Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8951 - 9000 OF 16394 RESULTS

January 1, 2012

Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials

Pancreatology, ISSN: 14243911 14243903

Rebecca J. Brais; Susan E. Davies; Maria O'Donovan; Ben W. Simpson; Natalie Cook; Darbonne; Sian Chilcott; Martijn P. Lolkema; Albrecht Neesse; Michelle Lockley; Pippa G. Corrie; Duncan I. Jodrell; Raaj K. Praseedom; Emmanuel L. Huguet; Asif Jah; Neville V. Jamieson; Frederic J. De Sauvage; David Tuveson; Nicholas R. Carroll

January 1, 2012

Dectin-1-dependent interleukin-22 contributes to early innate lung defense against aspergillus fumigatus

Infection and Immunity, ISSN: 00199567 10985522

Melissa A. Gessner; Jessica L. Werner; Lauren M. Lilly; Michael P. Nelson; Allison E. Metz; Chad W. Dunaway; Yvonne R. Chan; Wenjun Ouyang; Gordon D. Brown; Casey T. Weaver; Chad Steele

January 1, 2012

Evaluating the minimally important difference of the urticaria activity score and other measures of disease activity in patients with chronic idiopathic urticaria

Annals of Allergy, Asthma and Immunology, ISSN: 10811206 15344436

Susan D. Mathias; Ross D. Crosby; James L. Zazzali; Marcus Maurer; Sarbjit S. Saini

January 1, 2012

Treatment of HER2-positive breast cancer: Current status and future perspectives

Nature Reviews Clinical Oncology, ISSN: 17594774 17594782

Carlos L. Arteaga; Mark X. Sliwkowski; C.Kent Osborne; Edith A. Perez; Fabio Puglisi; Luca Gianni

January 1, 2012

Assessing and improving asymmetric flow field-flow fractionation of therapeutic proteins

Field-Flow Fractionation in Biopolymer Analysis,

Jun Liu; Qing Zhu; Steven J. Shire; Barthélemy Demeule

January 1, 2012

Editorial

Contemporary Clinical Trials, ISSN: 15517144 15592030

Zheng Su

January 1, 2012

Hybridization of conditional and predictive power for futility assessment in sequential clinical trials with time-to-event outcomes: A resampling approach

Contemporary Clinical Trials, ISSN: 15517144 15592030

Jing Yi; Liang Fang; Zheng Su

January 1, 2012

BEAM: A randomized phase II study evaluating the activity of bevacizumab in combination with carboplatin plus paclitaxel in patients with previously untreated advanced melanoma

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Kevin B. Kim; Jeffrey A. Sosman; John P. Fruehauf; Gerald Linette; Svetomir N. Markovic; David McDermott; Jeffrey S. Weber; Hoa Nguyen; Peter Cheverton; Daniel S. Chen; Amy Peterson; William E. Carson III; Steven J. O'Day

January 1, 2012

Thioredoxin 1 is responsible for antibody disulfide reduction in CHO cell culture

Journal of Biotechnology, ISSN: 01681656 18734863

Kristen L. Koterba; Trissa Borgschulte; Mike Laird

January 1, 2012

3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Dange V. Kumar; Roopa Rai; Ken A. Brameld; Jennifer Riggs; John R. Somoza; Ravi Rajagopalan; James W. Janc; Yu M. Xia; Tony L. Ton; Huiyong Hu; Isabelle Lehoux; Joseph D. Ho; Wendy B. Young; Barry Hart; Michael J. Green

January 1, 2012

Carbon-deuterium rotational-echo double-resonance NMR spectroscopy of lyophilized aspartame formulations

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Suman A. Luthra; Marcel Utz; Eric M. Gorman; Michael J. Pikal; Eric Munson; Joseph W. Lubach

January 1, 2012

Characterization of the isomerization products of aspartate residues at two different sites in a monoclonal antibody

Pharmaceutical Research, ISSN: 07248741 1573904X

Alavattam Sreedhara; Cordoba; Qing Zhu; Jeanne Kwong; Jun Liu

January 1, 2012

Effect of sulfobutyl ether beta-cyclodextrin modifier on selectivity of reversed phase hplc separations

Journal of Liquid Chromatography and Related Technologies, ISSN: 10826076 1520572X

Kenley K. Ngim; Qiqing Zhong; Kavita Mistry; Nik P. Chetwyn

January 1, 2012

Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice

mAbs, ISSN: 19420862 19420870

Rong Deng; Meng; Kwame Hoyte; Jeff Lutman; Yanmei Lu; Suhasini Iyer; Laura DeForge; Frank-Peter Theil; Fielder; Saileta Prabhu

