Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9301 - 9350 OF 15795 RESULTS

March 1, 2010

Use of anti-VEGF adjuvant therapy in cancer: challenges and rationale

Trends in Molecular Medicine, ISSN: 14714914

Anil Bagri; Hosein Kouros-Mehr; Kevin G. Leong; Greg D. Plowman

March 1, 2010

Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available Pan-PI3-kinase and dual Pan-PI3-kinase/mTOR inhibitors for the treatment of cancer

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Daniel P. Sutherlin; Deepak Sampath; Megan Berry; Georgette M. Castanedo; Zhigang Chang; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Lori S. Friedman; Richard Goldsmith; Timothy P. Heffron; Leslie Lee; John Lesnick; Lewis; Simon Mathieu; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Wei Wei Prior; Laurent Salphati; Steve Sideris; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Wiesmann; Susan C. Wong; Bing-Yan Zhu

March 1, 2010

Membrane transporters in drug development

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Kathleen M. Giacomini; Huang; Donald J. Tweedie; Leslie Z. Benet; Kim L.R. Brouwer; Xiaoyan Chu; Amber Dahlin; Raymond Evers; Volker Fischer; Kathleen M. Hillgren; Keith Hoffmaster; Toshihisa Ishikawa; Dietrich Keppler; Richard B. Kim; Caroline A. Lee; Mikko Niemi; Polli; Yuichi Sugiyama; Peter W. Swaan; Joseph A. Ware; Stephen H. Wright; Sook Wah Yee; Zamek-Gliszczynski; Lei Zhang

March 1, 2010

Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation

DMM Disease Models and Mechanisms, ISSN: 17548403 17548411

Nathalie Ortega; Ke Wang; Napoleone Ferrara; Zena Werb; Thiennu H. Vu

March 1, 2010

Practical applications of quality risk management

BioProcess International, ISSN: 15426319

Mire-Sluis; Emma Ramnarine; Joseph Siemiatkoski; Dan Weese; Patrick Swann; Richard O'Keeffe; Joe Kutza; Julia Edwards; Lorna McLeod

February 25, 2010

ALK1 signaling regulates early postnatal lymphatic vessel development

Blood, ISSN: 15280020 00064971

Kyle Niessen; Gu Zhang; John B.B. Ridgway; Hao Chen; Minhong Yan

February 19, 2010

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

Cell, ISSN: 00928674

Baris Bingol; Chi-Fong Wang; David Arnott; Dongmei Cheng; Junmin Peng; Morgan Sheng

February 19, 2010

IFN-α-induced upregulation of CCR5 leads to expanded HIV tropism in vivo

PLoS Pathogens, ISSN: 15537374 15537366

Cheryl A. Stoddart; Mary E. Keir; Joseph M. McCune

February 18, 2010

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: Combating tumor evasion of antiangiogenic therapy

Blood, ISSN: 15280020 00064971

Saul J. Priceman; James L. Sung; Zory Shaposhnik; Jeremy B. Burton; Antoni X. Torres-Collado; Diana L. Moughon; Mai Johnson; Aldons J. Lusis; Donald A. Cohen; M. Luisa Iruela-Arispe; Lily Wu

February 18, 2010

Rere controls retinoic acid signalling and somite bilateral symmetry

Nature, ISSN: 00280836 14764687

Gonçalo C. Vilhais-Neto; Mitsuji Maruhashi; Karen T. Smith; Mireille Vasseur-Cognet; Andrew S. Peterson; Jerry L. Workman; Olivier Pourquié

February 15, 2010

A phase I safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignancies

Clinical Cancer Research, ISSN: 10780432

D. Ross Camidge; Roy S. Herbst; Michael S. Gordon; Gail Eckhardt; Razelle Kurzrock; Blythe Durbin; Josephine Ing; Tanyifor M. Tohnya; Jason Sager; Avi Ashkenazi; Gordon L. Bray; David Mendelson

February 15, 2010

From the authors

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Prescott G. Woodruff; Joseph R. Arron; John V. Fahy

