Genentech: Publications

January 1, 2011

A technical feasibility study of dornase alfa delivery with eflow® vibrating membrane nebulizers: Aerosol characteristics and physicochemical stability

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Thomas M. Scherer; David E. Geller; Laura Owyang; Marcus Tservistas; Manfred Keller; Norbert Boden; Kenneth C. Kesser; Steven J. Shire

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January 1, 2011

A 2-week, polysomnographic, safety study of sodium oxybate in obstructive sleep apnea syndrome

Sleep and Breathing, ISSN: 15209512 15221709

Charles F. P. George; Neil Feldman; Yanping Zheng; Teresa L. Steininger; Susanna M. Grzeschik; Chinglin Lai; Neil Inhaber

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January 1, 2011

Costs associated with second-line therapies for lung cancer

American Journal of Pharmacy Benefits, ISSN: 19454481

Stephen Lash; April Teitelbaum; Henry J. Henk; Carolina Reyes; Lucinda Benn

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January 1, 2011

Sphingolipids and expression regulation of genes in cancer

Progress in Lipid Research, ISSN: 01637827

Gauri A. Patwardhan; Yong-Yu Liu

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January 1, 2011

Developmental immunotoxicology assessment of rituximab in cynomolgus monkeys

Toxicological Sciences, ISSN: 10960929 10966080

Anu Vaidyanathan; Kathleen McKeever; Banmeet S. Anand; Stephen M. Eppler; Gerhard F. Weinbauer; Joseph Beyer

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January 1, 2011

Estimating area under the curve and relative exposure in a pharmacokinetic study with data below quantification limit

Journal of Biopharmaceutical Statistics, ISSN: 10543406 15205711

Liang Fang; Peng Chen; Chunlei Ke; Edward Lee

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January 1, 2011

Characterization of the basic charge variants of a human IgG1: Effect of copper concentration in cell culture media

mAbs, ISSN: 19420870 19420862

Timothy Kaschak; Daniel Boyd; Franklin Lu; Gayle E. Derfus; Brian Kluck; Bartek Nogal; Craig Emery; Christie Summers; Kai Zheng; Robert Bayer; Ashraf Amanullah; Boxu Yan

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January 1, 2011

Trehalose: Current use and future applications

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Satoshi Ohtake; Y. John Wang

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January 1, 2011

A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles

Genes and Immunity, ISSN: 14664879 14765470

Budarf; Philippe Goyette; Boucher; Lian; Robert R. Graham; Claudio; Hudson; Gladman; Clarke; Janet E. Pope; Peschken; Smith; Hanly; Rich; Boire; Barr; Zummer; Fortin; Joan E. Wither; John D. Rioux

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January 1, 2011

Effect of protein and solution properties on the donnan effect during the ultrafiltration of proteins

Biotechnology Progress, ISSN: 87567938 15206033

Glen Bolton; Austin W. Boesch; Jonida Basha; Daniel P. LaCasse; Kelley; Hari Acharya

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January 1, 2011

BOLD MRI Applied to a Murine Model of Peripheral Artery Disease

Methods in Molecular Biology, ISSN: 19406029 10643745

Joan M. Greve

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January 1, 2011

The BOLD Effect

Methods in Molecular Biology, ISSN: 19406029 10643745

Joan M. Greve

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January 1, 2011

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Cancer Cell, ISSN: 18783686 15356108

Raghuveer Singh Mali; Baskar Ramdas; Peilin Ma; Jianjian Shi; Veerendra Munugalavadla; Emily Sims; Lei Wei; Sasidhar Vemula; Sarah Nabinger; Charles B. Goodwin; Rebecca J. Chan; Fabiola Traina; Valeria Visconte; Ramon V. Tiu; Timothy A. Lewis; Andrew M. Stern; Qiang Wen; John D. Crispino; H. Scott Boswell; Reuben Kapur

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January 1, 2011

Root cause investigation of rubber seal cracking in pre-filled cartridges: Ozone and packaging effects

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440

Edwin K. Chan; Aaron Hubbard; Chung C. Hsu; Lionel Vedrine; Maa

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January 1, 2011

Reprogrammed quiescent B cells provide an effective cellular therapy against chronic experimental autoimmune encephalomyelitis

European Journal of Immunology, ISSN: 15214141 00142980

Elisabeth Calderón-Gómez; Vicky Lampropoulou; Ping Shen; Patricia Neves; Toralf Roch; Ulrik Stervbo; Sascha Rutz; Anja A. Kühl; Frank L. Heppner; Christoph Loddenkemper; Stephen M. Anderton; Jean M. Kanellopoulos; Pierre Charneau; Simon Fillatreau

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January 1, 2011

New prostate cancer drug encourages development of treatment pathway

Managed Care, ISSN: 10623388

Thomas Morrow

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January 1, 2011

Symptom burden and quality of life in patients with follicular lymphoma undergoing maintenance treatment with rituximab compared with observation

