Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6351 - 6400 OF 15806 RESULTS

January 1, 2015

Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Melissa Junttila; Vidusha Devasthali; Jason H. Cheng; Joseph Castillo; Ciara Metcalfe; Anne C. Clermont; Doug Den Otter; Emily Chan; Hani Bou-Reslan; Tim C. Cao; William F. Forrest; Michelle Nannini; French; Richard A. D. Carano; Mark Merchant; Klaus P. Hoeflich; Mallika Singh

January 1, 2015

Clinical outcomes and medication adherence in acute coronary syndrome patients with and without type 2 diabetes mellitus: A longitudinal analysis 2006-2011

Journal of Managed Care Pharmacy, ISSN: 10834087

Mark J. Cziraky; Vanessa S. Reddy; Rakesh Luthra; Yaping Xu; Kenneth Wilhelm; Thomas P. Power; Maxine D. Fisher

January 1, 2015

HSP105 recruits protein phosphatase 2A To dephosphorylate ß-catenin

Molecular and Cellular Biology, ISSN: 10985549 02707306

Nancy Yu; Michael Kakunda; Victoria Pham; Jennie R. Lill; Pan Du; Matthew Wongchenko; Yibing Yan; Ron Firestein; Xiaodong Huang

January 1, 2015

Retinal ganglion cells thinning in eyes with nonproliferative idiopathic macular telangiectasia type 2A

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Jay Chhablani; Abhilash Goud; Ganesh Babu Jonnadulla

January 1, 2015

Neurodegeneration in type 2 diabetes: Evidence from spectral-domain optical coherence tomography

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Jay Chhablani; Apoorva Sharma; Abhilash Goud; Hari Kumar Peguda; Harsha L. Rao; Viquar Unnisa Begum; Giulio Barteselli

January 1, 2015

Strain engineering to prevent norleucine incorporation during recombinant protein production in Escherichia coli

Biotechnology Progress, ISSN: 15206033 87567938

Karthik Veeravalli; Mike Laird; Mark Fedesco; Yu Zhang; X. Christopher Yu

January 1, 2015

IL-13 mediates IL-33-dependent mast cell and type 2 innate lymphoid cell effects on bronchial epithelial cells

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Deepti R. Nagarkar; Vladimir Ramirez-Carrozzi; David F. Choy; Kevin Lee; Robert Soriano; Guiquan Jia; Abbas Alexander; Zora Modrusan; Rajita Pappu; Joseph R. Arron

January 1, 2015

Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates

Clinical Pharmacokinetics, ISSN: 11791926 03125963

Yuan Chen; Divya Samineni; Sophie Mukadam; Harvey Wong; Shen; Dan Lu; Sandhya Girish; Cornelis E. Hop; Jin Y. Jin; Chunze Li

January 1, 2015

Creating a unique, multi-stakeholder Paediatric Oncology Platform to improve drug development for children and adolescents with cancer

European Journal of Cancer, ISSN: 18790852 09598049

Gilles Vassal; Raphaël F. Rousseau; Patricia Blanc; Lucas Moreno; Gerlind Bode; Stefan Schwoch; Martin Schrappe; Jeffrey Skolnik; Bergmann; Mary Brigid Bradley-Garelik; Vaskar Saha; Andy Pearson; Heinz Zwierzina

January 1, 2015

Clinical and economic burden of commercially insured patients with acromegaly in the United States: A retrospective analysis

Journal of Managed Care Pharmacy, ISSN: 10834087

Hilary Placzek; Yaping Xu; Yunming Mu; Susan M. Begelman; Maxine D. Fisher

January 1, 2015

Excess of heme induces tissue factor-dependent activation of coagulation in mice

Haematologica, ISSN: 15928721 03906078

Erica Sparkenbaugh; Pichika Chantrathammachart; Shaobin Wang; Will Jonas; Daniel Kirchhofer; David Gailani; Andras Gruber; Raj Kasthuri; Nigel S. Key; Nigel Mackman; Rafal Pawlinski

