Scientists / Publications

Publications

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DISPLAYING 5051 - 5100 OF 15792 RESULTS

Mass Spectrometric Characterization of Recombinant Proteins
Analytical Characterization of Biotherapeutics,
Corey Bakalarski; Wendy N. Sandoval; Jennie R. Lill
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Characterization of Residual Host Cell Protein Impurities in Biotherapeutics
Analytical Characterization of Biotherapeutics,
Denise C. Krawitz; Jason C. Rouse; Justin B. Sperry; Wendy N. Sandoval; Vanderlaan
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Practical considerations for assessing product ouality of biosynthetic proteins by HPLC
High-Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis, and Conformation,
Chloupek; John E. Battersby; William S. Hancock
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Analytical Characterization of Biotherapeutics
Analytical Characterization of Biotherapeutics,
Jennie R. Lill; Wendy N. Sandoval
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Characterization of Bispecific or Other Hybrid Molecules
Analytical Characterization of Biotherapeutics,
T. Noelle Lombana; Christoph Spiess
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Assessing Activity and Conformation of Recombinant Proteins
Analytical Characterization of Biotherapeutics,
Diego Ellerman; Till Maurer; Justin M. Scheer
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Results from the Phase III Randomized Trial of Onartuzumab plus Erlotinib Versus Erlotinib in Previously Treated Stage IIIB or IV Non–Small-Cell Lung Cancer: METLung
Journal of Clinical Oncology, ISSN: 15277755 0732183X
David Spigel; Martin J. Edelman; Kenneth O'Byrne; Luis Paz-Ares; Mocci; See Phan; David S. Shames; Dustin Smith; Wei Yu; Virginia Paton; Tony Mok
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Interleukin-13 in asthma and other eosinophilic disorders
Frontiers in Medicine, ISSN: 2296858X
Emma Doran; Fang Cai; Cecile Holweg; Kit Wong; Jochen Brumm; Joseph R. Arron
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Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs
Xenobiotica, ISSN: 13665928 00498254
Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Justin Ly; Jason Boggs; Alec Fettes; Andrew McClory; Yuzhong Deng; Cornelis E. Hop; S. Cyrus Khojasteh; Edna F. Choo
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Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death
Cell Death and Differentiation, ISSN: 14765403 13509047
Maria Cristina De Almagro; Tatiana Goncharov; Anita Izrael-Tomasevic; Stefanie Duttler; Matthias Kist; Eugene Varfolomeev; Xiumin Wu; Wyne P. Lee; Jeremy Murray; Webster; Kebing Yu; Donald S. Kirkpatrick; Kim Newton; Domagoj Vucic
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Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics
AAPS Journal, ISSN: 15507416
Siddharth Sukumaran; Crystal Zhang; Douglas Leipold; Ola M. Saad; Keyang Xu; Kapil Gadkar; Divya Samineni; Wang; Marija Milojic-Blair; Montserrat Carrasco-Triguero; Bonnee Rubinfeld; Fielder; Kedan Lin; Ramanujan
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Degradation Mechanisms of Polysorbate 20 Differentiated by 18O-labeling and Mass Spectrometry
Pharmaceutical Research, ISSN: 1573904X 07248741
Lin Zhang; Sandeep Yadav; Barthélemy Demeule; Y. John Wang; Olivier Mozziconacci; Christian Schöneich
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Specific Immune Response to Phospholipase B-Like 2 Protein, a Host Cell Impurity in Lebrikizumab Clinical Material
AAPS Journal, ISSN: 15507416
Saloumeh Kadkhodayan Fischer; Melissa Cheu; Kun Peng; John Lowe; James Araujo; Elaine R. Murray; Mcclintock; Matthews; Patricia Siguenza; An Song
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Photo-oxidation of IgG1 and Model Peptides: Detection and Analysis of Triply Oxidized His and Trp Side Chain Cleavage Products
Pharmaceutical Research, ISSN: 1573904X 07248741
Jessica Bane; Olivier Mozziconacci; Li Yi; Y. John Wang; Alavattam Sreedhara; Christian Schöneich
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TIGIT: A Key Inhibitor of the Cancer Immunity Cycle
Trends in Immunology, ISSN: 14714981 14714906
Nicholas A. Manieri; Eugene Y. Chiang; Jane L. Grogan
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Quantitative Systems Pharmacology: A Case for Disease Models
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Musante; Ramanujan; Brian J. Schmidt; Ghobrial; Lu; Heatherington
