Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 15151 - 15200 OF 16396 RESULTS

September 9, 1991

Isolation and characterization of a succinimide variant of methionyl human growth hormone

Journal of Biological Chemistry, ISSN: 00219258

Glen Teshima; Stults; Victor Ling; Eleanor Canova-Davis

September 6, 1991

Mutational analysis and protein engineering of receptor-binding determinants in human placental lactogen

Journal of Biological Chemistry, ISSN: 00219258

Henry B. Lowman; Cunningham; James A. Wells

September 6, 1991

Effects of MGSA/GROα on melanocyte transformation

Oncogene, ISSN: 09509232

Balentien; Mufson; Shattuck; Rik Derynck; Richmond

September 5, 1991

X-ray structure of human relaxin at 1·5 Å. Comparison to insulin and implications for receptor binding determinants

Journal of Molecular Biology, ISSN: 00222836

Eigenbrot; Michael Randal; Quan; Burnier; O'Connell; Rinderknecht; Anthony A. Kossiakoff

September 4, 1991

Autoradiographic localization of relaxin binding sites in rat brain

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Phyllis L. Osheroff; Phillips

August 20, 1991

Distinguishing mammalian sialidases by inhibition kinetics with novel derivatives of 5-acetamido-2,6-anhydro-3,5-dideoxy-d-glycero-d-galacto-non-2-enonic acid, an unsaturated derivative of N-acetylneuraminic acid

Carbohydrate Research, ISSN: 00086215

Warner; Louie; Michel Potier; Anthony Ribeiro

August 16, 1991

Structure-activity relationship study of human interleukin-3. Identification of residues required for biological activity by site-directed mutagenesis

Journal of Biological Chemistry, ISSN: 00219258

Lokker; N. Rao Movva; Ulrike Strittmatter; Barbara Fagg; Gerhard Zenke

August 1, 1991

Self-Association of Human and Porcine Relaxin As Assessed by Analytical Ultracentrifugation and Circular Dichroism

Biochemistry, ISSN: 15204995 00062960

Steven J. Shire; Leslie A. Holladay; Rinderknecht

July 31, 1991

Crystallization and preliminary X-ray diffraction studies of recombinant rabbit interferon-gamma

Biochemical and Biophysical Research Communications, ISSN: 10902104 0006291X

Cleopas T. Samudzi; Cynthia L. Gribskov; Louis E. Burton; Rubin

July 22, 1991

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

Journal of Biological Chemistry, ISSN: 00219258

Gibbs; Zoller

July 19, 1991

Increase in nerve growth factor-like immunoreactivity and decrease in choline acetyltransferase following contusive spinal cord injury

Brain Research, ISSN: 00068993

Bakhit; Armanini; Wai Lee T. Wong; Bennett; Jean R. Wrathall

July 12, 1991

Entorhinal cortex lesion or intrahippocampal colchicine injection increases peripheral type benzodiazepine binding sites in rat hippocampus

Brain Research, ISSN: 00068993

Michel Baudry; Anthony Altar

July 11, 1991

Self-association of tissue factor as revealed by chemical cross-linking

Journal of Biological Chemistry, ISSN: 00219258

Roy; Lisa R. Paborsky; Gordon A. Vehar

July 11, 1991

High resolution analysis of functional determinants on human tissue-type plasminogen activator

Journal of Biological Chemistry, ISSN: 00219258

William F. Bennett; Nicholas F. Paoni; Keyt; David Botstein; Andrew J.S. Jones; Presta; Florian M. Wurm; Zoller

July 5, 1991

Proteinases of the mammary gland: Developmental regulation in vivo and vectorial secretion in culture

Development (Cambridge), ISSN: 09501991

Rabih S. Talhouk; Jennie R. Chin; Elaine N. Unemori; Zena Werb; Mina J. Bissell

July 1, 1991

Synthesis of a Tetramethyl Analogue of Teleocidin

Journal of Organic Chemistry, ISSN: 15206904 00223263

Robert R. Webb II; Michael C. Venuti; Eigenbrot

June 1, 1991

Probing the Mechanism and Improving the Rate of Substrate-Assisted Catalysis in Subtilisin BPN′

Biochemistry, ISSN: 15204995 00062960

Paul J. Carter; Lars Abrahmsén; James A. Wells

June 1, 1991

Identification of Electrostatic Interactions That Determine the Phosphorylation Site Specificity of the cAMP-Dependent Protein Kinase