January 1, 2015

Performance bounds for particle filters using the optimal proposal

Monthly Weather Review, ISSN: 15200493 00270644

Chris Snyder; Thomas Bengtsson; Mathias Morzfeld

January 1, 2015

Using lysine-reactive fluorescent dye for surface characterization of a mAb

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Ming Lei; Kao; Christian Schöneich

January 1, 2015

Onartuzumab with or without bevacizumab in combination with weekly paclitaxel does not prolong QTc or adversely affect other ECG parameters in patients with locally recurrent or metastatic triple-negative breast cancer

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Marie T. Borin; Meng Chen; Mocci; Igor Rubets; Jason Chittenden; Wassim Aldairy; Mark Stroh

January 1, 2015

Semiconductor-based sequencing of formalin-fixed, paraffin-embedded colorectal cancer samples

Oncologist, ISSN: 1549490X 10837159

Shidong Jia; Liangxuan Zhang; Gary J. Latham

January 1, 2015

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Sharada Labadie; Peter Dragovich; Jinhua Chen; Benjamin P. Fauber; Jason Boggs; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Qunh Ho; Kwong Wah Lai; Shuguang Ma; Shiva Malek; David Peterson; Hans E. Purkey; Kirk D. Robarge; Laurent Salphati; Steve Sideris; Ultsch; Erica Vanderporten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou

January 1, 2015

Cell-specific aptamer characterization

Aptamers Selected by Cell-SELEX for Theranostics,

Tao Chen; Cuichen Wu; Weihong Tan

January 1, 2015

Clinical impact of chemotherapy-related adverse events in patients with metastatic breast cancer in an integrated health care system

Journal of Managed Care Pharmacy, ISSN: 10834087

Nazia Rashid; Han A. Koh; Hilda C. Baca; Zhaoliang Li; Susan Malecha; Oyewale Abidoye; Anthony Masaquel

January 1, 2015

New HPLC systems and products introduced at Pittcon 2015: A brief review

LC-GC Europe, ISSN: 14716577

Michael W. Dong

January 1, 2015

miRNAs in Transitions: EMT, MET, and EndoMT

MicroRNA in Regenerative Medicine,

Sato; David S. Shames; Yoshinori Hasegawa

January 1, 2015

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Nature Genetics, ISSN: 15461718 10614036

Durinck; Eric W. Stawiski; Andrea Pavía-Jiménez; Zora Modrusan; Payal Kapur; Bijay S. Jaiswal; Na Zhang; Vanina Toffessi-Tcheuyap; Thong T Nguyen; Kanika Bajaj Pahuja; Ying-Jiun Chen; Sadia Saleem; Subhra Chaudhuri; Sherry Heldens; Marlena Jackson; Samuel Peña-Llopis; Joseph Guillory; Toy; Connie Ha; Corissa J Harris; Eboni Holloman; Haley M Hill; Stinson; Rivers; Vasantharajan Janakiraman; Weiru Wang; Lisa N Kinch; Nick V Grishin; Peter M. Haverty; Bernard Chow; Julian S Gehring; Jens Reeder; Gregoire Pau; Thomas D Wu; Vitaly Margulis; Yair Lotan; Arthur Sagalowsky; Ivan Pedrosa; Frederic J. De Sauvage; James Brugarolas; Somasekar Seshagiri

January 1, 2015

Stromal infrastructure of the lymph node and coordination of immunity

Trends in Immunology, ISSN: 14714981 14714906

Jonathan Chang; Shannon J. Turley

January 1, 2015

Single-molecule optical methods analyzing receptor tyrosine kinase activation in living cells

Receptor Tyrosine Kinases: Methods and Protocols, ISSN: 10643745

Inhee Chung; Ira Mellman

January 1, 2015

Analytical Ultracentrifugation and Its Role in Development and Research of Therapeutical Proteins