Therapeutic Advances in Hematology, ISSN: 20406215 20406207

Mark S. Walker; Edward J. Stepanski; Arthur C. Houts; Carolina Reyes; Sacha Satram-Hoang; Lee S. Schwartzberg

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January 1, 2011

The postsynaptic organization of synapses

Cold Spring Harbor Perspectives in Biology, ISSN: 19430264

Morgan Sheng; Eunjoon Kim

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January 1, 2011

IL-10 Elicits IFNγ-Dependent tumor immune surveillance

Cancer Cell, ISSN: 18783686 15356108

John B. Mumm; Jan Emmerich; Xueqing Zhang; Ivan Chan; Lingling Wu; Smita Mauze; Steven Blaisdell; Beth Basham; Jie Dai; Jeff Grein; Catherine Sheppard; Kyu Hong; Collette Cutler; Scott Turner; Drake LaFace; Melanie A. Kleinschek; Michael Judo; Gulesi Ayanoglu; John Langowski; Danling Gu; Brittany Paporello; Erin Murphy; Venkataraman Sriram; Saraswathi Naravula; Bela Desai; Satya Medicherla; Wolfgang Seghezzi; Terrill McClanahan; Susan Cannon-Carlson; Amy M. Beebe; Martin Oft

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January 1, 2011

Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941

Cancer Cell, ISSN: 18783686 15356108

Teemu T. Junttila; Robert W. Akita; Kathryn Parsons; Carter Fields; Gail L. Phillips; Lori S. Friedman; Deepak Sampath; Mark X. Sliwkowski

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January 1, 2011

Requirement of nuclear factor κB for smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis

Neoplasia (United States), ISSN: 14765586 15228002

Dominic Stadel; Cristofanon; Behnaz Ahangarian Abhari; Deshayes; Zobel; Domagoj Vucic; Debatin; Fulda

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January 1, 2011

A convenient method to measure blood-plasma concentration ratio using routine plasma collection in in vivo pharmacokinetic studies

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy; Xiaolin Zhang; Jonathan Cheong

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January 1, 2011

P190A RhoGAP is required for mammary gland development

Developmental Biology, ISSN: 1095564X 00121606

Heckman-Stoddard; Vargo-Gogola; Herrick; Visbal; Lewis; Jeffrey Settleman; Rosen

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January 1, 2011

Ocrelizumab in relapsing-remitting multiple sclerosis: A phase 2, randomised, placebo-controlled, multicentre trial

The Lancet, ISSN: 1474547X 01406736

Ludwig Kappos; David Li; Peter A Calabresi; Paul O'Connor; Amit Bar-Or; Frederik Barkhof; Ming Yin; Leppert; Robert Glanzman; Jeroen Tinbergen; Stephen L. Hauser

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January 1, 2011

Shorter durations and lower doses of peginterferon alfa-2a are associated with inferior hepatitis B e antigen seroconversion rates in hepatitis B virus genotypes B or C

Hepatology, ISSN: 15273350 02709139

Liaw; Jia; Chan; Han; Tanwandee; Chuang; Tan; Chen; Edward J. Gane; Piratvisuth; Chen; Xie; Sung; Wat; Coen A. Bernaards; Cui; Marcellin

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January 1, 2011

The influence of hepatic transport on the distribution volumes and mean residence time of drug in the body and the accuracy of estimating these parameters by the traditional pharmacokinetic calculations

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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January 1, 2011

A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies

Cancer Cell, ISSN: 18783686 15356108

Gabriele Schaefer; Lauric Haber; Lisa Crocker; Steven Shia; Lily Shao; Dowbenko; Klara Totpal; Anne Wong; Chingwei V. Lee; Scott Stawicki; Robyn Clark; Carter Fields; Gail L. Phillips; Prell; Dimitry Danilenko; Yvonne Franke; Jean-Philippe Stephan; Jiyoung Hwang; Yan Wu; Jenny Bostrom; Mark X. Sliwkowski; Fuh; Eigenbrot

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January 1, 2011

DATforDCEMRI: An R package for deconvolution analysis and visualization of DCE-MRI data

Journal of Statistical Software, ISSN: 15487660

Gregory Z. Ferl

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January 1, 2011

Overview of SLC22A and SLCO families of drug uptake transporters in the context of cancer treatments

Current Drug Metabolism, ISSN: 18755453 13892002

Murray J. Cutler; Edna F. Choo

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January 1, 2011

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

Neoplasia (United States), ISSN: 14765586 15228002

Bram Laukens; Claudia Jennewein; Barbara Schenk; Nele Vanlangenakker; Alexander Schier; Cristofanon; Zobel; Deshayes; Domagoj Vucic; Irmela Jeremias; Mathieu J.M. Bertrand; Vandenabeele; Fulda

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January 1, 2011

Development of the Asthma Control Composite outcome measure to predict omalizumab response

Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206

Harris; Dennis A. Wong; Amy V. Kapp

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January 1, 2011

A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Sarbjit S. Saini; Karin Rosén; Hsin-Ju Hsieh; Dennis A. Wong; Edward Conner; Allen P. Kaplan; Sheldon Spector; Marcus Maurer

