Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 15201 - 15250 OF 16048 RESULTS

January 1, 1990

Expression as trpE fusion

Methods in Enzymology, ISSN: 15577988 00766879

Yansura

January 1, 1990

Optimizing cell and culture environment for production of recombinant proteins

Methods in Enzymology, ISSN: 15577988 00766879

Mather

January 1, 1990

Expression of heterologous genes in Bacillus subtilis

Methods in Enzymology, ISSN: 15577988 00766879

Henner

January 1, 1990

Gene expression technology: Preface

Methods in Enzymology, ISSN: 00766879

David V. Goeddel

January 1, 1990

Molecular and Genetic Approach to Enhancing Protein Secretion

Methods in Enzymology, ISSN: 15577988 00766879

Chisholm; Christina Y. Chen; Simpson; Ronald A. Hitzeman

January 1, 1990

Macrophage deactivating factor and transforming growth factors-β1, -β2, and -β3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-γ

Journal of Immunology, ISSN: 00221767

Aihao Ding; Carl Nathan; Graycar; Rik Derynck; Dennis J. Stuehr; Srimal

January 1, 1990

Functional interaction among catalytic residues in subtilisin BPN′

Proteins: Structure, Function and Bioinformatics, ISSN: 10970134 08873585

Paul J. Carter; James A. Wells

January 1, 1990

Crystal structure of subtilisin BPN′ variants containing disulfide bonds and cavities: Concerted structural rearrangements induced by mutagenesis

Proteins: Structure, Function and Bioinformatics, ISSN: 10970134 08873585

Katz; Anthony A. Kossiakoff

January 1, 1990

From virus to vaccine: Recombinant mammalian cell lines as substrates for the production of herpes simplex virus vaccines

Journal of Medical Virology, ISSN: 10969071 01466615

Lasky

January 1, 1990

Synergistic induction of polypeptides by tumor necrosis factor and interferon‐gamma in cells sensitive or resistant to tumor necrosis factor: Assessment by computer based analysis of two‐dimensional gels using the PDQUEST system

Electrophoresis, ISSN: 15222683 01730835

Beresini; Sugarman; Shepard; Lois B. Epstein

January 1, 1990

Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160

Nature, ISSN: 00280836

Berman; Timothy Gregory; Riddle; Nakamura; Mark Champe; James P. Porter; Florian M. Wurm; Robert D. Hershberg; E. Kathy Cobb; Eichberg

January 1, 1990

Expression of recombinant proteins in Escherichia coli using an oxygen-responsive promoter

Nature Biotechnology, ISSN: 0733222X

Chaitan Khosla; Joseph E. Curtis; Pat Bydalek; James R. Swartz; James E. Baileya

January 1, 1990

Epidermal Growth Factor Receptor Cytoplasmic Domain Mutations Trigger Ligand-Independent Transformation

Molecular and Cellular Biology, ISSN: 02707306

Sharon Massoglia; Gray; Dull; Munemitsu; Hsing-Jien Kung; Schlessinger; Axel Ullrich

January 1, 1990

Recombinant murine interferon‐γ inhibits the fusion of mouse alveolar macrophages in vitro but stimulates the formation of osteoclastlike cells on implanted syngeneic bone particles in mice in vivo

Journal of Bone and Mineral Research, ISSN: 15234681 08840431

Agnès Vignery; Tracy Niven-Fairchild; Michael H. Shepard

January 1, 1990

Relaxin in the peri-implantation period

Journal of Clinical Endocrinology and Metabolism, ISSN: 19457197 0021972X

Dennis R. Stewart; Abbie Celniker; Clinton A. Taylor Jr.; Jeffrey R. Cragun; James W. Overstreet

January 1, 1990

Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor

Journal of Immunology, ISSN: 00221767

Virginia C. Broudy; Kaushansky; Sara G. Shoemaker; Aggarwal; John W. Adamson

January 1, 1990

Tissue plasminogen activator: The biochemistry and pharmacology of variants produced by mutagenesis

