Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5851 - 5900 OF 15598 RESULTS

Semi-mechanistic multiple-analyte pharmacokinetic model for an antibody-drug-conjugate in cynomolgus monkeys
Pharmaceutical Research, ISSN: 1573904X 07248741
Dan Lu; Jin Y. Jin; Sandhya Girish; Priya Agarwal; Dongwei Li; Saileta Prabhu; Randall Dere; Ola M. Saad; Denise Nazzal; Neelima Koppada; Ramanujan; Chee Ng
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Design of coltuximab ravtansine, a CD19-targeting antibody-drug conjugate (ADC) for the treatment of B-cell malignancies: Structure-activity relationships and preclinical evaluation
Molecular Pharmaceutics, ISSN: 15438392 15438384
E. Erica Hong; Hans Erickson; Robert J. Lutz; Kathleen R. Whiteman; Gregory Jones; Yelena Kovtun; Veronique Blanc; John M. Lambert
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Imaging MALDI MS of dosed brain tissues utilizing an alternative analyte pre-extraction approach
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
Cristine Quiason; Sheerin Shahidi-Latham
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Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Edna F. Choo; Sarah Woolsey; Kevin Dement; Justin Ly; Kirsten Messick; Ann R. Qin; Ryan Takahashi
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A novel reaction mediated by human aldehyde oxidase: Amide hydrolysis of GDC-0834
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Jasleen K. Sodhi; Susan C. Wong; Donald S. Kirkpatrick; Lichuan Liu; S. Cyrus Khojasteh; Cornelis E. Hop; John T. Barr; Jeffrey P. Jones; Jason S Halladay
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Association of the interferon signature metric with serological disease manifestations but not global activity scores in multiple cohorts of patients with SLE
Lupus Science and Medicine, ISSN: 20538790
William P. Kennedy; Romeo MacIuca; Kristen Wolslegel; Tew; Abbas Alexander; Christina Chaivorapol; Alyssa M. Morimoto; Jacqueline McBride; Paul Brunetta; Bruce C. Richardson; John C. Davis; Timothy W. Behrens; Michael J. Townsend
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A cysteine-clamp gene drives embryo polarity in the midge Chironomus
Science, ISSN: 10959203 00368075
Jeff Klomp; Derek Athy; Chun Wai Kwan; Natasha I. Bloch; Thomas Sandmann; Steffen Lemke; Urs Schmidt-Ott
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Reproducibility: Changing the policies and culture of cell line authentication
Nature Methods, ISSN: 15487105 15487091
Leonard P. Freedman; Mark C. Gibson; Stephen P. Ethier; Howard R. Soule; Richard M. Neve; Yvonne A. Reid
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The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3 S,4 S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Christopher L. Shaffer; Nandini C. Patel; Jacob B. Schwarz; Renato J. Scialis; Yunjing Wei; Xinjun J. Hou; Longfei Xie; Kapil Karki; Dianne K. Bryce; Sarah M. Osgood; William E. Hoffmann; John T. Lazzaro; Cheng Chang; Dina F. McGinnis; Susan M. Lotarski; Jianhua Liu; R. Scott Obach; Mark L. Weber; Laigao Chen; Kenneth R. Zasadny; Patricia A. Seymour; Christopher J. Schmidt; Mihály Hajós; Raymond S. Hurst; Jayvardhan Pandit; Christopher J. O'Donnell
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SomaticSignatures: Inferring mutational signatures from single-nucleotide variants
Bioinformatics, ISSN: 14602059 13674803
Julian S. Gehring; Bernd Fischer; Michael Lawrence; Wolfgang Huber
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CNS Anticancer Drug Discovery and Development Conference White Paper
Neuro-Oncology, ISSN: 15235866 15228517
Victor A. Levin; Peter J. Tonge; James M. Gallo; Marc R. Birtwistle; Arvin C. Dar; Antonio Iavarone; Patrick J. Paddison; Timothy P. Heffron; William F. Elmquist; Jean E. Lachowicz; Ted W. Johnson; Forest M. White; Joohee Sul; Smith; Wang Shen; Jann N. Sarkaria; Ramakrishna Samala; Patrick Y. Wen; Donald A. Berry; Russell C. Petter
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Clinical outcomes with bevacizumab-containing and non-bevacizumab–containing regimens in patients with recurrent glioblastoma from US community practices
Journal of Neuro-Oncology, ISSN: 15737373 0167594X
Clara Chen; Arliene Ravelo; Elaine B. Yu; Rahul Dhanda; Ian Schnadig
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Registered report: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs
