Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4251 - 4300 OF 16812 RESULTS

February 1, 2020

Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy

Cancer Discovery, ISSN: 21598290 21598274

Claudia X. Dominguez; Sören Müller; Shilpa Keerthivasan; Koeppen; Jeffrey Hung; Sarah Gierke; Beatrice Breart; Oded Foreman; Travis W. Bainbridge; Alessandra Castiglioni; Yasin Senbabaoglu; Zora Modrusan; Yuxin Liang; Melissa Junttila; Christiaan N. Klijn; Richard Bourgon; Shannon J. Turley

February 1, 2020

Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics

Nature Structural and Molecular Biology, ISSN: 15459985 15459993

Annette M. Vogl; Lilian Phu; Raquel Becerra; Sebastian A. Giusti; Erik Verschueren; Trent Hinkle; Martín D. Bordenave; Max Adrian; Amy Heidersbach; Patricio Yankilevich; Fernando D. Stefani; Wolfgang Wurst; Casper C Hoogenraad; Donald S. Kirkpatrick; Damian Refojo; Morgan Sheng

February 1, 2020

Using human genetics to understand the disease impacts of testosterone in men and women

Nature Medicine, ISSN: 1546170X 10788956

Katherine S Ruth; Felix R Day; Jessica Tyrrell; Deborah J Thompson; Andrew R Wood; Anubha Mahajan; Robin N Beaumont; Laura Wittemans; Susan Martin; Alexander S. Busch; A. Mesut Erzurumluoglu; Benjamin Hollis; Tracy A. O’Mara; Mark I. McCarthy; Claudia Langenberg; Douglas F. Easton; Nicholas J Wareham; Stephen Burgess; Anna Murray; Ken K. Ong; Timothy M. Frayling; John R. Perry

February 1, 2020

Rituximab utilization for approved and off-label nononcology indications and patients’ experiences with the Patient Alert Card

Pharmacology Research and Perspectives, ISSN: 20521707

Khaled Sarsour; Senam Beckley-Kartey; Simone Melega; Adefowope Odueyungbo; Petra Kirchner; Natasha Khalife; Joanne Bangs

February 1, 2020

Tumor Time-Course Predicts Overall Survival in Non-Small Cell Lung Cancer Patients Treated with Atezolizumab: Dependency on Follow-Up Time

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Ida Netterberg; Rene Bruno; Ya-Chi Chen; Helen Winter; Chi-Chung Li; Jin Y. Jin; Lena E. Friberg

February 1, 2020

Next-Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development

Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236

Sharin E. Roth; Mark I. Avigan; David L. Bourdet; David A. Brott; Rachel J. Church; Ajit Dash; Douglas A. Keller; Philip J. Sherratt; Paul B. Watkins; Lucas Westcott-Baker; Silvia Lentini; Michael Merz; Lila Ramaiah; Shashi K. Ramaiah; Ann Marie Stanley; John F. Marcinak

February 1, 2020

Effect of omalizumab on lung function and eosinophil levels in adolescents with moderate-to-severe allergic asthma

Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206

William W. Busse; Marc Humbert; Tmirah Haselkorn; Benjamin Ortiz; Benjamin L. Trzaskoma; Patricia Stephenson; Lorena Garcia Conde; Farid Kianifard; Stephen Holgate

February 1, 2020

Predicting Remission Among Patients With Rheumatoid Arthritis Starting Tocilizumab Monotherapy: Model Derivation and Remission Score Development

ACR Open Rheumatology, ISSN: 25785745

Jamie E. Collins; Fredrik D. Johansson; Sara L. Gale; Seoyoung Kim; Swastina Shrestha; David A. Sontag; Jacklyn Stratton; Huong Trinh; Chang Xu; Elena Losina; Daniel Hal Solomon

February 1, 2020

Pregnancy outcomes in the omalizumab pregnancy registry and a disease-matched comparator cohort

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Jennifer Namazy; Lucie Blais; Elizabeth Andrews; Angela E. Scheuerle; Michael D. Cabana; John M. Thorp; Dale T. Umetsu; Joachim Veith; Diana Sun; Derrick G. Kaufman; Deborah L. Covington; Santanu Mukhopadhyay; Robert B. Fogel; Sandra Lopez-Leon; C. Victor Spain