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Bevacizumab plus paclitaxel versus placebo plus paclitaxel as first-line therapy for HER2-negative metastatic breast cancer (MERiDiAN): A double-blind placebo-controlled randomised phase III trial with prospective biomarker evaluation
European Journal of Cancer, ISSN: 18790852 09598049
David W. Miles; David Cameron; Igor Bondarenko; Lyudmila Manzyuk; Juan Carlos Alcedo; Roberto Ivan Lopez; Seock-Ah Im; Jean-Luc Canon; Yaroslav Shparyk; Denise A. Yardley; Norikazu Masuda; Jungsil Ro; Neelima Denduluri; Stanislas Hubeaux; Quah; Carlos Bais; O'Shaughnessy
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Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma
Gastroenterology, ISSN: 15280012 00165085
Yiwei Wang; Dan Huang; Kai-Yuan Chen; Min Cui; Weihuan Wang; Xiaoran Huang; Amad Awadellah; Qing Li; Ann Friedman; William Xin; Luca Di Martino; Fabio Cominelli; Alex Miron; Ricky Chan; James G. Fox; Yan Xu; Xiling Shen; Mathew F. Kalady; Sanford D. Markowitz; Ivan Maillard; John Lowe; Wei Xin; Lan Zhou
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Effect of pirfenidone on mortality: pooled analyses and meta-analyses of clinical trials in idiopathic pulmonary fibrosis
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Steven D Nathan; Carlo Albera; Williamson Bradford; Ulrich Costabel; Ian Glaspole; Marilyn K Glassberg; David Kardatzke; Monica Daigl; Klaus-Uwe Kirchgaessler; Lisa H Lancaster; David J Lederer; Carlos A Pereira; Jeffrey J. Swigris; Dominique Valeyre; Paul W. Noble
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Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD)
Journal of Alzheimer's Disease, ISSN: 18758908 13872877
Stephane Nave; Rachelle S. Doody; Mercè Boada; Timo Grimmer; Juha-Matti Savola; Paul Delmar; Meike Pauly-Evers; Tania Nikolcheva; Christian Czech; Edilio Borroni; Benedicte Ricci; Juergen Dukart; Marie Mannino; Tracie Carey; Emma Moran; Inma Gilaberte; Nicoletta Milani Muelhardt; Irene Gerlach; Luca Santarelli; Ostrowitzki; Fontoura; Krista Lanctôt
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Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer
Oncotarget, ISSN: 19492553
Soma Samanta; Shuzo Tamura; Louis Dubeau; Paulette Mhawech-Fauceglia; Yohei Miyagi; Hisamori Kato; Rich Lieberman; Ronald J. Buckanovich; Yvonne G. Lin; Nouri Neamati
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Glycan Characterization: Determining the Structure, Distribution, and Localization of Glycoprotein Glycans
Analytical Characterization of Biotherapeutics,
Briggs
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Integrated lead optimization: Translational models as we advance toward the clinic
AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371
Bianca M. Liederer; Xingrong Liu; Simon Wong; Daniel R Mudra
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Ubiquitin in cell-cycle regulation and dysregulation in cancer
Annual Review of Cancer Biology, ISSN: 24723428
Natalie A. Borg; Vishva M. Dixit
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Utilization of In Vitro Neurotoxicity Models in Pre-Clinical Toxicity Assessment
Stem Cells in Toxicology and Medicine,
Karin Staflin; Misner; Donna M. Dambach
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IL-13 is a therapeutic target in radiation lung injury
Scientific Reports, ISSN: 20452322
Su I. Chung; Jason A. Horton; Thirumalai R. Ramalingam; Ayla O. White; Eun Joo Chung; Kathryn E. Hudak; Bradley T. Scroggins; Joseph R. Arron; Thomas A. Wynn; Deborah E. Citrin
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Structure of crenezumab complex with aβ shows loss of β-hairpin
Scientific Reports, ISSN: 20452322
Ultsch; Bing Li; Till Maurer; Mary Mathieu; Oskar Adolfsson; Andreas Muhs; Andrea Pfeifer; Maria Pihlgren; Travis W. Bainbridge; Mike Reichelt; James A. Ernst; Eigenbrot; Fuh; Jasvinder K. Atwal; Ryan J. Watts; Weiru Wang
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Characterization of chain pairing variants of bispecific IgG Expressed in a single host cell by high-resolution native and denaturing mass spectrometry
Analytical Chemistry, ISSN: 15206882 00032700
Luis Schachner; Guanghui Han; Michael Dillon; Jianhui Zhou; Luke McCarty; Diego Ellerman; Yiyuan Yin; Christoph Spiess; Jennie R. Lill; Paul J. Carter; Wendy N. Sandoval
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Transition-Metal-Free Synthesis of Tertiary Aminocyclopropanes
Organic Letters, ISSN: 15237052 15237060
