Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7951 - 8000 OF 15795 RESULTS

Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I-III breast cancer (HannaH study): A phase 3, open-label, multicentre, randomised trial
The Lancet Oncology, ISSN: 14702045 14745488
Gustavo Ismael; Roberto Hegg; Susanne Muehlbauer; Dominik Heinzmann; Bert L. Lum; Sung-Bae Kim; Tadeusz Pienkowski; Mikhail Lichinitser; Vladimir Semiglazov; Melichar; Christian Jackisch
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QbD for biologics
BioProcess International, ISSN: 15426319
Steven Kozlowski; Wassim Nashabeh; Mark Schenerman; Howard Anderson; Ilse Blumentals; Kowid Ho; Rohin Mahtre; Barbara Rellahan; Victor Vinci; Lorna McLeod
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Pre-use/post-sterilization integrity testing of sterilizing grade filters
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440 19482124
Karen Bartel; Harold S. Baseman; Gabriele Gori; Richard V. Levy; Hemisha Ly; Maik W. Jornitz; Russell Madsen; Michiel Rook; Sue Schniepp
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Evaluating the Impact of Patient Recruitment and Retention Practices
Drug Information Journal, ISSN: 00928615
Mary Jo Lamberti; Adam Mathias; Jane E. Myles; Deborah Howe; Ken Getz
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A generic HPLC/UV platform method for cleaning verification
American Pharmaceutical Review, ISSN: 10998012
Michael W. Dong; Eileen X. Zhao; Derrick T. Yazzie; Christine Gu; Jackson D. Pellett
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Utilizing design of experiments to characterize assay robustness
Bioanalysis, ISSN: 17576180 17576199
Kyra J. Cowan; Erickson; Brian Sue; Reginald Delarosa; Bert Gunter; Daniel A. Coleman; Houston N. Gilbert; An Song; Saloumeh Kadkhodayan Fischer
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Sequencing and analysis of a South Asian-Indian personal genome
BMC Genomics, ISSN: 14712164
Ravi Gupta; Aakrosh Ratan; Changanamkandath Rajesh; Rong Chen; Hie Lim Kim; Richard Burhans; Webb Miller; Sam Santhosh; Ramana V. Davuluri; Atul J. Butte; Stephan C. Schuster; Somasekar Seshagiri; George Thomas
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Recurrent R-spondin fusions in colon cancer
Nature, ISSN: 00280836 14764687
Somasekar Seshagiri; Eric Stawiski; Durinck; Zora Modrusan; Elaine E. Storm; Caitlin B. Conboy; Subhra Chaudhuri; Yinghui Guan; Vasantharajan Janakiraman; Bijay S. Jaiswal; Joseph Guillory; Connie Ha; Gerrit J. P. Dijkgraaf; Stinson; Florian Gnad; Melanie A. Huntley; Jeremiah D. Degenhardt; Matthias Peter; Richard Bourgon; Weiru Wang; Koeppen; Robert Gentleman; Timothy Starr; Zemin Zhang; David A. Largaespada; Thomas D Wu; Frederic J. De Sauvage
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Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway
EMBO Journal, ISSN: 02614189 14602075
Guanglei Zhuang; Xiumin Wu; Zhaoshi Jiang; Ian Kasman; Jenny Yao; Yinghui Guan; Jason Oeh; Zora Modrusan; Carlos Bais; Deepak Sampath; Napoleone Ferrara
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Profiling antibody drug conjugate positional isomers: A system-of-equations approach
Analytical Chemistry, ISSN: 15206882 00032700
Lan N. Le; Jamie M. R. Moore; Jun Ouyang; Xiaoying Chen; Mary D. H. Nguyen; William J. Galush
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Transforming quality of care and improving outcomes after acute MI: Lessons from the national registry of myocardial infarction
JAMA - Journal of the American Medical Association, ISSN: 15383598 00987484
William J. French; Vanessa S. Reddy; Hal V. Barron
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Evaluation of an accurate mass approach for the simultaneous detection of drug and metabolite distributions via whole-body mass spectrometric imaging
Analytical Chemistry, ISSN: 00032700 15206882
Sheerin Shahidi-Latham; Sucharita M. Dutta; Maria C. Prieto Conaway; Patrick J. Rudewicz
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Identification and characterization of buried unpaired cysteines in a recombinant monoclonal igg1 antibody
Analytical Chemistry, ISSN: 00032700 15206882
