Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10951 - 11000 OF 16124 RESULTS

Role of Vascular Endothelial Growth Factor in Ocular Angiogenesis
Ophthalmology Clinics of North America, ISSN: 08961549
Naveed Shams; Tsontcho Ianchulev
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Vascular endothelial growth factor signaling pathways: Therapeutic perspective
Clinical Cancer Research, ISSN: 10780432
Marcin Kowanetz; Napoleone Ferrara
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Comparison of costs associated with the use of etanercept, infliximab, and adalimumab for the treatment of rheumatoid arthritis
Managed Care Interface, ISSN: 10965645
Michael F. Bullano; Brian J. McNeeley; Yanni F. Yu; Ralph Quimbo; Lauren P. Burawski; Elaine B. Yu; J. Michael Woolley
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Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
Genes and Development, ISSN: 08909369 15495477
Julie J. Miller; Matthew K. Summers; David V. Hansen; Maxence V. Nachury; Norman L. Lehman; Alexander V. Loktev; Peter K Jackson
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A series of collaborations between various pharmaceutical companies and regulatory authorities concerning the analysis of biomolecules using capillary electrophoresis
Chromatographia, ISSN: 00095893 16121112
Brian Nunnally; Park; Ketaki Patel; Mingfang Hong; Xinfeng Zhang; Shao-Xiong Wang; Brenda Rener; Angelia Reed-Bogan; Oscar Salas-Solano; Wendy Lau; Michel Girard; Heather Carnegie; Virginia Garcia-Cañas; Cheng; Ming Zeng; Margaret Ruesch; Ronald Frazier; Claudia Jochheim; Kshama Natarajan; K. Michael Jessop; Mansoor Saeed; Frank Moffatt; Seth Madren; Serigne Thiam; Kevin D. Altria
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Experience and scale and scope economies: Trade-offs and performance in development
Strategic Management Journal, ISSN: 01432095 10970266
Jeffrey T. Macher; Christopher S. Boerner
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Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia
International Immunology, ISSN: 09538178 14602377
Andrew G. Polson; Bing Zheng; Kristi Elkins; Wesley S. Chang; Du; Patrick Dowd; Lulu Yen; Christine Tan; Hongo; Koeppen; Allen Ebens
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Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum
Molecular Microbiology, ISSN: 0950382X 13652958
Katerina Artavanis-Tsakonas; Shahram Misaghi; Christy A. Comeaux; André Catic; Eric Spooner; Manoj T. Duraisingh; Hidde L. Ploegh
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ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage
Science, ISSN: 00368075 10959203
David Dornan; Harumi Shimizu; Angie Mah; Tanay Dudhela; Mike Eby; Karen M. O'Rourke; Somasekar Seshagiri; Vishva M. Dixit
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Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates
British Journal of Pharmacology, ISSN: 14765381 00071188
Kelley; Thomas R. Gelzleichter; Dong Xie; Wyne P. Lee; Darbonne; Ferhan Qureshi; Kim Kissler; Ezogelin Oflazoglu; Iqbal S. Grewal
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Axon guidance by diffusible chemoattractants: A gradient of netrin protein in the developing spinal cord
Journal of Neuroscience, ISSN: 02706474 02706474
Timothy E. Kennedy; Hao Wang; Wallace Marshall; Marc Tessier-Lavigne
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Activation of the Proapoptotic Death Receptor DR5 by Oligomeric Peptide and Antibody Agonists
Journal of Molecular Biology, ISSN: 00222836
Bing Li; Russell; Deanne M. Compaan; Klara Totpal; Scot A. Marsters; Avi Ashkenazi; Andrea G Cochran; Sarah G. Hymowitz; Sachdev S. Sidhu
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Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib
Cancer Research, ISSN: 00085472
Kendall Carey; Andrew J. Garton; Maria Romero; Jennifer Kahler; Stuart Thomson; Ross; Frances Park; Haley; Neil Gibson; Mark X. Sliwkowski
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Capillary electrophoresis-mass spectrometry as a characterization tool for therapeutic proteins
Analytical Biochemistry, ISSN: 10960309 00032697
Lynn Gennaro; Oscar Salas-Solano; Stacey Ma
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CpG island methylator phenotype and childhood leukemia
Clinical Cancer Research, ISSN: 10780432
Norman J. Lacayo; Jorge F. DiMartino; Michael C. Wei; Gary V. Dahl
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Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis
Science, ISSN: 00368075 10959203
Niko Föger; Linda Rangell; Dimitry Danilenko; Andrew A. Chan
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Formulation and delivery issues for monoclonal antibody therapeutics
