Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8351 - 8400 OF 15795 RESULTS

Evaluating the minimally important difference of the urticaria activity score and other measures of disease activity in patients with chronic idiopathic urticaria
Annals of Allergy, Asthma and Immunology, ISSN: 10811206 15344436
Susan D. Mathias; Ross D. Crosby; James L. Zazzali; Marcus Maurer; Sarbjit S. Saini
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Treatment of HER2-positive breast cancer: Current status and future perspectives
Nature Reviews Clinical Oncology, ISSN: 17594774 17594782
Carlos L. Arteaga; Mark X. Sliwkowski; C.Kent Osborne; Edith A. Perez; Fabio Puglisi; Luca Gianni
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Assessing and improving asymmetric flow field-flow fractionation of therapeutic proteins
Field-Flow Fractionation in Biopolymer Analysis,
Jun Liu; Qing Zhu; Steven J. Shire; Barthélemy Demeule
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Editorial
Contemporary Clinical Trials, ISSN: 15517144 15592030
Zheng Su
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Hybridization of conditional and predictive power for futility assessment in sequential clinical trials with time-to-event outcomes: A resampling approach
Contemporary Clinical Trials, ISSN: 15517144 15592030
Jing Yi; Liang Fang; Zheng Su
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BEAM: A randomized phase II study evaluating the activity of bevacizumab in combination with carboplatin plus paclitaxel in patients with previously untreated advanced melanoma
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Kevin B. Kim; Jeffrey A. Sosman; John P. Fruehauf; Gerald Linette; Svetomir N. Markovic; David McDermott; Jeffrey S. Weber; Hoa Nguyen; Peter Cheverton; Daniel S. Chen; Amy Peterson; William E. Carson III; Steven J. O'Day
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Thioredoxin 1 is responsible for antibody disulfide reduction in CHO cell culture
Journal of Biotechnology, ISSN: 01681656 18734863
Kristen L. Koterba; Trissa Borgschulte; Mike Laird
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3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Dange V. Kumar; Roopa Rai; Ken A. Brameld; Jennifer Riggs; John R. Somoza; Ravi Rajagopalan; James W. Janc; Yu M. Xia; Tony L. Ton; Huiyong Hu; Isabelle Lehoux; Joseph D. Ho; Wendy B. Young; Barry Hart; Michael J. Green
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Carbon-deuterium rotational-echo double-resonance NMR spectroscopy of lyophilized aspartame formulations
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Suman A. Luthra; Marcel Utz; Eric M. Gorman; Michael J. Pikal; Eric Munson; Joseph W. Lubach
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Characterization of the isomerization products of aspartate residues at two different sites in a monoclonal antibody
Pharmaceutical Research, ISSN: 07248741 1573904X
Alavattam Sreedhara; Cordoba; Qing Zhu; Jeanne Kwong; Jun Liu
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Effect of sulfobutyl ether beta-cyclodextrin modifier on selectivity of reversed phase hplc separations
Journal of Liquid Chromatography and Related Technologies, ISSN: 10826076 1520572X
Kenley K. Ngim; Qiqing Zhong; Kavita Mistry; Nik P. Chetwyn
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Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice
mAbs, ISSN: 19420862 19420870
Rong Deng; Meng; Kwame Hoyte; Jeff Lutman; Yanmei Lu; Suhasini Iyer; Laura DeForge; Frank-Peter Theil; Fielder; Saileta Prabhu
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Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration
mAbs, ISSN: 19420870 19420862
Zheng; Devin B. Tesar; Lisa Benincosa; Herbert F. Birnböck; C. Andrew Boswell; Daniela Bumbaca; Kyra J. Cowan; Dimitry Danilenko; Daugherty; Fielder; Hans Peter Grimm; Amita Joshi; Nicole Justies; Gerry Kolaitis; Nicholas Lewin-Koh; Jing Li; Sami McVay; Jennifer O'Mahony; Michael Otteneder; Michael P. Pantze; Wendy Putnam; Zhihua Julia Qiu; Jane Ruppel; Thomas Singer; Oliver B. Stauch; Frank-Peter Theil; Jennifer Visich; Yang; Yong Ying; Leslie A. Khawli; Wolfgang F. Richter
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Transferrin antibodies into the brain
Neuropsychopharmacology, ISSN: 0893133X 1740634X
Dennis; Ryan J. Watts
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A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain
Nature Cell Biology, ISSN: 14657392 14764679
Ben Chih; Peter S. Liu; Yvonne Chinn; Cecile Chalouni; László Kömüves; Hass; Wendy N. Sandoval; Andrew S. Peterson
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In vitro-in vivo extrapolation of clearance: Modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Patrick Poulin; Jane R. Kenny; Cornelis E. Hop; Sami Haddad
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Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
David F. Choy; Daniel K. Hsu; Dhaya Seshasayee; Maxwell A. Fung; Zora Modrusan; Flavius Martin; Fu-Tong Liu; Joseph R. Arron
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Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Science Translational Medicine, ISSN: 19466242
Zejuan Sheng; Shuo Zhang; Daisy J. Bustos; Tracy L. Kleinheinz; Claire E. Le Pichon; Sara L. Dominguez; Hilda Solanoy; Jason H. Drummond; Xiaolin Zhang; Xiao Ding; Fang Cai; Qinghua Song; Xianting Li; Zhenyu Yue; Marcel P Van Der Brug; Burdick; Janet Gunzner; Huifen Chen; Xingrong Liu; Anthony A. Estrada; Zachary K. Sweeney; Kimberly Scearce-Levie; John Moffat; Donald S. Kirkpatrick; Haitao Zhu
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Targeting a cystic fibrosis mutation opens door for personalized treatment.
