Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5001 - 5050 OF 16091 RESULTS

Transaminase Levels and Hepatic Events During Tocilizumab Treatment: Pooled Analysis of Long-Term Clinical Trial Safety Data in Rheumatoid Arthritis
Arthritis and Rheumatology, ISSN: 23265205 23265191
Mark C. Genovese; Joel M. Kremer; Ronald Van Vollenhoven; Rieke Alten; Juan Jose Scali; Ariella Kelman; Sophie Dimonaco; Laura Brockwell
View on Scopus
Prevalence and clinical association of MET gene overexpression and amplification in patients with NSCLC: Results from the European Thoracic Oncology Platform (ETOP) Lungscape project
Lung Cancer, ISSN: 18728332 01695002
Lukas Bubendorf; Urania Dafni; Martin Schöbel; Stephen P. Finn; Verena Tischler; Aleksandra Sejda; Antonio Marchetti; Erik Thunnissen; Eric K. Verbeken; Arne Warth; Irene Sansano; Richard Cheney; Ernst Jan M. Speel; Daisuke Nonaka; Kim Monkhorst; Hager; Miguel Martorell; Spasenija Savic; Keith M. Kerr; Qiang Tan; Zoi Tsourti; Thomas R. Geiger; Roswitha Kammler; Katja Schulze; Ashis Das-Gupta; David S. Shames; Solange Peters; Rolf A Stahel
View on Scopus
Impact of rituximab on patient-reported outcomes in patients with rheumatoid arthritis from the US Corrona Registry
Clinical Rheumatology, ISSN: 14349949 07703198
Leslie R. Harrold; Ani John; Jennie Best; Steve Zlotnick; Chitra Karki; Youfu Li; Jeffrey D. Greenberg; Joel M. Kremer
View on Scopus
Response Letter
Breast Cancer Research and Treatment, ISSN: 15737217 01676806
Gail L. Phillips
View on Scopus
“Two-in-One” approach for bioassay selection for dual specificity antibodies
Journal of Immunological Methods, ISSN: 18727905 00221759
Ho Young Lee; Gabriele Schaefer; Ingrid Lesaca; Chingwei V. Lee; Wong; Guoying Jiang
View on Scopus
Strategies of Drug Transporter Quantitation by LC-MS: Importance of Peptide Selection and Digestion Efficiency
AAPS Journal, ISSN: 15507416
Buyun Chen; Liling Liu; Hoangdung Ho; Yuan Chen; Ze Yang; Xiaorong Liang; Jian Payandeh; Brian J. Dean; Cornelis E. Hop; Yuzhong Deng
View on Scopus
Development of a bioassay as a measure of drozitumab-mediated apoptosis induced by soluble Fc gamma receptors
Journal of Immunological Methods, ISSN: 18727905 00221759
Jeongsup Shim; Ally Huang; Aaron S. Miller
View on Scopus
Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Hsin-Fang Wu; Nadya Hristeva; Jae H. Chang; Xiaorong Liang; Ruina Li; Lynda A. Frassetto; Leslie Z. Benet
View on Scopus
Regional disparities in the quality of stroke care
American Journal of Emergency Medicine, ISSN: 15328171 07356757
Seth Seabury; Katalin Bognar; Yaping Xu; Caroline Huber; S. Renee Commerford; Darren Tayama
View on Scopus
A Phase I Pharmacokinetic Study of Trastuzumab Emtansine (T-DM1) in Patients with Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer and Normal or Reduced Hepatic Function
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Chunze Li; Priya Agarwal; Ekaterina Gibiansky; Jin Y. Jin; Susan Dent; Anthony Gonçalves; Ihsan Nijem; Alexander Strasak; Marie-Laurence Harle-Yge; Nataliya Chernyukhin; Patricia M. LoRusso; Sandhya Girish
View on Scopus
Emicizumab prophylaxis in hemophilia A with inhibitors
New England Journal of Medicine, ISSN: 15334406 00284793