Annual Review of Pharmacology and Toxicology, ISSN: 00664251

Deborah L. Higgins; William F. Bennett

January 1, 1990

Engineering human prolactin to bind to the human growth hormone receptor

Science, ISSN: 00368075

Cunningham; Henner; James A. Wells

January 1, 1990

Biological properties of a CD4 immunoadhesin

Nature, ISSN: 00280836

Randal A. Byrn; Joyce Mordenti; Catherine Lucas; Smith; Scot A. Marsters; Jennifer S. Johnson; Cossum; Steven M. Chamow; Florian M. Wurm; Timothy Gregory; Jerome E. Groopman; Capon

January 1, 1990

Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C

EMBO Journal, ISSN: 02614189

Jakobovits; Rosenthal; Capon

January 1, 1990

Characterization of a soluble form of human CD4: Peptide analyses confirm the expected amino acid sequence, identify glycosylation sites and demonstrate the presence of three disulfide bonds

European Journal of Biochemistry, ISSN: 14321033 00142956

Reed J. Harris; Steven M. Chamow; Timothy Gregory; Spellman

January 1, 1990

Properties of a cleaved two‐chain form of recombinant human growth hormone

International Journal of Peptide and Protein Research, ISSN: 13993011 03678377

Eleanor Canova-Davis; Ida P. Baldonado; Moore; Rudman; William F. Bennett; William S. Hancock

January 1, 1990

A Sensitive Radioimmunoprecipitation Assay for the Detection and Quantitation of Antibodies to the Envelope Glycoprotein gp120 of the Human Immunodeficiency Virus (HIV-1)

AIDS Research and Human Retroviruses, ISSN: 19318405 08892229

Catherine Lucas; Peterson; Bennett; Frie; Berman; Chen

January 1, 1990

Serotonin Receptor “Families” in the Central Nervous System: An Overview

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Peroutka; ANNE W. SCHMIDT; Andrew J. Sleight; Harrington

January 1, 1990

Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes

Molecular and Cellular Biology, ISSN: 02707306

M. Andrew Hoyt; Stearns; David Botstein

January 1, 1990

The carboxy terminus of human immunodeficiency virus type 1 gp160 limits its proteolytic processing and transport in transfected cell lines

Journal of Virology, ISSN: 0022538X

Haffar; Nakamura; Berman

December 20, 1989

Purification of a ubiquitin protein peptidase from yeast with efficient in vitro assays

Journal of Biological Chemistry, ISSN: 00219258

Liu; Miller; William J. Kohr; Silber

December 20, 1989

Enzyme-linked bio-immunoassay for IFN-γ by HLA-DR induction

Journal of Immunological Methods, ISSN: 00221759

Ursula E.M. Gibson; Susan M. Kramer

December 1, 1989

Transgenic mice as a model to test the immunogenicity of proteins altered by site-specific mutagenesis

Molecular Biology and Medicine, ISSN: 07351313

Stewart; Hollingshead; Pitts; Chang; Martin; Oakley

December 1, 1989

Ectopic expression of interferon gamma and class II MHC induce the development of insulin-dependent diabetes mellitus in transgenic mice

Genes and gene products in the development of diabetes mellitus: proceedings of the 3rd Nordisk Insulin Symposium 'Genes ane gene products in the development of diabetes mellitus'. ICS866,

Sarvetnick; Liggitt; Stewart

December 1, 1989

Expression, purification, and characterization of recombinant BP53, the GH-dependent IGF binding protein

Insuline-like Growth Factor binding proteins: proceedings of a workshop on Insuline-like Growth Factor binding proteins. ICS881,

Mukku; Courter; Gorman; Parker; Larsen; William I. Wood

December 1, 1989

Expression of recombinant platelet glycoprotein IIbIIIa results in a functional fibrinogen-binding complex

Journal of Biological Chemistry, ISSN: 00219258

Bodary; Napier; McLean

November 15, 1989

Plasma desorption mapping of the tryptic digest of 23-kDa recombinant human growth hormone

Analytical Biochemistry, ISSN: 10960309 00032697

Ling Chen; Robert J. Cotter; Stults

November 1, 1989

Immunization procedures for E. coli proteins

Applied Biochemistry and Biotechnology, ISSN: 02732289 15590291

Vincent R. Anicetti; Martin A. Simonetti; Linda L. Blackwood; Andrew J.S. Jones; Chen

