Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5601 - 5650 OF 15598 RESULTS

Population pharmacokinetics of oseltamivir in non-pregnant and pregnant women
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Venkateswaran C. Pillai; Kelong Han; Richard H. Beigi; Gary D. Hankins; Shannon Clark; Mary F. Hebert; Thomas R. Easterling; Anne Zajicek; Zhaoxia Ren; Steve N. Caritis; Raman Venkataramanan
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Clinical pharmacology, creating current and future success in drug development
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Mark Rogge; Mark J. Dresser; Michael J. Fossler; Donald Heald; S. Aubrey Stoch; Konstantina M. Vanevski; Akintunde Bello
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Semi-mechanism-based population pharmacokinetic modeling of the hedgehog pathway inhibitor vismodegib
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Lu; Wang; Gao; Mark J. Dresser; Richard A. Graham; Jin Y. Jin
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Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates
Pharmaceutical Research, ISSN: 1573904X 07248741
Amrita Kamath; Suhasini Iyer
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Stratified medicine in inflammatory disorders: From theory to practice
Clinical Immunology, ISSN: 15217035 15216616
Joseph R. Arron; Michael J. Townsend; Mary E. Keir; Brian L. Yaspan; Andrew A. Chan
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A mechanistic pharmacokinetic/pharmacodynamic model of factor D inhibition in cynomolgus monkeys by lampalizumab for the treatment of geographic atrophy
Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565
Kha Le; Leonid Gibiansky; Jeremy Good; Teresa Davancaze; Menno Van Lookeren Campagne; Kelly M. Loyet; Alyssa M. Morimoto; Jin Jin; Lisa A. Damico; William D. Hanley
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A novel design for randomized immuno-oncology clinical trials with potentially delayed treatment effects
Contemporary Clinical Trials Communications, ISSN: 24518654
Pei He; Zheng Su
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Blinding properties of methods for supplying drug kits to investigational sites
Contemporary Clinical Trials Communications, ISSN: 24518654
Ron Yu; Daniel A. Coleman
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Efficient conditional knockout targeting vector construction using co-selection BAC recombineering (CoSBR)
Nucleic Acids Research, ISSN: 13624962 03051048
Robert J. Newman; Merone Roose-Girma; Søren Warming
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Survival and Racial Differences of Non-Small Cell Lung Cancer in the United States Military
Journal of General Internal Medicine, ISSN: 15251497 08848734
Christina Brzezniak; Sacha Satram-Hoang; Hans-Peter Goertz; Carolina Reyes; Ashok Gunuganti; Christopher Gallagher; Corey A. Carter
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nature, ISSN: 14764687 00280836
Nobuhiko Kayagaki; Irma B. Stowe; Bettina L. Lee; Karen M. O'Rourke; Keith R. Anderson; Søren Warming; Trinna L. Cuellar; Benjamin Haley; Merone Roose-Girma; Qui Phung; Peter S. Liu; Jennie R. Lill; Hong Li; Jiansheng Wu; Sarah K. Kummerfeld; Juan Zhang; Wyne P. Lee; Scott J. Snipas; Guy S. Salvesen; Lucy X. Morris; Linda Fitzgerald; Yafei Zhang; Edward M. Bertram; Christopher C. Goodnow; Vishva M. Dixit
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Prepregnancy Risk Factors for Preterm Birth and the Role of Maternal Nativity in a Low-Income, Hispanic Population
Maternal and Child Health Journal, ISSN: 15736628 10927875
Stephanie A. Leonard; Catherine M. Crespi; Denise Gee; Yuda Zhu; Shannon E. Whaley
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Interactions between Peptide and Preservatives: Effects on Peptide Self-Interactions and Antimicrobial Efficiency in Aqueous Multi-Dose Formulations
Pharmaceutical Research, ISSN: 1573904X 07248741
Heljo; Ross; Isidro E. Zarraga; Pappenberger; Hanns-Christian Mahler
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Inhibition of DYRK1A and GSK3B induces human β-cell proliferation
Nature Communications, ISSN: 20411723