Johannes Oldenburg; Johnny N. Mahlangu; Benjamin Kim; Christophe Schmitt; Michael U. Callaghan; Guy Young; Elena Santagostino; Rebecca Krusejarres; Claude Negrier; Craig Kessler; Nancy Valente; Elina Asikanius; Gallia Levy; Jerzy Windyga; Midori Shima
View on Scopus
In Retrospect: The inflammasome turns 15
Nature, ISSN: 14764687 00280836
Lamkanfi; Vishva M. Dixit
View on Scopus
Phase II trial of atezolizumab as first-line or subsequent therapy for patients with programmed death-ligand 1-selected advanced non-small-cell lung cancer (BIRCH)
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Solange Peters; Scott Gettinger; Melissa L. Johnson; Pasi A. Jänne; Marina C. Garassino; Daniel Christoph; Chee Keong Toh; Naiyer A. Rizvi; Jamie E. Chaft; Enric Carcereny; Jyoti D. Patel; Laura Q.M. Chow; Marianna Koczywas; Cheryl Ho; Martin Früh; Michel Van Den Heuvel; Jeffrey Rothenstein; Martin Reck; Luis Paz-Ares; Frances A. Shepherd; Takayasu Kurata; Zhengrong Li; Jiaheng Qiu; Marcin Kowanetz; Mocci; Geetha Shankar; Alan Sandler; Enriqueta Felip
View on Scopus
Changes to International Nonproprietary Names for antibody therapeutics 2017 and beyond: of mice, men and more
mAbs, ISSN: 19420870 19420862
Paul W. H. I. Parren; Paul J. Carter; Pluckthun
View on Scopus
Tuning the specificity of a Two-in-One Fab against three angiogenic antigens by fully utilizing the information of deep mutational scanning
mAbs, ISSN: 19420870 19420862
Patrick Koenig; Sarah Sanowar; Chingwei V. Lee; Fuh
View on Scopus
Injury-induced actin cytoskeleton reorganization in podocytes revealed by super-resolution microscopy
JCI insight, ISSN: 23793708
Hani Suleiman; Robyn Roth; Sanjay Jain; John E. Heuser; Andrey S. Shaw; Jeffrey H. Miner
View on Scopus
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease
Science Translational Medicine, ISSN: 19466242 19466234
Claire E. Le Pichon; William J. Meilandt; Sara L. Dominguez; Hilda Solanoy; Han Lin; Hai Ngu; Alvin Gogineni; Arundhati Sengupta Ghosh; Zhiyu Jiang; Seung-Hye Lee; Janice Maloney; Vineela D. Gandham; Christine D. Pozniak; Bei Wang; Sebum Lee; Michael Siu; Snahel Patel; Zora Modrusan; Xingrong Liu; York Rudhard; Miriam Baca; Amy Gustafson; Joshua S. Kaminker; Richard A. D. Carano; Eric J. Huang; Oded Foreman; Robby M. Weimer; Kimberly Scearce-Levie; Joe Lewcock
View on Scopus
Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates
Bioconjugate Chemistry, ISSN: 15204812 10431802
Jack D. Sadowsky; Thomas H. Pillow; Jinhua Chen; Fang Fan; Changrong He; Yanli Wang; Gang Yan; Hui Yao; Zijin Xu; Shanique Martin; Donglu Zhang; Phillip Chu; Josefa Dela Cruz Chuh; Aimee O'Donohue; Guangmin Li; Geoffrey Del Rosario; Jintang He; Luna Liu; Carl Ng; Dian Su; Gail L. Phillips; Katherine R. Kozak; Shang-Fan Yu; Keyang Xu; Douglas Leipold; John Wai
View on Scopus
The Ox40/Ox40 ligand pathway promotes pathogenic Th cell responses, plasmablast accumulation, and lupus nephritis in NZB/W F1 mice
Journal of Immunology, ISSN: 15506606 00221767
Jonathan Sitrin; Eric Suto; Arthur Wuster; Jeffrey Eastham-Anderson; Kim; Cary D. Austin; Wyne P. Lee; Timothy W. Behrens
View on Scopus
Effectiveness outcomes and health related quality of life impact of disease progression in patients with advanced nonsquamous NSCLC treated in real-world community oncology settings: Results from a prospective medical record registry study
Health and Quality of Life Outcomes, ISSN: 14777525
