Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4701 - 4750 OF 15657 RESULTS

Stem cell plasticity enables hair regeneration following Lgr5 + cell loss
Nature Cell Biology, ISSN: 14764679 14657392
Joerg D. Hoeck; Brian Biehs; Antonina V. Kurtova; Noelyn Kljavin; Felipe de Sousa e Melo; Bruno Alicke; Koeppen; Zora Modrusan; Robert Piskol; Frederic J. De Sauvage
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Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Xiaojing Wang; Aleksandr Kolesnikov; Suzanne Tay; Grace Chan; Qi Chao; Steven Do; Jason H. Drummond; Allen Ebens; Ning Liu; Justin Ly; Eric Harstad; Huiyong Hu; John Moffat; Veerendra Munugalavadla; Jeremy Murray; Dionysos S. Slaga; Vickie Tsui; Matthew Volgraf; Heidi J. A. Wallweber; Jae H. Chang
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A survey of renal impairment pharmacokinetic studies for new oncology drug approvals in the USA from 2010 to early 2015: A focus on development strategies and future directions
Anti-Cancer Drugs, ISSN: 14735741 09594973
Jim J. Xiao; Jiyun S. Chen; Bert L. Lum; Richard A. Graham
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Mechanical ventilation in idiopathic pulmonary fibrosis: A nationwide analysis of ventilator use, outcomes, and resource burden
BMC Pulmonary Medicine, ISSN: 14712466
Joshua J. Mooney; Karina Raimundo; Eunice Chang; Michael S. Broder
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A modular and adaptive mass spectrometry-based platform for support of bioprocess development toward optimal host cell protein clearance
mAbs, ISSN: 19420870 19420862
Donald Walker; Feng Yang; Joe Carver; Koman Joe; David A. Michels; X. Christopher Yu
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Glycation of antibodies: Modification, methods and potential effects on biological functions
mAbs, ISSN: 19420870 19420862
Bingchuan Wei; Kelsey Berning; Quan; Taylor Zhang
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Mice deficient in NRROS show abnormal microglial development and neurological disorders
Nature Immunology, ISSN: 15292916 15292908
Kit Wong; Rajkumar Noubade; Paolo Manzanillo; Naruhisa Ota; Oded Foreman; Jason A. Hackney; Brad A. Friedman; Rajita Pappu; Kimberly Scearce-Levie; Wenjun Ouyang
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Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates
Bioconjugate Chemistry, ISSN: 15204812 10431802
Xiuxia Sun; Jose Ponte; Nicholas C. Yoder; Rassol Laleau; Jennifer A. Coccia; Leanne Lanieri; Qifeng Qiu; Rui Wu; E. Erica Hong; Megan Bogalhas; Lintao Wang; Ling Dong; Yulius Y. Setiady; Erin K. Maloney; Olga Ab; Xiaoyan Zhang; Jan Pinkas; Thomas A. Keating; Ravi Chari; Hans Erickson; John M. Lambert
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Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: Final update of the pivotal ERIVANCE BCC study
BMC Cancer, ISSN: 14712407
Aleksandar Sekulic; Michael R. Migden; Nicole Basset-Seguin; Claus Garbe; Anja Gesierich; Christopher D. Lao; Chris Miller; Laurent Mortier; Dedee F. Murrell; Omid Hamid; Jorge F. Quevedo; Jeannie Hou; Edward McKenna; Natalie Dimier; Sarah Williams; Dirk Schadendorf; Axel Hauschild
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High-Resolution Accurate-Mass Mass Spectrometry Enabling In-Depth Characterization of in Vivo Biotransformations for Intact Antibody-Drug Conjugates
Analytical Chemistry, ISSN: 15206882 00032700
Jintang He; Dian Su; Carl Ng; Luna Liu; Shang-Fan Yu; Thomas H. Pillow; Geoffrey Del Rosario; Martine Darwish; Byoung-Chul Lee; Rachana Ohri; Hongxiang Zhou; Xueji Wang; Jiawei Lu; Surinder Kaur; Keyang Xu
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Effects of RG7652, a Monoclonal Antibody Against PCSK9, on LDL-C, LDL-C Subfractions, and Inflammatory Biomarkers in Patients at High Risk of or With Established Coronary Heart Disease (from the Phase 2 EQUATOR Study)