January 1, 2012

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

mAbs, ISSN: 19420870 19420862

Zheng; Devin B. Tesar; Lisa Benincosa; Herbert F. Birnböck; C. Andrew Boswell; Daniela Bumbaca; Kyra J. Cowan; Dimitry Danilenko; Daugherty; Fielder; Hans Peter Grimm; Amita Joshi; Nicole Justies; Gerry Kolaitis; Nicholas Lewin-Koh; Jing Li; Sami McVay; Jennifer O'Mahony; Michael Otteneder; Michael P. Pantze; Wendy Putnam; Zhihua Julia Qiu; Jane Ruppel; Thomas Singer; Oliver B. Stauch; Frank-Peter Theil; Jennifer Visich; Yang; Yong Ying; Leslie A. Khawli; Wolfgang F. Richter

January 1, 2012

Transferrin antibodies into the brain

Neuropsychopharmacology, ISSN: 0893133X 1740634X

Dennis; Ryan J. Watts

January 1, 2012

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

Nature Cell Biology, ISSN: 14657392 14764679

Ben Chih; Peter S. Liu; Yvonne Chinn; Cecile Chalouni; László Kömüves; Hass; Wendy N. Sandoval; Andrew S. Peterson

January 1, 2012

In vitro-in vivo extrapolation of clearance: Modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Jane R. Kenny; Cornelis E. Hop; Sami Haddad

January 1, 2012

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

Science Translational Medicine, ISSN: 19466242

Zejuan Sheng; Shuo Zhang; Daisy J. Bustos; Tracy L. Kleinheinz; Claire E. Le Pichon; Sara L. Dominguez; Hilda Solanoy; Jason H. Drummond; Xiaolin Zhang; Xiao Ding; Fang Cai; Qinghua Song; Xianting Li; Zhenyu Yue; Marcel P Van Der Brug; Burdick; Janet Gunzner; Huifen Chen; Xingrong Liu; Anthony A. Estrada; Zachary K. Sweeney; Kimberly Scearce-Levie; John Moffat; Donald S. Kirkpatrick; Haitao Zhu

January 1, 2012

Targeting a cystic fibrosis mutation opens door for personalized treatment.

Managed Care, ISSN: 10623388

Thomas Morrow

January 1, 2012

Influence of the compound selection process on the performance of human clearance prediction methods

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Harvey Wong; Sock-Cheng Lewin-Koh; Frank-Peter Theil; Cornelis E. Hop

January 1, 2012

A very short history of structure-based design: How did we get here and where do we need to go?

Journal of Computer-Aided Molecular Design, ISSN: 0920654X 15734951

Jeff Blaney

January 1, 2012

Pioneers of oncology nursing.

ONS connect, ISSN: 19351623

Bertie Ford

January 1, 2012

Role of ADME Studies in Selecting Drug Candidates: Dependence of ADME Parameters on Physicochemical Properties

Encyclopedia of Drug Metabolism and Interactions,

C. E.C.A. Hop

January 1, 2012

A very short history of structure-based design: How did we get here and where do we need to go?

Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X

Jeff Blaney

January 1, 2012

Reaction Phenotyping

Encyclopedia of Drug Metabolism and Interactions,

Yuan Chen; Jialin Mao; Adrian J. Fretland

January 1, 2012

DEGAS: Sharing and tracking target compound ideas with external collaborators

Journal of Chemical Information and Modeling, ISSN: 1549960X 15499596

Man-Ling Lee; Ignacio Aliagas; Jennafer Dotson; Jianwen A. Feng; Alberto Gobbi; Timothy P. Heffron

January 1, 2012

Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

David F. Choy; Daniel K. Hsu; Dhaya Seshasayee; Maxwell A. Fung; Zora Modrusan; Flavius Martin; Fu-Tong Liu; Joseph R. Arron

January 1, 2012

Noninvasive optical sensor technology in shake flasks

BioProcess International, ISSN: 15426319

Wen-Lin Tsai; Jennifer Autsen; Julie Ma; Terry Hudson; Jun Luo

January 1, 2012

Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice

Mucosal Immunology, ISSN: 19330219 19353456

Jennifer Cox; Noelyn Kljavin; Naruhisa Ota; Leonard; Merone Roose-Girma; Laurie Diehl; Wenjun Ouyang; Nico Ghilardi

January 1, 2012

Anti-angiogenesis therapy in melanoma

Targeted Therapeutics in Melanoma,

Daniel S. Chen

January 1, 2012

Randomized and balancing allocation schemes for clinical trials: Computational perspectives on design and deployment

Designs for Clinical Trials: Perspectives on Current Issues,

Vincent J. Carey; Robert Gentleman

January 1, 2012

ggbio: an R package for extending the grammar of graphics for genomic data

Genome Biology, ISSN: 14656914

Tengfei Yin; Dianne Cook; Michael Lawrence

December 30, 2011

SpeCond: A method to detect condition-specific gene expression

Genome Biology, ISSN: 14747596 1474760X

Florence M.G. Cavalli; Richard Bourgon; Juan M. Vaquerizas; Nicholas M. Luscombe

December 23, 2011

The A-MYSM Power of Deubiquitinases

Immunity, ISSN: 10747613 10974180

Ignacio A. Demarco; Harinder Singh

December 22, 2011

Cancer immunotherapy comes of age

Nature, ISSN: 14764687 00280836

Ira Mellman; George Coukos; Glenn Dranoff

December 22, 2011

The authors reply

New England Journal of Medicine, ISSN: 00284793 15334406

Joseph R. Arron; Jonathan Corren; Matthews

December 21, 2011

Identification of surprisingly diverse type IV Pili, across a broad range of gram-positive bacteria

