Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10101 - 10150 OF 16124 RESULTS

GPS navigation of the protein-stability landscape
Nature Biotechnology, ISSN: 10870156 15461696
Donald S. Kirkpatrick; Vishva M. Dixit
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A three-dimensional view of the molecular machinery of RNA interference
Nature, ISSN: 00280836 14764687
Martin Jinek; Jennifer A. Doudna
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Effect of polyols on polyethylene glycol (PEG)-induced precipitation of proteins: Impact on solubility, stability and conformation
International Journal of Pharmaceutics, ISSN: 03785173
Vineet Kumar; Vikas Sharma; Devendra S. Kalonia
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In situ precipitation and vacuum drying of interferon alpha-2a: Development of a single-step process for obtaining dry, stable protein formulation
International Journal of Pharmaceutics, ISSN: 03785173
Vineet Kumar; Vikas Sharma; Devendra S. Kalonia
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PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation
EMBO Reports, ISSN: 1469221X 14693178
Elsa N. N'Diaye; Kimberly K. Kajihara; Ivy Hsieh; J. Hiroshi Morisaki; Jayanta Debnath; Eric J. Brown
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Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim
Immunity, ISSN: 10747613
Kaufmann; Philipp J. Jost; Marc Pellegrini; Puthalakath; Gugasyan; Gerondakis; Erika Cretney; Mark J. Smyth; John Silke; Razq Hakem; Philippe Bouillet; Tak W. Mak; Vishva M. Dixit; Andreas Strasser
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Re-estimating the sample size of an on-going blinded trial based on the method of randomization block sums
Statistics in Medicine, ISSN: 02776715 10970258
Jitendra Ganju; Biao Xing
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By the scientists, for the scientists
Journal of Cell Biology, ISSN: 00219525 00219525
Ira Mellman
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Addition of bevacizumab to fluorouracil-based first-line treatment of metastatic colorectal cancer: Pooled analysis of cohorts of older patients from two randomized clinical trials
Journal of Clinical Oncology, ISSN: 0732183X
Fairooz F. Kabbinavar; Herbert Hurwitz; Jing Yi; Somnath Sarkar; Oliver Rosen
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Noncompetitive Inhibition of Hepatocyte Growth Factor-dependent Met Signaling by a Phage-derived Peptide
Journal of Molecular Biology, ISSN: 00222836
Eric Tam; Steven T. Runyon; Santell; Quan; Xiaoyi Yao; Daniel Kirchhofer; Nicholas J. Skelton; Lazarus
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PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment
Cancer Cell, ISSN: 15356108
Yongping Crawford; Ian Kasman; Lanlan Yu; Cuiling Zhong; Xiumin Wu; Zora Modrusan; Joshua S. Kaminker; Napoleone Ferrara
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The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Wei Li; Dimitry Danilenko; Bunting; Rajkumar Ganesan; Susan Sa Ronald Ferrando; Thomas D Wu; Ganesh Kolumam; Wenjun Ouyang; Daniel Kirchhofer
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Engineering as a means to improve the pharmacokinetics of injected therapeutic proteins
Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes,
Dennis; Yik Andy Yeung; Henry B. Lowman; Robert F. Kelley
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In vitro-in vivo correlations of pharmacokinetics, pharmacodynamics, and metabolism for antibody therapeutics
Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes,
C. Andrew Boswell; Rong Deng; Kedan Lin; Wendy Putnam; Cherry Lei; Frank-Peter Theil; Amita Joshi; Fielder; Leslie A. Khawli
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Assessing Medical Information Needs via an Internet-Based Survey
Therapeutic Innovation and Regulatory Science, ISSN: 21684790
Stacey M. Fung; Laura Merriman; Maureen Cawley
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Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia
Blood, ISSN: 15280020 00064971
Kazuko Miyazaki; Norimasa Yamasaki; Hideaki Oda; Takeshi Kuwata; Yohei Kanno; Masaki Miyazaki; Yukiko Komeno; Jiro Kitaura; Zen-Ichiro Honda; Søren Warming; Nancy A. Jenkins; Neal G. Copeland; Toshio Kitamura; Takuro Nakamura; Hiroaki Honda
