Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 11001 - 11050 OF 16124 RESULTS

Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Evette S. Radisky; Justin M. Lee; Chia-Jung Karen Lu; Daniel E. Koshland Jr.
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De novo proteomic sequencing of a monoclonal antibody raised against OX40 ligand
Analytical Biochemistry, ISSN: 10960309 00032697
Victoria Pham; William J. Henzel; David Arnott; Sarah G. Hymowitz; Wendy N. Sandoval; Bao-Tran Truong; Henry B. Lowman; Jennie R. Lill
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Tumor-driven paracrine platelet-derived growth factor receptor α signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma
Clinical Cancer Research, ISSN: 10780432
Max L. Tejada; Lanlan Yu; Jianying Dong; Kenneth Jung; Meng; Franklin V. Peale Jr.; Gretchen D. Frantz; Linda Hall; Xiao Huan Liang; Hans-Peter Gerber; Napoleone Ferrara
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The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: Results of a phase IIb randomized, double-blind, placebo-controlled, dose-ranging trial
Arthritis and Rheumatism, ISSN: 00043591
Paul Emery; Roy Fleischmann; Anna Filipowicz-Sosnowska; Joy Schechtman; Leszek Szczepanski; Arthur Kavanaugh; Artur J. Racewicz; Ronald Van Vollenhoven; Nicole F. Li; Sunil Agarwal; Eva W. Hessey; Tim Shaw
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Assessing the impact of cancer: Development of a new instrument for long-term survivors
Psycho-Oncology, ISSN: 10579249 10991611
Brad J. Zebrack; Patricia A. Ganz; Coen A. Bernaards; Laura Petersen; Laura Abraham
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IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
Journal of Clinical Investigation, ISSN: 00219738 15588238
David Yen; Jeanne Cheung; Heleen Scheerens; Frédérique Poulet; Terrill McClanahan; Brent Mckenzie; Melanie A. Kleinschek; Alexander M. Owyang; Jeanine Mattson; Wendy M. Blumenschein; Erin Murphy; Manjiri Sathe; Daniel J. Cua; Robert A. Kastelein; Donna Rennick
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The role of rituximab in the treatment of canine lymphoma: An ex vivo evaluation
Veterinary Journal, ISSN: 10900233
Joseph A Impellizeri; Howell; Kathleen McKeever; Steven E Crow
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Safety of efalizumab in adults with chronic moderate to severe plaque psoriasis: A phase IIIb, randomized, controlled trial
International Journal of Dermatology, ISSN: 00119059 13654632
Kim Papp; Reni Bressinck; Scott Fretzin; Bernard Goffe; Steven Kempers; Kenneth B. Gordon; Ivor Caro; Patricia Walicke; Xiaolin Wang; Alan Menter
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The Pre-Hospital Electrocardiogram and Time to Reperfusion in Patients With Acute Myocardial Infarction, 2000-2002. Findings From the National Registry of Myocardial Infarction-4
Journal of the American College of Cardiology, ISSN: 07351097
Jeptha P. Curtis; Edward L. Portnay; Yongfei Wang; Robert L. McNamara; Jeph Herrin; Elizabeth H. Bradley; David J. Magid; Martha Blaney; John G. Canto; Harlan M. Krumholz
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Comments on plasmalemmal vesicle associated protein-1 as a novel marker implicated in brain tumor angiogenesis [3]
Clinical Cancer Research, ISSN: 10780432
Laura A. Strickland; Koeppen
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The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus
Arthritis Research and Therapy, ISSN: 14786354 14786362
Anthony P. Manderson; Francesco Carlucci; Peter J. Lachmann; Lazarus; Richard J. Festenstein; H. Terence Cook; Mark J. Walport; Marina Botto
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Relapse, rebound, and psoriasis adverse events: An advisory group report
Journal of the American Academy of Dermatology, ISSN: 01909622
Wayne Carey; Scott Glazer; Alice Gottlieb; Mark Lebwohl; Craig Leonardi; Alan Menter; Kim Papp; Amy Chen Rundle; Darryl P. Toth
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The clinical and economic burden of psoriasis
Managed Care Interface, ISSN: 10965645
Elisabeth H. Hazard; Spencer B. Cherry; Deepa Lalla; J. Michael Woolley; Helen Wilfehrt; Chiun-Fang Chiou
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A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery
Development (Cambridge), ISSN: 09501991
David A. Elliott; Mark J. Solloway; Natalie Wise; Christine Biben; Mauro W. Costa; Milena B. Furtado; Martin Lange; Sally Dunwoodie; Richard P. Harvey
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Dickkopf-1, an inhibitor of Wnt signaling, is regulated by progesterone in human endometrial stromal cells
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X
Suzana Tulac; Michael T. Overgaard; Amy E. Hamilton; Nelson L'ntshotsholé Jumbe; Ernest Suchanek; Linda C. Giudice
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Depressive symptoms in coronary artery disease patients after hypertension treatment
Annals of Pharmacotherapy, ISSN: 10600280
L. Douglas Ried; Michael J. Tueth; Taylor; Brian C. Sauer; Larry M. Lopez; Carl J. Pepine
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Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13 II is required for viral infectivity in vivo
Journal of Virology, ISSN: 0022538X
Hajime Hiraragi; Seung-Jae Kim; Andrew J. Phipps; Micol Silic-Benussi; Vincenzo Ciminale; Lee Ratner; Patrick L. Green; Michael D. Lairmore
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Efalizumab retreatment in patients with moderate to severe chronic plaque psoriasis
Journal of the American Academy of Dermatology, ISSN: 01909622
Kim Papp; Bruce Miller; Kenneth B. Gordon; Ivor Caro; Paul Kwon; Peter Compton; Craig Leonardi
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Use of drotrecogin alfa (activated) in older patients with severe sepsis
Pharmacotherapy, ISSN: 02770008
Sherri L. Alexander; Frank R. Ernst
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Long-term continuous efalizumab therapy in patients with moderate to severe chronic plaque psoriasis: Updated results from an ongoing trial
Journal of the American Academy of Dermatology, ISSN: 01909622
Alice Gottlieb; Tiffani K. Hamilton; Ivor Caro; Paul Kwon; Peter Compton; Craig Leonardi
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Office-based low-field extremity magnetic resonance imaging: Is the glass half empty or half full?