January 29, 2020

Genome-wide analysis of differential gene expression and splicing in excitatory neurons and interneuron subtypes

Journal of Neuroscience, ISSN: 15292401 02706474

Melanie A. Huntley; Karpagam Srinivasan; Brad A. Friedman; Tzu-Ming Wang; Ada X. Yee; Yuanyuan Wang; Joshua S. Kaminker; Morgan Sheng; David V. Hansen; Jesse E. Hanson

January 28, 2020

Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration

Cell Reports, ISSN: 22111247

Luz D. Orozco; Hsu-Hsin Chen; Christian Cox; Kenneth J. Katschke Jr.; Rommel Arceo; Carmina Espiritu; Patrick Caplazi; Sarajane Saturnio Nghiem; Ying-Jiun Chen; Zora Modrusan; Amy Dressen; Leonard D. Goldstein; Christine Clarke; Tushar Bhangale; Brian L. Yaspan; Marion Jeanne; Michael J. Townsend; Menno Van Lookeren Campagne; Jason A. Hackney

January 23, 2020

Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Protected Benzoin-Derived Enol Carbonates

Advanced Synthesis and Catalysis, ISSN: 16154169 16154150

Rémi Lavernhe; Eric J. Alexy; Haiming Zhang; Brian M. Stoltz

January 22, 2020

Pharmacokinetics and pharmacodynamic effect of crenezumab on plasma and cerebrospinal fluid beta-amyloid in patients with mild-to-moderate Alzheimer's disease

Alzheimer's Research and Therapy, ISSN: 17589193

Yoshida; Anita Moein; Tobias Bittner; Ostrowitzki; Helen Lin; Lee Honigberg; Jin Y. Jin; Angelica Quartino

January 21, 2020

Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Hae-Min Park; Valerie J. Winton; Jared J. Drader; Sheri Manalili Wheeler; Greg A. Lazar; Neil L Kelleher; Yichin Liu; John C. Tran; Philip D. Compton

January 15, 2020

Phase Ia study of anti-NAPI2B antibody–drug conjugate lifastuzumab vedotin DNIB0600A in patients with non–small cell lung cancer and platinum-resistant ovarian cancer

Clinical Cancer Research, ISSN: 15573265 10780432

David E. Gerber; Jeffery R. Infante; Michael S. Gordon; Sarah B. Goldberg; Miguel Martín; Enriqueta Felip; Maria Martinez Garcia; Joan H. Schiller; David Spigel; Julie Cordova; Valerie Westcott; Wang; David S. Shames; Younjeong Choi; Robert S. Kahn; Randall Dere; Divya Samineni; Jian Xu; Kedan Lin; Katie Wood; Stephanie Royer-Joo; Lemahieu; Schuth; Vaze; Daniel Maslyar; Eric W. Humke; Howard A. Burris

January 14, 2020

GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models

Cell Reports, ISSN: 22111247

Jesse E. Hanson; Keran Ma; Justin Elstrott; Martin Weber; Sandrine Saillet; Abdullah S. Khan; Jeffrey Simms; Benjamin Liu; Thomas A. Kim; Gui-Qiu Yu; Yelin Chen; Tzu-Ming Wang; Zhiyu Jiang; Bianca M. Liederer; Gauri Deshmukh; Hilda Solanoy; Connie Chan; Benjamin D. Sellers; Matthew Volgraf; Jacob B. Schwarz; David Hackos; Robby M. Weimer; Morgan Sheng; T. Michael Gill; Kimberly Scearce-Levie; Jorge J. Palop

January 9, 2020

A brief history of human disease genetics

Nature, ISSN: 14764687 00280836

Melina Claussnitzer; Judy H. Cho; Rory Collins; Nancy J. Cox; Emmanouil T. Dermitzakis; Matthew E. Hurles; Sekar Kathiresan; Eimear E. Kenny; Cecilia M. Lindgren; Daniel G. MacArthur; Kathryn N. North; Sharon E. Plon; Heidi L. Rehm; Neil Risch; Charles Rotimi; Jay Shendure; Nicole Soranzo; Mark I. McCarthy