November 1, 1989

Characterization of recombinant human lymphotoxin (tumor necrosis factor-β) produced by a mammalian cell line

Archives of Biochemistry and Biophysics, ISSN: 10960384 00039861

Hains; Aggarwal

November 1, 1989

Mutational analysis of the conserved domains of a T-region border repeat of Agrobacterium tumefaciens

Plant Molecular Biology, ISSN: 01674412 15735028

van Haaren; Sedee; Herman A. de Boer; Schilperoort; Hooykaas

October 20, 1989

Crystallization and preliminary X-ray diffraction studies of bovine recombinant immune interferon

Journal of Molecular Biology, ISSN: 00222836

Rubin; Louis E. Burton

October 15, 1989

γ-Interferon-induced monocyte major histocompatibility complex class II antigen expression in individuals with acquired immune deficiency syndrome

Cellular Immunology, ISSN: 10902163 00088749

Otoniel Martínez-Maza; Ronald T. Mitsuyasu; Steven A. Miles; Janis V. Giorgi; Daniel F. Heitjan; Stephen A. Sherwin; John L. Fahey

September 8, 1989

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

Cell, ISSN: 00928674

Grace H.W. Wong; Jim H. Elwell; Larry W. Oberley; David V. Goeddel

August 11, 1989

The complete nucleotide sequence of the human gonadotropin-releasing hormone gene

Nucleic Acids Research, ISSN: 03051048

Hayflick; Adelman; Peter H. Seeburg

August 11, 1989

Expression of the H-ras proto-oncogene is controlled by alternative splicing

Cell, ISSN: 00928674

Justus B. Cohen; Susan D. Broz; Levinson

August 1, 1989

pH Dependence of the Reversible and Irreversible Thermal Denaturation of γ Interferons

Biochemistry, ISSN: 15204995 00062960

Michael G. Mulkerrin; Wetzel

July 1, 1989

Epidermal Growth Factor and Transforming Growth Factor a Bind Differently to the Epidermal Growth Factor Receptor

Biochemistry, ISSN: 15204995 00062960

Winkler; Lynn O'Connor; Marcy Winget; Brian M. Fendly

July 1, 1989

A phase I trial of recombinant human interferon-γ in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome (AIDS)

Journal of Clinical Immunology, ISSN: 02719142 15732592

H.Clifford Lane; Richard T. Davey Jr.; Stephen A. Sherwin; Henry Masur; Alain H. Rook; Jody F. Manischewitz; Gerald V. Quinnan; Phillip D. Smith; Margaret E. Easter; Anthony S. Fauci

June 21, 1989

Simple modification of a commercial flow cytometer to triple laser excitation. Simultaneous five-color fluorescence detection

Journal of Immunological Methods, ISSN: 00221759

John D. Woronicz; Glenn C. Rice

June 15, 1989

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

Biochemical and Biophysical Research Communications, ISSN: 10902104 0006291X

Napoleone Ferrara; William J. Henzel

June 15, 1989

Substance P primes human neutrophil activation: A mechanism for neurological regulation of inflammation

Biochemical and Biophysical Research Communications, ISSN: 10902104 0006291X

Axel Perianin; Ralph Snyderman; Bernard Malfroy

May 30, 1989

Multiple chromatographic forms of the formylpeptide chemoattractant receptor and their relationship to GTP-binding proteins

Biochemical and Biophysical Research Communications, ISSN: 10902104 0006291X

Paul G. Polakis; Tony Evans; Ralph Snyderman

May 30, 1989

Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: A member of a super family of zinc-metallohydrolases

Biochemical and Biophysical Research Communications, ISSN: 10902104 0006291X

Bernard Malfroy; Helen Kado-Fong; Claude Gros; Bruno Giros; Jean-Charles Schwartz; Renate Hellmiss

May 1, 1989

Native gel activity stain and preparative electrophoretic method for the detection and purification of pyridine nucleotide-linked dehydrogenases

Analytical Biochemistry, ISSN: 10960309 00032697

Jana L. Seymour; Lazarus

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