Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 11801 - 11850 OF 16394 RESULTS

March 1, 2004

Association between HER-2/neu and Vascular Endothelial Growth Factor Expression Predicts Clinical Outcome in Primary Breast Cancer Patients

Clinical Cancer Research, ISSN: 10780432

Gottfried E. Konecny; Meng; Untch; Wang; Ingo Bauerfeind; Melinda Epstein; Petra Stieber; Jean-Michel Vernes; Johnny Gutierrez; Kyu Hong; Malgorzata Beryt; Hermann Hepp; Dennis J. Slamon; Pegram

March 1, 2004

Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies

Drug Development Research, ISSN: 02724391

Reed J. Harris; Reven J. Shire; Charles Winter

March 1, 2004

Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice

Journal of Immunology, ISSN: 00221767

Nico Ghilardi; Noelyn Kljavin; Qi Chen; Sophie Lucas; Austin L. Gurney; Frederic J. De Sauvage

March 1, 2004

Computational and experimental studies on Human Misshapen/NIK-related kinase MINK-1

Current Medicinal Chemistry, ISSN: 09298673

Kunbin Qu; Yanmei Lu; Nan Lin; Rajinder Singh; Xiang Xu; Donald G. Payan; Dong Xu

March 1, 2004

Gata2 specifies serotonergic neurons downstream of sonic hedgehog

Development (Cambridge), ISSN: 09501991

Sarah E. Craven; Kim-Chew Lim; Weilan Ye; James Douglas Engel; Frederic J. De Sauvage; Arnon Rosental

March 1, 2004

Dynamic Expression of Lef/Tcf Family Members and β-Catenin during Chick Gastrulation, Neurulation, and Early Limb Development

Developmental Dynamics, ISSN: 10588388

Maike Schmidt; Margaret Patterson; Elizabeth Farrell; Andrea Münsterberg

February 27, 2004

Definition of the Consensus Motif Recognized by γ-Adaptin Ear Domains

Journal of Biological Chemistry, ISSN: 00219258

Rafael Mattera; Brigitte Ritter; Sachdev S. Sidhu; Peter S. McPherson; Juan S. Bonifacino

February 27, 2004

Human De-Etiolated-Regulates c-Jun by Assembling a CUL4A Ubiquitin Ligase

Science, ISSN: 00368075

Ingrid E. Wertz; Karen M. O'Rourke; Zemin Zhang; David Dornan; David Arnott; Raymond J. Deshaies; Vishva M. Dixit

February 26, 2004

Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor

Oncogene, ISSN: 09509232

Alyssa M. Morimoto; Nguyen Tan; Kristina West; McArthur; Guy C. Toner; William C. Manning; Beverly D. Smolich; Julie M. Cherrington

February 24, 2004

Recurrent events analysis in the presence of time-dependent covariates and dependent censoring

Journal of the Royal Statistical Society. Series B: Statistical Methodology, ISSN: 13697412

Maja Miloslavsky; Sündüz Keleş; Mark J. van der Laan; Butler

February 20, 2004

Tumor Necrosis Factor: An Apoptosis JuNKie?

Cell, ISSN: 00928674

Eugene Varfolomeev; Avi Ashkenazi

February 20, 2004

Engineered Human IgG Antibodies with Longer Serum Half-lives in Primates

Journal of Biological Chemistry, ISSN: 00219258

Paul R. Hinton; Mary G. Johlfs; Joanna M. Xiong; Kelly Hanestad; Kelly C. Ong; Chuck Bullock; Steve Keller; Meina Tao Tang; J. Yun Tso; Max Vásquez; Naoya Tsurushita

February 15, 2004

Combining Liquid Chromatography with MALDI Mass Spectrometry Using a Heated Droplet Interface

Analytical Chemistry, ISSN: 00032700

Boyan Zhang; Chris McDonald; Liang Li

February 10, 2004

Similar Molecular Interactions of Factor VII and Factor VIIa with the Tissue Factor Region that Allosterically Regulates Enzyme Activity

Biochemistry, ISSN: 00062960

Robert F. Kelley; Yang; Eigenbrot; Paul Moran; Peek; Michael T. Lipari; Daniel Kirchhofer

February 9, 2004

Vancomycin disulfide derivatives as antibacterial agents

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

YongQi Mu; Matthew B. Nodwell; John Pace; Jeng-Pyng Shaw; J. Kevin Judice

February 1, 2004

Endocytosed Cation-Independent Mannose 6-Phosphate Receptor Traffics via the Endocytic Recycling Compartment en Route to the trans-Golgi Network and a Subpopulation of Late Endosomes