Mark S. Walker; Wong; Arliene Ravelo; Paul J. E. Miller; Lee S. Schwartzberg
View on Scopus
Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure
Cancer Cell, ISSN: 18783686 15356108
Gulfem D. Guler; Charles Tindell; Pitti; Catherine Wilson; Katrina Nichols; Tommy K. Cheung; Hyo-Jin Kim; Matthew Wongchenko; Yibing Yan; Benjamin Haley; Trinna L. Cuellar; Webster; Navneet Alag; Ganapati V. Hegde; Erica L. Jackson; Tracy Leah Nance; Paul Garrett Giresi; Kuan-Bei Chen; Jinfeng Liu; Suchit Jhunjhunwala; Jeffrey Settleman; Jean-Philippe Stephan; David Arnott; Marie Classon
View on Scopus
Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-Carbon Olefins via Enol Tosylation and Suzuki-Miyaura Coupling
Journal of the American Chemical Society, ISSN: 15205126 00027863
Beryl X. Li; Diane N. Le; Kyle A. Mack; Andrew McClory; Ngiap-Kie Lim; Theresa Cravillion; Scott Savage; Chong Han; David B. Collum; Haiming Zhang; Francis Gosselin
View on Scopus
Introduction of Trifluoroethylamine as Amide Isostere by C-H Functionalization of Heteroarenes
Organic Letters, ISSN: 15237052 15237060
Marie-Gabrielle Braun; Georgette M. Castanedo; Ling Qin; Patrick Salvo; Samir Z. Zard
View on Scopus
Application and methodology of the non-destructive19F time-domain NMR technique to measure the content in fluorine-containing drug products
Journal of Visualized Experiments, ISSN: 1940087X
Maria Victoria Silva Elipe; Lan Li; Karthik Nagapudi; Alan M. Kook; Carlos Cobas; Isaac Iglesias; Chen Peng
View on Scopus
Cumulative oral corticosteroid use increases risk of glucocorticoid-related adverse events in patients with newly diagnosed pemphigus
Journal of the American Academy of Dermatology, ISSN: 10976787 01909622
David Wormser; Chen; Paul Brunetta; Diana Sun; Michael S. Broder; Eunice Chang; Sheila R. Reddy
View on Scopus
SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans
Nature Medicine, ISSN: 1546170X 10788956
Emma Kaitlynn Allen; Adrienne G. Randolph; Tushar Bhangale; Pranay Dogra; Maikke B. Ohlson; Christine M. Oshansky; Anthony E. Zamora; John P. Shannon; David Finkelstein; Amy Dressen; John DeVincenzo; Miguela Caniza; Ben Youngblood; Carrie M. Rosenberger; Paul G. Thomas
View on Scopus
Overcoming disease-specific matrix effect in a clinical pharmacokinetic assay using a microfluidic immunoassay technology
Bioanalysis, ISSN: 17576199 17576180
Kathi Williams; Erickson; Saloumeh Kadkhodayan Fischer
View on Scopus
Evaluation of the toxicity of intravitreally injected PLGA microspheres and rods in monkeys and rabbits: Effects of depot size on inflammatory response
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Evan A Thackaberry; Cindy A. Farman; Fiona Zhong; Florence Lorget; Karin Staflin; Angelique Cercillieux; Paul Miller; Chris Schuetz; Debby P. Chang; Amin Famili; Daugherty; Karthikan Rajagopal; Vlad Bantseev
View on Scopus
Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL
Journal of Experimental Medicine, ISSN: 15409538 00221007
Arturo I. Machuca-Parra; Alexander A. Bigger-Allen; Angie V. Sanchez; Anissa Boutabla; Jonathan Cardona-Vélez; Dhanesh Amarnani; Magali Saint-Geniez; Christian W. Siebel; Leo A. Kim; Patricia A. D'Amore; Joseph F. Arboleda-Velasquez
View on Scopus