Taylor Zhang; Jennifer Zhang; Daniel Hewitt; Ben Tran; Xiaoying Gao; Zhihua Julia Qiu; Max L. Tejada; Hélène Gazzano-Santoro; Kao
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Step-economic synthesis of (+)-crocacin C: A concise crotylboronation/[3,3] -sigmatropic rearrangement approach
Journal of Organic Chemistry, ISSN: 00223263 15206904
Adele E. Pasqua; Frank D. Ferrari; Chris Hamman; Yanzhou Liu; James J. Crawford; Rodolfo Marquez
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Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Hoanh Tran; Paul G. Polakis
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Balancing continuous and categorical baseline covariates in sequential clinical trials using the area between empirical cumulative distribution functions
Statistics in Medicine, ISSN: 02776715 10970258
Yunzhi Lin; Zheng Su
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Cardiovascular and systemic microvascular-effects of anti-vascular endothelial growth factor therapy for cancer
Journal of the American College of Cardiology, ISSN: 07351097 15583597
J. Todd Belcik; Yue Qi; Beat A. Kaufmann; Aris Xie; Sherron Bullens; Terry K. Morgan; Susan P. Bagby; Ganesh Kolumam; Joe Kowalski; Jon A. Oyer; Bunting; Jonathan R. Lindner
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Pari passu dimers of dimers
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Mark X. Sliwkowski
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Functional significance of isoform diversification in the protocadherin gamma gene cluster
Neuron, ISSN: 08966273 10974199
Weisheng V. Chen; Francisco J. Alvarez; Julie L. Lefebvre; Brad A. Friedman; Chiamaka Nwakeze; Eric Geiman; Courtney Smith; Chan Aye Thu; Juan Carlos Tapia; Bosiljka Tasic; Joshua R. Sanes; Tom Maniatis
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Quantification and characterization of micrometer and submicrometer subvisible particles in protein therapeutics by use of a suspended microchannel resonator
Analytical Chemistry, ISSN: 00032700 15206882
Ankit Patel; Doris Lau; Jun Liu
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Function, targets, and evolution of Caenorhabditis elegans piRNAs
Science, ISSN: 10959203 00368075
Marloes P. Bagijn; Leonard D. Goldstein; Alexandra Sapetschnig; Eva-Maria Weick; Samir Bouasker; Nicolas J. Lehrbach; Martin J. Simard; Eric A. Miska
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Patient out-of-pocket payments for oral oncolytics: Results from a 2009 us claims data analysis
American Journal of Managed Care, ISSN: 10880224
Martin L. Raborn; Elise M. Pelletier; Daniel B. Smith; Carolina Reyes
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A mutation in APP protects against Alzheimer‘s disease and age-related cognitive decline
Nature, ISSN: 00280836
Thorlakur Jonsson; Jasvinder K. Atwal; Stacy Steinberg; Jon Snaedal; Palmi V. Jonsson; Sigurbjorn Bjornsson; Hreinn Stefansson; Patrick Sulem; Daniel Gudbjartsson; Janice Maloney; Kwame Hoyte; Amy Gustafson; Yichin Liu; Yanmei Lu; Tushar Bhangale; Robert R. Graham; Johanna Huttenlocher; Gyda Bjornsdottir; Ole A. Andreassen; Erik G. Jönsson; Aarno Palotie; Timothy W. Behrens; Olafur T. Magnusson; Augustine Kong; Unnur Thorsteinsdottir; Ryan J. Watts; Kari Stefansson
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An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan
Aging Cell, ISSN: 14749718 14749726
Kwame Twumasi-Boateng; Tim W. Wang; Linda Tsai; Kuang-Hui Lee; Ali Salehpour; Sudarshan Bhat; Man-Wah Tan; Michael Shapira
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Effect of rifampin and rifabutin on the pharmacokinetics of lersivirine and effect of lersivirine on the pharmacokinetics of rifabutin and 25-O-desacetyl-rifabutin in healthy subjects
Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596
Manoli Vourvahis; John Davis; Rong Wang; Gary Layton; Heng Wee Choo; Chew Lan Chong; Margaret Tawadrous
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The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis
Protein Science, ISSN: 09618368 1469896X
Christian N. Cunningham; Daniel R. Southworth; Kristin A. Krukenberg; David A. Agard
