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Publications

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DISPLAYING 4901 - 4950 OF 15657 RESULTS

CYP1A1-mediated intramolecular rearrangement of aminoazepane in GDC-0339
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Xiaojing Wang; Nathaniel Segraves; Jing Wang; Jae H. Chang; S. Cyrus Khojasteh; Shuguang Ma
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Considerations from the IQ induction working group in response to drug-drug interaction guidance from regulatory agencies: Focus on downregulation, CYP2C induction, and CYP2B6 positive control
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Niresh Hariparsad; Diane Ramsden; Jairam Palamanda; Joshua G. DeKeyser; Odette A. Fahmi; Jane R. Kenny; Heidi J. Einolf; Michael A. Mohutsky; Magalie Pardon; Y. Amy Siu; Liangfu Chen; Michael Sinz; Barry C Jones; Robert L. Walsky; Shannon Dallas; Suresh K. Balani; George Zhang; David Buckley; Donald J. Tweedie
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Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors
Advances in Anatomic Pathology, ISSN: 15334031 10724109
Shona Hendry; Roberto Salgado; Thomas Gevaert; Prudence A. Russell; Tom John; Bibhusal Thapa; Michael Christie; Koen Van De Vijver; Mónica V. Estrada; Paula I. Gonzalez-Ericsson; Melinda E. Sanders; Benjamin Solomon; Cinzia Solinas; Gert G.G.M. Van Den Eynden; Yves Allory; Matthias Preusser; Johannes Hainfellner; Giancarlo Pruneri; Andrea Vingiani; Sandra Demaria; W Fraser Symmans; Nuciforo; Laura Comerma; Thompson; Sunil Lakhani; Seong-Rim Kim; Stuart J. Schnitt; Cecile Colpaert; Christos Sotiriou; Stefan J. Scherer; Michail Ignatiadis; Sunil Badve; Robert H. Pierce; Giuseppe Viale; Nicolas Sirtaine; Frederique Penault-Llorca; Tomohagu Sugie; Susan Fineberg; Soonmyung Paik; Ashok Srinivasan; Andrea Richardson; Yihong Wang; Ewa Chmielik; Jane Brock; Douglas B. Johnson; Justin M. Balko; Stephan Wienert; Veerle Bossuyt; Stefan Michiels; Nils Ternes; Nicole Burchardi; Stephen J Luen; Peter Savas; Frederick Klauschen; Peter H. Watson; Brad H. Nelson; Carmen Criscitiello; Sandra O'Toole; Denis Larsimont; Roland De Wind; Giuseppe Curigliano; Fabrice Andre; Magali Lacroix-Triki; Mark Van De Vijver; Federico Rojo; Giuseppe Floris; Shahinaz Bedri; Joseph Sparano; David Rimm; Torsten Nielsen; Zuzana Kos; Stephen M. Hewitt; Baljit Singh; Gelareh Farshid; Sibylle Loibl; Kimberly H. Allison; Nadine Tung; Sylvia Adams; Karen Willard-Gallo; Hugo M. Horlings; Leena Gandhi; Andre Moreira; Fred R. Hirsch; Maria V. Dieci; Maria Urbanowicz; Iva Brcic; Konstanty Korski; Fabien Gaire; Koeppen; Amy Lo; Jennifer M. Giltnane; Marlon C. Rebelatto; Keith E. Steele; Jiping Zha; Kenneth Emancipator; Jonathan W. Juco; Carsten Denkert; Jorge S. Reis-Filho; Sherene Loi; Stephen B. Fox
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Vemurafenib treatment for patients with locally advanced, unresectable stage IIIC or metastatic melanoma and activating exon 15 BRAF mutations other than V600E
Melanoma Research, ISSN: 14735636 09608931
Sigrun Hallmeyer; Rene Gonzalez; David Lawson; Lee Cranmer; Gerald Linette; Igor Puzanov; Bret Taback; C. Lance Cowey; Antoni Ribas; Gregory Daniels; Timothy Moore; Geoffrey T. Gibney; Hussein Tawbi; Eric Whitman; Geraldine Lee; Yong Mun; Shiyao Liu; Omid Hamid
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Enhancing the resolution of 1H and 13C solid-state NMR spectra by reduction of anisotropic bulk magnetic susceptibility broadening
Physical Chemistry Chemical Physics, ISSN: 14639076
Michael P. Hanrahan; Amrit Venkatesh; Scott L. Carnahan; Julie L. Calahan; Joseph W. Lubach; Eric Munson; Aaron J. Rossini
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Enhancing reproducibility and collaboration via management of R package cohorts
Journal of Statistical Software, ISSN: 15487660
Gabriel Becker; Robert Gentleman; Cory Barr; Michael Lawrence
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Cathepsin B is dispensable for cellular processing of cathepsin B-cleavable antibody–drug conjugates