Managed Care, ISSN: 10623388
Thomas Morrow
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Influence of the compound selection process on the performance of human clearance prediction methods
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Harvey Wong; Sock-Cheng Lewin-Koh; Frank-Peter Theil; Cornelis E. Hop
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A very short history of structure-based design: How did we get here and where do we need to go?
Journal of Computer-Aided Molecular Design, ISSN: 0920654X 15734951
Jeff Blaney
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Pioneers of oncology nursing.
ONS connect, ISSN: 19351623
Bertie Ford
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A very short history of structure-based design: How did we get here and where do we need to go?
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Jeff Blaney
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Noninvasive optical sensor technology in shake flasks
BioProcess International, ISSN: 15426319
Wen-Lin Tsai; Jennifer Autsen; Julie Ma; Terry Hudson; Jun Luo
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Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice
Mucosal Immunology, ISSN: 19330219 19353456
Jennifer Cox; Noelyn Kljavin; Naruhisa Ota; Leonard; Merone Roose-Girma; Laurie Diehl; Wenjun Ouyang; Nico Ghilardi
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DEGAS: Sharing and tracking target compound ideas with external collaborators
Journal of Chemical Information and Modeling, ISSN: 1549960X 15499596
Man-Ling Lee; Ignacio Aliagas; Jennafer Dotson; Jianwen A. Feng; Alberto Gobbi; Timothy P. Heffron
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Anti-angiogenesis therapy in melanoma
Targeted Therapeutics in Melanoma,
Daniel S. Chen
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Randomized and balancing allocation schemes for clinical trials: Computational perspectives on design and deployment
Designs for Clinical Trials: Perspectives on Current Issues,
Vincent J. Carey; Robert Gentleman
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ggbio: an R package for extending the grammar of graphics for genomic data
Genome Biology, ISSN: 14656914
Tengfei Yin; Dianne Cook; Michael Lawrence
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Evaluation of time-dependent cytochrome P450 inhibition in a high-throughput, automated assay: Introducing a novel area under the curve shift approach
Drug Metabolism Letters, ISSN: 18723128
Sophie Mukadam; Suzanne Tay; Daniel Tran; Leslie Wang; Erlie Marie Delarosa; S. Cyrus Khojasteh; Jason S Halladay; Jane R. Kenny
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Phase i clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma
Investigational New Drugs, ISSN: 15730646 01676997
Jason Konner; Rachel N. Grisham; Jae Park; Owen A. O'Connor; Gillian Cropp; Robert Johnson; Alison L. Hannah; Martee L. Hensley; Paul Sabbatini; Svetlana Miranov; Samuel Danishefsky; David Hyman; David R. Spriggs; Jakob Dupont; Carol Aghajanian
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Investigating high-concentration monoclonal antibody powder suspension in nonaqueous suspension vehicles for subcutaneous injection
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Mayumi Bowen; Nick Armstrong; Maa
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Variable selection in multivariate modeling of drug product formula and manufacturing process
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Yong Cui; Xiling Song; King Chuang; Venkatramani; Sueanne Lee; Gregory Gallegos; Thirunellai Venkateshwaran; Minli Xie
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Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Erratum:Ungersma et al., vessel imaging with viable tumor analysis for quantification of tumor angiogenesis.(Magnetic Resonance in Medicine 2010 63 (1637-1647))
Magnetic Resonance in Medicine, ISSN: 15222594 07403194
Sharon E. Ungersma; Glenn Pacheco; Calvin Ho; Sharon Fong Yee; Ross; Nicholas Van Bruggen; Franklin V. Peale Jr.; Ross; Richard A. D. Carano