Weijun Shen; Brandon Taylor; Qihui Jin; Van Nguyen-Tran; Shelly Meeusen; You-Qing Zhang; Anwesh Kamireddy; Austin Swafford; Andrew F. Powers; John Walker; John Lamb; Badry Bursalaya; Michael Didonato; George Harb; Minhua Qiu; Christophe Filippi; Lisa Deaton; Carolina N. Turk; Wilma L. Suarez-Pinzon; Yahu Liu; Xueshi Hao; Tingting Mo; Shanshan Yan; Jing Li; Ann E. Herman; Bernhard J. Hering; Tom Wu; Martin Seidel; Peter McNamara; Richard Glynne; Bryan A. Laffitte
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Kinome screen identifies PFKFB3 and glucose metabolism as important regulators of the insulin/insulin-like growth factor (IGF)-1 signaling pathway
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Sophie Trefely; Poh-Sim Khoo; James R. Krycer; Rima Chaudhuri; Daniel J. Fazakerley; Benjamin L. Parker; Ghazal Sultani; James Lee; Jean-Philippe Stephan; Eric Torres; Kenneth Jung; Coenraad Kuijl; David E. James; Jagath R. Junutula; Jacqueline Stöckli
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The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression
Science, ISSN: 10959203 00368075
Hung; Pratt; Sundararaman; Towsend; Christina Chaivorapol; Tushar Bhangale; Robert R. Graham; Ward Ortmann; Criswell; Yeo; Timothy W. Behrens
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Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies
Neuron, ISSN: 10974199 08966273
Nga Bien-Ly; C. Andrew Boswell; Surinc Er Jeet; Thomas G. Beach; Kwame Hoyte; Wilman Luk; Vera Shihadeh; Sheila Ulufatu; Oded Foreman; Yanmei Lu; Jason Devoss; Marcel P Van Der Brug; Ryan J. Watts
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Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses
Immunity, ISSN: 10974180 10747613
Tangsheng Yi; Jianhua Li; Hsin Chen; Jiaxi Wu; Jinping An; Ying Xu; Yongmei Hu; Clifford Lowell; Jason G. Cyster
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PTEN loss in circulating tumour cells correlates with PTEN loss in fresh tumour tissue from castration-resistant prostate cancer patients
British Journal of Cancer, ISSN: 15321827 00070920
Elizabeth A. Punnoose; Roberta Ferraldeschi; Edith Szafer-Glusman; Eric K Tucker; Sankar Mohan; Penelope Flohr; Ruth Riisnaes; Susana Miranda; Ines Figueiredo; Daniel Nava Rodrigues; Aurelius Omlin; Carmel Pezaro; Jin Zhu; Lukas Amler; Premal Patel; Yibing Yan; Natalee Bales; Shannon L. Werner; Jessica Louw; Ajay Pandita; Dena Marrinucci; Gerhardt Attard; De Bono
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Randomized phase II trial comparing obinutuzumab (GA101) with rituximab in patients with relapsed CD20+ indolent B-Cell non-hodgkin lymphoma: Final analysis of the GAUSS study
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Laurie H. Sehn; Andre Goy; Fritz C. Offner; Giovanni Martinelli; Dolores Caballero; Ole Gadeberg; Tara Baetz; Zelenetz; Gianluca Gaidano; Luis E. Fayad; Rena Buckstein; Jonathan W. Friedberg; Michael Crump; Branimir Jaksic; Pier Luigi Zinzani; Swaminathan Padmanabhan Iyer; Deniz Sahin; Akiko Chai; Guenter Fingerle-Rowson; Oliver W. Press
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Absolute Quantitation of Intact Recombinant Antibody Product Variants Using Mass Spectrometry
Analytical Chemistry, ISSN: 15206882 00032700
Frank D. Macchi; Feng Yang; Charlene Li; Chenchen Wang; Anh Nguyen Dang; Joseph C. Marhoul; Hui-Min Zhang; Timothy Tully; Hongbin Liu; X. Christopher Yu; David A. Michels
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Palladium-Catalyzed Ring Expansion of Spirocyclopropanes to Form Caprolactams and Azepanes
Journal of Organic Chemistry, ISSN: 15206904 00223263
Olivier René; Iain A. Stepek; Alberto Gobbi; Benjamin P. Fauber; Simon Gaines
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Role of Cosolute-Protein Interactions in the Dissociation of Monoclonal Antibody Clusters
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Thomas M. Scherer
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Notch signal strength controls cell fate in the haemogenic endothelium
Nature Communications, ISSN: 20411723
Leonor Gama-Norton; Eva Ferrando; Cristina Ruiz-Herguido; Zenhy Liu; Jordi Guiu; Abul B.M.M.K. Islam; Sung-Uk Lee; Minhong Yan; Cynthia J. Guidos; Nuria López-Bigas; Takahiro Maeda; Lluis Espinosa; Raphael Kopan; Anna Bigas