Advanced Drug Delivery Reviews, ISSN: 0169409X
Daugherty; Mrsny
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Convergent and divergent ligand specificity among PDZ domains of the LAP and zonula occludens (ZO) families
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Yingnan Zhang; Sherry Yeh; Brent A. Appleton; Heike A. Held; P. Jaya Kausalya; Dominic C. Y. Phua; Wai Lee T. Wong; Lasky; Wiesmann; Walter Hunziker; Sachdev S. Sidhu
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Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1 Insights into determinants of PDZ domain specificity
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Brent A. Appleton; Yingnan Zhang; Ping Wu; Jianping Yin; Walter Hunziker; Nicholas J. Skelton; Sachdev S. Sidhu; Wiesmann
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Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Gábor Pál; Jean-Louis K. Kouadio; Dean R. Artis; Anthony A. Kossiakoff; Sachdev S. Sidhu
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Delineation of the cell-extrinsic apoptosis pathway in the zebrafish
Cell Death and Differentiation, ISSN: 14765403 13509047
Eimon; Kratz; Eugene Varfolomeev; Sarah G. Hymowitz; Howard M. Stern; Jiping Zha; Avi Ashkenazi
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Functional characterization of the Bcl-2 gene family in the zebrafish
Cell Death and Differentiation, ISSN: 14765403 13509047
Kratz; Eimon; Kiran Mukhyala; Howard M. Stern; Jiping Zha; Andreas Strasser; Reece K. Hart; Avi Ashkenazi
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Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure-safety relationship in patients with non-small cell lung cancer
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Jian-Feng Lu; Stephen M. Eppler; Julie Wolf; Marta Hamilton; Ashok Rakhit; Rene Bruno; Bert L. Lum
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Predicting benefit from anti-angiogenic agents in malignancy
Nature Reviews Cancer, ISSN: 1474175X
Adrian M. Jubb; Adam J. Oates; Scott N. Holden; Koeppen
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UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1
Nature Neuroscience, ISSN: 10976256
Megan E. Williams; Lu; William L. McKenna; Raesha Washington; Adam Boyette; Phyllis Strickland; Dillon; Kaprielian; Marc Tessier-Lavigne; Hinck
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Matching patients with drugs: Triumphs and challenges
Personalized Medicine, ISSN: 17410541 1744828X
Waring
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The Crystal Structure of the Costimulatory OX40-OX40L Complex
Structure, ISSN: 09692126
Deanne M. Compaan; Sarah G. Hymowitz
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A high throughput electrochemiluminescent cell-binding assay for therapeutic anti-CD20 antibody selection
Journal of Immunological Methods, ISSN: 00221759
Yanmei Lu; Wai Lee T. Wong; Meng
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Developmental neurobiology: A destructive switch for neurons
Nature, ISSN: 14764687 00280836
Peter K Jackson
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Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
Oncogene, ISSN: 09509232 14765594
Shulewitz; Soloviev; Thomas D Wu; Koeppen; Paul G. Polakis; Sakanaka
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Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells
Cell Cycle, ISSN: 15514005 15384101
Norman L. Lehman; Emmy W. Verschuren; Jerry Y. Hsu; Athena M. Cherry; Peter K Jackson
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Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo
Biochemical Journal, ISSN: 02646021
Harumi Shimizu; David Saliba; Maura Wallace; Lee Finlan; Patrick R. R. Langridge-Smith; Ted R. Hupp
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Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
Journal of Experimental Medicine, ISSN: 00221007 00221007
Shabaana A. Khader; Santiago Partida-Sanchez; Guy Bell; Dawn M. Jelley-Gibbs; Susan L. Swain; John E. Pearl; Nico Ghilardi; Frederic J. De Sauvage; Frances E. Lund; Andrea M. Cooper
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Death-receptor activation halts clathrin-dependent endocytosis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Cary D. Austin; David Lawrence; Andrew A. Peden; Eugene Varfolomeev; Klara Totpal; Ann De Mazière; Judith Klumperman; David Arnott; Victoria Pham; Richard H. Scheller; Avi Ashkenazi
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Inhibin-B levels in healthy young adult men and prepubertal boys: Is obesity the cause for the contemporary decline in sperm count because of fewer sertoli cells?