American Journal of Cardiology, ISSN: 18791913 00029149
Amos Baruch; Mosesova; John Davis; Nageshwar Budha; Alexandr Vilimovskij; Robert S. Kahn; Kun Peng; Kyra J. Cowan; Laura Pascasio Harris; Thomas R. Gelzleichter; Josh Lehrer; John C. Davis; Whittemore G. Tingley
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GUIDEseq: A bioconductor package to analyze GUIDE-Seq datasets for CRISPR-Cas nucleases
BMC Genomics, ISSN: 14712164
Lihua Julie Zhu; Michael Lawrence; Ankit Gupta; Hervé Pagès; Alper Kucukural; Manuel Garber; Scot A. Wolfe
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Phase I study of GDC-0425, a checkpoint kinase 1 inhibitor, in combination with gemcitabine in patients with refractory solid tumors
Clinical Cancer Research, ISSN: 15573265 10780432
Jeffery R. Infante; Antoine Hollebecque; Sophie Postel-Vinay; Todd M. Bauer; Elizabeth M. Blackwood; Marie Evangelista; Sami Mahrus; Franklin V. Peale Jr.; Xuyang Lu; Srikumar Sahasranaman; Rui Zhu; Yuan Chen; Xiao Ding; Elaine R. Murray; Jennifer L. Schutzman; Jennifer O. Lauchle; Jean-Charles Soria; Patricia M. LoRusso
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To the editor: Venetoclax and obinutuzumab in chronic lymphocytic leukemia
Blood, ISSN: 15280020 00064971
Kirsten Fischer; Othman Al-Sawaf; Anna-Maria Fink; Mark Dixon; Jasmin Bahlo; Simon Warburton; Thomas J. Kipps; Robert Weinkove; Sue Robinson; Till Seiler; Stephen Opat; Carolyn J. Owen; Javier López; Kathryn Humphrey; Rod A. Humerickhouse; Eugen Tausch; Lukas Frenzel; Barbara Eichhorst; Clemens M. Wendtner; Stephan Stilgenbauer; Anton W. Langerak; Jacque J.M. Van Dongen; Sebastian Böttcher; Matthias Ritgen; Valentin Goede; Mehrdad Mobasher; Michael Hallek
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Employment and absenteeism in working-age persons with multiple sclerosis
Journal of Medical Economics, ISSN: 1941837X 13696998
Amber Salter; Nina Parikh Thomas; Tuula Tyry; Cutter; Ruth Ann Marrie
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Hospital cost and length of stay in idiopathic pulmonary fibrosis
Journal of Medical Economics, ISSN: 1941837X 13696998
Joshua J. Mooney; Karina Raimundo; Eunice Chang; Michael S. Broder
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Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin
Structure, ISSN: 18784186 09692126
Justin T. Biel; Michael C. Thompson; Christian N. Cunningham; Jacob E. Corn; James S. Fraser
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Assessment of Correlation Between Early and Late Efficacy Endpoints to Identify Potential Surrogacy Relationships in Non-Hodgkin Lymphoma: a Literature-Based Meta-analysis of 108 Phase II and Phase III Studies
AAPS Journal, ISSN: 15507416
Rui Zhu; Dan Lu; Yu-Waye Chu; Akiko Chai; Michelle Green; Nancy Zhang; Jin Y. Jin
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Reply
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Phillip Lieberman; Dale T. Umetsu; Gillis Carrigan; Abdelkader Rahmaoui
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Melt extrusion vs. spray drying: The effect of processing methods on crystalline content of naproxen-povidone formulations
European Journal of Pharmaceutical Sciences, ISSN: 18790720 09280987
Abbe Haser; Tu Cao; Joseph W. Lubach; Tony Listro; Larry Acquarulo; Feng Zhang
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Activity-based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights
FEBS Journal, ISSN: 17424658 1742464X
David S. Hewings; Flygare; Matthew Bogyo; Ingrid E. Wertz
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Impact of physiologically based pharmacokinetic models on regulatory reviews and product labels: Frequent utilization in the field of oncology