February 15, 2010

Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells

Journal of Experimental Medicine, ISSN: 00221007 15409538

Natasha K Crellin; Sara Trifari; Charles D. Kaplan; Tom Cupedo; Hergen Spits

February 15, 2010

Activation of epithelial STAT3 regulates intestinal homeostasis

Cell Cycle, ISSN: 15514005 15384101

Clemens Neufert; Geethanjali Pickert; Yan Zheng; Nadine Wittkopf; Moritz Warntjen; Alexei Nikolaev; Wenjun Ouyang; Markus F. Neurath; Christoph Becker

February 12, 2010

Multiple Novel Classes of APRIL-specific Receptor-blocking Peptides Isolated by Phage Display

Journal of Molecular Biology, ISSN: 00222836

Nathaniel C. Gordon; Samantha Lien; Jeremy Johnson; Heidi J. A. Wallweber; Thuy Tran; Bridget Currell; Mary Mathieu; Quan; Melissa A. Starovasnik; Sarah G. Hymowitz; Robert F. Kelley

February 11, 2010

Chronic DLL4 blockade induces vascular neoplasms

Nature, ISSN: 00280836 14764687

Minhong Yan; Christopher Callahan; Joseph Beyer; Krishna P. Allamneni; Gu Zhang; John B.B. Ridgway; Kyle Niessen; Greg D. Plowman

February 10, 2010

Fast and SNP-tolerant detection of complex variants and splicing in short reads

Bioinformatics, ISSN: 13674803 14602059

Thomas D Wu; Serban Nacu

February 3, 2010

Benzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 Message

Toxicological Sciences, ISSN: 10960929 10966080

Phuong Minh Nguyen; Miki Susanto Park; Marilynn Chow; Jae H. Chang; Lisa Wrischnik; William K. Chan

February 1, 2010

Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors

Cancer Research, ISSN: 00085472 15387445

Kyle A. Edgar; Jeffery J. Wallin; Megan Berry; Leslie Lee; Wei Wei Prior; Deepak Sampath; Lori S. Friedman; Marcia Belvin

February 1, 2010

Association of methotrexate and tumour necrosis factor antagonists with risk of infectious outcomes including opportunistic infections in the CORRONA registry

Annals of the Rheumatic Diseases, ISSN: 00034967 14682060

Greenberg; Reed; Joel M. Kremer; Tindall; Arthur Kavanaugh; Zheng; Bishai; Hochberg

February 1, 2010

Small-molecule pan-IAP antagonists: A patent review

Expert Opinion on Therapeutic Patents, ISSN: 13543776

Flygare; Wayne J. Fairbrother

February 1, 2010

Active, but not passive cigarette smoking was inversely associated with mammographic density

Cancer Causes and Control, ISSN: 09575243 15737225

Lesley Butler; Ellen B. Gold; Shannon M. Conroy; Carolyn J. Crandall; Gail A. Greendale; Nina Oestreicher; Charles P. Quesenberry Jr.; Laurel A. Habel

February 1, 2010

Baseline autoantibody profiles predict normalization of complement and anti-dsDNA autoantibody levels following Rituximab treatment in systemic lupus erythematosus

Lupus, ISSN: 09612033

Tew; Rabbee; Kristen Wolslegel; Hsin-Ju Hsieh; John G. Monroe; Timothy W. Behrens; Paul Brunetta; Mary E. Keir

February 1, 2010

Pathways mediating VEGF-independent tumor angiogenesis

Cytokine and Growth Factor Reviews, ISSN: 13596101

Napoleone Ferrara

February 1, 2010

BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Gregory J. Cost; Yevgeniy Freyvert; Annamaria Vafiadis; Yolanda Santiago; Jeffrey C. Miller; Edward J. Rebar; Trevor N. Collingwood; Andrew Snowden; Philip D. Gregory

February 1, 2010

Targeting the tumor microenvironment with Src kinase inhibition

Clinical Cancer Research, ISSN: 10780432

Alicia S Chung; Napoleone Ferrara

February 1, 2010

Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture

PLoS Computational Biology, ISSN: 1553734X 15537358

Ju Han; Hang Chang; Orsi Giricz; Genee Y. Lee; Frederick L. Baehner; Joe W. Gray; Mina J. Bissell; Paraic A. Kenny; Bahram Parvin

February 1, 2010

Bioavailability in healthy adults of efavirenz capsule contents mixed with a small amount of food

