Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9901 - 9950 OF 15583 RESULTS

February 28, 2008

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

New England Journal of Medicine, ISSN: 15334406 00284793

Geoffrey Hom; Robert R. Graham; Barmak Modrek; Kimberly E. Taylor; Ward Ortmann; Sophie Garnier; Annette T. Lee; Sharon A. Chung; Ricardo C. Ferreira; P. V. Krishna Pant; Dennis G. Ballinger; Kosoy; F. Yesim Demirci; M. Ilyas Kamboh; Amy H. Kao; Tian; Iva Gunnarsson; Anders A. Bengtsson; Solbritt Rantapää-Dahlqvist; Michelle Petri; Manzi; Michael F. Seldin; Lars Rönnblom; Ann-Christine Syvänen; Lindsey A. Criswell; Peter K. Gregersen; Timothy W. Behrens

February 28, 2008

Stem Cell Factor Functions as an Outgrowth-Promoting Factor to Enable Axon Exit from the Midline Intermediate Target

Neuron, ISSN: 08966273

Bryan B. Gore; Karen G. Wong; Marc Tessier-Lavigne

February 20, 2008

Are Phase 2 screening trials in Oncology obsolete?

Statistics in Medicine, ISSN: 02776715 10970258

Holmgren

February 20, 2008

Vesicle priming and recruitment by ubMunc13-2 are differentially regulated by calcium and calmodulin

Journal of Neuroscience, ISSN: 02706474 02706474

Dragoslav Zikich; Aviv Mezer; Frederique Varoqueaux; Anton Sheinin; Harald Junge; Esther Nachliel; Rely Melamed; Nils Brose; Menachem Gutman; Uri Ashery

February 19, 2008

Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Farbod Shojaei; Mallika Singh; Jennifer D. Thompson; Napoleone Ferrara

February 15, 2008

A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior

Analytical Biochemistry, ISSN: 10960309 00032697

Quan; Emily W. Alcala; Irena Petkovska; Domenic Matthews; Eleanor Canova-Davis; Ron Taticek; Stacey Ma

February 14, 2008

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

New England Journal of Medicine, ISSN: 15334406 00284793

Stephen L. Hauser; Waubant; Douglas L. Arnold; Timothy Vollmer; Jack Antel; Robert J. Fox; Amit Bar-Or; Michael Panzara; Neena Sarkar; Sunil Agarwal; Annette Langer-Gould; Craig H. Smith

February 8, 2008

Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Pierre A. Barthelemy; Helga Raab; Brent A. Appleton; Christopher J. Bond; Ping Wu; Wiesmann; Sachdev S. Sidhu

February 5, 2008

Engineering and Overproduction of Polyketide Natural Products

Modern Biopharmaceuticals: Design, Development and Optimization,

Martha Lovato Tse; Chaitan Khosla

February 5, 2008

pH dependent effect of glycosylation on protein stability

European Journal of Pharmaceutical Sciences, ISSN: 09280987

Wei Wang; Kris Antonsen; Y. John Wang; Wang

February 1, 2008

Racial variation in the incidence, care, and outcomes of severe sepsis: Analysis of population, patient, and hospital characteristics

American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970

Amber E. Barnato; Sherri L. Alexander; Walter T. Linde-Zwirble; Derek C. Angus

February 1, 2008

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

Nature Genetics, ISSN: 10614036 15461718

John B. Harley; Marta E. Alarcón-Riquelme; Lindsey A. Criswell; Chaim O. Jacob; Robert P. Kimberly; Kathy L. Moser; Betty P. Tsao; Timothy J. Vyse; Carl D. Langefeld; Swapan K. Nath; Joel M. Guthridge; Beth L. Cobb; Daniel B. Mirel; Miranda C. Marion; Adrienne H. Williams; Jasmin Divers; Wei Wang; Summer G. Frank; Bahram Namjou; Stacey B. Gabriel; Annette T. Lee; Peter K. Gregersen; Timothy W. Behrens; Kimberly E. Taylor; Michelle M.A. Fernando; Raphael Zidovetzki; Patrick M. Gaffney; Jeffrey C. Edberg; John D. Rioux; Joshua O. Ojwang; Judith A. James; Merrill; Gary S. Gilkeson; Michael F. Seldin; Hong Yin; Emily C. Baechler; Quan-Zhen Li; Edward K. Wakeland; Gail R. Bruner; Kenneth M. Kaufman; Jennifer A. Kelly

February 1, 2008

Duration of chronic toxicity studies for biotechnology-derived pharmaceuticals: Is 6 months still appropriate?

Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295

Janet Clarke; Christopher Hurst; Pauline L. Martin; John Vahle; Rafael Ponce; Barbara Mounho; Shawn Heidel; Laura Andrews; Theresa Reynolds; Joy A. Cavagnaro

February 1, 2008

Allergen skin tests and free IgE levels during reduction and cessation of omalizumab therapy

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Jonathan Corren; Gail Shapiro; Reimann; Yamo Deniz; Dennis A. Wong; Daniel C. Adelman; Alkis Togias

February 1, 2008

Transplantation: It may take two to tango and to treat

Immunology and Cell Biology, ISSN: 08189641 14401711

Flavius Martin

February 1, 2008

Cleaning validation for biopharmaceutical manufacturing at Genentech

BioPharm International, ISSN: 1542166X

A. Hamid Mollah

February 1, 2008

Economic evaluation of rituximab plus cyclophosphamide, vincristine and prednisolone for advanced follicular lymphoma

Leukemia and Lymphoma, ISSN: 10428194 10292403

John Hornberger; Carolina Reyes; Deborah Lubeck; Nancy Valente

February 1, 2008

Interaction between bevacizumab and murine VEGF-A: A reassessment

Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783

Lanlan Yu; Xiumin Wu; Zhiyong Cheng; Chingwei V. Lee; Jennifer Lecouter; Claudio Campa; Fuh; Henry B. Lowman; Napoleone Ferrara

February 1, 2008

Effect of food on the pharmacokinetics of erlotinib, an orally active epidermal growth factor receptor tyrosine-kinase inhibitor, in healthy individuals

Anti-Cancer Drugs, ISSN: 09594973

Jie Ling; Scott Fettner; Bert L. Lum; Myriam Riek; Ashok Rakhit

February 1, 2008

Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling

Immunology and Cell Biology, ISSN: 08189641 14401711

Nicholas S. Wilson; Louise J. Young; Fiona Kupresanin; Shalin H. Naik; David Vremec; William R. Heath; Shizuo Akira; Ken Shortman; Jeff Boyle; Eugene Maraskovsky; Gabrielle T Belz; Jose A. Villadangos

January 30, 2008

Netrin-1 is a novel myelin-associated inhibitor to axon growth

Journal of Neuroscience, ISSN: 02706474 02706474

Karin Löw; Maya Culbertson; Frank Bradke; Marc Tessier-Lavigne; Mark H. Tuszynski

January 23, 2008

SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system

EMBO Journal, ISSN: 02614189 14602075

Vikki M. Weake; Kenneth K. Lee; Sebastián Guelman; Chia-Hui Lin; Christopher Seidel; Susan M. Abmayr; Jerry L. Workman

January 22, 2008

Dual effects of Tween 80 on protein stability

International Journal of Pharmaceutics, ISSN: 03785173

Wei Wang; Y. John Wang; Wang

January 15, 2008

Role for lysosomal enzyme β-hexosaminidase in the control of mycobacteria infection

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Ingrid Chou Koo; Yamini M. Ohol; Ping Wu; J. Hiroshi Morisaki; Jeffery S. Cox; Eric J. Brown

January 15, 2008

Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer

Clinical Cancer Research, ISSN: 10780432

Peisheng Hu; Robyn S. Arias; Rebecca E. Sadun; Yu-Chih Nien; Nan Zhang; Helen Sabzevari; M. E. Christine Lutsiak; Leslie A. Khawli; Alan L. Epstein