Molecular Biology of the Cell, ISSN: 10591524

Sharron X. Lin; William Mallet; Amy Y. Huang; Frederick R. Maxfield

February 1, 2004

EphB2 as a Therapeutic Antibody Drug Target for the Treatment of Colorectal Cancer

Cancer Research, ISSN: 00085472

Mao; Luis; Ross; Johnny Silva; Christine Tan; Crowley; Clarissa Chui; Gretchen Franz; Peter Senter; Koeppen; Paul G. Polakis

February 1, 2004

Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency

Molecular and Cellular Biology, ISSN: 02707306

Kim Newton; French; Minhong Yan; Gretchen D. Frantz; Vishva M. Dixit

February 1, 2004

Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice

International Immunology, ISSN: 09538178

Conchi Mora; Iqbal S. Grewal; F. Susan Wong; Richard A. Flavell

February 1, 2004

APRIL-Deficient Mice Have Normal Immune System Development

Molecular and Cellular Biology, ISSN: 02707306

Eugene Varfolomeev; Frank C. Kischkel; Flavius Martin; Dhaya Seshasayee; Hua Wang; David Lawrence; Christine Olsson; Lucrece Tom; Sharon Erickson; French; Peter Schow; Iqbal S. Grewal; Avi Ashkenazi

February 1, 2004

Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4

Molecular and Cellular Biology, ISSN: 02707306

Kim Newton; Xiaoqing Sun; Vishva M. Dixit

January 30, 2004

PEST Domain-Enriched Tyrosine Phosphatase (PEP) Regulation of Effector/Memory T Cells

Science, ISSN: 00368075

Kiminori Hasegawa; Flavius Martin; Guangming Huang; Daniel B. Tumas; Laurie Diehl; Andrew A. Chan

January 29, 2004

Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion

Oncogene, ISSN: 09509232

Beatrix Schäfer; Andreas Gschwind; Axel Ullrich

January 26, 2004

Quinine/Quinidine-Induced Thrombocytopenia: A Great Imitator

Archives of Internal Medicine, ISSN: 00039926

Josina C. Reddy; Shuman; Richard H. Aster

January 23, 2004

Factorial screening of antibody purification processes using three chromatography steps without protein A

Journal of Chromatography A, ISSN: 00219673

Deborah K. Follman; Fahrner

January 22, 2004

Recordings from Single Neocortical Nerve Terminals Reveal a Nonselective Cation Channel Activated by Decreases in Extracellular Calcium

Neuron, ISSN: 08966273

Stephen M. Smith; Jeremy B. Bergsman; Nobutoshi C. Harata; Richard H. Scheller; Richard W. Tsien

January 15, 2004

Alteplase for Treatment of Occluded Peripherally Inserted Central Catheters: Safety and Efficacy in 240 Patients

Journal of Vascular and Interventional Radiology, ISSN: 10510443

Rita Ng; Xin Li; Tri Tu; Charles P. Semba

January 9, 2004

Rip2 Participates in Bcl10 Signaling and T-cell Receptor-mediated NF-κB Activation

Journal of Biological Chemistry, ISSN: 00219258

Astrid A. Ruefli-Brasse; Wyne P. Lee; Stephen D. Hurst; Vishva M. Dixit

January 8, 2004

Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

Nature, ISSN: 00280836

Honglin Zhou; Ingrid E. Wertz; Karen M. O'Rourke; Ultsch; Somasekar Seshagiri; Mike Eby; Wei Xiao; Vishva M. Dixit

January 2, 2004

Structure-activity relationships by mass spectrometry: Identification of novel MMP-3 inhibitors

Bioorganic and Medicinal Chemistry, ISSN: 09680896

Denise A. Ockey; Jennafer Dotson; Martin Struble; Stults; James H. Bourell; Clark; Thomas Gadek

January 1, 2004

Quantification of bone lesions in rheumatoid arthritis by MRI multispectral tissue class transition analysis

Seminars in Musculoskeletal Radiology, ISSN: 1098898X 10897860

Richard A. D. Carano; John A. Lynch

January 1, 2004

Effect of cardiac dysfunction of treatment outcomes in women receiving trastuzumab for HER2-overexpressing metastatic breast cancer

Clinical Breast Cancer, ISSN: 15268209

Debasish Tripathy; Andrew Seidman; Deborah Keefe; Clifford Hudis; Virginia Paton; Lieberman

January 1, 2004

Quality assurance practices for pharmaceutical industry-based drug information departments: A review and case study

Drug Information Journal, ISSN: 00928615

Stacey M. Fung; Joyce Serrano Martin

January 1, 2004

Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis

Cancer Cell, ISSN: 15356108

Nan Tang; Lianchun Wang; Jeffrey Esko; Frank J. Giordano; Yan Huang; Hans-Peter Gerber; Napoleone Ferrara; Randall S. Johnson