American Journal of Health-System Pharmacy, ISSN: 15352900 10792082

Sanjeev Kaul; Ping Ji; Michael W. Lu; Kim L. Nguyen; Tong Shangguan; Dennis Grasela

February 1, 2010

Modular architecture of Munc13/calmodulin complexes: Dual regulation by Ca 2 and possible function in short-term synaptic plasticity

EMBO Journal, ISSN: 02614189 14602075

Fernando Rodríguez-Castãeda; Mitcheell Maestre-Martínez; Nicolas Coudevylle; Kalina Dimova; Harald Junge; Noa Lipstein; Donghan Lee; Stefan Becker; Nils Brose; Olaf Jahn; Teresa Carlomagno; Christian Griesinger

February 1, 2010

Editorial overview

Current Opinion in Immunology, ISSN: 09527915

Ira Mellman; Peter Cresswell

February 1, 2010

Outlier options: Consider simple parametric tests to find an outlier's significance

Quality Progress, ISSN: 0033524X

Julia E. Seaman; I. Elaine Allen

February 1, 2010

Ixabepilone: Providing new hope for women with breast cancer after anthracycline and taxane failure

Clinical journal of oncology nursing, ISSN: 10921095 1538067X

Alisha Stein

January 29, 2010

Understanding and mitigating conductivity transitions in weak cation exchange chromatography

Journal of Chromatography A, ISSN: 00219673

Jace Fogle; Jenny Hsiung

January 25, 2010

Dynamics of the bacterial intermediate filament crescentin in vitroand in vivo

PLoS ONE, ISSN: 19326203

Osigwe Esue; Laura Rupprecht; Sean X. Sun; Denis Wirtz

January 22, 2010

Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development

Cell, ISSN: 00928674

Beate M. Lichtenberger; Poi Kiang Tan; Heide Niederleithner; Napoleone Ferrara; Peter Petzelbauer; Maria Sibilia

January 19, 2010

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo

Developmental Cell, ISSN: 15345807

Eric Camerer; Adrian Barker; Daniel N. Duong; Rajkumar Ganesan; Hiroshi Kataoka; Ivo Cornelissen; Molly R. Darragh; Arif Hussain; Yao-Wu Zheng; Yoga Srinivasan; Christopher Brown; Shan-Mei Xu; Jean B. Regard; Chen-Yong Lin; Charles S. Craik; Daniel Kirchhofer; Shaun R. Coughlin

January 19, 2010

Stromal cell-derived factor-1/CXCL12 contributes to MMTV-Wnt1 tumor growth involving Gr1+CD11b+ cells

PLoS ONE, ISSN: 19326203

Bob Y. Liu; Soloviev; Peter Chang; John Lee; Xiaodong Huang; Cuiling Zhong; Napoleone Ferrara; Paul G. Polakis; Sakanaka

January 19, 2010

β1 Integrin Establishes Endothelial Cell Polarity and Arteriolar Lumen Formation via a Par3-Dependent Mechanism

Developmental Cell, ISSN: 15345807

Ann C. Zovein; Alfonso Luque; Kirsten A. Turlo; Jennifer J. Hofmann; Kathleen M. Yee; Michael S. Becker; Reinhard Fässler; Ira Mellman; Timothy F. Lane; M. Luisa Iruela-Arispe

January 19, 2010

Utilization of lysozyme charge ladders to examine the effects of protein surface charge distribution on binding affinity in ion exchange systems

Langmuir, ISSN: 07437463

Wai Keen Chung; Steven T. Evans; Alexander S. Freed; James J. Keba; Zachary C. Baer; Kaushal Rege; Steven M. Cramer

January 18, 2010

Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1

Journal of Experimental Medicine, ISSN: 00221007 15409538

Hongkang Xi; Kenneth J. Katschke Jr.; Karim Y. Helmy; Paige A. Wark; Noelyn Kljavin; Hilary F. Clark; Jeffrey Eastham-Anderson; Theresa Shek; Merone Roose-Girma; Nico Ghilardi; Menno Van Lookeren Campagne

January 15, 2010

Corrigendum to "GDC-0449-A potent inhibitor of the hedgehog pathway" [Bioorg. Med. Chem. Lett. 19 (2009) 5576] (DOI:10.1016/j.bmcl.2009.08.049)