January 11, 2008

Laboratory evolution of Escherichia coli thioredoxin for enhanced catalysis of protein oxidation in the periplasm reveals a phylogenetically conserved substrate specificity determinant

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Lluis Masip; Daniel Klein-Marcuschamer; Shu Quan; James C. A. Bardwell; George Georgiou

January 10, 2008

Response-independent survival benefit in metastatic colorectal cancer: A comparative analysis of N9741 and AVF2107

Journal of Clinical Oncology, ISSN: 0732183X

Grothey; Eric Hedrick; Robert Mass; Somnath Sarkar; Sam Suzuki; Ramesh K. Ramanathan; Herbert Hurwitz; Richard M. Goldberg; Daniel J. Sargent

January 8, 2008

Synthetic antibodies for specific recognition and crystallization of structured RNA

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Jing-Dong Ye; Valentina Tereshko; John K. Frederiksen; Akiko Koide; Frederic A. Fellouse; Sachdev S. Sidhu; Shohei Koide; Anthony A. Kossiakoff; Joseph A. Piccirilli

January 3, 2008

Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models

Oncogene, ISSN: 09509232 14765594

Luc Desnoyers; Rama Pai; Ron Ferrando; Kathy Hötzel; Tom Le; Ross; Richard A. D. Carano; Aloma L. D'Souza; Jing Qing; Iman Mohtashemi; Avi Ashkenazi; French

January 1, 2008

Accounting for Interim Analyses in the Assessment of Program Expected Net Present Value

Therapeutic Innovation and Regulatory Science, ISSN: 21684790

Lee D. Kaiser; Jeffrey D. Helterbrand; Hal V. Barron

January 1, 2008

Quantification of viable tumor microvascular characteristics by multispectral analysis

Magnetic Resonance in Medicine, ISSN: 15222594 07403194

Berry; Kai H. Barck; MaryAnn Go; Ross; Xiumin Wu; Simon P. Williams; Alvin Gogineni; Mary J. Cole; Nicholas Van Bruggen; Fuh; Franklin V. Peale Jr.; Napoleone Ferrara; Ross; Ralph H. Schwall; Richard A. D. Carano

January 1, 2008

Improved health-related quality of life for patients with active rheumatoid arthritis receiving rituximab - Results of the dose-ranging assessment: International clinical evaluation of rituximab in rheumatoid arthritis (DANCER) trial

Journal of Rheumatology, ISSN: 0315162X

Philip J. Mease; Dennis A. Revicki; Jacek Szechinski; Maria Greenwald; Alan Kivitz; Leonor Barile-Fabris; Jatinderpal Kalsi; Jennifer Eames; Marjatta Leirisalo-Repo

January 1, 2008

The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: Computer-based simulation (SimCYP™) predicts in vivo metabolic inhibition

European Journal of Clinical Pharmacology, ISSN: 00316970

Ashok Rakhit; Michael P. Pantze; Scott Fettner; Hannah M. Jones; Jean-Eric Charoin; Myriam Riek; Bert L. Lum; Marta Hamilton

January 1, 2008

In reply

Annals of Emergency Medicine, ISSN: 01960644

Andrew R. Erdman

January 1, 2008

hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of β-catenin

Cancer Biology and Therapy, ISSN: 15384047 15558576

Min Yang; Marian L. Waterman; Rainer Brachmann

January 1, 2008

Subspecialty differences in asthma characteristics and management

Mayo Clinic Proceedings, ISSN: 00256196

Hubert Chen; Charles A. Johnson; Tmirah Haselkorn; June H. Lee; Elliot Israel

January 1, 2008

Characterization of a complex glycoprotein whose variable metabolic clearance in humans is dependent on terminal N-acetylglucosamine content

Biologicals, ISSN: 10451056 10958320

Rodney Keck; Namita Nayak; Laura Lerner; Shanta Raju; Stacey Ma; Thomas Schreitmueller; Steven M. Chamow; Kathy Moorhouse; Claire Kotts; Andrew J.S. Jones

January 1, 2008

Blocking vascular endothelial growth factor-A inhibits the growth of pituitary adenomas and lowers serum prolactin level in a mouse model of multiple endocrine neoplasia type 1

Clinical Cancer Research, ISSN: 10780432

Nina Korsisaari; Ross; Xiumin Wu; Marcin Kowanetz; Navneet Pal; Linda Hall; Jeffrey Eastham-Anderson; William F. Forrest; Nicholas Van Bruggen; Franklin V. Peale Jr.; Napoleone Ferrara

January 1, 2008

Recommended changes to oncology clinical trial design: Revolution or evolution?