Biochemistry, ISSN: 15204995 00062960

Gibbs; Zoller

June 1, 1991

Use of Recombinant DNA Derived Human Relaxin To Probe the Structure of the Native Protein

Biochemistry, ISSN: 15204995 00062960

Eleanor Canova-Davis; T. Jeremy Kessler; Paul-Jane Lee; David T.W. Fei; Patrick Griffin; Stults; John D. Wade; Rinderknecht

June 1, 1991

MHC class II-associated variation in the production of tumor necrosis factor in mice and humans: Relevance to the pathogenesis of autoimmune diseases

Immunologic Research, ISSN: 0257277X 15590755

Chaim O. Jacob; Gail D. Lewis; Hugh O. McDevitt

May 15, 1991

An SfiI restriction map of the Bacillus subtilis 168 genome

Gene, ISSN: 03781119

Amjad; Castro; Sandoval; Wu; Yang; Henner; Piggot

May 6, 1991

Both D factor/LIF and IL-6 inhibit the differentation of mouse teratocarcinoma F9 cells

FEBS Letters, ISSN: 00145793

Kazunori Hirayoshi; Akio Tsuru; Michiaki Yamashita; Tomida; Yuri Yamamoto-Yamaguchi; Kiyoshi Yasukawa; Hozumi; David V. Goeddel; Kazuhiro Nagata

May 1, 1991

Monoclonal antibody therapy of human cancer: Taking the HER2 protooncogene to the clinic

Journal of Clinical Immunology, ISSN: 15732592 02719142

Shepard; Gail D. Lewis; Jay Sarup; Brian M. Fendly; Daniel A. Maneval; Joyce Mordenti; Figari; Claire Kotts; Michael A. Palladino; Axel Ullrich; Dennis J. Slamon

May 1, 1991

Effect of recombinant inhibin on gonadotropin secretion during proestrus and estrus in the rat

Endocrinology, ISSN: 19457170 00137227

Catherine Rivier; Ralph H. Schwall; Anthony J. Mason; Louis E. Burton; Wylie Vale

May 1, 1991

Further characterization of insulin-like-growth factor binding proteins in rat osteoblast-like cell cultures: Modulation by 17β-estradiol and human growth hormone

Endocrinology, ISSN: 19457170 00137227

Theresa L. Chen; Frances Liu; Rebecca L. Bates; Hintz

May 1, 1991

Apolipoprotein(a): Expression and Characterization of a Recombinant Form of the Protein in Mammalian Cells

Biochemistry, ISSN: 15204995 00062960

Marlys L. Koschinsky; James E. Tomlinson; Zioncheck; Karen Schwartz; Dan L. Eaton; Lawn

April 17, 1991

Manganese-stimulated phosphorylation of a rat pancreatic protein: identity with elongation factor 2

Biochimica et Biophysica Acta - Molecular Cell Research, ISSN: 01674889

Simon A.B. Knight; William J. Kohr; Murray Korc

April 1, 1991

Engineering Subtilisin and Its Substrates for Efficient Ligation of Peptide Bonds in Aqueous Solution

Biochemistry, ISSN: 15204995 00062960

Lars Abrahms; Jeffrey Tom; Burnier; Karen A. Butcher; Anthony A. Kossiakoff; James A. Wells

April 1, 1991

Conformationally Restricted Arginine Analogues

Journal of Organic Chemistry, ISSN: 15206904 00223263

Thomas R. Webb; Eigenbrot

April 1, 1991

Deamidation of Soluble CD4 at Asparagine-52 Results in Reduced Binding Capacity for the HIV-1 Envelope Glycoprotein gpl20

Biochemistry, ISSN: 15204995 00062960

Glen Teshima; James P. Porter; Yim; Victor Ling; Andrew W. Guzzetta

March 1, 1991

Tissue Plasminogen Activator Has an O-Linked Fucose Attached to Threonine-61 in the Epidermal Growth Factor Domain

Biochemistry, ISSN: 15204995 00062960

Reed J. Harris; Leonard; Andrew W. Guzzetta; Spellman

March 1, 1991

Carbohydrate Structures of Recombinant Soluble Human CD4 Expressed in Chinese Hamster Ovary Cells

Biochemistry, ISSN: 15204995 00062960

Spellman; Leonard; Basa; Ivana Gelineo; Van Halbeek

February 19, 1991

Glycophospholipid membrane anchor attachment. Molecular analysis of the cleavage/attachment site