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Lipids assist the membrane insertion of a BAM-independent outer membrane protein
Scientific Reports, ISSN: 20452322
Gerard H. M. Huysmans; Ingrid Guilvout; Mohamed Chami; Nicholas N. Nickerson; Anthony P. Pugsley
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Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe
Cell Reports, ISSN: 22111247
Jaakko Mattila; Essi Havula; Erja Suominen; Mari Teesalu; Ida Surakka; Riikka Hynynen; Helena Kilpinen; Juho Väänänen; Iiris Hovatta; Reijo Käkelä; Samuli Ripatti; Thomas Sandmann; Ville Hietakangas
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Safety of onartuzumab in patients with solid tumors: Experience to date from the onartuzumab clinical trial program
PLoS ONE, ISSN: 19326203
Roland Morley; Alison Cardenas; Peter Hawkins; Yasuyo Suzuki; Virginia Paton; See Phan; Mark Merchant; Jessie Hsu; Wei Yu; Qi Xia; Daniel Koralek; Patricia Luhn; Wassim Aldairy
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A subset of human bromodomains recognizes butyryllysine and crotonyllysine histone peptide modifications
Structure, ISSN: 18784186 09692126
E. Megan Flynn; Oscar W Huang; Florence Poy; Mariano Oppikofer; Steve Bellon; Yong Tang; Andrea G Cochran
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A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia
Leukemia and Lymphoma, ISSN: 10292403 10428194
Thomas J. Kipps; Herbert Eradat; Sebastian Grosicki; John Catalano; Walter Cosolo; Iryna S. Dyagil; Sreeni Yalamanchili; Akiko Chai; Srikumar Sahasranaman; Elizabeth A. Punnoose; Deborah Hurst; Halyna Pylypenko
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Intravitreal administration of known phototoxicants in the rabbit fails to produce phototoxicity: Implications for phototoxicity testing of intravitreally administered small molecule therapeutics
Cutaneous and Ocular Toxicology, ISSN: 15569535 15569527
Evan A Thackaberry; Cindy A. Farman; Vlad Bantseev; Chris Schuetz; Julia F. Baker; Michael H. Brown; Douglas B. Learn
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Unliganded fibroblast growth factor receptor 1 forms density-independent dimers
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Laetitia Comps-Agrar; Diana Ronai Dunshee; Dan L. Eaton; Junichiro Sonoda
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Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Snahel Patel; Seth F. Harris; Paul Gibbons; Gauri Deshmukh; Amy Gustafson; Terry Kellar; Han Lin; Xingrong Liu; Yanzhou Liu; Yichin Liu; Changyou Ma; Kimberly Scearce-Levie; Arundhati Sengupta Ghosh; Young G. Shin; Hilda Solanoy; Jian Wang; Bei Wang; Jianping Yin; Michael Siu; Joe Lewcock
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Gene expression of INPP5F as an independent prognostic marker in fludarabine-based therapy of chronic lymphocytic leukemia
Blood Cancer Journal, ISSN: 20445385
Palermo; Maisel; Martin Barrett; Helen Smith; Guillemette Duchateau-Nguyen; Tri Quang Nguyen; Ru-Fang Yeh; Annika Dufour; Tadeusz Robak; David Dornan; Martin Weisser
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Negishi Approach to 1,5-Disubstituted 3-Amino-1H-1,2,4-triazoles
Organic Letters, ISSN: 15237052 15237060
Jeff Shen; Brian Wong; Christine Gu; Haiming Zhang
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IgSimulator: A versatile immunosequencing simulator
Bioinformatics, ISSN: 14602059 13674803
Yana Safonova; Alla Lapidus; Jennie R. Lill
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The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease
Trends in Immunology, ISSN: 14714981 14714906
Jose Ordovas-Montanes; Seth Rakoff-Nahoum; Siyi Huang; Lorena Riol-Blanco; Olga Barreiro; Ulrich H. von Andrian
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Patient-centered decision support in acute ischemic stroke: Qualitative study of patients' and providers' perspectives
Circulation: Cardiovascular Quality and Outcomes, ISSN: 19417705 19417713
Carole Decker; Emily Chhatriwalla; Elizabeth Gialde; Brian Garavalia; Debbie Summers; Miriam E. Quinlan; Eric Cheng; Marilyn Rymer; Jeffrey L. Saver; Er Chen; David M. Kent; John A. Spertus