European Journal of Cancer, ISSN: 09598049

Ratain; Rachel W. Humphrey; Gary Gordon; Gwendolyn Fyfe; Peter C. Adamson; Thomas R. Fleming; Walter M. Stadler; Donald A. Berry; Carl C. Peck

January 1, 2008

High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate

British Journal of Haematology, ISSN: 00071048 13652141

Gladys S. Ingle; Pamela Chan; J. Michael Elliott; Wesley S. Chang; Koeppen; Jean-Philippe Stephan; Suzie J. Scales

January 1, 2008

Computational approaches for predicting causal missense mutations in cancer genome projects

Current Bioinformatics, ISSN: 15748936

Lawrence S. Hon; Joshua S. Kaminker; Zemin Zhang

January 1, 2008

Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus

Nature Genetics, ISSN: 10614036 15461718

Deborah S. Cunninghame Graham; Robert R. Graham; Harinder Manku; Andrew K. Wong; John C. Whittaker; Patrick M. Gaffney; Kathy L. Moser; John D. Rioux; David Altshuler; Timothy W. Behrens; Timothy J. Vyse

January 1, 2008

Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins

Nucleic Acids Research, ISSN: 03051048 13624962

Jue Zeng; Jizhou Yan; Ting Wang; Deborah Mosbrook-Davis; Kyle T. Dolan; Ryan Christensen; Gary D. Stormo; David Haussler; Richard H. Lathrop; Rainer Brachmann; Shawn M. Burgess

January 1, 2008

In vivo imaging of mucosal CD4+ T cells using single photon emission computed tomography in a murine model of colitis

Journal of Immunological Methods, ISSN: 00221759

Bittoo Kanwar; Dong Wei Gao; Andrew B. Hwang; James P. Grenert; Simon P. Williams; Benjamin Franc; Joseph M. McCune

January 1, 2008

Ongoing sonic hedgehog signaling is required for dorsal midline formation in the developing forebrain

Developmental Neurobiology, ISSN: 19328451 1932846X

Monica Hayhurst; Bryan B. Gore; Marc Tessier-Lavigne; Susan K. McConnell

January 1, 2008

Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast

Molecular Biology of the Cell, ISSN: 10591524

Matthew J. Brauer; Curtis Huttenhower; Edoardo M. Airoldi; Rachel Rosenstein; John C. Matese; David Gresham; Viktor M. Boer; Olga G. Troyanskaya; David Botstein

January 1, 2008

Optimization approaches in the routine analysis of monoclonal antibodies by capillary electrophoresis

LC-GC Europe, ISSN: 14716577

Oscar Salas-Solano; Lynn Gennaro; Chantal Felten

January 1, 2008

The proteasome inhibitor bortezomib in combination with gemcitabine and carboplatin in advanced non-small cell lung cancer: A California Cancer Consortium phase I study

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Angela M. Davies; Christopher Ruel; Primo N. Lara; Derick H. Lau; Paul H. Gumerlock; Richard Bold; Stephen Shibata; Heinz-Josef Lenz; David P. Schenkein; David R. Gandara

January 1, 2008

The business case for energy management in high-tech industries

Energy Efficiency, ISSN: 1570646X 15706478

Evan Mills; Gary Shamshoian; Michele Blazek; Phil Naughton; Robert S. Seese; William Tschudi; Dale Sartor

January 1, 2008

Comparison of two approaches for handling missing covariates in logistic regression

Educational and Psychological Measurement, ISSN: 15523888 00131644

Chao-Ying Joanne Peng; Jin Zhu

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