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Yoshida; Nageshwar Budha; Jin Y. Jin
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Seasonal variability of severe asthma exacerbations and clinical benefit from lebrikizumab
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Tracy Staton; Joseph R. Arron; Julie Olsson; Cécile T.J. Holweg; Matthews; David F. Choy
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The Clinical Importance of Changes in Diabetic Retinopathy Severity Score
Ophthalmology, ISSN: 15494713 01616420
Michael S. Ip; Jiameng Zhang; Jason S. Ehrlich
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Evaluation of heavy chain C-terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells
Biotechnology Progress, ISSN: 15206033 87567938
Zhilan Hu; Danming Tang; Shahram Misaghi; Guoying Jiang; X. Christopher Yu; Mandy Yim; David Shaw; Snedecor; Mike Laird; Amy Shen
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Novel mechanism of decyanation of GDC-0425 by cytochrome P450
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Jason S Halladay; Michael Siu; Yuan Chen; Cornelis E. Hop; S. Cyrus Khojasteh; Shuguang Ma
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Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GATSBY): an international randomised, open-label, adaptive, phase 2/3 study
The Lancet Oncology, ISSN: 14745488 14702045
Peter C Thuss-Patience; Manish A. Shah; Atsushi Ohtsu; Eric Van Cutsem; Jaffer A. Ajani; Hugo Castro; Wasat Mansoor; Hyun Cheol Chung; Gyorgy Bodoky; Kohei Shitara; Gail L. Phillips; Tina van der Horst; Marie-Laurence Harle-Yge; Betsy Althaus; Yoon-Koo Kang
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Erlotinib and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF): an international, multicentre, single-arm, phase 2 trial
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Rafael Rosell; Urania Dafni; Enriqueta Felip; Alessandra Curioni-Fontecedro; Oliver Gautschi; Solange Peters; Bartomeu Massutí; Ramon Palmero; Santiago Ponce Aix; Enric Carcereny; Martin Früh; Miklos Pless; Sanjay Popat; Athanasios Kotsakis; Sinead Cuffe; Paolo Bidoli; Adolfo Favaretto; Patrizia Froesch; Noemí Reguart; Javier Puente; Linda Coate; Fabrice Barlesi; Daniel Rauch; Michael Thomas; Carlos Camps; Jose Gómez-Codina; Margarita Majem; Rut Porta; Riyaz Shah; Emer Hanrahan; Roswitha Kammler; Barbara Ruepp; Manuela Rabaglio; Marie Kassapian; Niki Karachaliou; Rachel Tam; David S. Shames; Molina; Rolf A Stahel
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Mapping the Binding Interface of VEGF and a Monoclonal Antibody Fab-1 Fragment with Fast Photochemical Oxidation of Proteins (FPOP) and Mass Spectrometry
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
Ying Zhang; Aaron T. Wecksler; Patricia Molina; Galahad Deperalta; Michael L. Gross
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Routine Assessment of Patient Index Data 3 and the American College of Rheumatology/European League Against Rheumatism Provisional Remission Definitions as Predictors of Radiographic Outcome in a Rheumatoid Arthritis Clinical Trial With Tocilizumab
Arthritis Care and Research, ISSN: 21514658 2151464X
Muznay N. Khawaja; Martin J. Bergman; Jeffrey Yourish; Jinglan Pei; William Reiss; Edward Keystone
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Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions
Molecular Pharmaceutics, ISSN: 15438392 15438384
Justin Ly; Kirsten Messick; Ann R. Qin; Ryan Takahashi; Edna F. Choo
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Omalizumab in children with uncontrolled allergic asthma: Review of clinical trial and real-world experience