January 9, 2020

Log D Contributions of Substituents Commonly Used in Medicinal Chemistry

ACS Medicinal Chemistry Letters, ISSN: 19485875

Matthew L. Landry; James J. Crawford

January 7, 2020

Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity

ChemMedChem, ISSN: 18607187 18607179

Thomas H. Pillow; Pragya Adhikari; Robert A. Blake; Jinhua Chen; Geoffrey Del Rosario; Gauri Deshmukh; Isabel Figueroa; Karen Gascoigne; Amrita Kamath; Susan Kaufman; Tracy L. Kleinheinz; Katherine R. Kozak; Brandon Latifi; Douglas Leipold; Chun Sing Li; Ruina Li; Melinda M. Mulvihill; Aimee O'Donohue; Rebecca K. Rowntree; Jack D. Sadowsky; John Wai; Xinxin Wang; Cong Wu; Zijin Xu; Hui Yao; Shang-Fan Yu; Donglu Zhang; Richard Zang; Hongyan Zhang; Hao Zhou; Xiaoyu Zhu; Peter Dragovich

January 7, 2020

Probing the Impact of the Knob-into-Hole Mutations on the Structure and Function of a Therapeutic Antibody

Analytical Chemistry, ISSN: 15206882 00032700

Peilu Liu; Xuan Gao; Victor Lundin; Catherine Shi; Yilma T. Adem; Kevin Lin; Guoying Jiang; Kao; Feng Yang; David A. Michels; Alan G. Marshall; Hui-Min Zhang

January 5, 2020

Assessing the utility of in vitro microtubule assays for studying mechanisms of peripheral neuropathy with the microtubule inhibitor class of cancer chemotherapy

Chemico-Biological Interactions, ISSN: 18727786 00092797

Genualdi; Stuart C. Feinstein; Wilson; Jordan; Nicola J. Stagg

January 3, 2020

Dual photoredox/nickel-catalyzed conversion of aryl halides to aryl aminooxetanes: Computational evidence for a substrate-dependent switch in mechanism

ACS Catalysis, ISSN: 21555435

Kavoos Kolahdouzan; Ryan Khalaf; Jessica M. Grandner; Yongsheng Chen; Jack A. Terrett; Malcolm P. Huestis

January 2, 2020

Cost-effectiveness of omalizumab for the treatment of moderate-to-severe uncontrolled allergic asthma in the United States

Current Medical Research and Opinion, ISSN: 14734877 03007995

Patrick W. Sullivan; Qianyi Li; S. Pinar Bilir; Joseph Dang; Abhishek Kavati; Ming Yang; Yamina Rajput

January 2, 2020

Exposure–response analysis of venetoclax in combination with rituximab in patients with relapsed or refractory chronic lymphocytic leukemia: pooled results from a phase 1b study and the phase 3 MURANO study

Leukemia and Lymphoma, ISSN: 10292403 10428194

Rong Deng; Leonid Gibiansky; Tong Lu; Xiaobin Li; Dan Lu; Chunze Li; Sandhya Girish; Jue Wang; Michelle Boyer; Noopur Shankar; Kathryn Humphrey; Kevin J. Freise; Ahmed Hamed Salem; John F. Seymour; Kater; Dale Miles

January 1, 2020

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection

Genome Research, ISSN: 15495469 10889051

Chun Jimmie Ye; Jenny Chen; Alexandra-Chloé Villani; Rachel E. Gate; Meena Subramaniam; Tushar Bhangale; Mark N. Lee; Towfique Raj; Raktima Raychowdhury; Weibo Li; Noga Rogel; Sean Simmons; Selina H. Imboywa; Portia I. Chipendo; Cristin McCabe; Michelle H. Lee; Irene Y. Frohlich; Barbara E. Stranger; Philip L. De Jager; Aviv Regev; Timothy W. Behrens; Nir Hacohen

January 1, 2020

Exome sequencing reveals a novel splice site variant in HUWE1 gene in patients with suspected Say-Meyer syndrome

European Journal of Medical Genetics, ISSN: 18780849 17697212

Babylakshmi Muthusamy; Thong T Nguyen; Aravind K. Bandari; Salah Basheer; Lakshmi Dhevi N. Selvan; Deepshikha Chandel; Jesna Manoj; Srimonta Gayen; Somasekar Seshagiri; Satish Chandra Girimaji; Akhilesh Pandey