Journal of Biological Chemistry, ISSN: 00219258

Paul Moran; Helga Raab; William J. Kohr; Caras

February 8, 1991

Receptor-mediated transport of human recombinant nerve growth factor from olfactory bulb to forebrain cholinergic nuclei

Brain Research, ISSN: 00068993

C.Anthony Altar; Bakhit

February 1, 1991

Lectin cell adhesion molecules (LEC‐CAMs): A new family of cell adhesion proteins involved with inflammation

Journal of Cellular Biochemistry, ISSN: 10974644 07302312

Lasky

February 1, 1991

Neutron Structure of Subtilisin BPN′: Effects of Chemical Environment on Hydrogen-Bonding Geometries and the Pattern of Hydrogen-Deuterium Exchange in Secondary Structure Elements

Biochemistry, ISSN: 15204995 00062960

Ultsch; Steven White; Anthony A. Kossiakoff; Charles Eigenbrot

February 1, 1991

Construction, Expression, and Purification of Recombinant Kringle 1 of Human Plasminogen and Analysis of Its Interaction with ω-Amino Acids

Biochemistry, ISSN: 15204995 00062960

Nick Menhart; Louis C. Sehl; Francis J. Castellino; Robert F. Kelley

January 17, 1991

Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Paul G. Polakis; Bonnee Rubinfeld; Tony Evans; Frank McCormick

January 17, 1991

Recombinant human nerve growth factor is biologically active and labels novel high-affinity binding sites in rat brain

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

C.Anthony Altar; Louis E. Burton; Bennett; Dugich-Djordjevic

January 17, 1991

Membrane-binding domain of the small G protein G25K contains an S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl terminus

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Yamane; Christopher C. Farnsworth; Hongying Xie; Tony Evans; William N. Howald; Michael H. Gelb; John A. Glomset; Steven Clarke; Bernard K.-K. Fung

January 1, 1991

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

Neuron, ISSN: 08966273

Lucy R. Berkemeier; Winslow; David R. Kaplan; Nikolics; David V. Goeddel; Rosenthal

January 1, 1991

Mutant α subunits of Gi2 inhibit cyclic AMP accumulation

Nature, ISSN: 00280836

Yung H. Wong; Alex Federman; Ann M. Pace; Ian Zachary; Tony Evans; Jacques Pouysségur; Henry R. Bourne

January 1, 1991

Murine tumor cells transduced with the gene for tumor necrosis factor-α: Evidence for paracrine immune effects of tumor necrosis factor against tumors

Journal of Immunology, ISSN: 00221767

Asher; James J. Mulé; Attan Kasid; Restifo; Salo; Reichert; Jaffe; Brian M. Fendly; Kriegler; Steven A. Rosenberg

January 1, 1991

Transforming growth factor β1 (TGF-β1) induced neutrophil recruitment to synovial tissues: Implications for TGF-β-driven synovial inflammation and hyperplasia

Journal of Experimental Medicine, ISSN: 00221007

Roy A. Fava; Nancy J. Olsen; Arnold E. Postlethwaite; Kenneth N. Broadley; Jeffery M. Davidson; Lillian B. Nanney; Catherine Lucas; Townes

January 1, 1991

Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Lewis; Louis A. Tartaglia; Angela Lee; Bennett; Glenn C. Rice; Grace H.W. Wong; Ellson Y. Chen; David V. Goeddel

January 1, 1991

An internally positioned signal can direct attachment of a glycophospholipid membrane anchor

Journal of Cell Biology, ISSN: 00219525

Caras

January 1, 1991

Probing the signal for glycophosphatidylinositol anchor attachment using decay accelerating factor as a model system

Cell Biology International Reports, ISSN: 03091651

Caras

January 1, 1991

Measurement of transient cDNA expression in mammalian cells using flow cytometric cell analysis and sorting

Communications in Clinical Cytometry, ISSN: 10970320 01964763

Glenn C. Rice; Diane Pennica; James Borree; Steven R. Williams

January 1, 1991

Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)

Science, ISSN: 00368075

Koller; David G Lowe; Bennett; Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo; David V. Goeddel

January 1, 1991

A sugar‐specific porin, ScrY, is involved in sucrose uptake in enteric bacteria

Molecular Microbiology, ISSN: 13652958 0950382X

Schmid; Reinhard Ebner; Jahreis; Lengeler; Titgemeyer

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