Arthritis and Rheumatism, ISSN: 00043591
David E. Yocum; Philip G. Conaghan; Ewa Olech; Charles G. Peterfy
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Sinorhizobium meliloti bluB is necessary for production of 5,6-dimethylbenzimidazole, the lower ligand of B12
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Gordon R. O. Campbell; Michiko E. Taga; Kavita Mistry; Javier Lloret; Peter J. Anderson; John R. Roth; Graham C. Walker
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Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Conrad Yap Edosada; Quan; Wiesmann; Thuy Tran; Daniel P. Sutherlin; Mark E. Reynolds; J. Michael Elliott; Helga Raab; Wayne J. Fairbrother; Beni B. Wolf
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Characterization of dual substrate binding sites in the homodimeric structure of Escherichia coli mRNA interferase MazF
Journal of Molecular Biology, ISSN: 00222836
Guang-Yao Li; Yonglong Zhang; Mitchell C.Y. Chan; Tapas K. Mal; Klaus P. Hoeflich; Masayori Inouye; Mitsuhiko Ikura
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Tyrosine plays a dominant functional role in the paratope of a synthetic antibody derived from a four amino acid code
Journal of Molecular Biology, ISSN: 00222836
Frederic A. Fellouse; Pierre A. Barthelemy; Robert F. Kelley; Sachdev S. Sidhu
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Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice
Cancer Research, ISSN: 00085472
Lauren Wallner; Jinlu Dai; June Escara-Wilke; Jian Zhang; Zhi Yao; Yi Lu; Mohit Trikha; Jeffrey A. Nemeth; Mohamed H. Zaki; Evan T. Keller
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CDK2/cyclinA inhibitors: Targeting the cyclinA recruitment site with small molecules derived from peptide leads
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Georgette M. Castanedo; Clark; Shumei Wang; Vickie Tsui; Mengling Wong; John B. Nicholas; Dineli Wickramasinghe; James C. Marsters Jr.; Daniel P. Sutherlin
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A versatile platform for nanotechnology based on circular permutation of a chaperonin protein
Nanotechnology, ISSN: 09574484
Paavola; Chan; Li; Mazzarella; McMillan; Trent
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Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin™ Fab
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Fuh; Ping Wu; Wei-Ching Liang; Ultsch; Chingwei V. Lee; Moffat; Wiesmann
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CRIg: A macrophage complement receptor required for phagocytosis of circulating pathogens
Cell, ISSN: 00928674
Karim Y. Helmy; Kenneth J. Katschke Jr.; Nick N. Gorgani; Noelyn Kljavin; J. Michael Elliott; Laurie Diehl; Suzie J. Scales; Nico Ghilardi; Menno Van Lookeren Campagne
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Calorimetric investigation of protein/amino acid interactions in the solid state
International Journal of Pharmaceutics, ISSN: 03785173
Fei Tian; Samir Sane; J. Howard Rytting
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Cryopyrin activates the inflammasome in response to toxins and ATP
Nature, ISSN: 14764687 00280836
Sanjeev Mariathasan; David S. Weiss; Kim Newton; Jacqueline McBride; Karen M. O'Rourke; Merone Roose-Girma; Wyne P. Lee; Yvette Weinrauch; Denise M. Monack; Vishva M. Dixit
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The role of receptor internalization in CD95 signaling
EMBO Journal, ISSN: 02614189 14602075
Kyeong-Hee Lee; Christine Feig; Vladimir Tchikov; Robert Schickel; Cora Hallas; Stefan Schütze; Marcus E. Peter; Andrew A. Chan
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A recombinant 63-kDa form of Bacillus anthracis protective antigen produced in the yeast Saccharomyces cerevisiae provides protection in rabbit and primate inhalational challenge models of anthrax infection
Vaccine, ISSN: 0264410X
Robert W. Hepler; Rosemarie Kelly; Tessie B. McNeely; Hongxia Fan; Maria C. Losada; Hugh George; Andrea Woods; Leslie D. Cope; Alka Bansal; James C. Cook; Gina Zang; Steven L. Cohen; Xiaorong Wei; Paul M. Keller; Elizabeth Leffel; Joseph G. Joyce; Louise Pitt; Loren D. Schultz; Kathrin U. Jansen; Myra Kurtz
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Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly2-Pro1-cleaving specificity
FEBS Letters, ISSN: 00145793
Conrad Yap Edosada; Quan; Thuy Tran; Victoria Pham; Wiesmann; Wayne J. Fairbrother; Beni B. Wolf
