Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9401 - 9450 OF 15795 RESULTS

The chemical toolbox for monitoring protein fatty acylation and prenylation
Nature Chemical Biology, ISSN: 15524469 15524450
Rami N. Hannoush; Jinglucy Sun
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O-fucose modulates notch-controlled blood lineage commitment
American Journal of Pathology, ISSN: 15252191 00029440
Quanjian Yan; David Yao; Lebing L. Wei; Yuanshuai Huang; Jay Myers; Lihua Zhang; Wei Xin; Jeongsup Shim; Yunfang Man; Bronislawa Petryniak; Stanton Gerson; John Lowe; Lan Zhou
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Incidence of New Choroidal Neovascularization in Fellow Eyes of Patients Treated in the MARINA and ANCHOR Trials
American Journal of Ophthalmology, ISSN: 00029394
Irene Barbazetto; Namrata Saroj; Howard Shapiro; Pamela Wong; Allen C. Ho; K. Bailey Freund
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Ranibizumab for Macular Edema following Central Retinal Vein Occlusion. Six-Month Primary End Point Results of a Phase III Study
Ophthalmology, ISSN: 01616420
David M. Brown; Peter A. Campochiaro; Rishi Singh; Zhengrong Li; Sarah Gray; Namrata Saroj; Amy Chen Rundle; Roman G. Rubio; Wendy Yee Murahashi
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Early menstrual characteristics associated with subsequent diagnosis of endometriosis
American Journal of Obstetrics and Gynecology, ISSN: 00029378
Susan A. Treloar; Tanya A. Bell; Christina M. Nagle; David M. Purdie; Adèle C. Green
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Ranibizumab for Macular Edema following Branch Retinal Vein Occlusion. Six-Month Primary End Point Results of a Phase III Study
Ophthalmology, ISSN: 01616420
Peter A. Campochiaro; Jeffrey S. Heier; Leonard Feiner; Sarah Gray; Namrata Saroj; Amy Chen Rundle; Wendy Yee Murahashi; Roman G. Rubio
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Vessel imaging with viable tumor analysis for quantification of tumor angiogenesis
Magnetic Resonance in Medicine, ISSN: 15222594 07403194
Sharon E. Ungersma; Glenn Pacheco; Calvin Ho; Sharon Fong Yee; Ross; Nicholas Van Bruggen; Franklin V. Peale Jr.; Ross; Richard A. D. Carano
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Manipulation of host cell death pathways during microbial infections
Cell Host and Microbe, ISSN: 19346069 19313128
Lamkanfi; Vishva M. Dixit
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An automated method for nonparametric kinetic analysis of clinical DCE-MRI data: Application to glioblastoma treated with bevacizumab
Magnetic Resonance in Medicine, ISSN: 15222594 07403194
Gregory Z. Ferl; Lu Xu; Michel Friesenhahn; Lisa J. Bernstein; Daniel P. Barboriak; Ruediger E. Port
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Asthma and the prospective risk of anaphylactic shock and other allergy diagnoses in a large integrated health care delivery system
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Carlos Iribarren; Irina V. Tolstykh; Mary K. Miller; Mark D. Eisner
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Two lab tests help clinicians diagnose and predict ischemic stroke.
Managed Care, ISSN: 10623388
Thomas Morrow
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On developing a process for conducting extractable-leachable assessment of components used for storage of biopharmaceuticals
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Aditya A. Wakankar; Y. John Wang; Eleanor Canova-Davis; Stacey Ma; Dieter Schmalzing; Josh Grieco; Terry Milby; Theresa Reynolds; Mazzarella; Ed Hoff; Stephen Gomez; Sheryl Martin-Moe
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Co-expression of ferrochelatase allows for complete heme incorporation into recombinant proteins produced in E. coli
Protein Expression and Purification, ISSN: 10465928
Jawahar Sudhamsu; Mariam Kabir; Michael V. Airola; Bhumit A. Patel; Syun-Ru Yeh; Denis L. Rousseau; Brian R. Crane
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Functions of type II pneumocyte-derived vascular endothelial growth factor in alveolar structure, acute inflammation, and vascular permeability
American Journal of Pathology, ISSN: 15252191 00029440
Marco Mura; Matthew Binnie; Bing Han; Chengjin Li; Cristiano F. Andrade; Atsushi Shiozaki; Yu Zhang; Napoleone Ferrara; David Hwang; Thomas K. Waddell; Shaf Keshavjee; Mingyao Liu
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Ricinus communis agglutinin I leads to rapid down-regulation of VEGFR-2 and endothelial cell apoptosis in tumor blood vessels
American Journal of Pathology, ISSN: 15252191 00029440
Weon-Kyoo You; Ian Kasman; Dana D. Hu-Lowe; Donald M. McDonald
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Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization
Analytical Biochemistry, ISSN: 10960309 00032697
Brian D. Connolly; Thomas W. Patapoff; Y. John Wang; Jamie M. R. Moore; Tim J. Kamerzell
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Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors
American Journal of Pathology, ISSN: 15252191 00029440
Seth B. Coffelt; Claire E. Lewis; Luigi Naldini; J. Martin Brown; Napoleone Ferrara; Michele De Palma
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PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth
Cell, ISSN: 00928674
Carlos Bais; Xiumin Wu; Jenny Yao; Suya Yang; Yongping Crawford; Krista McCutcheon; Christine Tan; Ganesh Kolumam; Jean-Michel Vernes; Jeffrey Eastham-Anderson; Peter Haughney; Marcin Kowanetz; Thijs Hagenbeek; Ian Kasman; Hani Bou-Reslan; Ross; Nicholas Van Bruggen; Richard A. D. Carano; Yu-Ju Gloria Meng; Hongo; Jean-Philippe Stephan; Masabumi Shibuya; Napoleone Ferrara
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Vision-Related Function after Ranibizumab Treatment by Better- or Worse-Seeing Eye. Clinical Trial Results from MARINA and ANCHOR
Ophthalmology, ISSN: 01616420
Neil M. Bressler; Tom S. Chang; Ivan J. Suñer; Jennifer T. Fine; Chantal M. Dolan; James Ward; Tsontcho Ianchulev
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On the influence of protein binding on pharmacological activity of drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the hedgehog pathway inhibitor GDC-0449 in dogs: An investigation using preclinical studies and physiologically based pharmacokinetic modeling
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Harvey Wong; Frank-Peter Theil; Yong Cui; James C. Marsters Jr.; S. Cyrus Khojasteh; Laurent Vernillet; Hank La; Xiling Song; Hong Wang; Eric Morinello; Yuzhong Deng; Cornelis E. Hop
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Signaling to NF-kappaB: regulation by ubiquitination.
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Ingrid E. Wertz; Vishva M. Dixit
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Secretory Cell Hyperplasia and Defects in Notch Activity in a Mouse Model of Leukocyte Adhesion Deficiency Type II
Gastroenterology, ISSN: 00165085
Christopher C.M. Waterhouse; Steven Johnson; Mia Phillipson; Lori Zbytnuik; Björn Petri; Margaret Kelly; John Lowe; Paul Kubes
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Safety and efficacy of combining sunitinib with bevacizumab + paclitaxel/carboplatin in non-small cell lung cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Mark A. Socinski; Frank A. Scappaticci; Meghna Samant; Margaret M. Kolb; Kozloff
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Specific interactions in high concentration antibody solutions resulting in high viscosity
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Sandeep Yadav; Jun Liu; Steven J. Shire; Devendra S. Kalonia
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Longterm safety of patients receiving rituximab in rheumatoid arthritis clinical trials
Journal of Rheumatology, ISSN: 0315162X
Ronald Van Vollenhoven; Paul Emery; Bingham; Edward Keystone; Roy Fleischmann; Daniel E. Furst; Katherine Macey; Marianne Sweetser; Ariella Kelman; Rao Ravi
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Statistical techniques to construct assays for identifying likely responders to a treatment under evaluation from cell line genomic data.
BMC Cancer, ISSN: 14712407
Erich P. Huang; Jane Fridlyand; Nicholas Lewin-Koh; Peng Yue; Xiaoyan Shi; David Dornan; Bart Burington
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Targeting inhibitor of apoptosis (IAP) proteins in cancer
Apoptosis: Modern Insights into Disease from Molecules to Man,
Eugene Varfolomeev; Domagoj Vucic
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Cancer: MiRNA addiction - Depending on life's little things
Current Biology, ISSN: 09609822
David Dornan; Jeffrey Settleman
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A generic headspace GC method for residual solvents in pharmaceuticals: Benefits, rationale, and adaptations for new chemical entities
LCGC North America, ISSN: 15275949
Lulu Dai; Amanda C. Quiroga; Kelly Zhang; Heather B. Runes; Derrick T. Yazzie; Kavita Mistry; Nik P. Chetwyn; Michael W. Dong
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An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Satish K. Singh; Nataliya Afonina; Michel Awwad; Karoline Bechtold-Peters; Jeffrey T. Blue; Danny Chou; Cromwell; Hans-Juergen Krause; Hanns-Christian Mahler; Brian K. Meyer; Linda O. Narhi; Doug P. Nesta; Thomas Spitznagel
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Single-use technology and its carbon and water footprints, part 2: "Bioreactors - To be or not to be: That is the question"
American Pharmaceutical Review, ISSN: 10998012
Lindsay Leveen
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Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model
British Journal of Dermatology, ISSN: 13652133 00070963
Wang; Fujita; Prado; Tousson; Hsu; Arndt J Schottelius; Kelly; Yang; Wu; Chen; Xu; Elmets; Mountz; Edwards Iii
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Pharmaceutical Medical Information Contact Centers: Results of Three Benchmarking Surveys
Therapeutic Innovation and Regulatory Science, ISSN: 21684790
