Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 14101 - 14150 OF 15796 RESULTS

January 1, 1993

Triply Convergent Synthesis of 15-(Phenoxymethyl) and 4,5-Allenyl Prostaglandins. Preparation of an Individual Isomer of Enprostil

Journal of Organic Chemistry, ISSN: 15206904 00223263

Owen W. Gooding; Colin C. Beard; Gary F. Cooper; Jackson

January 1, 1993

Thermodynamic Analysis of an Antibody Functional Epitope

Biochemistry, ISSN: 15204995 00062960

Robert F. Kelley; Mark P. O'Connell

January 1, 1993

Peptide Stability in Drug Development: In vitro Peptide Degradation in Plasma and Serum

Annual Reports in Medicinal Chemistry, ISSN: 00657743

Powell

January 1, 1993

Identification and Structural Analysis of the Tetrasaccharide NeuAcα(2→6)Galβ(1→4)GlcNAcβ(1→3)Fucαl→O-Linked to Serine 61 of Human Factor IX

Biochemistry, ISSN: 15204995 00062960

Reed J. Harris; Basa; Victor Ling; Spellman; Van Halbeek; John Glushka; Kenneth J. Smith

January 1, 1993

Neurotrophin-4/5 is a mammalian-specific survival factor for distinct populations of sensory neurons

Journal of Neuroscience, ISSN: 02706474

Alun M. Davies; Antony Horton; Louis E. Burton; Charles H. Schmelzer; Richard L. Vandlen; Rosenthal

January 1, 1993

Overproduction of recombinant proteins by escherichia coli - employing the combinations of two and three different types of multicopy plasmids - in a 60-litre working volume airlift tower loop reactor

Process Biochemistry, ISSN: 13595113

Lutz Brandes; Xiaoan Wu; Hans E. Maschke; Karl Schügerl

January 1, 1993

The Human Erythrocyte Inflammatory Peptide (Chemokine) Receptor. Biochemical Characterization, Solubilization, and Development of a Binding Assay for the Soluble Receptor

Biochemistry, ISSN: 15204995 00062960

Richard Horuk; Timothy J. Colby; Darbonne; Thomas J. Schall; Kuldeep Neote

January 1, 1993

Vascular endothelial growth factor

Trends in Cardiovascular Medicine, ISSN: 10501738

Napoleone Ferrara

January 1, 1993

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

Nature, ISSN: 00280836

K.Jin Kim; Bing Li; Jane Winer; Armanini; Nancy Gillett; Phillips; Napoleone Ferrara

January 1, 1993

Difficulties in Precise Quantitation of CD4+T Lymphocytes for Clinical Trials: A Review

Biologicals, ISSN: 10958320 10451056

David T.W. Fei; Paxton; Chen

January 1, 1993

5‐Hydroxytryptamine Receptors

Journal of Neurochemistry, ISSN: 14714159 00223042

Peroutka

January 1, 1993

The molecular basis for growth hormone-receptor interactions

Recent Progress in Hormone Research, ISSN: 00799963

James A. Wells; Cunningham; Fuh; Henry B. Lowman; Bass; Michael G. Mulkerrin; Ultsch; Abraham M. Devos

January 1, 1993

Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: A model of glioblastoma multiforme pathophysiology

Molecular Biology of the Cell, ISSN: 10591524

Corey K. Goldman; Jin Kim; Wai Lee T. Wong; Vickie King; Tommy Brock; G. Yancey Gillespie

January 1, 1993

Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling

Journal of Immunology, ISSN: 00221767

Klaus Ley; Baker; Myron I. Cybulsky; Gimbrone Jr.; Francis W. Luscinskas

January 1, 1993

Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain

Journal of Biological Chemistry, ISSN: 00219258

Elisabeth T. Barfod; Yi Zheng; Wun-Jing Kuang; Matthew J. Hart; Tony Evans; Richard A. Cerione; Avi Ashkenazi

January 1, 1993

Engineering Fab' fragments for efficient F(ab)2 formation in Escherichia coli and for improved in vivo stability

Journal of Immunology, ISSN: 00221767

Maria L. Rodrigues; Snedecor; Christina Y. Chen; Wai Lee T. Wong; Shaily Garg; Gregory S. Blank; Daniel A. Maneval; Paul J. Carter

January 1, 1993

Structural and functional aspects of RGD-containing protein antagonists of glycoprotein IIb-IIIa

Current Opinion in Biotechnology, ISSN: 09581669

Lazarus; Robert S. McDowell

January 1, 1993

Synthetic chimeras of mouse growth factor‐associated glandular kallikreins. I. Kinetic properties

Protein Science, ISSN: 1469896X 09618368

Michael Blaber; Paul J. Isackson; Ralph A. Bradshaw; Burnier; James C. Marsters Jr.