Cancer Research, ISSN: 15387445 00085472
Niña G. Caculitan; Josefa Chuh; Yong Ma; Donglu Zhang; Katherine R. Kozak; Yichin Liu; Thomas H. Pillow; Jack D. Sadowsky; Tommy K. Cheung; Qui Phung; Benjamin Haley; Byoung-Chul Lee; Robert W. Akita; Mark X. Sliwkowski; Andrew G. Polson
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2017 White paper on recent issues in bioanalysis: Rise of hybrid lba/lcms immunogenicity assays (part 2: Hybrid lba/lcms biotherapeutics, biomarkers & immunogenicity assays and regulatory agencies' inputs)
Bioanalysis, ISSN: 17576199 17576180
Hendrik Neubert; An Song; Anita Lee; Cong Wei; Jeff Duggan; Keyang Xu; Eric Woolf; Christopher Evans; Joe Palandra; Omar Laterza; Shashi Amur; Isabella Berger; Mark Bustard; Mark T. Cancilla; Shang-Chiung Chen; Seongeun Julia Cho; Eugene Ciccimaro; Isabelle Cludts; Cocea; Celia D'Arienzo; Lieza Danan-Leon; Lorella Di Donato; Fabio Garofolo; Sam Haidar; Akiko Ishii-Watabe; Hao Jiang; John Kadavil; Sean Kassim; Pekka Kurki; Olivier Le Blaye; Kai Liu; Rod Mathews; Gustavo Mendes Lima Santos; Makoto Niwa; Joao Pedras-Vasconcelos; Mark Qian; Brian Rago; Ola M. Saad; Yoshiro Saito; Natasha Savoie; Dian Su; Matthew Szapacs; Nilufer Tampal; Stephen Vinter; Jian Wang; Jan Welink; Emma Whale; Amanda Wilson; Xue
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The comparative effectiveness and cost-effectiveness of ranibizumab for neovascular macular degeneration revisited
International Journal of Retina and Vitreous, ISSN: 20569920
Gary C. Brown; Melissa M. Brown; Heidi B. Lieske; Adam Turpcu; Yamina Rajput
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Practical considerations for assessing product ouality of biosynthetic proteins by HPLC
High-Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis, and Conformation,
Chloupek; John E. Battersby; William S. Hancock
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Results from the Phase III Randomized Trial of Onartuzumab plus Erlotinib Versus Erlotinib in Previously Treated Stage IIIB or IV Non–Small-Cell Lung Cancer: METLung
Journal of Clinical Oncology, ISSN: 15277755 0732183X
David Spigel; Martin J. Edelman; Kenneth O'Byrne; Luis Paz-Ares; Mocci; See Phan; David S. Shames; Dustin Smith; Wei Yu; Virginia Paton; Tony Mok
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Interleukin-13 in asthma and other eosinophilic disorders
Frontiers in Medicine, ISSN: 2296858X
Emma Doran; Fang Cai; Cecile Holweg; Kit Wong; Jochen Brumm; Joseph R. Arron
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Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs
Xenobiotica, ISSN: 13665928 00498254
Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Justin Ly; Jason Boggs; Alec Fettes; Andrew McClory; Yuzhong Deng; Cornelis E. Hop; S. Cyrus Khojasteh; Edna F. Choo
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Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death
Cell Death and Differentiation, ISSN: 14765403 13509047
Maria Cristina De Almagro; Tatiana Goncharov; Anita Izrael-Tomasevic; Stefanie Duttler; Matthias Kist; Eugene Varfolomeev; Xiumin Wu; Wyne P. Lee; Jeremy Murray; Webster; Kebing Yu; Donald S. Kirkpatrick; Kim Newton; Domagoj Vucic
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Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics
AAPS Journal, ISSN: 15507416
Siddharth Sukumaran; Crystal Zhang; Douglas Leipold; Ola M. Saad; Keyang Xu; Kapil Gadkar; Divya Samineni; Wang; Marija Milojic-Blair; Montserrat Carrasco-Triguero; Bonnee Rubinfeld; Fielder; Kedan Lin; Ramanujan
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Degradation Mechanisms of Polysorbate 20 Differentiated by 18O-labeling and Mass Spectrometry
Pharmaceutical Research, ISSN: 1573904X 07248741
Lin Zhang; Sandeep Yadav; Barthélemy Demeule; Y. John Wang; Olivier Mozziconacci; Christian Schöneich
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Specific Immune Response to Phospholipase B-Like 2 Protein, a Host Cell Impurity in Lebrikizumab Clinical Material
AAPS Journal, ISSN: 15507416