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Inflammasomes: Guardians of cytosolic sanctity
Immunological Reviews, ISSN: 01052896 1600065X
Lamkanfi; Vishva M. Dixit
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The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
Nature Immunology, ISSN: 15292908 15292916
Xin Yu; Kristin Harden; Lino C. Gonzalez Jr.; Michelle Francesco; Eugene Y. Chiang; Bryan Irving; Irene Tom; Ivelja; Refino; Hilary F. Clark; Dan L. Eaton; Jane L. Grogan
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Industrialization of mAb production technology: The bioprocessing industry at a crossroads
mAbs, ISSN: 19420862
Kelley
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In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models
Molecular Cancer Therapeutics, ISSN: 15357163
Kenneth Kolinsky; Shen; Yu-E. Zhang; Joseph Kohles; Ute Dugan; Zioncheck; David Heimbrook; Kathryn Packman; Higgins
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Applying simulation tools to evaluate and minimize operating costs of biotech manufacturing facilities
American Pharmaceutical Outsourcing, ISSN: 15296318
Frank Menkel; Rick Johnston; Arden Yang
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Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells
Nature Immunology, ISSN: 15292908 15292916
Tom Cupedo; Natasha K Crellin; Natalie Papazian; Elwin J. Rombouts; Kees Weijer; Jane L. Grogan; Willem E. Fibbe; Jan J. Cornelissen; Hergen Spits
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Panitumumab monotherapy in patients with metastatic colorectal cancer and cetuximab infusion reactions: A series of four case reports
Clinical Colorectal Cancer, ISSN: 15330028
Alan Langerak; George River; Edith Mitchell; Puneet Cheema; Mona Shing
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Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis
Immunobiology, ISSN: 01712985
Stefan Ehlers; Tanja Schreiber; Annette Dunzendorfer; John Lowe; Christoph Hölscher
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Quality by design: The next phase
BioProcess International, ISSN: 15426319
Mire-Sluis; Mark Schenerman; Rohin Mhatre; Siddharth Advant; John Dougherty; Steven Kozlowski; Wassim Nashabeh; Lorna McLeod
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Ion-specific modulation of protein interactions: Anion-induced, reversible oligomerization of a fusion protein
Protein Science, ISSN: 09618368 1469896X
Yatin Gokarn; R. Matthew Fesinmeyer; Atul Saluja; Shawn Cao; Jane Dankberg; Andrew Goetze; Richard L. Remmele Jr.; Linda O. Narhi; David N. Brems
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Mechanism, function and regulation of microtubule-dependent microtubule amplification in mitosis
Molecules and Cells, ISSN: 10168478
Hui Zhu; Kayleen Fang; Guowei Fang
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Polar localization of virulence-related Esx-1 secretion in mycobacteria
PLoS Pathogens, ISSN: 15537366 15537374
Fredric Carlsson; Shilpa A. Joshi; Linda Rangell; Eric J. Brown
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Improved vision-related function after ranibizumab vs photodynamic therapy: A randomized clinical trial
Archives of Ophthalmology, ISSN: 00039950 15383601
Neil M. Bressler; Tom S. Chang; Jennifer T. Fine; Chantal M. Dolan; James Ward
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VEGF inhibition: Insights from preclinical and clinical studies
Cell and Tissue Research, ISSN: 0302766X
Yongping Crawford; Napoleone Ferrara
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Lipoxin A4 and serum amyloid a differentially modulate phospholipase D in human fibroblast-like synoviocytes
European Journal of Inflammation, ISSN: 1721727X
Sodin-Semrl; Antico; Mikus; Lakota; Varga; Fiore
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Computational prediction of the functional effects of amino acid substitutions in signal peptides using a model-based approach
Human Mutation, ISSN: 10597794
Lawrence S. Hon; Yan Zhang; Joshua S. Kaminker; Zemin Zhang
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Erythropoietin dosing in children with chronic kidney disease: Based on body size or on hemoglobin deficit?