January 1, 1993

Solution Structure of Human Type-α Transforming Growth Factor Determined by Heteronuclear NMR Spectroscopy and Refined by Energy Minimization with Restraints

Biochemistry, ISSN: 15204995 00062960

Franklin J. Moy; Yu-Chin Li; Peter Rauenbuehler; Winkler; Harold A. Scheraga; Gaetano T Montelione

January 1, 1993

Cysteine Pairing in the Glycoprotein IIbIIIa Antagonist Kistrin Using NMR, Chemical Analysis, and Structure Calculations

Biochemistry, ISSN: 15204995 00062960

Marc Adler; Paul J. Carter; Lazarus; Gerhard Wagner

January 1, 1993

Mapping of the Binding Interfaces of the Proteins of the Bacterial Phosphotransferase System, HPr and IIAglc

Biochemistry, ISSN: 15204995 00062960

Yuan Chen; Peter E. Wright; Jonathan Reizer; Milton H. Saier Jr.; Wayne J. Fairbrother

January 1, 1993

Assignment of 1H, 15N, and 13C Resonances, Identification of Elements of Secondary Structure and Determination of the Global Fold of the DNA-Binding Domain of GAL4

Biochemistry, ISSN: 15204995 00062960

Masahiro Shirakawa; Yasuharu Serikawa; Yoshimasa Kyogoku; Wayne J. Fairbrother; Peter E. Wright; Tadayasu Ohkubo

January 1, 1993

Expression, purification, and characterization of recombinant ornatin e, a potent glycoprotein iib-iiia antagonist

Protein Expression and Purification, ISSN: 10465928

Paul Mazur; Dennis; Jana L. Seymour; Lazarus

January 1, 1993

Crystallization and stoichiometry of binding of a complex between a rat intestinal Fc receptor and Fc

Journal of Molecular Biology, ISSN: 00222836

Andrew H. Huber; Robert F. Kelley; Louis N. Gastinel; Pamela J. Bjorkman

January 1, 1993

Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland

Endocrinology, ISSN: 19457170 00137227

Mark Feldman; Weifeng Ruan; Cunningham; James A. Wells; David Kleinberg

January 1, 1993

Homotypic leukocyte aggregation triggered by a monoclonal antibody specific for a novel epitope expressed by the integrin β1 subunit: Conversion of nonresponsive cells by transfecting human integrin α4 subunit cDNA

Journal of Cellular Biochemistry, ISSN: 10974644 07302312

John L. Bednarczyk; James N. Wygant; Margit C. Szabo; Laura Molinari‐Storey; Renz; Sherman Fong; Bradley W. McIntyre

January 1, 1993

Epstein-Barr virus-derived vectors for transient and stable expression of recombinant proteins

BioTechniques, ISSN: 07366205

Cachianes; Ho; Weber; Steven R. Williams; David V. Goeddel; Leung

January 1, 1993

L- and E-selectin can recognize the same naturally occurring ligands on high endothelial venules

Journal of Immunology, ISSN: 00221767

Mebius; Susan R. Watson

January 1, 1993

Substrate phage: Selection of protease substrates by monovalent phage display

Science, ISSN: 00368075

Matthews; James A. Wells

January 1, 1993

Determination of type I receptor specificity by the type II receptors for TGF-β or activin

Science, ISSN: 00368075

Reinhard Ebner; Ruey-Hwa Chen; Sean Lawler; Zioncheck; Rik Derynck

January 1, 1993

Optimizing binding and catalysis by phage display

Protein Engineering, Design and Selection, ISSN: 17410134 17410126

James A. Wells; Henry B. Lowman; Matthews

January 1, 1993

Effects of tumor necrosis factor-α treatment on mortality in murine cytomegalovirus-infected mice