Methods in Enzymology, ISSN: 15577988 00766879

Jun Liu; Sandeep Yadav; Andya; Barthélemy Demeule; Steven J. Shire

January 1, 2015

Cytokines

Rheumatology: Sixth Edition,

John J. O'Shea; Massimo Gadina; Richard M. Siegel; Joshua Farber

January 1, 2015

Biosimilars in rheumatology

Rheumatology: Sixth Edition,

Jeffrey N. Siegel

January 1, 2015

Principles and techniques in molecular biology

Rheumatology: Sixth Edition,

Elaine F. Remmers; Michael J. Ombrello; Richard M. Siegel

January 1, 2015

Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice

Gastroenterology, ISSN: 15280012 00165085

Nikè V.J.A. Büller; Sanne L. Rosekrans; Ciara Metcalfe; Jarom Heijmans; Willemijn A. Van Dop; Evelyn Fessler; Marnix Jansen; Christina Ahn; Jacqueline L.M. Vermeulen; B. Florien Westendorp; Els C. Robanus-Maandag; G. Johan Offerhaus; Jan Paul Medema; Geert R.A.M. D'Haens; Manon E. Wildenberg; Frederic J. De Sauvage; Vanesa Muncan; Gijs R. Van Den Brink

January 1, 2015

DUBs, the regulation of cell identity and disease

Biochemical Journal, ISSN: 14708728 02646021

Johanna Heideker; Ingrid E. Wertz

January 1, 2015

The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8+ T cell responses

OncoImmunology, ISSN: 2162402X 21624011

Robert J. Johnston; Xin Yu; Jane L. Grogan

January 1, 2015

Separation science in drug development, Part 2: High‑throughput characterization

LC-GC Europe, ISSN: 14716577

Baiwei Lin; Joseph H. Pease; Michael W. Dong

January 1, 2015

TRPA1 as a drug target - Promise and challenges

Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN: 14321912 00281298

Jun Chen; David Hackos

January 1, 2015

Effects of copper on CHO cells: Cellular requirements and product quality considerations

Biotechnology Progress, ISSN: 15206033 87567938

Inn H. Yuk; Stephen Russell; Yun Tang; Wei-Ting Hsu; Brad Mauger; Rigzen P. S. Aulakh; Jun Luo; Martin Gawlitzek; John C. Joly

January 1, 2015

p21-activated kinase 2 regulates endothelial development and function through the Bmk1/Erk5 pathway

Molecular and Cellular Biology, ISSN: 10985549 02707306

Maria Radu; Karen Lyle; Klaus P. Hoeflich; Olga Villamar-Cruz; Koeppen; Jonathan Chernoff

January 1, 2015

Group I Paks as therapeutic targets in NF2-deficient meningioma

Oncotarget, ISSN: 19492553

Hoi Yee Chow; Biao Dong; Sergio G. Duron; David Campbell; Christy C. Ong; Klaus P. Hoeflich; Long-Sheng Chang; D. Bradley Welling; Zeng-Jie Yang; Jonathan Chernoff

January 1, 2015

Quorum sensing regulates the osmotic stress response in Vibrio harveyi

Journal of Bacteriology, ISSN: 10985530 00219193

Julia C. Van Kessel; Steven T. Rutherford; Jian-Ping Cong; Sofia Quinodoz; James Healy; Bonnie L. Bassler

January 1, 2015

Characterizing monoclonal antibody structure by carboxyl group footprinting

mAbs, ISSN: 19420870 19420862

Parminder Kaur; Sara Tomechko; Janna Kiselar; Wuxian Shi; Galahad Deperalta; Aaron T. Wecksler; Giridharan Gokulrangan; Victor Ling; Mark R. Chance

January 1, 2015

Separation methods and orthogonal techniques

ACS Symposium Series, ISSN: 19475918 00976156

David A. Michels; Anna Y. Ip; Thomas M. Dillon; Kurt Brorson; Scott Lute; Brittany Chavez; Ken M. Prentice; Lowell J. Brady; Karen J. Miller

December 30, 2014

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Vikas Sharma; Thomas W. Patapoff; Bruce Kabakoff; Satyan Pai; Eric Hilario; Boyan Zhang; Charlene Li; Oleg V. Borisov; Robert F. Kelley; Ilya Chorny; Joe Zhongxiang Zhou; Ken A. Dill; Trevor E. Swartz

December 30, 2014

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

T. Justin Rettenmaier; Jack D. Sadowsky; Nathan D. Thomsen; Steven C. Chen; Allison K. Doak; Michelle R. Arkin; James A. Wells