eLife, ISSN: 2050084X
Irawati Kandela; James Chou; Kartoa Chow; Elizabeth Iorns; William Gunn; Fraser Tan; Nicole Perfito; Timothy Errington
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Neo approaches to cancer vaccines
Science, ISSN: 10959203 00368075
Lélia Delamarre; Ira Mellman; Mahesh Yadav
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EPZ011989, A potent, orally-available EZH2 inhibitor with robust in vivo activity
ACS Medicinal Chemistry Letters, ISSN: 19485875
John E. Campbell; Kevin W. Kuntz; Sarah K. Knutson; Natalie M. Warholic; Heike Keilhack; Tim J. Wigle; Alejandra Raimondi; Christine R. Klaus; Nathalie Rioux; Akira Yokoi; Satoshi Kawano; Yukinori Minoshima; Hyeong-Wook Choi; Margaret Porter Scott; Nigel J. Waters; Jesse J. Smith; Richard Chesworth; Mikel P. Moyer; Robert A. Copeland
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Tetrahydroindazoles as interleukin-2 inducible T-cell kinase inhibitors. Part II. Second-generation analogues with enhanced potency, selectivity, and pharmacodynamic modulation in vivo
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Jason D. Burch; Kathy Barrett; Yuan Chen; Jason Devoss; Eigenbrot; Richard Goldsmith; Moulay Hicham Alaoui Ismaili; Kevin Lau; Zhonghua Lin; Daniel F. Ortwine; Ali A. Zarrin; Paul A. McEwan; John J. Barker; Claire Ellebrandt; Daniel Kordt; Daniel B. Stein; Xiaolu Wang; Yong Chen; Baihua Hu; Xiaofeng Xu; Po-Wai Yuen; Yamin Zhang; Zhonghua Pei
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Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies
Science Translational Medicine, ISSN: 19466242 19466234
Liping L. Sun; Diego Ellerman; Mary Mathieu; Maria Hristopoulos; Xiaocheng Chen; Yijin Li; Xiaojie Yan; Robyn Clark; Arthur Reyes; Stefanich; Elaine Mai; Judy Young; Clarissa Johnson; Mahrukh Huseni; Xinhua Wang; Chen; Peiyin Wang; Hong Wang; Noel Dybdal; Yu-Waye Chu; Nicholas Chiorazzi; Justin M. Scheer; Teemu T. Junttila; Klara Totpal; Dennis; Allen Ebens
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Castration-resistant Lgr5+ cells are long-lived stem cells required for prostatic regeneration
Stem Cell Reports, ISSN: 22136711
Bu-Er Wang; Xi Wang; Jason E. Long; Jeffrey Eastham-Anderson; Ron Firestein; Melissa Junttila
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A site of varicella-zoster virus vulnerability identified by structural studies of neutralizing antibodies bound to the glycoprotein complex gHgL
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Yi Xing; Stefan L. Oliver; TuongVi Nguyen; Claudio Ciferri; Avishek Nandi; Julie Hickman; Cinzia Giovani; Edward Yang; Giuseppe Palladino; Charles Grose; Yasushi Uematsu; Anders E. Lilja; Ann M. Arvin; Andrea Carfi
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Erratum to Modeling precision treatment of breast cancer [Genome Biology, 14, (2013), R110]
Genome Biology, ISSN: 1474760X 14747596
Anneleen Daemen; Obi L. Griffith; Laura M. Heiser; Nicholas J. Wang; Oana M. Enache; Zachary Sanborn; Francois Pepin; Durinck; James E. Korkola; Malachi Griffith; Joe S. Hur; Nam Huh; Jongsuk Chung; Leslie Cope; Mary Jo Fackler; Christopher Umbricht; Saraswati Sukumar; Pankaj Seth; Vikas P. Sukhatme; Lakshmi Jakkula; Yiling Lu; Gordon B. Mills; Raymond J Cho; Eric A. Collisson; Laura J. van't Veer; Paul T. Spellman; Joe W. Gray
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A size exclusion-reversed phase two dimensional-liquid chromatography methodology for stability and small molecule related species in antibody drug conjugates
Journal of Chromatography A, ISSN: 18733778 00219673
Yi Li; Christine Gu; Jason Gruenhagen; Kelly Zhang; Peter M. Yehl; Nik P. Chetwyn; Colin D. Medley
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Translational value of mouse models in oncology drug development
Nature Medicine, ISSN: 1546170X 10788956
Stephen Gould; Melissa Junttila; Frederic J. De Sauvage
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Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Pradeep Nair; Heather Flores; Alvin Gogineni; Scot A. Marsters; David Lawrence; Robert F. Kelley; Hai Ngu; Meredith Sagolla; László Kömüves; Richard Bourgon; Jeffrey Settleman; Avi Ashkenazi
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PI3 kinase/mTOR inhibition increases sensitivity of ER positive breast cancers to CDK4/6 inhibition by blocking cell cycle re-entry driven by cyclinD1 and inducing apoptosis