HELOISE: Phase IIIb randomized multicenter study comparing standard-of-care and higher-dose trastuzumab regimens combined with chemotherapy as first-line therapy in patients with human epidermal growth factor receptor 2–positive metastatic gastric or gastroesophageal junction adenocarcinoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Manish A. Shah; Rui-hua Xu; Bang; Paulo M. Hoff; Tianshu Liu; Luis A. Herráez-Baranda; Fan Xia; Amit Garg; Mona Shing; Tabernero
View on Scopus
SeqArray-a storage-efficient high-performance data format for WGS variant calls
Bioinformatics, ISSN: 14602059 13674803
Xiuwen Zheng; Stephanie M. Gogarten; Michael Lawrence; Adrienne Stilp; Matthew P. Conomos; Bruce S. Weir; Cathy C. Laurie; David Levine
View on Scopus
Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk
Nature Genetics, ISSN: 15461718 10614036
Terence D. Capellini; Hao Chen; Jiaxue Cao; Andrew C. Doxey; Ata M. Kiapour; Michael Schoor; David M. Kingsley
View on Scopus
Multiplexed ion beam imaging analysis for quantitation of protein expresssion in cancer tissue sections
Laboratory Investigation, ISSN: 15300307 00236837
Sandra Rost; Jennifer M. Giltnane; Jennifer M. Bordeaux; Chuck Hitzman; Koeppen; Scot D. Liu
View on Scopus
A phase 1, randomized, double-blind, placebo-controlled, single-ascending-dose study to investigate the safety, tolerability, and pharmacokinetics of an anti-influenza B virus monoclonal antibody, MHAB5553A, in healthy volunteers
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Jeremy Lim; Michael A. Derby; Yaping Zhang; Rong Deng; Richard Larouche; Malia Anderson; Mauricio Maia; Stephanie Carrier; Isabelle Pelletier; Johanne Girard; Priya Kulkarni; Elizabeth Newton; Jorge A. Tavel
View on Scopus
Feasibility Assessment of a MALDI FTICR Imaging Approach for the 3D Reconstruction of a Mouse Lung
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
E. Ellen Jones; Cristine Quiason; Stephanie Dale; Sheerin Shahidi-Latham
View on Scopus
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
Archives of Toxicology, ISSN: 14320738 03405761
William R. Proctor; Alison J. Foster; Jennifer Vogt; Claire Summers; Brian Middleton; Mark A. Pilling; Daniel Shienson; Monika Kijanska; Simon Ströbel; Jens M. Kelm; Paul Morgan; Simon Messner; Dominic Williams
View on Scopus
Clinical Pharmacokinetics and Pharmacodynamics of Atezolizumab in Metastatic Urothelial Carcinoma
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Mark Stroh; Helen Winter; Mathilde Marchand; Laurent Claret; Stephen M. Eppler; Jane Ruppel; Oyewale Abidoye; Siew-Leng Teng; Lin; Dayog; Rene Bruno; Jin Y. Jin; Sandhya Girish
View on Scopus
Trastuzumab uptake and its relation to efficacy in an animal model of HER2-positive breast cancer brain metastasis
Breast Cancer Research and Treatment, ISSN: 15737217 01676806
Gail L. Phillips; Merry C. Nishimura; Jennifer A. Lacap; Samir Kharbanda; Elaine Mai; Janet Y. Tien; Kim Malesky; Simon P. Williams; Jan Marik; Phillips
View on Scopus
Role of regional absorption and gastrointestinal motility on variability in oral absorption of a model drug
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Ajit S. Narang; Anand Balakrishnan; John Morrison; Jinjiang Li; Jennifer Wang; Huidong Gu; Katrina Taylor; Kenneth Santone; Jon Ehrmann; Sophie Beyer; Xujin Lu; Rod Ketner; Jennifer Pizzano; Tami Orcutt; Eric Shields; Heidi Dulac; Sharon Aborn; Margaret Batchelder; Kimberley Lentz
View on Scopus