Saloumeh Kadkhodayan Fischer; Melissa Cheu; Kun Peng; John Lowe; James Araujo; Elaine R. Murray; Mcclintock; Matthews; Patricia Siguenza; An Song
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Photo-oxidation of IgG1 and Model Peptides: Detection and Analysis of Triply Oxidized His and Trp Side Chain Cleavage Products
Pharmaceutical Research, ISSN: 1573904X 07248741
Jessica Bane; Olivier Mozziconacci; Li Yi; Y. John Wang; Alavattam Sreedhara; Christian Schöneich
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TIGIT: A Key Inhibitor of the Cancer Immunity Cycle
Trends in Immunology, ISSN: 14714981 14714906
Nicholas A. Manieri; Eugene Y. Chiang; Jane L. Grogan
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Quantitative Systems Pharmacology: A Case for Disease Models
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Musante; Ramanujan; Brian J. Schmidt; Ghobrial; Lu; Heatherington
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Bevacizumab plus paclitaxel versus placebo plus paclitaxel as first-line therapy for HER2-negative metastatic breast cancer (MERiDiAN): A double-blind placebo-controlled randomised phase III trial with prospective biomarker evaluation
European Journal of Cancer, ISSN: 18790852 09598049
David W. Miles; David Cameron; Igor Bondarenko; Lyudmila Manzyuk; Juan Carlos Alcedo; Roberto Ivan Lopez; Seock-Ah Im; Jean-Luc Canon; Yaroslav Shparyk; Denise A. Yardley; Norikazu Masuda; Jungsil Ro; Neelima Denduluri; Stanislas Hubeaux; Quah; Carlos Bais; O'Shaughnessy
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Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma
Gastroenterology, ISSN: 15280012 00165085
Yiwei Wang; Dan Huang; Kai-Yuan Chen; Min Cui; Weihuan Wang; Xiaoran Huang; Amad Awadellah; Qing Li; Ann Friedman; William Xin; Luca Di Martino; Fabio Cominelli; Alex Miron; Ricky Chan; James G. Fox; Yan Xu; Xiling Shen; Mathew F. Kalady; Sanford D. Markowitz; Ivan Maillard; John Lowe; Wei Xin; Lan Zhou
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Effect of pirfenidone on mortality: pooled analyses and meta-analyses of clinical trials in idiopathic pulmonary fibrosis
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Steven D Nathan; Carlo Albera; Williamson Bradford; Ulrich Costabel; Ian Glaspole; Marilyn K Glassberg; David Kardatzke; Monica Daigl; Klaus-Uwe Kirchgaessler; Lisa H Lancaster; David J Lederer; Carlos A Pereira; Jeffrey J. Swigris; Dominique Valeyre; Paul W. Noble
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Efficacy and Safety of Onartuzumab in Combination With First-Line Bevacizumab- or Pemetrexed-Based Chemotherapy Regimens in Advanced Non-Squamous Non–Small-Cell Lung Cancer
Clinical Lung Cancer, ISSN: 19380690 15257304
Heather A. Wakelee; Zanete Zvirbule; Filippo De Braud; C. Daniel Kingsley; Tarek Mekhail; Thomas Lowe; Wolfgang Schütte; Hervé Lena; William Lawler; Fadi S. Braiteh; Thomas Cosgriff; Diego Kaen; Michelle Boyer; Jessie Hsu; See Phan; Silvia Novello
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Tumour-infiltrating lymphocytes in advanced HER2-positive breast cancer treated with pertuzumab or placebo in addition to trastuzumab and docetaxel: a retrospective analysis of the CLEOPATRA study
The Lancet Oncology, ISSN: 14745488 14702045
Stephen J Luen; Roberto Salgado; Stephen B. Fox; Peter Savas; Jennifer Eng-Wong; Emma Clark; Astrid Kiermaier; Sandra M. Swain; Baselga; Stefan Michiels; Sherene Loi
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Quantitative proteomics reveals fundamental regulatory differences in oncogenic hras and isocitrate dehydrogenase (IDH1) driven astrocytoma
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Sophia Doll; Anatoly Urisman; Juan A. Oses-Prieto; David Arnott; Alma Burlingame
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Genotype-phenotype correlations in pathology caused by collagen type IV alpha 1 and 2 mutations
Matrix Biology, ISSN: 15691802 0945053X
Marion Jeanne; Douglas B. Gould