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More similar than different: Host cell protein production using three null CHO cell lines
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Inn H. Yuk; Julie C. Nishihara; Donald Walker; Eric Huang; Feny Gunawan; Jayashree Subramanian; Abigail F.J. Pynn; X. Christopher Yu; Judith Zhu-Shimoni; Vanderlaan; Denise C. Krawitz
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Synthetic protein lipidation
Current Opinion in Chemical Biology, ISSN: 18790402 13675931
Rami N. Hannoush
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Modular protein expression by RNA trans-splicing enables flexible expression of antibody formats in mammalian cells from a dual-host phage display vector
Protein Engineering, Design and Selection, ISSN: 17410134 17410126
Yonglei Shang; Devin B. Tesar; Isidro Hötzel
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Considerations on the appropriateness of the John Cunningham virus antibody assay use in patients with rheumatoid arthritis
Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172
Dominic Borie; Joel M. Kremer
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The airway microbiome in patients with severe asthma: Associations with disease features and severity
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Yvonne J. Huang; Snehal Nariya; Harris; Susan V. Lynch; David F. Choy; Joseph R. Arron; Homer Boushey
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Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor
Prostate, ISSN: 10970045 02704137
Kayvan R. Keshari; David M. Wilson; Mark Van Criekinge; Renuka Sriram; Bertram L. Koelsch; Zhen J. Wang; Henry F. Vanbrocklin; Donna M. Peehl; Thomas O'Brien; Deepak Sampath; Richard A. D. Carano; John Kurhanewicz
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Pathology consultation on gene mutations in acute myeloid leukemia
American Journal of Clinical Pathology, ISSN: 19437722 00029173
James Ziai; Alexa J. Siddon
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Phase II Randomized Study of Ixabepilone Versus Observation in Patients with Significant Residual Disease after Neoadjuvant Systemic Therapy for HER2-Negative Breast Cancer
Clinical Breast Cancer, ISSN: 19380666 15268209
Ana M. Gonzalez-Angulo; Xiudong Lei; Richardo H. Alvarez; Marjorie Green; James L. Murray; Vicente Valero; Kimberly B. Koenig; Nuhad K. Ibrahim; Jennifer K. Litton; Lakshmy Nair; Savitri Krishnamurthy; Hortobagyi; Funda Meric-Bernstam
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Asthma exacerbations and lung function in patients with severe or difficult-to-treat asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
William J. Calhoun; Tmirah Haselkorn; Dave P. Miller; Theodore A. Omachi
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Population Pharmacokinetics and Pharmacodynamics of Lampalizumab Administered Intravitreally to Patients with Geographic Atrophy
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Kha Le; Leonid Gibiansky; Menno Van Lookeren Campagne; Jeremy Good; Teresa Davancaze; Kelly M. Loyet; Alyssa M. Morimoto; Erich C. Strauss; Jin Y. Jin
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MTORC2 balances AKT activation and eIF2α serine 51 phosphorylation to promote survival under stress
Molecular Cancer Research, ISSN: 15573125 15417786
Clara Tenkerian; Jothilatha Krishnamoorthy; Zineb Mounir; Urszula Kazimierczak; Arkady Khoutorsky; Kirk A. Staschke; Arnold S. Kristof; Shuo Wang; Maria Hatzoglou; Antonis E. Koromilas
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Drug-induced Skin Lesions in Cynomolgus Macaques Treated with Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulators
Toxicologic Pathology, ISSN: 15331601 01926233
Gopinath S. Palanisamy; John M. Marcek; Gregg D. Cappon; Jessica Whritenour; Christopher L. Shaffer; Joseph T. Brady; Christopher Houle
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Membrane display and functional analysis of juxtacrine ligand-receptor signaling
BioTechniques, ISSN: 19409818 07366205
Pradeep Nair; Hai Ngu; Eric Torres; Scot A. Marsters; David Lawrence; Jean-Philippe Stephan; László Kömüves; Avi Ashkenazi
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