cell gene expression profiling
BMC Genomics, ISSN: 14712164
Leonard D. Goldstein; Ying-Jiun J. Chen; Jude Dunne; Alain Mir; Hermann Hubschle; Joseph Guillory; Yuan; Jingli A. Zhang; Stinson; Bijay S. Jaiswal; Kanika Bajaj Pahuja; Ishminder Mann; Thomas D. Schaal; Leo Chan; Sangeetha Anandakrishnan; Chun-wah Lin; Patricio Espinoza; Syed Husain; Harris Shapiro; Karthikeyan Swaminathan; Sherry Wei; Maithreyan Srinivasan; Somasekar Seshagiri; Zora Modrusan
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A General Strategy for the Construction of Functionalized Azaindolines via Domino Palladium-Catalyzed Heck Cyclization/Suzuki Coupling
Organic Letters, ISSN: 15237052 15237060
Tabitha T. Schempp; Blake E. Daniels; Steven T. Staben; Craig E. Stivala
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Highly Diastereoselective α-Arylation of Cyclic Nitriles
Organic Letters, ISSN: 15237052 15237060
Michael E. Dalziel; Penghao Chen; Diane Carrera; Haiming Zhang; Francis Gosselin
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Structure-Based Correlation of Light-Induced Histidine Reactivity in A Model Protein
Analytical Chemistry, ISSN: 15206882 00032700
Ming Lei; Toshiro Carcelen; Benjamin T. Walters; Camellia Zamiri; Quan; Yuzhe Hu; Julie C. Nishihara; Holly Yip; Nicholas Woon; Taylor Zhang; Kao; Christian Schöneich
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Pharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates
mAbs, ISSN: 19420870 19420862
Miroslav Dostalek; Thomayant Prueksaritanont; Robert F. Kelley
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The cost-effectiveness of alectinib in anaplastic lymphoma kinase-positive (ALK+) advanced NSCLC previously treated with crizotinib
Journal of Medical Economics, ISSN: 1941837X 13696998
Josh J. Carlson; Canestaro; Arliene Ravelo; Wong
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Biotransformation and bioactivation reactions–2016 literature highlights
Drug Metabolism Reviews, ISSN: 10979883 03602532
S. Cyrus Khojasteh; Ivonne M. C. M. Rietjens; Deepak Dalvie; Grover Miller
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A phase 1 study to evaluate the safety and LDL cholesterol–lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9
Clinical Cardiology, ISSN: 19328737 01609289
Amos Baruch; Diana Luca; Robert S. Kahn; Kyra J. Cowan; Maya Leabman; Nageshwar Budha; Cecilia Chiu; Yan Wu; Daniel Kirchhofer; Andrew S. Peterson; John C. Davis; Whittemore G. Tingley
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Randomized phase II trial of parsatuzumab (Anti-EGFL7) or placebo in combination with FOLFOX and bevacizumab for first-line metastatic colorectal cancer
Oncologist, ISSN: 1549490X 10837159
Rocío García-Carbonero; Eric Van Cutsem; Rivera; Jacek Jassem; Ira Gore; Niall C. Tebbutt; Fadi S. Braiteh; Guillem Argiles; Zev A. Wainberg; Roel Funke; Maria Anderson; Bruce Mccall; Mark Stroh; Eric Wakshull; Priti Hegde; Weilan Ye; Daniel S. Chen; Ilsung Chang; Ina Rhee; Herbert Hurwitz
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Pharmacokinetics and safety of vismodegib in patients with advanced solid malignancies and hepatic impairment
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Ghassan K. Abou-Alfa; Lionel D. Lewis; Patricia M. LoRusso; Michael Maitland; Priya Chandra; Sravanthi Cheeti; Dawn Colburn; Sarah Williams; Brian Simmons; Richard A. Graham
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Results of a harmonized endotoxin recovery study protocol evaluation by 14 BioPhorum Operations Group (BPOG) member companies
Biologicals, ISSN: 10958320 10451056
Jay Bolden; Michael Knight; Shahrzad Stockman; Bastian Omokoko
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