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The above letters were referred to genentech, the manufacturer of bevacizumab, which offers the following reply [22]
New England Journal of Medicine, ISSN: 00284793
Hal V. Barron
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Biogenerics at the crossroads
Nature Biotechnology, ISSN: 10870156 15461696
Carole S. Ben-Maimon; Robert L. Garnick
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Large-scale trends in the evolution of gene structures within 11 animal genomes
PLoS Computational Biology, ISSN: 1553734X 15537358
Mark Yandell; Chris J. Mungall; Chris Smith; Simon Prochnik; Joshua S. Kaminker; George Hartzell; Suzanna E. Lewis; Gerald M. Rubin
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Targeting VEGF & EGFR pathways in solid tumors
Journal of Gynecologic Oncology Nursing, ISSN: 15369935
Karen Oleszewski
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The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection
Nature Immunology, ISSN: 15292908 15292916
Dario S. Zamboni; Koichi S. Kobayashi; Tiana Kohlsdorf; Yasunori Ogura; E. Michelle Long; Russell E. Vance; Keisuke Kuida; Sanjeev Mariathasan; Vishva M. Dixit; Richard A. Flavell; William F. Dietrich; Craig R. Roy
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Community-based trial of a triple-combination agent for the treatment of facial melasma
Cutis, ISSN: 00114162
Pearl Grimes; A. Paul Kelly; Helen Torok; Isaac Willis
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Synapse disassembly and formation of new synapses in postnatal muscle upon conditional inactivation of MuSK
Molecular and Cellular Neuroscience, ISSN: 10447431
Boris A. Hesser; Oliver Henschel; Veit Witzemann
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Enantioselective total synthesis of batzelladine F and definition of its structure
Journal of the American Chemical Society, ISSN: 00027863
Frederick Cohen; Larry E. Overman
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Metabolism and excretion of erlotinib, a small molecule inhibitor of epidermal growth factor receptor tyrosine kinase, in healthy male volunteers
Drug Metabolism and Disposition, ISSN: 00909556
Jie Ling; Kim A. Johnson; Zhuang Miao; Ashok Rakhit; Michael P. Pantze; Marta Hamilton; Bert L. Lum; Chandra Prakash
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A rapid method for estimation of baculovirus titer based on viable cell size
Journal of Virological Methods, ISSN: 01660934
Vasantharajan Janakiraman; William F. Forrest; Bernard Chow; Somasekar Seshagiri
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Evaluation of the absolute oral bioavailability and bioequivalence of erlotinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in a randomized, crossover study in healthy subjects
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Paul Frohna; Jian-Feng Lu; Stephen M. Eppler; Marta Hamilton; Julie Wolf; Ashok Rakhit; Jie Ling; Sara Kenkare-Mitra; Bert L. Lum
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Effect of overexpression of a soluble pyridine nucleotide transhydrogenase (UdhA) on the production of poly(3-hydroxybutyrate) in Escherichia coli
Biotechnology Progress, ISSN: 87567938
Ailen M. Sánchez; Jared Andrews; Insiya Hussein; George N. Bennett; Ka-Yiu San
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Mitochondrial localization of CNP2 is regulated by phosphorylation of the N-terminal targeting signal by PKC: Implications of a mitochondrial function for CNP2 in glial and non-glial cells
Molecular and Cellular Neuroscience, ISSN: 10447431
John Lee; Ryan C. O'Neill; Min Woo Park; Michel Gravel; Peter E. Braun
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Vascular endothelial growth factor A signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival
Journal of the American Society of Nephrology, ISSN: 10466673
Vera Eremina; Shiying Cui; Hans-Peter Gerber; Napoleone Ferrara; Jody Haigh; Andras Nagy; Masatsugu Ema; Janet Rossant; Serge Jothy; Jeffrey H. Miner; Susan E. Quaggin
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The vascular basement membrane: A niche for insulin gene expression and β cell proliferation
Developmental Cell, ISSN: 15345807
Ganka Nikolova; Normund Jabs; Irena Konstantinova; Anna Domogatskaya; Karl Tryggvason; Lydia Sorokin; Reinhard Fässler; Guoqiang Gu; Hans-Peter Gerber; Napoleone Ferrara; Douglas A. Melton; Eckhard Lammert
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