January 1, 2020

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

Cell Death and Differentiation, ISSN: 14765403 13509047

Snahel Patel; Webster; Eugene Varfolomeev; Youngsu C. Kwon; Jason H. Cheng; Juan Zhang; Dugger; Katherine E. Wickliffe; Maltzman; Swathi Sujatha-Bhaskar; Pawan Bir Kohli; Sreemathy Ramaswamy; Gauri Deshmukh; Bianca M. Liederer; Rina Fong; Gregory L. Hamilton; Patrick J. Lupardus; Patrick Caplazi; Wyne P. Lee; Menno Van Lookeren Campagne; Adam R. Johnson; Brent Mckenzie; Melissa Junttila; Kim Newton; Domagoj Vucic

January 1, 2020

An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice

Journal of Cellular Physiology, ISSN: 10974652 00219541

Jungeun Yu; Christian W. Siebel; Lauren Schilling; Ernesto Canalis

January 1, 2020

Autophagy of Sensory Neurons in the Trigeminal and Dorsal Root Ganglia of Cynomolgus Monkeys (Macaca fascicularis)

Toxicologic Pathology, ISSN: 15331601 01926233

Mark T. Butt; Reina N. Fuji; Mike Reichelt; Alok K. Sharma; Sarah Cramer

January 1, 2020

Nasal gene expression changes with inhaled corticosteroid treatment in asthma

Allergy: European Journal of Allergy and Clinical Immunology, ISSN: 13989995 01054538

Ilse M. Boudewijn; Andy Lan; Alen Faiz; Claire A. Cox; Sharon Brouwer; Siebrig Schokker; Sebastiaan J. Vroegop; Nawijn; Prescott G. Woodruff; Stephanie Christenson; Paul Hagedoorn; Henderik W. Frijlink; David F. Choy; Uilke Brouwer; Marissa Wisman; Dirkje S. Postma; James Fingleton; Beasley; van den Berge; Victor Guryev

January 1, 2020

The Value of Prior Response to Anti–Vascular Endothelial Growth Factor for Age-Related Macular Degeneration: A HARBOR Subanalysis

Kidney International Reports, ISSN: 24686530

Rahul N. Khurana; Louis K. Chang; Lauren Hill; Avanti Ghanekar; Ivaylo Stoilov

January 1, 2020

Unobstructed Multiscale Imaging of Tissue Sections for Ultrastructural Pathology Analysis by Backscattered Electron Scanning Microscopy

Journal of Histochemistry and Cytochemistry, ISSN: 15515044 00221554

Mike Reichelt; Meredith Sagolla; Anand K. Katakam; Webster

January 1, 2020

Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI

Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236

Nicholas Steven Jones; Yoshida; Laurent Salphati; Jane R. Kenny; Matthew Durk; Leslie Chinn

January 1, 2020

Stress Factors in mAb Drug Substance Production Processes: Critical Assessment of Impact on Product Quality and Control Strategy

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Tapan K. Das; Linda O. Narhi; Alavattam Sreedhara; Tim Menzen; Christoph Grapentin; Danny Chou; Valentyn Antochshuk; Vasco Filipe

January 1, 2020

The great escape: tumour cell plasticity in resistance to targeted therapy

Nature Reviews Drug Discovery, ISSN: 14741784 14741776

Soufiane Boumahdi; Frederic J. De Sauvage

January 1, 2020

High-Resolution Characterization of ADCs by Orbitrap LCMS

Methods in Molecular Biology, ISSN: 19406029 10643745

Jintang He; Surinder Kaur; Keyang Xu

January 1, 2020

Spectral-Domain OCT Predictors of Visual Outcomes after Ranibizumab Treatment for Macular Edema Resulting from Retinal Vein Occlusion

Ophthalmology Retina, ISSN: 24686530

Glenn Yiu; R. Joel Welch; Yinwen Wang; Zhe Wang; Pin-Wen Wang; Zdenka Haskova

January 1, 2020

Physical Stability Studies of Antibody-Drug Conjugates (ADCs) Under Stressed Conditions

Methods in Molecular Biology, ISSN: 19406029 10643745

Yilma T. Adem

January 1, 2020

Real-world practice patterns in veterans with metastatic castration-resistant prostate cancer