Antiviral Research, ISSN: 01663542

Anderson; Yolanda S. Lie; Mari-Anne L. Low; Fennie

January 1, 1993

Bovine L-selectin: A peripheral lymphocyte homing receptor

Veterinary Immunology and Immunopathology, ISSN: 01652427

Bosworth; Dowbenko; Shuster; Harp

January 1, 1993

Models of human endocrine disorders in transgenic rodents

Trends in Endocrinology and Metabolism, ISSN: 10432760

Stewart

January 1, 1993

Genetic aspects of cancer

Advances in Human Genetics, ISSN: 0065275X

Goddard; Solomon

January 1, 1993

Inactivation of the IGF‐I Gene in Mice Results in Perinatal Lethality

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Powell-Braxton; Hollingshead; Giltinan; Sharon Pitts-Meek; Stewart

January 1, 1993

Purification, receptor binding analysis, and biological characterization of human melanoma growth stimulating activity (MGSA). Evidence for a novel MGSA receptor

Journal of Biological Chemistry, ISSN: 00219258

Richard Horuk; Yansura; Dorothea Reilly; Steven A. Spencer; James H. Bourell; William J. Henzel; Glenn C. Rice; Elaine N. Unemori

January 1, 1993

Production of monocyte chemotactic protein–1 in human type B synoviocytes. synergistic effect of tumor necrosis factor α and interferon‐γ

Arthritis and Rheumatism, ISSN: 15290131 00043591

Mohamed Hachicha; Palaniswami Rathanaswami; Thomas J. Schall; Shaun R. McColl

January 1, 1993

Blocking monoclonal antibodies to αVβ3 integrin: A unique epitope of αVβ3 integrin is present on human osteoclasts

Experimental Cell Research, ISSN: 00144827

Anan Chuntharapai; Bodary; Horton; K.Jin Kim

January 1, 1993

Molecular recognition in biological systems: From activation to inhibition

Biochemical Society Transactions, ISSN: 03005127

Anthony A. Kossiakoff; Thomas R. Hynes; De Vos

January 1, 1993

Comparison of the Permeability Characteristics of a Human Colonic Epithelial (Caco-2) Cell Line to Colon of Rabbit, Monkey, and Dog Intestine and Human Drug Absorption

Pharmaceutical Research, ISSN: 1573904X 07248741

Rubas; Nancy Jezyk; George M. Grass

January 1, 1993

The Relationship Between Powder Inhaler Resistance and Peak Inspiratory Conditions in Healthy Volunteers — Implications for In Vitro Testing

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung, ISSN: 15579026 08942684

Clark; Hollingworth

January 1, 1993

L-selectin-IgG chimera - In vitro and in vivo

Agents and Actions, ISSN: 00654299

Susan R. Watson

January 1, 1993

Strain specificity and binding affinity requirements of neutralizing monoclonal antibodies to the C4 domain of gp120 from human immunodeficiency virus type 1

Journal of Virology, ISSN: 0022538X

Nakamura; Randal A. Byrn; Denise M. Wilkes; Judy Fox; Hobbs; Hastings; Wessling; Michael A. Norcross; Brian M. Fendly; Berman

January 1, 1993

Crystal structure of the complex between human growth hormone and the extracellular domain of its reception

Biomedicine and Pharmacotherapy, ISSN: 07533322

De Vos

January 1, 1993

Melanoma growth-stimulatory activity/GRO decreases collagen expression by human fibroblasts. Regulation by C-X-C but not C-C cytokines

Journal of Biological Chemistry, ISSN: 00219258

Elaine N. Unemori; Edward P. Amento; Eugene A. Bauer; Richard Horuk

January 1, 1993

Signal transduction mediated by growth hormone receptor and its chimeric molecules with the granulocyte colony-stimulating factor receptor

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Etsuko Ishizaka-Ikeda; Rikiro Fukunaga; William I. Wood; David V. Goeddel; Shigekazu Nagata

January 1, 1993

Interleukin-8: A review

Cancer Investigation, ISSN: 07357907

Hébert; Baker

January 1, 1993

Application of the Periodic Bond Chain (PBC) Theory and Attachment Energy Consideration to Derive the Crystal Morphology of Hexamethylmelamine

Pharmaceutical Research, ISSN: 1573904X 07248741

Hartman; Chan

January 1, 1993

Inhibition of interferon-γ by an interferon-γ receptor immunoadhesin

Immunology, ISSN: 00192805

Haak-Frendscho; Scot A. Marsters; Steven M. Chamow; Peers; Simpson; Avi Ashkenazi

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