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Efficacy and Safety Results From a Phase II, Placebo-Controlled Study of Onartuzumab Plus First-Line Platinum-Doublet Chemotherapy for Advanced Squamous Cell Non–Small-Cell Lung Cancer
Clinical Lung Cancer, ISSN: 19380690 15257304
Fred R. Hirsch; Ramaswamy Govindan; Zanete Zvirbule; Fadi S. Braiteh; Achim Rittmeyer; Cristóbal Belda-Iniesta; Dolores Isla; Thomas Cosgriff; Michelle Boyer; Masamichi Ueda; See Phan; David R. Gandara
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A first-in-human phase I study of the ATP-competitive AKT inhibitor Ipatasertib demonstrates Robust and safe targeting of AKT in patients with solid tumors
Cancer Discovery, ISSN: 21598290 21598274
Saura; Desamparados Roda; Susana Roselló; Oliveira; Teresa Macarulla; José Alejandro Pérez-Fidalgo; Rafael Morales-Barrera; Juan Manuel Sanchis-García; Luna Musib; Nageshwar Budha; Jin Zhu; Michelle Nannini; Wai Y. Chan; Sandra M. Sanabria-Bohorquez; Raymond D. Meng; Kui Lin; Yibing Yan; Premal Patel; Baselga; Tabernero; Andrés Cervantes
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Building proteomic tool boxes to monitor MHC class I and class II peptides
Proteomics, ISSN: 16159861 16159853
Frances-Rose Schumacher; Lélia Delamarre; Suchit Jhunjhunwala; Zora Modrusan; Qui Phung; Joshua E. Elias; Jennie R. Lill
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Preclinical efficacy of an antibody-drug conjugate targeting mesothelin correlates with quantitative89 Zr-ImmunoPET
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Anton G. T. Van Terwisscha Scheltinga; Annie Ogasawara; Glenn Pacheco; Alexander N. Vanderbilt; Jeff N. Tinianow; Nidhi Gupta; Dongwei Li; Ron Firestein; Jan Marik; Suzie J. Scales; Simon P. Williams
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IL-22R ligands IL-20, IL-22, and IL-24 promote wound healing in diabetic db/db mice
PLoS ONE, ISSN: 19326203
Ganesh Kolumam; Xiumin Wu; Wyne P. Lee; Jason A. Hackney; Jose Zavala-Solorio; Vineela D. Gandham; Dimitry Danilenko; Puneet Arora; Xiaoting Wang; Wenjun Ouyang
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Mass cytometry panel optimization through the designed distribution of signal interference
Cytometry Part A, ISSN: 15524930 15524922
Chikara Takahashi; Amelia Au-Yeung; Franklin Fuh; Teresa Ramirez-Montagut; Christopher R. Bolen; W Rodney Mathews; William E. O'Gorman
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Bruton's tyrosine kinase small molecule inhibitors induce a distinct pancreatic toxicity in rats
Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565
Rebecca Erickson; Leah Schutt; Jacqueline M. Tarrant; Michelle Mcdowell; Lichuan Liu; Adam R. Johnson; Sock-Cheng Lewin-Koh; Maj Hedehus; Ross; Richard A. D. Carano; Karin Staflin; Fiona Zhong; James J. Crawford; Shelly Zhong; Karin Reif; Arna Katewa; Harvey Wong; Wendy B. Young; Donna M. Dambach; Misner
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Assessing sex differences in the risk of cardiovascular disease and mortality per increment in systolic blood pressure: A systematic review and meta-analysis of follow-up studies in the United States
PLoS ONE, ISSN: 19326203
Yu-Chung Wei; Nysia I. George; Ching-Wei Chang; Karen A. Hicks
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A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains
Journal of Alzheimer's Disease, ISSN: 18758908 13872877
Patrick C. G. Haddick; Jessica L. Larson; Nisha Rathore; Tushar Bhangale; Qui Phung; Karpagam Srinivasan; David V. Hansen; Jennie R. Lill; Brian W. Kunkle; Jonathan L. Haines; Lindsay A. Farrer; John S.K. Kauwe; Gerard D. Schellenberg; Paul K. Crane; Alison M. Goate; Timothy W. Behrens; Ryan J. Watts; Robert R. Graham; Joshua S. Kaminker; Marcel P Van Der Brug
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Differences in health care use and costs among patients with cancer receiving intravenous chemotherapy in physician offices versus in hospital outpatient settings
Journal of Oncology Practice, ISSN: 1935469X 15547477
Maxine D. Fisher; Rajeshwari Punekar; Yeun Mi Yim; Art Small; Joseph R. Singer; Jay Schukman; Barbara L. McAneny; Rakesh Luthra; Jennifer Malin