Preparation and evaluation of L- and D-5-[18F]fluorotryptophan as PET imaging probes for indoleamine and tryptophan 2,3-dioxygenases
Nuclear Medicine and Biology, ISSN: 18729614 09698051
Tang Tang; Herman S. Gill; Annie Ogasawara; Jeff N. Tinianow; Alexander N. Vanderbilt; Simon P. Williams; Georgia Hatzivassiliou; Sharla White; Wendy N. Sandoval; Kevin Dement; Mengling Wong; Jan Marik
View on Scopus
Thaw-and-use target cells pre-labeled with calcein AM for antibody-dependent cell-mediated cytotoxicity assays
Journal of Immunological Methods, ISSN: 18727905 00221759
Shan Chung; Van Nguyen; Yuwen L. Lin; Lynn Kamen; An Song
View on Scopus
Corrigendum to “Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics” [Regul. Toxicol. Pharmacol. (2017) 221–230](S0273230017300727)(10.1016/j.yrtph.2017.03.013)
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Christina de Zafra; Vito G. Sasseville; Steven Matsumoto; Christian Freichel; Milton; Timothy K. MacLachlan; Cindy A. Farman; Iona Raymond; Swati Gupta; Ronald Newton; Elke-Astrid Atzpodien; Evan A Thackaberry
View on Scopus
Voltage-gated sodium channels viewed through a structural biology lens
Current Opinion in Structural Biology, ISSN: 1879033X 0959440X
Thomas Clairfeuille; Hui Xu; Christopher M. Koth; Jian Payandeh
View on Scopus
Inorganic and Organic Ions
Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques,
Xiaodong Liu; Christopher A. Pohl; Kelly Zhang
View on Scopus
Opportunities and challenges in phenotypic drug discovery: An industry perspective
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
John Moffat; Fabien Vincent; Jonathan A. Lee; Jörg Eder; Marco Prunotto
View on Scopus
Sustainable Practices in Medicinal Chemistry Part 2: Green by Design
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Ignacio Aliagas; Raphaëlle Berger; Kristin Goldberg; Rachel T. Nishimura; John Reilly; Paul Richardson; Daniel Richter; Edward C. Sherer; Brian A. Sparling; Marian C. Bryan
View on Scopus
Trial of tocilizumab in giant-cell arteritis
New England Journal of Medicine, ISSN: 15334406 00284793
John H. Stone; Katie Tuckwell; Sophie Dimonaco; Micki Klearman; Aringer; Daniel Blockmans; Elisabeth Brouwer; Maria C. Cid; Bhaskar Dasgupta; Juergen Rech; Carlo Salvarani; Schett; Schulze-Koops; Spiera; Sebastian Unizony; Neil Collinson
View on Scopus
Structural insights into lipoprotein N-acylation by Escherichia coli apolipoprotein N-acyltransferase
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Cameron Noland; Michele D. Kattke; Jingyu Diao; Susan L. Gloor; Homer Pantua; Mike Reichelt; Anand K. Katakam; Donghong Yan; Jing Kang; Inna Zilberleyb; Min Xu; Sharookh B. Kapadia; Jeremy Murray
View on Scopus
Identifying and mitigating batch effects in whole genome sequencing data
BMC Bioinformatics, ISSN: 14712105
Jennifer A. Tom; Jens Reeder; William F. Forrest; Robert R. Graham; Julie Hunkapiller; Timothy W. Behrens; Tushar Bhangale
View on Scopus
Inhibitory effects of trapping agents of sulfur drug reactive intermediates against major human cytochrome P450 isoforms
International Journal of Molecular Sciences, ISSN: 14220067 16616596
Jasleen K. Sodhi; Erlie Marie Delarosa; Jason S Halladay; James Driscoll; Teresa Mulder; Patrick M. Dansette; S. Cyrus Khojasteh
View on Scopus
© 2025 Genentech, Inc. All rights reserved. This site is intended for US residents only.