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Bevacizumab maintenance in patients with advanced non-small-cell lung cancer, clinical patterns, and outcomes in the eastern cooperative oncology group 4599 study: Results of an exploratory analysis
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Ariel Lopez-Chavez; Todd Young; Sophie Fages; Larry Leon; Joan H. Schiller; Afshin Dowlati; Julie Brahmer; David H. Johnson; Alan Sandler
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Comparative assessment of In Vitro-In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Patrick Poulin; Cornelis E. Hop; Quynh Ho; Jason S Halladay; Sami Haddad; Jane R. Kenny
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Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Ozan S. Kumru; Jun Liu; Junyan A. Ji; Wilson Cheng; Y. John Wang; Tingting Wang; Sangeeta B. Joshi; C. Russell Middaugh; David B. Volkin
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SpeCond: A method to detect condition-specific gene expression
Genome Biology, ISSN: 14747596 1474760X
Florence M.G. Cavalli; Richard Bourgon; Juan M. Vaquerizas; Nicholas M. Luscombe
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The A-MYSM Power of Deubiquitinases
Immunity, ISSN: 10747613 10974180
Ignacio A. Demarco; Harinder Singh
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Cancer immunotherapy comes of age
Nature, ISSN: 14764687 00280836
Ira Mellman; George Coukos; Glenn Dranoff
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The authors reply
New England Journal of Medicine, ISSN: 00284793 15334406
Joseph R. Arron; Jonathan Corren; Matthews
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Identification of surprisingly diverse type IV Pili, across a broad range of gram-positive bacteria
PLoS ONE, ISSN: 19326203
Saheed Imam; Zhongqiang Chen; David S. Roos; Mechthild Pohlschröder
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Workshop summary: Novel aspects of the functions of the TRAFs and cIAPs
Advances in Experimental Medicine and Biology, ISSN: 00652598
John Silke; Domagoj Vucic
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TRAF2 and cellular IAPs: A critical link in TNFR family signaling
Advances in Experimental Medicine and Biology, ISSN: 00652598
Domagoj Vucic
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Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.
Science Translational Medicine, ISSN: 19466242
Ai-Luen Wu; Ganesh Kolumam; Scott Stawicki; Yongmei Chen; Jun Li; Jose Zavala-Solorio; Khanhky Phamluong; Feng; Li; Scot A. Marsters; Lance Kates; Nicholas Van Bruggen; Maya Leabman; Anne Wong; David A. West; Howard M. Stern; Luis; Hok Seon Kim; Yansura; Andrew S. Peterson; Ellen H. Filvaroff; Yan Wu; Junichiro Sonoda
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Influence of 17β-estradiol on gene expression of paracoccidioides during mycelia-to-yeast transition
PLoS ONE, ISSN: 19326203
Jata Shankar; Thomas D Wu; Karl V. Clemons; Jomar P. Monteiro; Laurence F. Mirels; David A. Stevens
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Metabolic disease: Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
Science Translational Medicine, ISSN: 19466242 19466234
Ai-Luen Wu; Ganesh Kolumam; Scott Stawicki; Yongmei Chen; Jun Li; Jose Zavala-Solorio; Khanhky Phamluong; Bo Feng; Li Li; Scot A. Marsters; Lance Kates; Nicholas Van Bruggen; Maya Leabman; Anne Wong; David West; Howard M. Stern; Luis; Hok Seon Kim; Yansura; Andrew S. Peterson; Ellen H. Filvaroff; Yan Wu; Junichiro Sonoda
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The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly
Cell, ISSN: 10974172 00928674
Jorge Z. Torres; Matthew K. Summers; David Peterson; Matthew J. Brauer; James Lee; Silvia Senese; Ankur A. Gholkar; Yu-Chen Lo; Xingye Lei; Kenneth Jung; David C. Anderson; David P. Davis; Lisa D. Belmont; Peter K Jackson
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Process validation challenges for technology transfer
Pharmaceutical Outsourcing, ISSN: 19453337
Judy H. Chang
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