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Kirk D. Robarge; Shirley A. Brunton; Georgette M. Castanedo; Yong Cui; Dina; Richard Goldsmith; Stephen Gould; Oivin Guichert; Janet Gunzner; Jason S Halladay; Wei Jia; S. Cyrus Khojasteh; Michael F. T. Koehler; Karen Kotkow; Hank La; Rebecca L. LaLonde; Kevin Lau; Leslie Lee; Derek Marshall; James C. Marsters Jr.; Lesley J. Murray; Changgeng Qian; Lee L. Rubin; Laurent Salphati; Mark S. Stanley; John H.A. Stibbard; Daniel P. Sutherlin; Savita Ubhayakar; Shumei Wang; Susan C. Wong; Minli Xie

January 15, 2010

Reversing HOXA9 oncogene activation by PI3K inhibition: Epigenetic mechanism and prognostic significance in human glioblastoma

Cancer Research, ISSN: 00085472 15387445

Bruno M. Costa; Justin S. Smith; Ying Chen; Justin Chen; Phillips; Kenneth D. Aldape; Giuseppe Zardo; Janice M. Nigro; C. David James; Jane Fridlyand; Rui M. Reis; Joseph F. Costello

January 15, 2010

Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis

Journal of Immunology, ISSN: 00221767 15506606

Nadine Kassner; Manuela Krueger; Hideo Yagita; Andrzej Dzionek; Andreas Hutloff; Richard Kroczek; Alexander Scheffold; Sascha Rutz

January 11, 2010

Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3

Journal of Cell Biology, ISSN: 00219525 00219525

Yunling Xu; Li Yuan; Judy Mak; Luc Pardanaud; Maresa Caunt; Ian Kasman; Bruno Larrivee; Raquel del Toro; Steven Suchting; Alexander Medvinsky; Jillian Silva; Jian Yang; Jean-Léon Thomas; Alexander W. Koch; Kari Alitalo; Anne Eichmann; Anil Bagri

January 8, 2010

Four-component synthesis of fully substituted 1,2,4-triazoles

Angewandte Chemie - International Edition, ISSN: 14337851

Steven T. Staben; Nicole Blaquiere

January 8, 2010

Industrial case study: Evaluation of a mixed-mode resin for selective capture of a human growth factor recombinantly expressed in E. coli

Journal of Chromatography A, ISSN: 00219673

Kimberly A. Kaleas; Charles H. Schmelzer; Shelly A. Pizarro

January 7, 2010

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

Nature, ISSN: 00280836 14764687

Martin Schwickart; Xiaodong Huang; Jennie R. Lill; Jinfeng Liu; Ron Ferrando; French; Heather Maecker; Karen M. O'Rourke; J.Fernando Bazan; Jeffrey Eastham-Anderson; Peng Yue; David Dornan; David C.S. Huang; Vishva M. Dixit

January 1, 2010

Molecular imaging of the initial inflammatory response in atherosclerosis: Implications for early detection of disease

Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN: 10795642

Beat A. Kaufmann; Chad L. Carr; J. Todd Belcik; Aris Xie; Yue Qi; Scott Chadderdon; Evan S. Caplan; Jaspreet Khangura; Sherron Bullens; Bunting; Jonathan R. Lindner

January 1, 2010

Comparative biotransformation of pyrazinone-containing corticotropin- releasing factor receptor-1 antagonists: Minimizing the reactive metabolite formation

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Xiaoliang Zhuo; Richard A. Hartz; Joanne J. Bronson; Harvey Wong; Vijay T. Ahuja; Vivekananda M. Vrudhula; John E. Leet; Stella Huang; John E. Macor; Yue-Zhong Shu

January 1, 2010

A mouse knockout library for secreted and transmembrane proteins

Nature Biotechnology, ISSN: 15461696 10870156

Tracy Tzu-Ling Tang; Li Li; Zhijun Tang; Yun Li; Wei Yu Lin; Flavius Martin; Deanna Grant; Mark J. Solloway; Leon Parker; Weilan Ye; William F. Forrest; Nico Ghilardi; Tamás Oravecz; Kenneth A. Platt; Dennis S. Rice; Gwenn M. Hansen; Alejandro Abuin; Derek E. Eberhart; Godowski; Kathleen H. Holt; Andrew S. Peterson; Brian P. Zambrowicz; Frederic J. De Sauvage

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