December 26, 2014

Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Giovanni Cervi; Paola Magnaghi; Daniela Asa; Nilla Avanzi; Alessandra Badari; Daniela Borghi; Michele Caruso; Alessandra Cirla; Liviana Cozzi; Eduard Felder; Arturo Galvani; Fabio Gasparri; Antonio Lomolino; Steven Magnuson; Beatrice Malgesini; Ilaria Motto; Maurizio Pasi; Simona Rizzi; Barbara Salom; Graziella Sorrentino; Sonia Troiani; Barbara Valsasina; Thomas O'Brien; Antonella Isacchi; Daniele Donati; Roberto D'Alessio

December 20, 2014

Identification of the WNT1 residues required for palmitoylation by Porcupine

FEBS Letters, ISSN: 18733468 00145793

Miranda; Lisa M. Galli; Enriquez; Linda A. Szabo; Xinxin Gao; Rami N. Hannoush; Laura W. Burrus

December 19, 2014

Depletion of the Central Metabolite NAD leads to oncosismediated cell death

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Christopher J. Del Nagro; Yang Xiao; Linda Rangell; Mike Reichelt; Thomas O'Brien

December 19, 2014

Synthesis of Akt inhibitor ipatasertib. part 1. Route scouting and early process development of a challenging cyclopentylpyrimidine intermediate

Organic Process Research and Development, ISSN: 1520586X 10836160

Jonathan W. Lane; Keith L. Spencer; Sagar R. Shakya; Nicholas C. Kallan; Peter J. Stengel; Travis Remarchuk

December 19, 2014

Synthesis of Akt inhibitor ipatasertib. part 2. Total synthesis and first kilogram scale-up

Organic Process Research and Development, ISSN: 1520586X 10836160

Travis Remarchuk; Frederic St-Jean; Diane Carrera; Scott Savage; Herbert M. Yajima; Brian Wong; Srinivasan Babu; Alan Deese; Jeffrey Stults; Michael W. Dong; David Askin; Jonathan W. Lane; Keith L. Spencer

December 18, 2014

Preclinical efficacy of MEK inhibition in NRAS-mutant AML

Blood, ISSN: 15280020 00064971

Michael R. Burgess; Eugene Hwang; Ari J. Firestone; Tannie Huang; Jin Xu; Johannes Zuber; Natacha Bohin; Tiffany Wen; Scott C. Kogan; Kevin M. Haigis; Deepak Sampath; Scott W. Lowe; Kevin Shannon; Qing Li

December 18, 2014

Preclinical efficacy of MEK inhibition in NRAS-mutant AML

Blood, ISSN: 15280020 00064971

Michael R. Burgess; Eugene Hwang; Ari J. Firestone; Tannie Huang; Jin Xu; Johannes Zuber; Natacha Bohin; Tiffany Wen; Scott Kogan; Kevin M. Haigis; Deepak Sampath; Scott W. Lowe; Kevin Shannon; Qing Li

December 16, 2014

Effect of gastric pH on erlotinib pharmacokinetics in healthy individuals: Omeprazole and ranitidine

Anti-Cancer Drugs, ISSN: 14735741 09594973

Heidemarie Kletzl; Mylene Giraudon; Patricia Sanwald Ducray; Markus Abt; Marta Hamilton; Bert L. Lum

December 15, 2014

MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Xiangnan Du; Benjamin C. Lin; Qian-Rena Wang; Hao Li; Ellen Ingalla; Janet Y. Tien; Isabelle Rooney; Avi Ashkenazi; Elicia M. Penuel; Jing Qing

December 15, 2014

A reversed sulfonamide series of selective RORc inverse agonists

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Monique B. Van Niel; Benjamin P. Fauber; Matthew W. Cartwright; Simon Gaines; Jonathan C. Killen; Olivier René; Stuart I. Ward; Gladys De Leon Boenig; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Emanuela Gancia; Arunima Ganguli; Alberto Gobbi; Julie Hawkins; Adam R. Johnson; James R. Kiefer; Hank La; Peter Lockey; Maxine Norman; Wenjun Ouyang; Ann R. Qin; Nicole Wakes; Bohdan Waszkowycz; Harvey Wong

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