January 1, 2004

Quantitative structure-pharmacokinetic parameters relationships (QSPKR) analysis of antimicrobial agents in humans using simulated annealing k-nearest-neighbor and partial least-square analysis methods

Journal of Pharmaceutical Sciences, ISSN: 00223549

Chee Ng; Yun-De Xiao; Wendy Putnam; Bert L. Lum; Alexander Tropsha

January 1, 2004

Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal

Cytotherapy, ISSN: 14653249

Judy C. Young; Wu; Hansteen; Du; Sambucetti; Remiszewski; O'Farrell; Hill; Lavau; Lesley J. Murray

January 1, 2004

Inhibitors of tissue factor•factor VIIa for anticoagulant therapy

Current Medicinal Chemistry, ISSN: 09298673

Lazarus; Alan G. Olivero; Eigenbrot; Daniel Kirchhofer

January 1, 2004

Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesis

Annals of Allergy, Asthma and Immunology, ISSN: 10811206

Jonathan Corren; David Diaz-Sanchez; Andrew Saxon; Yamo Deniz; Reimann; Sinclair; Teresa Davancaze; Daniel C. Adelman

January 1, 2004

WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair

American Journal of Pathology, ISSN: 00029440

French; Raji J. Kaul; Aloma L. D'Souza; Crowley; Bao; Gretchen D. Frantz; Ellen H. Filvaroff; Luc Desnoyers

January 1, 2004

Bioprocess equipment: Characterization of energy dissipation rate and its potential to damage cells

Biotechnology Progress, ISSN: 87567938

Mike Mollet; Ningning Ma; Yang Zhao; Robert Brodkey; Ron Taticek; Jeffrey J. Chalmers

January 1, 2004

Structure-based models of cadherin-mediated cell adhesion: The evolution continues

Cellular and Molecular Life Sciences, ISSN: 1420682X

Alexander W. Koch; Manzur; Shan

January 1, 2004

Targeting death receptors in cancer with Apo2L/TRAIL

Current Opinion in Pharmacology, ISSN: 14714892

Kelley; Avi Ashkenazi

January 1, 2004

Neonatal hypoglycemia in a growth hormone registry: Incidence and pathogenesis

Journal of Pediatric Endocrinology and Metabolism, ISSN: 0334018X

Jennifer J. Bell; Gilbert P. August; Sandra L. Blethen; Joyce Baptista

January 1, 2004

The Sema domain of Met is necessary for receptor dimerization and activation

Cancer Cell, ISSN: 15356108

Monica Kong-Beltran; Jennifer Stamos; Dineli Wickramasinghe

January 1, 2004

Phage display-derived ligands provide structural insight into insulin-like growth factor I function

Spectroscopy, ISSN: 07124813

Nicholas J. Skelton; Schaffer; Deshayes; Tamas Blandl; Steven T. Runyon; Nakamura; Sachdev S. Sidhu

January 1, 2004

Thrombolysis for lower extremity deep venous thrombosis

Techniques in Vascular and Interventional Radiology, ISSN: 10892516

Charles P. Semba; Mahmood K Razavi; Stephen T. Kee; Daniel Y. Sze; Michael D. Dake

January 1, 2004

Challenges in the development of high protein concentration formulations

Journal of Pharmaceutical Sciences, ISSN: 00223549

Steven J. Shire; Shahrokh; Jun Liu

January 1, 2004

Benzyl alcohol-induced destabilization of interferon-γ: A study by hydrogen-deuterium isotope exchange

Journal of Pharmaceutical Sciences, ISSN: 00223549

Scott A. Tobler; Bryan W. Holmes; Cromwell; Erik J. Fernandez

January 1, 2004

Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products

Journal of Immunological Methods, ISSN: 00221759

Mire-Sluis; Yu Chen Barrett; Viswanath Devanarayan; Koren; Hank Liu; Mauricio Maia; Thomas Parish; George Scott; Gopi Shankar; Elizabeth Shores; Steven J. Swanson; Gary Taniguchi; Daniel Wierda; Linda A. Zuckerman

January 1, 2004

EG-VEGF: A novel mediator of endocrine-specific angiogenesis, endothelial phenotype, and function

Annals of the New York Academy of Sciences, ISSN: 00778923

Jennifer Lecouter; Rui Lin; Napoleone Ferrara

Join Our Team

The little things we do every day add up to big breakthroughs. Making a difference in the lives of millions starts when you make a change in yours.

Two Scientists Walk Into a Bar

Two Scientists Walk Into a Bar

Listen to our podcast, where researchers talk about their work answering the toughest questions in human biology.