Patrick Cyr; Alexandre Côté-Raiche; Sarah M. Bronner
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Rhodium(III)-Catalyzed C-H Functionalization of 1-(2H)-Phthalazinones at C8
Journal of Organic Chemistry, ISSN: 15206904 00223263
Malcolm P. Huestis
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Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter
Oncogene, ISSN: 14765594 09509232
Xueping Qu; Thomas Sandmann; Frierson; Ling Fu; Eloisa Fuentes; Kimberly Walter; Kwame Okrah; Rumpel; Moskaluk; Shan Lu; Wang; Richard Bourgon; Elicia M. Penuel; Andrea Pirzkall; Lukas Amler; Lackner; Tabernero; Garret M. Hampton; Omar Kabbarah
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Phase Ib study of duligotuzumab (MEHD7945A) plus cisplatin/5-fluorouracil or carboplatin/paclitaxel for first-line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck
Cancer, ISSN: 10970142 0008543X
Antonio Jimeno; Jean-Pascal Machiels; Lori Wirth; Pol Specenier; Tanguy Y. Seiwert; Feby Mardjuadi; Xiaodong Wang; Amy V. Kapp; Stephanie Royer-Joo; Elicia M. Penuel; Bruce Mccall; Andrea Pirzkall; Paul M. Clement
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Impact of blood-brain barrier integrity on tumor growth and therapy response in brain metastases
Clinical Cancer Research, ISSN: 15573265 10780432
Matthias Osswald; Jonas Blaes; Yunxiang Liao; Gergely Solecki; Miriam Gömmel; Anna S. Berghoff; Laurent Salphati; Jeffery J. Wallin; Phillips; Wick; Frank Winkler
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The molecular landscape of high-risk early breast cancer: Comprehensive biomarker analysis of a phase III adjuvant population
npj Breast Cancer, ISSN: 23744677
Wilson; Yu; Xuyang Lu; Jill M. Spoerke; Yuanyuan Xiao; Carol O’brien; Heidi Savage; Huw; Wei Zou; Koeppen; William F. Forrest; Jane Fridlyand; Ling Fu; Rachel Tam; Erica Schleifman; Teiko Sumiyoshi; Luciana L. Molinero; Garret M. Hampton; O'Shaughnessy; Lackner
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Communicating laboratory test results for rheumatoid factor: What do patients and physicians want?
Patient Preference and Adherence, ISSN: 1177889X
Ariella Kelman; Caroline O. Robinson; Elisenda Cochin; Nina J. Ahluwalia; Julia Braverman; Emil Chiauzzi; Kristina Simacek
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ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models
Molecular Neurodegeneration, ISSN: 17501326
Mitchell S. Wold; Junghyun Lim; Véronik Lachance; Zhiqiang Deng; Zhenyu Yue
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Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Terry Crawford; F. Anthony Romero; Kwong Wah Lai; Vickie Tsui; Alexander M. Taylor; Gladys De Leon Boenig; Cameron Noland; Jeremy Murray; Justin Ly; Edna F. Choo; Thomas Hunsaker; Emily Chan; Mark Merchant; Samir Kharbanda; Karen Gascoigne; Susan Kaufman; Beresini; Jiangpeng Liao; Wenfeng Liu; Kevin Chen; Zhongguo Chen; Andrew R. Conery; Alexandre Côté; Hariharan Jayaram; Ying Jiang; James R. Kiefer; Tracy L. Kleinheinz; Yingjie Li; Jonathan M. Maher; Eneida Pardo; Florence Poy; Kerry L. Spillane; Fei Wang; Jian Wang; Xiaocang Wei; Zhaowu Xu; Zhongya Xu; Ivana Yen; Laura E. Zawadzke; Xiaoyu Zhu; Steve Bellon; Richard T Cummings; Andrea G Cochran; Brian K Albrecht; Steven Magnuson
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Custom-designed affinity capture LC-MS F(ab′)2 assay for biotransformation assessment of site-specific antibody drug conjugates
Analytical Chemistry, ISSN: 15206882 00032700
Dian Su; Carl Ng; Mehraban Khosraviani; Shang-Fan Yu; Ely Cosino; Surinder Kaur; Keyang Xu
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Automated affinity capture and on-tip digestion to accurately quantitate in vivo deamidation of therapeutic antibodies
Analytical Chemistry, ISSN: 15206882 00032700
John C. Tran; Daniel Tran; Amy Hilderbrand; Nisana Andersen; Tao Huang; Karin Reif; Isidro Hötzel; Stefanich; Yichin Liu; Jianyong Wang
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Acid-base interactions in amorphous solid dispersions of lumefantrine prepared by spray-drying and hot-melt extrusion using X-ray photoelectron spectroscopy
International Journal of Pharmaceutics, ISSN: 18733476 03785173
Yang Song; Dmitry Zemlyanov; Xin Chen; Ziyang Su; Haichen Nie; Joseph W. Lubach; Daniel Smith; Stephen Byrn; Rodolfo Pinal
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Predicting Passive Permeability of Drug-like Molecules from Chemical Structure: Where Are We?