Urologic Oncology: Seminars and Original Investigations, ISSN: 18732496 10781439

Ahmad S. Halwani; Kelli M. Rasmussen; Vikas Patil; Catherine C. Li; Christina M. Yong; Zachary Burningham; Sumati Gupta; Sujata Narayanan; Shih Wen Lin; Susheela Carroll; Shivani K. Mhatre; Julie N. Graff; Robert Dreicer; Brian C. Sauer

January 1, 2020

Challenges of Using Closed System Transfer Devices With Biological Drug Products: An Industry Perspective

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Alavattam Sreedhara; Camellia Zamiri; Sirj Goswami; Sarah Weiser; Michael Cram; Twinkle R. Christian; Bharat Jagannathan

January 1, 2020

Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies

mAbs, ISSN: 19420870 19420862

Cholpon Tilegenova; Saeed Izadi; Jianping Yin; Christine S. Huang; Jiansheng Wu; Diego Ellerman; Sarah G. Hymowitz; Benjamin T. Walters; Cleo M. Salisbury; Paul J. Carter

January 1, 2020

Fiery Cell Death: Pyroptosis in the Central Nervous System

Trends in Neurosciences, ISSN: 1878108X 01662236

Brienne A. McKenzie; Vishva M. Dixit; Christopher Power

January 1, 2020

The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti-integrin therapies

Medicinal Research Reviews, ISSN: 10981128 01986325

Iris Dotan; Matthieu Allez; Silvio Danese; Mary E. Keir; Swati Tole; Jacqueline McBride

January 1, 2020

Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies

mAbs, ISSN: 19420870 19420862

Chunze Li; Cindy Zhang; Zao Li; Divya Samineni; Dan Lu; Wang; Shang-Chiung Chen; Rong Zhang; Priya Agarwal; Bernard M. Fine; Sandhya Girish

January 1, 2020

Harnessing MerTK agonism for targeted therapeutics

mAbs, ISSN: 19420870 19420862

Vivekananda Kedage; Diego Ellerman; Yongmei Chen; Wei-Ching Liang; Jovencio Borneo; Yan Wu; Minhong Yan

January 1, 2020

Integrated Two-Analyte Population Pharmacokinetic Model of Polatuzumab Vedotin in Patients With Non-Hodgkin Lymphoma

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Dan Lu; Tong Lu; Leonid Gibiansky; Xiaobin Li; Chunze Li; Priya Agarwal; Colby S. Shemesh; Rong Shi; Randall Dere; Jamie Hirata; Dale Miles; Pascal Chanu; Sandhya Girish; Jin Yan Jin

January 1, 2020

A Multicompany Assessment of Submicron Particle Levels by NTA and RMM in a Wide Range of Late-Phase Clinical and Commercial Biotechnology-Derived Protein Products

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Mario Hubert; Dennis T. Yang; Stanley C. Kwok; Anacelia Rios; Tapan K. Das; Ankit Patel; Klaus Wuchner; Valentyn Antochshuk; Friederike Junge; George M. Bou-Assaf; Shawn Cao; Miguel Saggu; Luis Montrond; Nataliya Afonina; Parag Kolhe; Vakhtang Loladze; Linda O. Narhi

January 1, 2020

Changes in organic anion transporting polypeptide uptake in HEK293 overexpressing cells in the presence and absence of human plasma

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Christine M. Bowman; Eugene C. Chen; Liuxi Chen; Yi-Chen Chen; Xiaorong Liang; Matthew Wright; Yuan Chen; Jialin Mao

January 1, 2020

Rate of Adverse Events and Associated Health Care Costs for the Management of Inflammatory Bowel Disease in Germany

Clinical Therapeutics, ISSN: 1879114X 01492918

Thomas Wilke; Antje Groth; Gráinne H. Long; Amanda R. Tatro; Diana Sun

January 1, 2020

Cardiovascular Safety of Tocilizumab Versus Etanercept in Rheumatoid Arthritis: A Randomized Controlled Trial

Arthritis and Rheumatology, ISSN: 23265205 23265191

Jon T. Giles; Naveed Sattar; Sherine Gabriel; Paul M Ridker; Steffen Gay; Charles Warne; David Musselman; Laura Brockwell; Emma Shittu; Micki Klearman; Thomas Fleming

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