Annals of Oncology, ISSN: 15698041 09237534
Maria Teresa Herrera-Abreu; Uzma S. Asghar; Elliot; Alex Pearson; Michelle Nannini; Young; Deepak Sampath; Mitch Dowsett; Martin; Nicholas C. Turner
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PI3 kinase/mTOR inhibition increases sensitivity of ER positive breast cancers to CDK4/6 inhibition by blocking cell cycle re-entry driven by cyclinD1 and inducing apoptosis
Annals of Oncology, ISSN: 15698041 09237534
Maria Teresa Herrera-Abreu; Uzma S. Asghar; Elliot; Alex Pearson; Michelle Nannini; Young; Deepak Sampath; Mitch Dowsett; Martin; Nicholas C. Turner
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Filling of High-Concentration Monoclonal Antibody Formulations into Pre-filled Syringes: Investigating Formulation-Nozzle Interactions To Minimize Nozzle Clogging
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124
Wendy Shieu; Oliver B. Stauch; Maa
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In reply
Oncologist, ISSN: 1549490X
Shidong Jia; Liangxuan Zhang; Gary J. Latham
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RAC2 loss-of-function mutation in 2 siblings with characteristics of common variable immunodeficiency
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Omar K. Alkhairy; Nima Rezaei; Robert R. Graham; Hassan Abolhassani; Stephan Borte; Kjell Hultenby; Chenglin Wu; Asghar Aghamohammadi; David A. Williams; Timothy W. Behrens; Lennart Hammarström; Qiang Pan-Hammarström
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A novel IL-25 signaling pathway through STAT5
Journal of Immunology, ISSN: 15506606 00221767
Ling Wu; Jarod A. Zepp; Wen Qian; Bradley Martin; Wenjun Ouyang; Weiguo Yin; Kevin D. Bunting; Mark Aronica; Serpil Erzurum; Xiaoxia Li
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Characterization of free thiol variants of an IgG1 by reversed phase ultra high pressure liquid chromatography coupled with mass spectrometry
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Hongbin Liu; Justin Jeong; Kao; Taylor Zhang
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Visual impairment and blindness avoided with ranibizumab in hispanic and non-hispanic whites with diabetic macular edema in the United States
Ophthalmology, ISSN: 15494713 01616420
Rohit Varma; Neil M. Bressler; Quan V. Doan; Mark Danese; Chantal M. Dolan; Abraham Lee; Adam Turpcu
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Validation of an ICD-9-based claims algorithm for identifying patients with chronic idiopathic/spontaneous urticaria
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Dasha Cherepanov; Karina Raimundo; Eunice Chang; Marianne Eagan; James L. Zazzali; Paul G. Solari; Bruce Decotiis; Iftikhar Hussain; Syed Maseeh Rehman; Nada Shahab; Stephen A. Tilles; Michael S. Broder
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Yersinia pseudotuberculosisYopD mutants that genetically separate effector protein translocation from host membrane disruption
Molecular Microbiology, ISSN: 13652958 0950382X
Walter Adams; Jessica Morgan; Laura Kwuan; Victoria Auerbuch
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Health state utilities for chronic lymphocytic leukemia: Importance of prolonging progression-free survival
Leukemia and Lymphoma, ISSN: 10292403 10428194
Charlotte E. Kosmas; Sarah L. Shingler; Kunal Samanta; Christof Wiesner; Paul A. H. Moss; Ursula Becker; Andrew J. Lloyd
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Allosteric modulation of proteinase 3 activity by anti-neutrophil cytoplasmic antibodies in granulomatosis with polyangiitis
Journal of Autoimmunity, ISSN: 10959157 08968411
Lisa C. Hinkofer; Amber M. Hummel; John H. Stone; Hoffman; Merkel; E. Robert F. Spiera; St.clair; W. Joseph McCune; John C. Davis; Specks; Dieter E. Jenne
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Caspase-11: Arming the guards against bacterial infection
Immunological Reviews, ISSN: 1600065X 01052896
Irma B. Stowe; Bettina L. Lee; Nobuhiko Kayagaki
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Collagenase as an effective tool for drug quantitation in tissues
Bioanalysis, ISSN: 17576199 17576180
Ann R. Qin; Xiaorong Liang; Yuzhong Deng; Brian J. Dean; Sheerin Shahidi-Latham