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Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin
Hepatology, ISSN: 02709139 15273350
Stephen A. Harrison; Hamzeh; Jian Han; Prashant K. Pandya; Muhammed Y. Sheikh; John M. Vierling
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Pharmacokinetics and safety of coadministered oseltamivir and rimantadine in healthy volunteers: An open-label, multiple-dose, randomized, crossover study
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Georgina Cirrincione-Dall; Barbara J. Brennan; Rosa M. Ballester-Sanchis; Mercidita T. Navarro; Brian E. Davies
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Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth
Nature Neuroscience, ISSN: 10976256 15461726
Erik Mire; Cecilia Mezzera; Eduardo Leyva-Diáz; Ana V. Paternain; Paola Squarzoni; Lisa Bluy; Mar Castillo-Paterna; María José López; Sandra Peregrín; Marc Tessier-Lavigne; Sonia Garel; Joan Galcerán; Juan Lerma; Guillermina López-Bendito
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Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors
Journal of Pathology, ISSN: 00223417 10969896
Alicia S Chung; Marcin Kowanetz; Xiumin Wu; Guanglei Zhuang; Hai Ngu; David Finkle; László Kömüves; Franklin V. Peale Jr.; Napoleone Ferrara
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Longitudinal changes in asthma control with omalizumab: 2-year interim data from the EXCELS study
Journal of Asthma, ISSN: 02770903 15324303
Mark D. Eisner; James L. Zazzali; Mary K. Miller; Mary S. Bradley; Michael Schatz
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Stability of GABAB receptor oligomers revealed by dual TR-FRET and drug-induced cell surface targeting
FASEB Journal, ISSN: 08926638 15306860
Laetitia Comps-Agrar; Julie Kniazeff; Arsten Brock; Eric Trinquet; Jean-Philippe Pin
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Validation of a tool to assess medication treatment satisfaction in patients with Type2 diabetes: The Diabetes Medication System Rating Questionnaire (DMSRQ)
Diabetic Medicine, ISSN: 07423071 14645491
Peyrot; Harshaw; Shillington; Yaping Xu; Rubin
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Pcadmix: Principal components-based assignment of ancestry along each chromosome in individuals with admixed ancestry from two or more populations
Human Biology, ISSN: 00187143 15346617
Abra Brisbin; Katarzyna Bryc; Jake Byrnes; Fouad Zakharia; Larsson Omberg; Jeremiah D. Degenhardt; Andy Reynolds; Harry Ostrer; Jason G. Mezey; Carlos D. Bustamante
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DNA methylation alterations in response to pesticide exposure in vitro
Environmental and Molecular Mutagenesis, ISSN: 08936692 10982280
Xiao Zhang; Andrew D. Wallace; Pan Du; Warren A. Kibbe; Nadereh Jafari; Hehuang Xie; Simon Lin; Andrea A. Baccarelli; Marcelo Bento Soares; Lifang Hou
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Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: The phase III FILM trial
Annals of the Rheumatic Diseases, ISSN: 00034967 14682060
Stohl W.; Juan Gomez-Reino; Ewa Olech; Jean Dudler; Roy Fleischmann; Cristiano A. F. Zerbini; Ashrafzadeh; Susanna M. Grzeschik; Rebecca Bieraugel; Jennifer Green; Steve Francom; Wolfgang Dummer
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Overcoming soluble target interference in an anti-therapeutic antibody screening assay for an antibody-drug conjugate therapeutic
Bioanalysis, ISSN: 17576180 17576199
Montserrat Carrasco-Triguero; Connie Mahood; Marija Milojic-Blair; Caroline Amaya; Jane Ruppel; Kyu Hong; Joo-Hee Yi; Surinder Kaur
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Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma
American Journal of Neuroradiology, ISSN: 01956108 1936959X
Jose A. Carrillo; Albert Lai; Phioanh L. Nghiemphu; Kim; Phillips; Samir Kharbanda; Moftakhar; Lalaezari; William H. Yong; Benjamin M. Ellingson; Timothy Cloughesy; Whitney B. Pope
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Protein microarrays, biosensors, and cell-based methods for secretome-wide extracellular protein-protein interaction mapping
Methods, ISSN: 10462023 10959130
Lino C. Gonzalez Jr.