Molecular Pharmaceutics, ISSN: 15438392 15438384
Broccatelli; Laurent Salphati; Emile G. Plise; Jonathan Cheong; Alberto Gobbi; Man-Ling Lee; Ignacio Aliagas
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The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation
PLoS Pathogens, ISSN: 15537374 15537366
Dmitry Ratner; M. Pontus A. Orning; Megan K. Proulx; Donghai Wang; Mikhail A. Gavrilin; Mark D. Wewers; Alnemri; Peter F. Johnson; Bettina L. Lee; Joan Mecsas; Nobuhiko Kayagaki; Jon D. Goguen; Egil Lien
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Validation of synthetic CRISPR reagents as a tool for arrayed functional genomic screening
PLoS ONE, ISSN: 19326203
Jenille Tan; Scott E. Martin
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Balancing blood sample volume with 3Rs: Implementation and best practices for small molecule toxicokinetic assessments in rats
ILAR Journal, ISSN: 19306180 10842020
Eric Harstad; Roxanne Andaya; Jessica A. Couch; Xiao Ding; Xiaorong Liang; Bianca M. Liederer; Kirsten Messick; Trung Nguyen; Michelle G. Schweiger; Jacqueline M. Tarrant; Shelly Zhong; Brian J. Dean
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Refinement, reduction, and replacement of animal toxicity tests by computational methods
ILAR Journal, ISSN: 19306180 10842020
Kevin A. Ford
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Thaw-and-use target cells pre-labeled with calcein AM for antibody-dependent cell-mediated cytotoxicity assays
Journal of Immunological Methods, ISSN: 00221759
Shan Chung; Van Nguyen; Yuwen L. Lin; Lynn Kamen; An Song
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Incidence of Gastrointestinal Perforations in Patients with Rheumatoid Arthritis Treated with Tocilizumab from Clinical Trial, Postmarketing, and Real-World Data Sources
Rheumatology and Therapy, ISSN: 21986584 21986576
Sharareh Monemi; Erhan Berber; Khaled Sarsour; Jianmei Wang; Kathy Lampl; Kamal N. Bharucha; Attila Pethoe-Schramm
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Long-Term Safety and Efficacy of Subcutaneously Administered Tocilizumab for Adult Rheumatoid Arthritis: A Multicenter Phase 3b Long-term Extension Study
Rheumatology and Therapy, ISSN: 21986584 21986576
Alan Kivitz; Thomas Wallace; Ewa Olech; Michael Borofsky; Jenny Devenport; Jinglan Pei; Margaret Michalska
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Survival in patients with non-metastatic breast cancer treated with adjuvant trastuzumab in clinical practice
SpringerPlus, ISSN: 21931801
Christopher Gallagher; Kenneth More; Anthony Masaquel; Tripthi V. Kamath; Annie Guérin; Raluca Ionescu-Ittu; Roy Nitulescu; Marjolaine Gauthier-Loiselle; Nicholas Sicignano; Elizabeth Butts; Eric Q. Wu; Brian Barnett
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A supported liquid extraction LC–MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma
Biomedical chromatography : BMC, ISSN: 10990801 02693879
Xiao Ding; Yuan Chen; Srikumar Sahasranaman; Shi; McKnight; Brian J. Dean
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