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Comparison of the effectiveness of frontline chemoimmunotherapy regimens for follicular lymphoma used in the United States
Leukemia and Lymphoma, ISSN: 10292403 10428194
Loretta J. Nastoupil; Sinha; Michelle Byrtek; Ryan Ziemiecki; Taylor; Jonathan W. Friedberg; Jean L. Koff; Brian K. Link; James R. Cerhan; Keith Dawson; Christopher R. Flowers
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Clinical applications of choroidal imaging technologies
Indian Journal of Ophthalmology, ISSN: 19983689 03014738
Jay Chhablani; Giulio Barteselli
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Protection of Human myeloid dendritic cell subsets against influenza a virus infection is differentially regulated upon TLR stimulation
Journal of Immunology, ISSN: 15506606 00221767
Faezzah Baharom; Saskia Thomas; Andrea Bieder; Maria Hellmér; Julia Volz; Kerrie J. Sandgren; Gerald M. McInerney; Gunilla B. Karlsson Hedestam; Ira Mellman; Anna Smed-Sörensen
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Lactosylceramide-accumulation in lipid-rafts mediate aberrant-autophagy, inflammation and apoptosis in cigarette smoke induced emphysema
Apoptosis, ISSN: 1573675X 13608185
Manish Bodas; Taehong Min; Neeraj Vij
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Antibody positron emission tomography imaging in anticancer drug development
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Laetitia E. Lamberts; Simon P. Williams; Anton G. T. Terwisscha Van Scheltinga; Marjolijn N. Lub-De Hooge; Carolien P. Schröder; Jourik A. Gietema; Adrienne H. Brouwers; Elisabeth G. E. De Vries
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Humoral immune response to vaccines in patients with rheumatoid arthritis treated with tocilizumab: Results of a randomised controlled trial (VISARA)
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Bingham; Warren Rizzo; Alan Kivitz; Azra Hassanali; Ruchi Upmanyu; Micki Klearman
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MET Suppresses Epithelial VEGFR2 via Intracrine VEGF-induced Endoplasmic Reticulum-associated Degradation
EBioMedicine, ISSN: 23523964
Tom T. Chen; Ellen H. Filvaroff; Jing Peng; Scot A. Marsters; Adrian M. Jubb; Koeppen; Mark Merchant; Avi Ashkenazi
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PTEN loss is associated with worse outcome in HER2-Amplified breast cancer patients but is not associated with trastuzumab resistance
Clinical Cancer Research, ISSN: 15573265 10780432
Howard M. Stern; Humphrey Gardner; Tomasz Burzykowski; Wafaa Elatre; Carol O'Brien; Lackner; Gary A. Pestano; Angela Santiago; Ivonne Villalobos; Wolfgang Eiermann; Tadeusz Pienkowski; Miguel Martín; Nicholas J. Robert; John Crown; Nuciforo; Valerie Bée; John Mackey; Dennis J. Slamon; Michael F. Press
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Development and applications of AlphaScreen-based FcRn binding assay to characterize monoclonal antibodies
Journal of Immunological Methods, ISSN: 18727905 00221759
Qiang Wu; Ho Young Lee; Wong; Guoying Jiang; Hélène Gazzano-Santoro
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High resolution separation of recombinant monoclonal antibodies by size-exclusion ultra-high performance liquid chromatography (SE-UHPLC)
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Renee Yang; Yun Tang; Bing Zhang; Xuemei Lu; Alice Liu; Taylor Zhang
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Interpretation of meta-analysis evaluating progression-free survival as a surrogate endpoint for overall survival in glioblastoma
Neuro-Oncology, ISSN: 15235866 15228517
Kelong Han; Melanie Ren; Wick; Lauren E. Abrey; Asha Das; Jin Y. Jin; David A. Reardon
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Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Charles E. Frost; Wonkyung Byon; Yan Song; Jessie Wang; Alan E. Schuster; Rebecca A. Boyd; Donglu Zhang; Zhigang Yu; Clapton Dias; Andrew Shenker; Frank Lacreta
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Obinutuzumab plus fludarabine/cyclophosphamide or bendamustine in the initial therapy of CLL patients: The phase 1b GALTON trial
Blood, ISSN: 15280020 00064971
Jennifer R. Brown; Susan O'Brien; C. Daniel Kingsley; Herbert Eradat; John M. Pagel; James Lymp; Jamie Hirata; Thomas J. Kipps
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