Pediatric Nephrology, ISSN: 0931041X
Ruediger E. Port; Otto Mehls
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Twenty-four well plate miniature bioreactor system as a scale-down model for cell culture process development
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Aaron Chen; Rajesh Chitta; David Chang; Ashraf Amanullah
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Sparse combinatorial inference with an application in cancer biology
Bioinformatics, ISSN: 13674803 14602059
Sach Mukherjee; Steven Pelech; Richard M. Neve; Wen-Lin Kuo; Safiyyah Ziyad; Paul T. Spellman; Joe W. Gray; Terence P. Speed
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Coordinated concentration changes of transcripts and metabolites in Saccharomyces cerevisiae
PLoS Computational Biology, ISSN: 1553734X 15537358
Patrick H. Bradley; Matthew J. Brauer; Joshua D. Rabinowitz; Olga G. Troyanskaya
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Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP21
Biochemical Journal, ISSN: 02646021 14708728
John W. Blankenship; Eugene Varfolomeev; Tatiana Goncharov; Anna V. Fedorova; Donald S. Kirkpatrick; Anita Izrael-Tomasevic; Lilian Phu; David Arnott; Mariam Aghajan; Zobel; J.Fernando Bazan; Wayne J. Fairbrother; Deshayes; Domagoj Vucic
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Slow growth induces heat-shock resistance in normal and respiratory-deficient yeast
Molecular Biology of the Cell, ISSN: 10591524
Charles Lu; Matthew J. Brauer; David Botstein
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Anion exchange chromatography provides a robust, predictable process to ensure viral safety of biotechnology products
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Daniel M. Strauss; Gorrell; Magdalena Plancarte; Gregory S. Blank; Qi Chen; Bin Yang
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Consideration of the linear concentration increase of the unbound drug fraction in plasma
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Applying the CONSORT and STROBE Statements to Evaluate the Reporting Quality of Neovascular Age-related Macular Degeneration Studies
Ophthalmology, ISSN: 01616420
Anne E. Fung; Ram Palanki; Sophie J. Bakri; Eric E. Depperschmidt; Andrea Gibson
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Compatibility of a protein topical gel with wound dressings
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Junyan A. Ji; Oleg V. Borisov; Erika Ingham; Victor Ling; Y. John Wang
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Determination of mean residence time of drug in plasma and the influence of the initial drug elimination and distribution on the calculation of pharmacokinetic parameters
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Improving antibody binding affinity and specificity for therapeutic development.
Methods in Molecular Biology, ISSN: 10643745
Jenny Bostrom; Chingwei V. Lee; Lauric Haber; Fuh
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Predicting asthma control using patient attitudes toward medical care: The REACT score
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Craig A. Jones; Bruce G. Bender; Tmirah Haselkorn; James E. Fish; David R. Mink; Stephen P. Peters; Weiss
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Relative weight at ages 10 and 16 years and risk of endometriosis: A case-control analysis
Human Reproduction, ISSN: 14602350 02681161
Christina M. Nagle; Tanya A. Bell; David M. Purdie; Susan A. Treloar; Olsen; Grover; Adèle C. Green
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On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy; S. Cyrus Khojasteh; Jason S Halladay; Cornelis E. Hop
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Absence of neuromyelitis optica igg antibody in an active relapsing-remitting multiple sclerosis population
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, ISSN: 15365166 10708022
Craig H. Smith; Waubant; Annette Langer-Gould
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Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Joshua D. Ramsey; Michelle L. Gill; Tim J. Kamerzell; E. Shane Price; Sangeeta B. Joshi; Steven M. Bishop; Cynthia N. Oliver; C. Russell Middaugh
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Growth response, near-adult height, and patterns of growth and puberty in patients with Noonan syndrome treated with growth hormone
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X
Alicia A. Romano; Ken Dana; Bert Bakker; Daniel Aaron Davis; Joanne Julius Hunold; Joan R. Jacobs; Barbara M. Lippe
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