Pete Guillot; Stacey M. Fung
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Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture
PLoS Computational Biology, ISSN: 15537358 1553734X
Ju Han; Hang Chang; Orsi Giricz; Genee Y. Lee; Frederick L. Baehner; Joe W. Gray; Mina J. Bissell; Paraic A. Kenny; Bahram Parvin
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Foreword
Separation Science and Technology, ISSN: 15205754 01496395
James M. van Alstine; Philip M. Lester
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Robust preparation of novel imidazo[5,1-b][1,3,4]oxadiazoles
Organic and Biomolecular Chemistry, ISSN: 14770520
Tuan P. Tran; Nandini C. Patel; Brian Samas; Jacob B. Schwarz
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Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17
Journal of Experimental Medicine, ISSN: 00221007 15409538
Melba Muñoz; Markus Heimesaat; Kerstin Danker; Daniela Struck; Uwe Lohmann; Rita Plickert; Stefan Bereswill; André Fischer; Ildikò Rita Dunay; Kerstin Wolk; Christoph Loddenkemper; Hans-Willi Krell; Claude Libert; Leif R. Lund; Oliver Frey; Christoph Hölscher; Yoichiro Iwakura; Nico Ghilardi; Wenjun Ouyang; Thomas Kamradt; Robert Sabat; Oliver Liesenfeld
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Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Bing Li; Hongkang Xi; Laurie Diehl; Wyne P. Lee; Lizette Sturgeon; Jason Chinn; Laura DeForge; Robert F. Kelley; Wiesmann; Menno Van Lookeren Campagne; Sachdev S. Sidhu
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Interlaced size exclusion liquid chromatography of monoclonal antibodies
Journal of Chromatography A, ISSN: 00219673
Dell Farnan; G. Tony Moreno; Stults; Andreas Becker; Guillaume Tremintin; Mark van Gils
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Cutting edge: Depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice
Journal of Immunology, ISSN: 00221767 15506606
Kim; Katharina Lahl; Shohei Hori; Christoph Loddenkemper; Ashutosh Chaudhry; Paul DeRoos; Alexander Y. Rudensky; Tim Sparwasser
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IL-23 is required for protection against systemic infection with Listeria monocytogenes
Journal of Immunology, ISSN: 00221767 15506606
Karen D. Meeks; Amy N. Sieve; Jay K. Kolls; Nico Ghilardi; Rance E. Berg
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X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eugene Varfolomeev; Bruno Alicke; J. Michael Elliott; Zobel; Kristina West; Harvey Wong; Justin M. Scheer; Avi Ashkenazi; Stephen Gould; Wayne J. Fairbrother; Domagoj Vucic
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Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody
Structure, ISSN: 09692126
Rajkumar Ganesan; Eigenbrot; Yan Wu; Wei-Ching Liang; Steven Shia; Michael T. Lipari; Daniel Kirchhofer
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Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation
Cancer Cell, ISSN: 15356108
Bijay S. Jaiswal; Vasantharajan Janakiraman; Noelyn Kljavin; Subhra Chaudhuri; Howard M. Stern; Weiru Wang; Zhengyan Kan; Hashem A. Dbouk; Brock A. Peters; Waring; Trisha Dela Vega; Denise M. Kenski; Krista K. Bowman; Maria N. Lorenzo; Hong Li; Jiansheng Wu; Zora Modrusan; Stinson; Mike Eby; Peng Yue; Joshua S. Kaminker; Frederic J. De Sauvage; Jonathan M. Backer; Somasekar Seshagiri
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Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy
Breast Cancer Research, ISSN: 14655411 1465542X
Nancy Dumont; Yongping Crawford; Mahvash Sigaroudinia; Shefali S. Nagrani; Matthew B. Wilson; Gertrude C. Buehring; Gulisa Turashvili; Samuel A. Aparicio; Mona L. Gauthier; Colleen A. Fordyce; Kimberly M. McDermott; Thea D. Tlsty
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Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2
Molecular Pharmaceutics, ISSN: 15438384 15438392
Henriette E. Meyer Zu Schwabedissen; Joseph A. Ware; Rommel G. Tirona; Richard B. Kim
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Transport-metabolism interplay
Molecular Pharmaceutics, ISSN: 15438384 15438392
Laurent Salphati
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Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Martin L. Sos; Stefanie Fischer; Roland Ullrich; Martin Peifer; Johannes M. Heuckmann; Mirjam Koker; Stefanie Heynck; Isabel Stückrath; Jonathan Weiss; Florian Fischer; Kathrin Michel; Aviva Goel; Lucia Regales; Katerina Politi; Samanthi Perera; Matthäus Getlik; Lukas C. Heukamp; Sascha Ansén; Thomas Zander; Rameen Beroukhim; Hamid Kashkar; Kevan Shokat; William R. Sellers; Daniel Rauh; Christine Orr; Klaus P. Hoeflich; Lori S. Friedman; Kwok-Kin Wong; William Pao; Roman K. Thomas
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Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells
Carcinogenesis, ISSN: 01433334 14602180
Cho S. Aung; Weilan Ye; Greg D. Plowman; Amelia A. Peters; Gregory R. Monteith; Sarah J. Roberts-Thomson
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