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Bradley E. Chipps; Bob Lanier; Henry Milgrom; Antoine Deschildre; Gunilla Hedlin; Stanley J. Szefler; Meyer Kattan; Farid Kianifard; Benjamin Ortiz; Tmirah Haselkorn; Ahmar Iqbal; Karin Rosén; Benjamin L. Trzaskoma; William W. Busse
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Cost and health care utilization in patients with asthma and high oral corticosteroid use
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Michael S. Broder; Karina Raimundo; Ka Ming Ngai; Eunice Chang; Noelle M. Griffin; Liam G. Heaney
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The future of asthma research and development: A roadmap from the European Asthma Research and Innovation Partnership (EARIP)
European Respiratory Journal, ISSN: 13993003 09031936
Sarah Masefield; Jessica Edwards; Kjeld Hansen; Dominique Hamerlijnck; Karin Lisspers; Marc Van Der Schee; Liliana Silva; Matthews; Mina Gaga; Ian Adcock; Stephen Holgate; Samantha Walker; Pippa Powell
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Next-Generation Sequencing Reveals Novel Mutations in X-linked Intellectual Disability
OMICS A Journal of Integrative Biology, ISSN: 15578100 15362310
Babylakshmi Muthusamy; Lakshmi Dhevi N. Selvan; Thong T Nguyen; Jesna Manoj; Eric Stawiski; Bijay S. Jaiswal; Weiru Wang; Remya Raja; Vedam Laxmi Ramprasad; Ravi Gupta; Sakthivel Murugan; Jayarama S. Kadandale; Keshava Prasad; Kavita Reddy; Andrew S. Peterson; Akhilesh Pandey; Somasekar Seshagiri; Satish Chandra Girimaji; Harsha Gowda
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Processing impact on monoclonal antibody drug products: Protein subvisible particulate formation induced by grinding stress
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Benson Gikanga; Devon Roshan Eisner; Robert Ovadia; Eric S. Day; Oliver B. Stauch; Maa
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Effect of fluorouracil, leucovorin, and oxaliplatin with or without onartuzumab in HER2-negative, MET-positive gastroesophageal adenocarcinoma: The METGastric randomized clinical trial
JAMA Oncology, ISSN: 23742445 23742437
Manish A. Shah; Bang; Florian Lordick; Maria Alsina; Meng Chen; Stephen P. Hack; Jean-Marie Bruey; Dustin Smith; Ian McCaffery; David S. Shames; See Phan; David Cunningham
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Modulating therapeutic activity and toxicity of pyrrolobenzodiazepine antibody-drug conjugates with self-immolative disulfide linkers
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Thomas H. Pillow; Melissa Schutten; Shang-Fan Yu; Rachana Ohri; Jack D. Sadowsky; Kirsten Achilles Poon; Willy A. Solis; Fiona Zhong; Geoffrey Del Rosario; MaryAnn Go; Jeffrey Lau; Sharon Fong Yee; Jintang He; Luna Liu; Carl Ng; Keyang Xu; Douglas Leipold; Amrita Kamath; Donglu Zhang; Luke Masterson; Stephen J. Gregson; Philip W. Howard; Fan Fang; Jinhua Chen; Janet Gunzner; Katherine R. Kozak; Spencer; Paul G. Polakis; Andrew G. Polson; Flygare; Jagath R. Junutula
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Peptidoglycan association of murein lipoprotein is required for KpsD-dependent group 2 capsular polysaccharide expression and serum resistance in a uropathogenic escherichia coli isolate
mBio, ISSN: 21507511 21612129
Jingyu Diao; Catrien Bouwman; Donghong Yan; Jing Kang; Anand K. Katakam; Peter S. Liu; Homer Pantua; Abbas Alexander; Nicholas N. Nickerson; Cary D. Austin; Mike Reichelt; Wendy N. Sandoval; Min Xu; Chris Whitfield; Sharookh B. Kapadia
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Vascular safety of ranibizumab in patients with diabetic macular edema: A pooled analysis of patient-level data from randomized clinical trials
JAMA Ophthalmology, ISSN: 21686165