PLoS ONE, ISSN: 19326203

Saheed Imam; Zhongqiang Chen; David S. Roos; Mechthild Pohlschröder

December 15, 2011

Workshop summary: Novel aspects of the functions of the TRAFs and cIAPs

Advances in Experimental Medicine and Biology, ISSN: 00652598

John Silke; Domagoj Vucic

December 15, 2011

TRAF2 and cellular IAPs: A critical link in TNFR family signaling

Advances in Experimental Medicine and Biology, ISSN: 00652598

Domagoj Vucic

December 14, 2011

Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.

Science Translational Medicine, ISSN: 19466242

Ai-Luen Wu; Ganesh Kolumam; Scott Stawicki; Yongmei Chen; Jun Li; Jose Zavala-Solorio; Khanhky Phamluong; Feng; Li; Scot A. Marsters; Lance Kates; Nicholas Van Bruggen; Maya Leabman; Anne Wong; David A. West; Howard M. Stern; Luis; Hok Seon Kim; Yansura; Andrew S. Peterson; Ellen H. Filvaroff; Yan Wu; Junichiro Sonoda

December 14, 2011

Influence of 17β-estradiol on gene expression of paracoccidioides during mycelia-to-yeast transition

PLoS ONE, ISSN: 19326203

Jata Shankar; Thomas D Wu; Karl V. Clemons; Jomar P. Monteiro; Laurence F. Mirels; David A. Stevens

December 14, 2011

Metabolic disease: Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1

Science Translational Medicine, ISSN: 19466242 19466234

Ai-Luen Wu; Ganesh Kolumam; Scott Stawicki; Yongmei Chen; Jun Li; Jose Zavala-Solorio; Khanhky Phamluong; Bo Feng; Li Li; Scot A. Marsters; Lance Kates; Nicholas Van Bruggen; Maya Leabman; Anne Wong; David West; Howard M. Stern; Luis; Hok Seon Kim; Yansura; Andrew S. Peterson; Ellen H. Filvaroff; Yan Wu; Junichiro Sonoda

December 9, 2011

The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly

Cell, ISSN: 10974172 00928674

Jorge Z. Torres; Matthew K. Summers; David Peterson; Matthew J. Brauer; James Lee; Silvia Senese; Ankur A. Gholkar; Yu-Chen Lo; Xingye Lei; Kenneth Jung; David C. Anderson; David P. Davis; Lisa D. Belmont; Peter K Jackson

December 7, 2011

Process validation challenges for technology transfer

Pharmaceutical Outsourcing, ISSN: 19453337

Judy H. Chang

December 6, 2011

Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours

British Journal of Cancer, ISSN: 00070920 15321827

Pan; Xu; Peach; Huang; Branstetter; Novotny; Herbst; Gail Eckhardt; Holland

December 2, 2011

Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Yifan Mao; Yonglei Shang; Victoria Pham; James A. Ernst; Jennie R. Lill; Suzie J. Scales; Jiping Zha

December 1, 2011

Long-term safety, tolerability, and efficacy of vismodegib in two patients with metastatic basal cell carcinoma and basal cell nevus syndrome

Dermatology Reports, ISSN: 20367392 20367406

Glen J. Weiss; Raoul Tibes; Lisa Blaydorn; Gayle Jameson; Molly Downhour; Erica White; Ivor Caro; Daniel D. Von Hoff

December 1, 2011

Phase 2 trial of linifanib (ABT-869) in patients with advanced renal cell cancer after sunitinib failure

European Journal of Cancer, ISSN: 09598049 18790852

Nizar M. Tannir; Yu-Ning Wong; Christian K. Kollmannsberger; Marc S. Ernstoff; David J. Perry; Leonard J. Appleman; Edwin M. Posadas; Daniel Cho; Toni K. Choueiri; Andrew Coates; Neeraj Gupta; Rajendra Pradhan; Jiang Qian; Jihong Chen; Frank A. Scappaticci; Justin L. Ricker; Dawn M. Carlson; Dror Michaelson

December 1, 2011

Incidence of retinal pigment epithelial tears after intravitreal ranibizumab injection for neovascular age-related macular degeneration

Ophthalmology, ISSN: 01616420 15494713

Emmett T. Cunningham Jr.; Leonard Feiner; Carol Chung; Lisa Tuomi; Jason S. Ehrlich

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