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NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN: 15221547 01931857
Elise S. Demitrack; Gail B. Gifford; Theresa M. Keeley; Nobukatsu Horita; Andrea Todisco; Kim Turgeon; Christian W. Siebel; Linda C. Samuelson
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A protective role for interleukin-1 signaling during mouse adenovirus type 1-induced encephalitis
Journal of Virology, ISSN: 10985514 0022538X
Luiza A. Castro-Jorge; Carla D. Pretto; Asa B. Smith; Oded Foreman; Kelly E. Carnahan; Katherine R. Spindler
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Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD)
Journal of Alzheimer's Disease, ISSN: 18758908 13872877
Stephane Nave; Rachelle S. Doody; Mercè Boada; Timo Grimmer; Juha-Matti Savola; Paul Delmar; Meike Pauly-Evers; Tania Nikolcheva; Christian Czech; Edilio Borroni; Benedicte Ricci; Juergen Dukart; Marie Mannino; Tracie Carey; Emma Moran; Inma Gilaberte; Nicoletta Milani Muelhardt; Irene Gerlach; Luca Santarelli; Ostrowitzki; Fontoura; Krista Lanctôt
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Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer
Oncotarget, ISSN: 19492553
Soma Samanta; Shuzo Tamura; Louis Dubeau; Paulette Mhawech-Fauceglia; Yohei Miyagi; Hisamori Kato; Rich Lieberman; Ronald J. Buckanovich; Yvonne G. Lin; Nouri Neamati
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Integrated lead optimization: Translational models as we advance toward the clinic
AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371
Bianca M. Liederer; Xingrong Liu; Simon Wong; Daniel R Mudra
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Ubiquitin in cell-cycle regulation and dysregulation in cancer
Annual Review of Cancer Biology, ISSN: 24723428
Natalie A. Borg; Vishva M. Dixit
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Utilization of In Vitro Neurotoxicity Models in Pre-Clinical Toxicity Assessment
Stem Cells in Toxicology and Medicine,
Karin Staflin; Misner; Donna M. Dambach
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IL-13 is a therapeutic target in radiation lung injury
Scientific Reports, ISSN: 20452322
Su I. Chung; Jason A. Horton; Thirumalai R. Ramalingam; Ayla O. White; Eun Joo Chung; Kathryn E. Hudak; Bradley T. Scroggins; Joseph R. Arron; Thomas A. Wynn; Deborah E. Citrin
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Structure of crenezumab complex with aβ shows loss of β-hairpin
Scientific Reports, ISSN: 20452322
Ultsch; Bing Li; Till Maurer; Mary Mathieu; Oskar Adolfsson; Andreas Muhs; Andrea Pfeifer; Maria Pihlgren; Travis W. Bainbridge; Mike Reichelt; James A. Ernst; Eigenbrot; Fuh; Jasvinder K. Atwal; Ryan J. Watts; Weiru Wang
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Characterization of chain pairing variants of bispecific IgG Expressed in a single host cell by high-resolution native and denaturing mass spectrometry
Analytical Chemistry, ISSN: 15206882 00032700
Luis Schachner; Guanghui Han; Michael Dillon; Jianhui Zhou; Luke McCarty; Diego Ellerman; Yiyuan Yin; Christoph Spiess; Jennie R. Lill; Paul J. Carter; Wendy N. Sandoval
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Rhodium(III)-Catalyzed C-H Functionalization of 1-(2H)-Phthalazinones at C8
Journal of Organic Chemistry, ISSN: 15206904 00223263
Malcolm P. Huestis
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Transition-Metal-Free Synthesis of Tertiary Aminocyclopropanes
Organic Letters, ISSN: 15237052 15237060
Patrick Cyr; Alexandre Côté-Raiche; Sarah M. Bronner
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Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter
Oncogene, ISSN: 14765594 09509232
Xueping Qu; Thomas Sandmann; Frierson; Ling Fu; Eloisa Fuentes; Kimberly Walter; Kwame Okrah; Rumpel; Moskaluk; Shan Lu; Wang; Richard Bourgon; Elicia M. Penuel; Andrea Pirzkall; Lukas Amler; Lackner; Tabernero; Garret M. Hampton; Omar Kabbarah
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