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January 1, 2011

Neuregulin-1-Mediated Autocrine Signaling Underlies Sensitivity to HER2 Kinase Inhibitors in a Subset of Human Cancers

Cancer Cell, ISSN: 18783686 15356108

Wilson; Diana Y. Lee; Berry; David S. Shames; Jeffrey Settleman

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January 1, 2011

A new roadmap for biopharmaceutical drug product development: Integrating development, validation, and quality by design

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Sheryl Martin-Moe; Fred Lim; Wong; Alavattam Sreedhara; Jagannathan Sundaram; Samir Sane

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January 1, 2011

Analysis of 2,2'-Azobis (2-amidinopropane) dihydrochloride degradation and hydrolysis in aqueous solutions

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Jay Werber; Y. John Wang; Michael Milligan; Xiaohua Li; Junyan A. Ji

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January 1, 2011

Solubilities and transfer free energies of hydrophobic amino acids in polyol solutions: Importance of the hydrophobicity of polyols

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Shermeen A. Abbas; Vikas Sharma; Thomas W. Patapoff; Devendra S. Kalonia

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January 1, 2011

Phase 2 trial of linifanib (ABT-869) in patients with advanced non-small cell lung cancer

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Eng-Huat Tan; Glenwood D. Goss; Ravi Salgia; Benjamin Besse; David R. Gandara; Nasser H. Hanna; James Chih-Hsin Yang; Raymond Thertulien; Michael Wertheim; Julien Mazieres; Thomas Hensing; Christa Lee; Neeraj Gupta; Rajendra Pradhan; Jiang Qian; Qin Qin; Frank A. Scappaticci; Justin L. Ricker; Dawn M. Carlson; Ross A. Soo

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January 1, 2011

Economic burden of impairment in children with severe or difficult-to-treat asthma

Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206

Stanley J. Szefler; Robert S. Zeiger; Tmirah Haselkorn; David R. Mink; Tripthi V. Kamath; James E. Fish; Bradley E. Chipps

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January 1, 2011

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4

mAbs, ISSN: 19420870 19420862

Daniela Bumbaca; Anne Wong; Elizabeth Drake; Arthur Reyes; Benjamin C. Lin; Jean-Philippe Stephan; Luc Desnoyers; Shen; Dennis

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January 1, 2011

Identification of amino acid residues responsible for the release of free drug from an antibody-drug conjugate utilizing lysine-succinimidyl ester chemistry

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Hung-Wei Chih; Benson Gikanga; Yi Yang; Boyan Zhang

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January 1, 2011

Mechanisms and molecules of neuronal wiring: A primer

Cold Spring Harbor Perspectives in Biology, ISSN: 19430264

Alex L. Kolodkin; Marc Tessier-Lavigne

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January 1, 2011

Using molecular simulations to probe pharmaceutical materials

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yong Cui

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January 1, 2011

New imaging paradigms in drug development: The PET imaging approach

Drug Discovery Today: Technologies, ISSN: 17406749

Jan Marik; Sandra M. Sanabria-Bohorquez; Simon P. Williams; Nicholas Van Bruggen

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January 1, 2011

P21-activated kinase 1: PAK'ed with potential

Oncotarget, ISSN: 19492553

Christy C. Ong; Adrian M. Jubb; Wei Zhou; Matthias Peter; Adrian L. Harris; Marcia Belvin; Lori S. Friedman; Koeppen; Klaus P. Hoeflich

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January 1, 2011

On the accuracy of estimation of basic pharmacokinetic parameters by the traditional noncompartmental equations and the prediction of the steady-state volume of distribution in obese patients based upon data derived from normal subjects

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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January 1, 2011

Perspective of clinical research in follicular NHL: Interaction between science and industry

Best Practice and Research: Clinical Haematology, ISSN: 15321924 15216926

Gregg D. Fine; Sandra J. Horning

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January 1, 2011

Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): A double-blind, placebo-controlled, phase 3 trial

The Lancet, ISSN: 1474547X 01406736

Roy S. Herbst; Rafat Ansari; Frederique Bustin; Patrick J. Flynn; Lowell Hart; Gregory A Otterson; Gordana Vlahovic; Chang-Heok Soh; Paula O'Connor; John Hainsworth

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January 1, 2011

Introduction to current and future protein therapeutics: A protein engineering perspective

Experimental Cell Research, ISSN: 10902422 00144827

Paul J. Carter

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January 1, 2011

Omalizumab in severe allergic asthma inadequately controlled with standard therapy: A randomized trial

Annals of Internal Medicine, ISSN: 15393704 00034819

Nicola A. Hanania; Oral Alpan; Daniel L. Hamilos; John Condemi; Reyes-Rivera; Jin Zhu; Karin Rosén; Mark D. Eisner; Dennis A. Wong; William W. Busse

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January 1, 2011

Fatty acid and water-soluble polymer-based controlled release drug delivery system

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Divyakant Desai; Sanjeev Kothari; Wei Chen; Jennifer Wang; Ming Huang; Laxmikant Sharma

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