Marco A. Zarbin; Cornelia Dunger-Baldauf; Zdenka Haskova; Prashil Koovejee; Marie-Catherine Mousseau; Philippe Margaron; Howard Snow; Paul E. Beaumont; Giovanni Staurenghi; Steve Francom
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Incidence, course, and management of toxicities associated with cobimetinib in combination with vemurafenib in the coBRIM study
Annals of Oncology, ISSN: 15698041
Brigitte Dréno; Antoni Ribas; James Larkin; Paolo A. Ascierto; Axel Hauschild; Luc Thomas; Jean-Jacques Grob; Daniel Koralek; Isabelle Rooney; Jessie Hsu; Edward McKenna; McArthur
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αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis
Journal of Crohn's and Colitis, ISSN: 18764479
Christopher A. Lamb; John C Mansfield; Tew; Don L. Gibbons; Anna K. Long; Peter M. Irving; Laurie Diehl; Jeffrey Eastham-Anderson; Maria B. Price; Graeme O'Boyle; David E J Jones; Sharon O'Byrne; Adrian C. Hayday; Mary E. Keir; Jackson G. Egen; John A. Kirby
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Cardiovascular and cerebrovascular events among patients receiving omalizumab: Results from EXCELS, a prospective cohort study in moderate to severe asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Carlos Iribarren; Abdelkader Rahmaoui; Aidan Long; Stanley J. Szefler; Mary S. Bradley; Gillis Carrigan; Mark D. Eisner; Hubert Chen; Theodore A. Omachi; Michael E. Farkouh; Kenneth J. Rothman
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Cardiovascular and cerebrovascular events among patients receiving omalizumab: Pooled analysis of patient-level data from 25 randomized, double-blind, placebo-controlled clinical trials
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Carlos Iribarren; Kenneth J. Rothman; Mary S. Bradley; Gillis Carrigan; Mark D. Eisner; Hubert Chen
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Longitudinal variation of serum periostin levels in adults with stable asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Ruth Semprini; Caswell-Smith; James Fingleton; Cécile T.J. Holweg; Matthews; Mark Weatherall; Beasley; Irene Braithwaite
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Activity-based probes for the multicatalytic proteasome
FEBS Journal, ISSN: 17424658 1742464X
David S. Hewings; Flygare; Ingrid E. Wertz; Matthew Bogyo
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Patient and physician preferences for anticancer drugs for the treatment of metastatic colorectal cancer: A discrete-choice experiment
Cancer Management and Research, ISSN: 11791322
Juan Marcos González; Sarika Ogale; Rob Morlock; Joshua Posner; A. Brett Hauber; Nicolas Sommer; Grothey
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Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult
eLife, ISSN: 2050084X
Martin Larhammar; Sarah Huntwork-Rodriguez; Zhiyu Jiang; Hilda Solanoy; Arundhati Sengupta Ghosh; Bei Wang; Joshua S. Kaminker; Kevin Huang; Jeffrey Eastham-Anderson; Michael Siu; Zora Modrusan; Madeline M. Farley; Marc Tessier-Lavigne; Joe Lewcock; Trent A. Watkins
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NPTX2 and cognitive dysfunction in Alzheimer’s Disease
eLife, ISSN: 2050084X
Mei-Fang Xiao; Desheng Xu; Michael T Craig; Kenneth A Pelkey; Chun-Che Chien; Yang Shi; Juhong Zhang; Susan Resnick; Olga Pletnikova; David Salmon; James Brewer; Steven Edland; Jerzy Wegiel; Benjamin Tycko; Alena Savonenko; Roger H. Reeves; Juan C. Troncoso; Chris J. McBain; Douglas Galasko; Paul F Wegiel
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Highly Regioselective and Practical Synthesis of 5-Bromo-4-chloro-3-nitro-7-azaindole
Organic Process Research and Development, ISSN: 10836160
Chong Han; Keena L. Green; Eugen Pfeifer; Francis Gosselin
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