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Drug absorption interactions between oral targeted anticancer agents and PPIs: Is pH-dependent solubility the achilles heel of targeted therapy
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Nageshwar Budha; Adam Frymoyer; Gillian S. Smelick; Jin Y. Jin; Marc R. Yago; Mark J. Dresser; Scott N. Holden; Leslie Z. Benet; Joseph A. Ware
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Nanolitre-scale crystallization using acoustic liquid-transfer technology
Acta Crystallographica Section D: Biological Crystallography, ISSN: 09074449 13990047
Armando G. Villasẽor; April Wong; Ada Shao; Ankur Garg; Timothy J. Donohue; Andreas Kuglstatter; Seth F. Harris
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Identification of Asp isomerization in proteins by 18O labeling and tandem mass spectrometry
Methods in Molecular Biology, ISSN: 10643745
Jennifer Zhang; Viswanatham Katta
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Methods to engineer and identify IgG1 variants with improved FcRn binding or effector function
Methods in Molecular Biology, ISSN: 10643745
Robert F. Kelley; Meng
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Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
Nature, ISSN: 00280836 14764687
Wilson; Jane Fridlyand; Yibing Yan; Elicia M. Penuel; Luciana Burton; Emily Chan; Jing Peng; Eva Lin; Wang; Jeffrey A. Sosman; Antoni Ribas; Jiang Li; John Moffat; Daniel P. Sutherlin; Koeppen; Mark Merchant; Richard M. Neve; Jeffrey Settleman
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The development of small-molecule IAP antagonists for the treatment of cancer
Topics in Medicinal Chemistry, ISSN: 18622461 1862247X
Deshayes; Jeremy Murray; Domagoj Vucic
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Inefficiency of randomization methods that balance on stratum margins and improvements with permuted blocks and a sequential method
Statistics in Medicine, ISSN: 02776715 10970258
Lee D. Kaiser
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Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease
Blood, ISSN: 15280020 00064971
Pichika Chantrathammachart; Nigel Mackman; Erica Sparkenbaugh; Jian-Guo Wang; Leslie V. Parise; Daniel Kirchhofer; Nigel S. Key; Rafal Pawlinski
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CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
Blood, ISSN: 15280020 00064971
Sebastian Willenborg; Tina Lucas; Geert Van Loo; Johanna A. Knipper; Thomas Krieg; Ingo Haase; Bent Brachvogel; Matthias Hammerschmidt; Andras Nagy; Napoleone Ferrara; Manolis Pasparakis; Sabine A. Eming
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Coarse-grained modeling of the self-association of therapeutic monoclonal antibodies
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Anuj Chaudhri; Isidro E. Zarraga; Tim J. Kamerzell; J. Paul Brandt; Thomas W. Patapoff; Steven J. Shire; Gregory A. Voth
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Antitumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical response
Clinical Cancer Research, ISSN: 10780432 15573265
Harvey Wong; Edna F. Choo; Bruno Alicke; Xiao Ding; Hank La; Erin McNamara; Frank-Peter Theil; Jay Tibbitts; Lori S. Friedman; Cornelis E. Hop; Stephen Gould
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