Journal of Andrology, ISSN: 01963635
Stephen J. Winters; Chenxi Wang; Eiman Abdelrahaman; Venus Hadeed; Mary Ann Dyky; Adam Brufsky
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Uncontrolled asthma: A review of the prevalence, disease burden and options for treatment
Respiratory Medicine, ISSN: 09546111
Stephen P. Peters; Gary Ferguson; Yamo Deniz; Colin Reisner
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A serum-free Vero production platform for a chimeric virus vaccine candidate
Cytotechnology, ISSN: 09209069 15730778
Inn H. Yuk; Gina B. Lin; Hui Ju; Inesse Sifi; Yvonne Lam; Armida Cortez; Danny Liebertz; J. Michael Berry; Richard M. Schwartz
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The pharmacokinetics of an albumin-binding Fab (AB.Fab) can be modulated as a function of affinity for albumin
Protein Engineering, Design and Selection, ISSN: 17410126 17410134
Allen Nguyen; Arthur Reyes; Min Zhang; Paul McDonald; Wai Lee T. Wong; Lisa A. Damico; Dennis
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Gender differences in IgE-mediated allergic asthma in the epidemiology and natural history of asthma: Outcomes and treatment regimens (TENOR) study
Journal of Asthma, ISSN: 02770903 15324303
June H. Lee; Tmirah Haselkorn; Bradley E. Chipps; Dave P. Miller; Sally E. Wenzel
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Wlds Protection Distinguishes Axon Degeneration following Injury from Naturally Occurring Developmental Pruning
Neuron, ISSN: 08966273
Eric D. Hoopfer; Todd McLaughlin; Ryan J. Watts; Oren Schuldiner; Dennis D.M. O'Leary; Liqun Luo
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Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia
Oncogene, ISSN: 09509232 14765594
Adrian M. Jubb; Sreedevi Chalasani; Gretchen D. Frantz; Ron Smits; Grabsch; Kavi; Maughan; Kenneth J. Hillan; Philip Quirke; Koeppen
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Effect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
Journal of the American College of Cardiology, ISSN: 07351097
Robert L. McNamara; Yongfei Wang; Jeph Herrin; Jeptha P. Curtis; Elizabeth H. Bradley; David J. Magid; Eric D. Peterson; Martha Blaney; Paul D. Frederick; Harlan M. Krumholz
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Basic helix-loop-helix gene hes6 delineates the sensory hair cell lineage in the inner ear
Developmental Dynamics, ISSN: 10588388 10970177
Dong Qian; Kristen Radde-Gallwitz; Michael Kelly; Björn Tyrberg; Jaesang Kim; Gao; Ping Chen
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Patient-perceived impact of resective epilepsy surgery
Neurology, ISSN: 00283878
Peter Chin; Berg; Spencer; Lee; Shinnar; Sperling; Langfitt; Walczak; Pacia; Bazil; Vassar; Vickrey
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Rationale for fixed dosing of pertuzumab in cancer patients based on population pharmacokinetic analysis
Pharmaceutical Research, ISSN: 07248741 1573904X
Chee Ng; Bert L. Lum; Veronica Gimenez; Steve Kelsey; David E. Allison
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Preclinical pharmacologic evaluation of MST-997, an orally active taxane with superior in vitro and in vivo efficacy in paclitaxel- and docetaxel-resistant tumor models
Clinical Cancer Research, ISSN: 10780432
Deepak Sampath; Lee M. Greenberger; Carl Beyer; Malathi Hari; Hao Liu; Michelle Baxter; Yang Sharon; Carol Rios; Carolyn Discafani
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Door-to-drug and door-to-balloon times: Where can we improve? Time to reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI)
American Heart Journal, ISSN: 00028703 10976744
Elizabeth H. Bradley; Jeph Herrin; Yongfei Wang; Robert L. McNamara; Martha J. Radford; David J. Magid; John G. Canto; Martha Blaney; Harlan M. Krumholz
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Deletion of exon I of SMAD7 in mice results in altered B cell responses
Journal of Immunology, ISSN: 00221767
Ronggui Li; Alexander Rosendahl; Greger Brodin; Alec M. Cheng; Aive Ahgren; Christina Sundquist; Sarang Kulkarni; Tony Pawson; Carl-Henrik Heldin; Rainer L. Heuchel
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Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab
Cancer Immunology, Immunotherapy, ISSN: 03407004
Adams; David E. Allison; Kelly Flagella; Presta; Janet Clarke; Noel Dybdal; Kathleen McKeever; Mark X. Sliwkowski
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B cell immunobiology in disease: Evolving concepts from the clinic
Annual Review of Immunology, ISSN: 07320582
Flavius Martin; Andrew A. Chan
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